• Journal of Korean Ophthalmic Optics Society
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• v.21 no.2
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• pp.137-146
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• 2016

Purpose: The relationship between retinal conditions such as macular thickness and retinal volume of the eyes with central serous chorioretinopathy(CSC) and visual acuity was investigated. Methods: A total of 136 eyes from 78 subjects was divided into 5 groups: CSC eyes under treatment and its asymptomatic contralateral eyes, fully cured CSC eyes after the diagnosis and its contralateral, and normal eyes. Their uncorrected visual acuity(UCVA), best corrected visual acuity(BCVA), retinal thickness and retinal volume were further examined. Results: All of UCVA, BCVA, retinal thickness and retinal volume of CSC eyes under treatment were significantly different from those of asymptomatic contralateral eyes, fully cured CSC eyes and normal eyes. BCVA of the asymptomatic contralateral eyes was not significantly different from it of normal eyes, however, its retinal thickness and volume were significantly different from those of normal eyes. Increased degree of retinal volume along with the increase of retinal volume was greater in CSC eyes and its asymptomatic contralateral eyes, fully cured CSC eyes and its contralateral eyes than normal eyes. Conclusions: From the present study, it was revealed that the retinal thickness and volume of asymptomatic contralateral eyes of CSC increase as well as CSC eyes, and the change of BCVA due to CSC occurs only when the retinal thickness and volume increase in some extent.

• The Journal of the Korea Contents Association
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• v.18 no.11
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• pp.655-664
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• 2018

Retina transforms the external light into electrical signal that stimulates visual cortex of the brain. Electrical modeling of the retina is useful to understand its structure and action that is a prerequisite to implement the retina as a hardware device. This paper introduces a 2-D electrical network model of vertebrate's retina considering signal pathway of retinal cells and synapses. We implemented a simulator of the retina based on the electrical network model to analyze its operation under various circumstances. Compared to the prior studies, It might contribute designing of artificial retina device in terms of that this study specifically observed input and output reactions of each cell and synapse node under various light intensity on the retina.

• The Monthly Diabetes
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• s.216
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• pp.36-38
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• 2007

당뇨가 오래되면 삶의 질을 떨어뜨리는 여러 가지 합병증들이 오게 되는데 그 중에서 시력을 위협하는 제일 심각한 합병증은 당뇨망막병증으로 이는 망막에 영양을 공급하는 혈관이상에 의해 발생하는 진행성 질환이다. 당뇨망막병증의 발생빈도는 당뇨의 유병기간과 밀접한 관계가 있다. 당뇨로 진단받고 5$\sim$10년이 지나면 25$\sim$50%가 망막병증이 생기고 15년이 지나면 거의 90%환자가 망막병증이 생긴다. 이밖에도 고혈압, 임신, 신장질환, 고지혈증과 같은 위험인자들이 있으며 어린이나 사춘기에 당뇨병이 있는 경우에는 조기에 망막병증의 빈도가 매우 높게 나타난다.

• Journal of the Institute of Convergence Signal Processing
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• v.5 no.1
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• pp.13-17
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• 2004

In order to measure the retina thickness, the retina photographing system and the multi-channel high speed image data acquisition system is developed. This system requires the optical processing techniques and the high speed image processing techniques. The HeNe laser beam is projected the retina in artificial eye and then we sensed the reflected laser signal using APD array. The laser projection system on retina using optical instruments is implemented. In order to project the plane laser beam on retina, laser photographing system used the polygon mirror for horizontal scanning and the galvano mirror for vertical scanning. We acquired retina images in each channel of APD array, transferred computer using PCI interface the image data after real-time A/D converting.

• Progress in Medical Physics
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• v.19 no.1
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• pp.73-79
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• 2008

Retinal prosthesis is regarded as the most feasible method for the blind caused by retinal diseases such as retinitis pigmentosa (RP) or age related macular degeneration (AMD). Recently Korean consortium launched for developing retinal prosthesis. One of the prerequisites for the success of retinal prosthesis is the optimization of the electrical stimuli applied through the prosthesis. Since electrical characteristics of degenerate retina are expected to differ from those of normal retina, we performed voltage stimulation experiment both in normal and degenerate retina to provide a guideline for the optimization of electrical stimulation for the upcoming prosthesis. After isolation of retina, retinal patch was attached with the ganglion cell side facing the surface of microelectrode arrays (MEA). $8{\times}8$ grid layout MEA (electrode diameter: $30{\mu}m$, electrode spacing: $200{\mu}m$, and impedance: $50k{\Omega}$ at 1 kHz) was used to record in-vitro retinal ganglion cell activity. Mono-polar electrical stimulation was applied through one of the 60 MEA channel, and the remaining channels were used for recording. The electrical stimulus was a constant voltage, charge-balanced biphasic, anodic-first square wave pulse without interphase delay, and 50 trains of pulse was applied with a period of 2 sec. Different electrical stimuli were applied. First, pulse amplitude was varied (voltage: $0.5{\sim}3.0V$). Second, pulse duration was varied $(100{\sim}1,200{\mu}s)$. Evoked responses were analyzed by PSTH from averaged data with 50 trials. Charge density was calculated with Ohm's and Coulomb's law. In normal retina, by varying the pulse amplitude from 0.5 to 3V with fixed duration of $500{\mu}s$, the threshold level for reliable ganglion cell response was found at 1.5V. The calculated threshold of charge density was $2.123mC/cm^2$. By varying the pulse duration from 100 to $1,200{\mu}s$ with fixed amplitude of 2V, the threshold level was found at $300{\mu}s$. The calculated threhold of charge density was $1.698mC/cm^2$. Even after the block of ON-pathway with L-(1)-2-amino-4-phosphonobutyric acid (APB), electrical stimulus evoked ganglion cell activities. In this APB-induced degenerate retina, by varying the pulse duration from 100 to $1200{\mu}s$ with fixed voltage of 2 V, the threshold level was found at $300{\mu}s$, which is the same with normal retina. More experiment with APB-induced degenerate retina is needed to make a clear comparison of threshold of charge density between normal and degenerate retina.

