• Korean Journal of Environmental Biology
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• v.25 no.4
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• pp.289-296
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• 2007

Di-(ethyhexyl) phthalate (DEHP), commonly used as a plasticizer for manufacturing flexible vinyl products, has been the topic of extensive research, especially concerning endocrine disrupting properties. Metallothionein (MT) is a low molecular weight (6,000$\sim$7,000 Da), cysteine-rich (22$\sim$23%), metal-binding protein and is known to be induced by extrinsic factors such as chemical agents and stresses. Some of the known function of MT include detoxification of heavy metals and alkylating agents and neutralization of free radicals. Nonetheless, the definitive physiological function of MT are still unknown. This study was carried out to investigate the effects of DEHP on the ultrastructural changes and the expression of MT of the rat liver. The rats were orally intubated with either corn oil (experimental control) or 0.5 mg, 1.5 mg and 4.5 mg DEHP kg$^{-1}$ day$^{-1}$ in 0.5 mL of corn oil for 15 days before sacrificing and sampling. DEHP induced mild ultrastrctural changes of some cell organelles such as rough endoplasmic reticulum, mitochondria, lysosomes and peroxisomes in the rat liver treated with DEHP. In the respect of immunogold labelling and Western blotting, MT expression of the liver tissue was up-regulated by DEHP. In conclusion, DEHP has effects on the ultrastructures and hepatic function for MT expression in rat.

• Applied Microscopy
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• v.33 no.1
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• pp.41-48
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• 2003

The hemopoiesis in human fetal spleen was studied with transmission electron microscope. There were undifferentiated proerythroblast, basophilic erythroblast, polychromatophilic erythroblast, and acidophilic erythroblast. Besides, enucleated nuclei and mitoses were present. Groups of erythroblastic cells were surrounded by certain cell. The structure was identical to erythropoietic island found in fetal liver. So, erythropoisis in spleen was developing in a pattern similar to fetal liver. Megakaryobalst were found in spleen, but there was no mature cells, cells in mitosis nor platelet formation. It was not clear whether megakaryoblast in circulation was trapped in spleen or participated in megakaryopoiesis. In summary, erythropoiesis took place in fetal spleen in a pattern similar to fetal liver and bone marrow. But it was not certain whether megakaryopoiesis took place in fetal spleen.

• Journal of Soil and Groundwater Environment
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• v.14 no.3
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• pp.68-79
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• 2009

Groundwater is the main water resource in Jeju Island because storage of surface water in reservoir is difficult in the island due to the permeable volcanic rocks. Because of this reason, the groundwater is expected to be very vulnerable to seawater intrusion by global warming, which will cause sea level rise. The long term change of mean sea level around the Korean Peninsula including Jeju Island was analyzed for this study. The sea level rise over the past 40 years was estimated to be of $2.16\;{\pm}\;1.71\;mm/yr$ around the Korean Peninsula. However, the rising trend around the eastern part of Jeju Island was more remarkable. In addition, the groundwater/seawater intrusion monitoring network operated by the Jeju Special Self-Governing Province shows that seawater intrusion becomes more prominent during dry 4-5 months in a year when the sea level increases. This implies that the fresh groundwater lens in the eastern part of Jeju Island is influenced by the sea level rise due to global warming in the long term scale.

• Horticultural Science & Technology
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• v.18 no.3
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• pp.360-367
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• 2000

'Yumyeong' peach has desirable characteristics of long shelf-life and specific non-melting nature with long harvesting period. However, some fruits harvested too late tend to show fruit pithiness symptom or internal breakdown. The study was conducted to investigate the differences between fruit flesh pithiness and internal breakdown symptoms, and to find out inducing factors of flesh pithiness in 'Yumyeong' peach. The incidence of flesh pithiness was higher in the fruits harvested late. Sugar and malic acid contents were not different between normal fruits and flesh pithiness fruits, but the acidity was significantly lower affected by low citric acid content in flesh pithiness fruit. In flesh pithiness fruits, calcium contents were low in both skin and flesh. Occurrence of flesh pithiness fruits was high in the years with low precipitation and high temperature for 2 months before harvest. In observations on morphological characteristics, the parts showing flesh pithiness consisted of smaller cells than the normal parts. Tonoplasts were disintegrated and the number of dead cells was high in internal breakdown fruits, while the tonoplasts were intact with contracted vacuoles in flesh pithiness fruits. Tylosises were observed in vascular tissues around the flesh pithiness, therefore, it was assumed that those tylosises restricts flesh tissue development resulting in flesh pithiness. Other varieties such as 'Fantasia' and 'Wolmi' also showed tylosis and smaller cells were observed in the flesh tissue of these cultivars, indicating abnormal growth of the flesh part. These results suggested the possibility of the occurrence of pithiness like symptoms in other peach varieties.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.12 no.1
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• pp.49-53
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• 2012

