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Hemopoiesis in Human Fetal Spleen  

Kim, Dae-Jin (Department of Anatomy, College of Medicine, Chung-Ang University)
Sim, Kyu-Min (Department of Anatomy, College of Medicine, Chung-Ang University)
Kim, Sung-Su (Department of Anatomy, College of Medicine, Chung-Ang University)
Lee, Won-Bok (Department of Anatomy, College of Medicine, Chung-Ang University)
Kim, Kyung-Yong (Department of Anatomy, College of Medicine, Chung-Ang University)
Publication Information
Applied Microscopy / v.33, no.1, 2003 , pp. 41-48 More about this Journal
Abstract
The hemopoiesis in human fetal spleen was studied with transmission electron microscope. There were undifferentiated proerythroblast, basophilic erythroblast, polychromatophilic erythroblast, and acidophilic erythroblast. Besides, enucleated nuclei and mitoses were present. Groups of erythroblastic cells were surrounded by certain cell. The structure was identical to erythropoietic island found in fetal liver. So, erythropoisis in spleen was developing in a pattern similar to fetal liver. Megakaryobalst were found in spleen, but there was no mature cells, cells in mitosis nor platelet formation. It was not clear whether megakaryoblast in circulation was trapped in spleen or participated in megakaryopoiesis. In summary, erythropoiesis took place in fetal spleen in a pattern similar to fetal liver and bone marrow. But it was not certain whether megakaryopoiesis took place in fetal spleen.
Keywords
Fetus; Hemopoiesis; Human; Spleen; TEM;
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