• Herbal Formula Science
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• v.20 no.2
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• pp.93-102
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• 2012

Objectives : Traditional medicine Gumiganghwal-tang (GT) has been used in Asia to treat inflammatory diseases including common cold, pain, fever, and algor. In this study we investigated the acute toxicity and safety of GT and fermented GT (FGT). Methods : Acute toxicity and safety were evaluated in male and female ICR mice orally administered 0 (control) and 2,000 mg/kg of GT and FGT. After the administration of GT and FGT, we observed mortality, body weight, clinical symptoms. After necropsy, organ weights were measured and blood analysis was performed. Results : There was no mortality and clinical symptoms according to the administration of GT and FGT. Comparing with control group, there were no significant alterations on the organ weight, complete blood cell count and biochemical parameters. Conclusions : Median lethal dose of GT and FGT considered to be over 2,000 mg/kg in both male and female mice, and recognized as safe with no toxicity.

• The Journal of Korean Medicine
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• v.32 no.1
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• pp.67-83
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• 2011

Objectives: The purpose of this study was to examine the single dose toxicity with oral administration and genotoxicities of Ssanghwa-tang fermented with Lactobacillus acidophyllus. Materials and Methods: Clinical signs, weight changes, lethal doses$(LD_{50})$, and postmortem evaluation were determined by Globally Harmonized Classification System(GHCS) in a single-dose oral toxicity study. In vitro mammalian chromosomal aberration test was conducted with Ames test by cell proliferation suppression assessment using the cultivated CHO-K1(Chinese hamster ovary fibroblast) origins. Bacterial reversion assay was performed using Salmonella typhimurium (TA98, TA100, TA1535, and TA1537) and Escherichia coli (WP2uvrA). In vivo micronucleus test was performed using ICR mouse bone marrow. Results: No clinical sign was observed and none of the groups with doses up to 2000 mg/kg showed significant acute oral toxicity in the single dose oral administration. None of the sample doses taken during the 6 to 18 hour groups showed significant aberrant metaphases comparing to the negative control group in the in vitro mammalian chromosomal aberration test. No evidence of mutagenicity was seen for Escherichia coli (WP2uvrA) or Salmonella typhimurium (TA98, TA100, TA1535, and TA1537). No significant increase in the frequency of micronuclei was seen in the micronucleus test. Conclusion: These results indicate that the $LD_{50}$ value of Ssanghwa-Tang fermented with Lactobacillus acidophyllus may be over 2000 mg/kg and it have no acute oral toxicity and genotoxicity.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.7
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• pp.1455-1462
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• 2012

In this paper, a BCD process based high-reliability 24-bit dual-port eFuse OTP Memory for PMICs is designed. We propose a comparison circuit at program-verify-read mode to test that the program datum is correct by using a dynamic pseudo NMOS logic circuit. The comparison result of the program datum with its read datum is outputted to PFb (pass fail bar) pin. Thus, the normal operation of the designed OTP memory can be verified easily by checking the PFb pin. Also we propose a sensing margin test circuit with a variable pull-up load out of consideration for resistance variations of programmed eFuse at program-verify-read mode. We design a 24-bit eFuse OTP memory which uses Magnachip's $0.35{\mu}m$ BCD process, and the layout size is $289.9{\mu}m{\times}163.65{\mu}m$ ($=0.0475mm^2$).

• Journal of Broadcast Engineering
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• v.13 no.4
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• pp.463-478
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• 2008

A Distributed Translator Network(DTxR) is a cost-effective and frequency-effective method which can use existing transmission utilities and can be constructed in a shorter time as compared with Multiple Frequency Network(MFN) or Single Frequency Network(SFN) using On Channel Repeater(OCR). In order to verify the feasibility of DTxR, this field test was done in 30 points of north-west area in Seoul using 3rd, 5th, and 6th generation DIV receivers. Electric field strength, noise margin and ease of reception were measured and subjective evaluation of video quality was done in these points during the field test. With the test result, an improvement of receiving quality was obtained and an ease of reception was increased in case of the 5th. and 6th. receiver. From the results, we conclude that DTxR is a feasible method in DIV networks.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.7
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• pp.1213-1223
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• 1994