X-linked adrenoleukodystrophy (ALD) is a rare inherited metabolic disease which results in impaired peroxisomal ${\beta}$-oxidation and the accumulation of very long chain fatty acids (VLCFA) in the adrenal cortex, the myelin of the central nervous system, and the testes. X-linked ALD is caused by mutations in the ABCD1 gene encoding an ATP-binding cassette transporter superfamily located in the peroxisomal membrane. This disease is characterized by a variety of phenotypes. The classic childhood cerebral ALD is a rapidly progressive demyelinating condition affecting the cerebral white matter before the age of 10 years in boys. We report the case of a 8-year-old with childhood cerebral X-linked ALD who developed inattention, hyperactivity, motor incoordination and hemiparesis. We diagnosed ALD with elevated plasma very long chain fatty acid level and diffuse high signal intensity lesions in both parieto-occipital white matter and cerebellar white matter in brain MRI. We identified a novel c.983delT (p.Met329CysfsX7) mutation of the ABCD1 gene. There is no correlation between X-ALD phenotype and mutations in the ABCD1 gene. Further studies for searching additional non-genetic factor which determine the phenotypic variation will be needed.

• Tunnel and Underground Space
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• v.19 no.4
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• pp.287-303
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• 2009

Rock mass in Baekrokdam at the summit of Hallasan in Jeju island is composed of two volcanic rock types: Baekrokdam trachybasalt at the eastern region and Hallasan trachyte at the western region. On-going rockfall and subsequent collapse of Baekrokdam wall rock are closely linked to the weathering of trachyte distributed in the western region of Baekrokdam. Samples of Hallasan trachyte showing different weathering grades had been collected and the polarizing microscopic observation, X-ray diffraction analysis and analysis for chemical weathering had been conducted. Formation of secondary minerals, especially clay minerals, by chemical weathering has not been identified, but the change of chemical weathering indices indicated that chemical weathering process had been proceeded to the degree for increasing and decreasing the contents of some chemical components. Changes in physical and mechanical rock properties due to weathering has also been examined. Artificial weathering test of freezing-thawing reveals that the process of crack initiation and propagation deteriorated the mechanical characteristics of Hallasan trachyte and $D_B$ = 1.5 or porosity = $20{\sim}21%$ would be the ultimate limiting value induced by the mechanical weathering processes.

• Korean Security Journal
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• no.17
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• pp.109-129
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• 2008

The purpose of this study is to analyze the relationship of market orientation, and business performance in the security firms. To achieve the goal of the study, it has used various methods to study. First of all, it has carried out documentary surveys through literatures review on market orientation and business performance of the security firms, and practical researches side by side. In the documentary surveys, it has developed the framework of study and questionnaires based on the domestic and foreign books, theses, materials of public institutions, and other materials. In the practical researches, basing on the selected study models and hypotheses, it has selected 15 security companies which are located in Seoul, Gyeonggi and Chungcheong Provinces with the stratified cluster random sampling method. It has polled the employees of the security companies for about 2 months from 5 August to 10 October 2006, distributing 20$\sim$50 pieces per company. It has distributed 600 pieces and used 565 pieces for analysis excepting unfaithful 35 pieces. The collected questionnaires were analyzed by SPSSWIN 14.0 program. and The methods to analyze the materials were factor analysis, reliability analysis, correlation analysis, multiple regression analysis, and path analysis through regression analysis. The results obtained from the study using analysis methods above are as follows. Finally, market orientation influences on business performance. In other words, the higher market orientation is, the better financial and non financial outcomes are.

• Journal of Plant Biotechnology
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• v.38 no.2
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• pp.162-168
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• 2011

High salinity is a common stress condition that adversely affects plant growth and crop production. In response to various environmental stresses, plants activate a number of defense genes that function to increase the tolerance. To isolate Arabidopsis genes that are involved in abiotic stress responses, we carried out genetic screening using various mutant lines. Among them, the blh8 ($\b{B}$EL1-$\b{L}$ike $\b{H}$omeodomain $\underline{8}$) mutant specifically shows chlorotic phenotypes to ionic (specifically, $Na^+$ and $K^+$) stresses, but no differences in root growth. In addition, BLH8 is related to plant development and abiotic stress as predicted by a Graphical Gaussian Model (GGM) network program. It implies that BLH8 functions as a putative transcription factor related to abiotic stress responses. Collectively, our results show that gene network analysis is a useful tool for isolating genes involved in stress adaptation in plants.