• Progress in Medical Physics
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• v.21 no.2
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• pp.209-217
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• 2010

Retinal prostheses are being developed to restore vision for the blind with retinal diseases such as retinitis pigmentosa (RP) or age-related macular degeneration (AMD). Since retinal prostheses depend upon electrical stimulation to control neural activity, optimal stimulation parameters for successful encoding of visual information are one of the most important requirements to enable visual perception. Therefore, in this paper, we focused on retinal ganglion cell (RGC) responses to different voltage stimulation parameters and compared threshold charge densities in normal and rd1 mice. For this purpose, we used in vitro preparation for the retina of normal and rd1 mice on micro-electrode arrays. When the neural network of rd1 mouse retinas is stimulated with voltage-controlled pulses, RGCs in degenerated retina also respond to voltage amplitude or voltage duration modulation as well in wild-type RGCs. But the temporal pattern of RGCs response is very different; in wild-type RGCs, single peak within 100 ms appears while in RGCs in degenerated retina multiple peaks (~4 peaks) with ~10 Hz rhythm within 400 ms appear. The thresholds for electrical activation of RGCs are overall more elevated in rd1 mouse retinas compared to wild-type mouse retinas: The thresholds for activation of RGCs in rd1 mouse retinas were on average two times higher ($70.50{\sim}99.87\;{\mu}C/cm^2$ vs. $37.23{\sim}61.65\;{\mu}C/cm^2$) in the experiment of voltage amplitude modulation and five times higher ($120.5{\sim}170.6\;{\mu}C/cm^2$ vs. $22.69{\sim}37.57\;{\mu}C/cm^2$) in the experiment of voltage duration modulation than those in wild-type mouse retinas. This is compatible with the findings from human studies that the currents required for evoking visual percepts in RP patients is much higher than those needed in healthy individuals. These results will be used as a guideline for optimal stimulation parameters for upcoming Korean-type retinal prosthesis.

• Progress in Medical Physics
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• v.18 no.1
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• pp.20-26
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• 2007

It is expected that synaptic construction and electrical characteristics In degenerate retina might be different from those In normal retina. Therefore, we analyzed the retinal waveform recorded with multielectrode array in normal and degenerate retina using principal component analysis (PCA) and Independent component analysis (ICA) and compared the results. PCA Is a well established method for retinal waveform while ICA has not tried for retinal waveform analysis. We programmed ICA toolbox for spatiotemporal analysis of retinal waveform. In normal mouse, the MEA spatial map shows a single hot spot perfectly matched with PCA-derived ON or OFF ganglion cell response. However In rd/rd mouse, the MEA spatial map shows numerous hot and cold spots whose underlying interactions and mechanisms need further Investigation for better understanding.

• The Monthly Diabetes
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• s.255
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• pp.12-17
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• 2011

최근 조사에 따르면 당뇨병 발병 10년을 기점으로 실명위험이 높아지는 것으로 분석됐다. 그 원인은 당뇨망막병증 때문. 대한안과학회가 지난 1년간 조사한 결과 당뇨병이 발병한 지 10년 이하의 환자들은 눈질환이 나타나지 않거나(25%), 비교적 실명위험이 적은 비증석성 당뇨망막병증(45%)이 발견됐다. 하지만 11년부터는 당뇨망막병증의 발생이 급격히 증가해 20년이 넘으면 최대 72%까지 그 위험성이 높아진다. 당뇨망막병증은 일단 발생하면 혈당조절이 잘 돼도 시력이 만힝 손상되고 교정도 힘들어 당뇨병에 걸리면 초기부터 안과진료를 받아 실명 위험을 줄여야한다. 이에 공안과에서 당부하는 당뇨망막병증에 관한 내용을 판화를 통해 쉽게 이해해보고자 한다.

• Proceedings of the Optical Society of Korea Conference
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• 2002.07a
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• pp.76-77
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• 2002

본 논문은 안과진료에 사용되는 3차원 망막영상 측정장비에 관한 것으로, 광학설계 프로그램(CODE-V)을 이용하여 망막영상에 대한 최적 설계를 검토하였다. 영상을 평면화 및 3차원화하여 보다 실제에 근접하게 하는 연구는 지속적으로 진행되고 있으며, 이러한 결과가 실제 적용되어 유용하게 사용되고 있다. 현재 안과에서 안구의 망막을 측정하는 대표적인 영상장비로 SLO가 있으며, 2차원의 망막영상이 모니터를 통해 보여지고, 환자의 망막영상을 보다 정밀하게 진단하고 있다. (중략)

• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.1
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• pp.96-101
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• 2004

In order to measure the retina thickness, there are to need the 3-D retina photographing and the high speed signal processing system. In this paper, we introduced the retina photographing system and the 16-channel high speed image data acquisition system. There are able to measure the retina thickness with sensing image the returned laser signal to APD sensor after there were projected the HeNe laser on retina. We developed the laser projection system to sense a reflected image of the retina using APD sensor, the 16-channel high speed A/D converter and PCI master interface card for image transmission into computer.