• Journal of Korea Water Resources Association
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• v.37 no.3
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• pp.219-231
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• 2004

The use of air diffuser system to ameliorate the reservoir by breaking stratification is now widespread. This study focuses on the hydrodynamic behavior of bubble plumes, which is the major mechanism of destratification and their combined effect of adjacent plumes on destratification efficiency. By introducing 2-phase Computational Fluid Dynamics(CFD) technique, we could suggest the optimal diffuser spacing having optimal destratification efficiency by simply analyzing the complex destratification procedures varying with the seasonal stratification intensity and bubble flow rate. Lab experiments were also carried out to verify CFD model in thermally stratified fresh water which quite differs from former researches using salts. This study showed that the mixing efficiency strongly depends on the spacing of neighboring plumes. When diffuser spacing is lower than 1.5 times the depth, the combined effect is stronger; as Plume Number(PN) is increased, the efficiency is strongly affected by spacing. If the distance is shorter than the depth of water, the efficiency increases linearly in proportion to PN. Otherwise, the efficiency increases non-linearly. These findings suggest that the combined effect should be more quantitatively taken into consideration for design and operation of air-diffuser destratification system, and recommend that the optimal destratification efficiency will be when plume number is 1000 and the spacing between neighboring diffusers is 1.5 times the depth.

• Proceedings of the Korea Water Resources Association Conference
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• 1998.02d
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• pp.1101-1179
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• 1998

최근에 내무부에서는 개발사업으로 인한 토사유출 피해 중 인명과 재산 피해와 같은 재해 성격을 가진 대규모 토사유출을 사전에 미리 저감시킬 목적으로 재해영향평가제를 도입하여 추진하고 있다. 이에 따라 건설 엔지니어링 업계에서는 대규모 개발 사업으로 인한 가속화된 토양손실량 예측과 침사지 설계에 많은 관심이 쏟아지고 있으나 이 분야의 기술축적과 자료부족으로 과업수행에 어려움을 겪고 있다. 본 강좌에서는 이러한 엔지니어링 업계의 기술적인 어려움을 다소 나마 해소할수 있도록 개발사업으로 인한 가속화된 토양손실량 예측방법과 침사지 설계 기준에 대해 외국의 자료를 바탕으로 그 동안 국내에서 수행한 각종 재해영향평가 자료를 검토하여 제시한다. 먼저, 재해영향평가제의 취지, 토사유출과 재해, 토사유출 재해 저감대책 등에 대해 간략히 설명한다. 다음, 침식량 예측 방법으로 미국의 범용토양 손실공식(USEL) 방법의 적용 절차에 대해 구체적으로 소개한다. 침사지 설계 편에서는 침사지 설계 개념과 구체적인 설계 절차를 제시하고 참사지 규모의 결정방법을 소개한다. 본 강좌의 교재는 미국교통연구단(TRB)의 국립합동도로연구프로그램(NCHRP)#70 자료를 주로 참고하였다. 이 자료는 부록에 원본 전부를 수록하였다. 다만 아직 이 분야 연구가 미흡한 관계로 본 강좌에서는 재해저감 측면에서 합리적인 침사지 설계 기준을 완전히 제시하지 못하고 있다. 참고로 국립방재연구소의 박무종/강대환 연구팀이 기존의 재해영향평가서 자료 중에서 10개를 선정하여 침사지 소요수면적 산정, USEL 적용, 강우침식도 R의 산정 등에 대해 사례 조사 분석한 결과를 부록에 수록하였다.을 기해야 한다. 있다. 청주권의 무심천도 계획상은 대청댐의 물을 공급 받을수도 있도록 되어 있으나 현실상으로 상수도 원수로서의 공급마저도 매년 심한 원수 수질 문제(5-6월, 10월경의 취수장 부근의 부영양화 현상으로 인한 악취와 물 맛의 문제)를 1984년부터 겪고 있다. 이와 같이 도시권 하천의 수자원은 자연적, 인위적, 경제적, 법적, 제도적 여러 제한 요소로서 특성을 가지고 있으며 이는 날로 심해 가고 있는 실정이다. 그러므로 최적 물관리 시스템의 개발이 새로이 시작하는 수자원 개발 사업에서는 계획 단계에서부터 절실히 요구되는 바이며 기존 시설물의 관리 운영은 과감히 그 운영 관리 기준을 보완 재 정비하여야 할 것이다. 지금까지 대부분의 수자원 종합 개발 계획이 홍수방이나 용수 공급 및 수력 개발 등에 주력하여 왔으나 이제는 보다 더 수자원의 환경 보전적 차원과 도시의 안정적 발달을 위한 지역 및 권역 계획과 연계지워져서 양적인 안정 공급과 더불어 질적인 향상과 연계지워서 경제-사회적 요구에 부응할 수 있도록 도시권의 수자원을 최적 관리할 수 있는 방안을 강구하여야 할 것이다. 이는 각 도시 하천의 수자원의 정량적·정성적인 특성 및 제한 요소를 충분히 감안하여 수요-공급 개념에 의하여 과감히 기존 시설(예: 팔당댐의 운영, 대청댐의 운영 등)의 관리 운영 체계를 개선하여 나가야 할 것이며, 수질 보전적-환경 보전 차원에서 저수관리 체계를 확고히 할 수 있는 방안을 강구하여야 할 것이다.펄스주입법에 의해 증착된 박박은 강유전성 이력을 나타내었다.지역과 비도시지역을 비교하는 조사 연구가 필요하며, 이러한 조사결과를 바탕으로 자녀의 식습관에 대