VSATs(Very Small Aperture Terminals) have introduced new concepts in satellite business communications and are typically used in a star network configuration to provide information directly to the user`s premise. The characteristics of this system are low earth station costs, easy in stallation, compact, and very high flexibility for a varierty of applications (Credit Checks, Electronic Mail, Video Conferencing, Reservation System, Database Inquires, Order Entry, etc.). So, the requests of VSAT service have considerably enlarged. The link design of a VSAT network using Korea Sat. is discussed in this paper. This paper is intended to collect in a convient way the principle formula and reference data necessary to make overall performance calcurations and to calcurate antenna size. HPA power size and link margin of earth stations for satellite communications systems. Generally, because the antenna size of the Hub station in the VSAT system is bigger than the Remote station, the method of power allocations of inbound and outbound carriers is utilized in this paper. The size of Hub station and Remote station are assumed to be 3.7m and 1.2m. respectively.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.6A
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• pp.583-591
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• 2008

OFDM (orthogonal frequency division multiplexing) has serious problem of high PAPR (peak-to-average power ratio). Recently, CI/OFDM (carrier interferometry OFDM) system has been proposed for the low PAPR. However, CI/OFDM system shows another problem of ICI because of phase offset mismatch due to the phase noise. In this paper, to simultaneously reduce the PAPR and ICI effects, we propose an A-CI/OFDM (advanced-CT/OFDM). This method improves the BER performance by use of the margin of phase offset at CI codes. Propose system to reduce the effect the phase noise, even though it shows a little bit higher PAPR than conventional CI/OFDM, so we apply the PTS among the PAPR reduction techniques to proposed system to mitigate this problem. Therefore, it improves the total BER performance because the proposed method can decrease the effect of phase noise and get the gain in PAPR reduction performance. From the simulation results, we can show the performance comparison between the conventional OFDM, CI/OFDM and A-CI/OFDM.

• Herbal Formula Science
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• v.19 no.2
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• pp.73-82
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• 2011

Objectives : This study aims to investigate the acute oral toxicity and safety of Samsoeum (Shensuyin) extracts and fermented Samsoeum extracts. Methods : For that objective, we used ICR mice. ICR mice were administerd orally with dosage of 1250mg/kg, 2500mg/kg and 5000mg/kg of Samsoeum extracts and fermented Samsoeum extracts. Results : We daily examined number of deaths, clinical signs, body weights and gross findings for 2 weeks. 1. The results of acute oral toxicity using ICR mice showed that LD50 of value over 5000 mg/kg. 2. Samsoeum extracts and fermented Samsoeum extracts not affect on bodyweight gross findings of ICR mice. 3. The results of Serum chemistry analysis and Complete Blood Count(CBC) through the autopsy were showed normal range values. Conclusions : Samsoeum extracts and fermented Samsoeum extracts did not show any toxic effects in ICR mice. And oral LD50 value was over 5000mg/kg in ICR mice and it is very safe for ICR mice.

• Herbal Formula Science
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• v.17 no.2
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• pp.65-72
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• 2009

Objectives : Yukmijihwang-tang (YJT) is known as a tonifying formula for reinforcement of yin deficiency conditions. The present study was carried out to investigate the potential acute toxicity of YJT in ICR male and female mice. Methods : We investigated the acute toxicity about boiling water-extracted YJT. The test article was orally administered once by gavage to 20 male and 20 female mice at dose levels of 0 (control group), 1250, 2500 and 5000 mg/kg body weight. Mortalities, clinical findings, autopsy and body weight changes were monitored daily for the 14 days following the administration according to the Regulation of Korean Food and Drug Administration. Results : We observed survival rates, general toxicity, change of body weight, and autopsy. Single oral administration of YJT with different dosages, no animals died of the test drug. Autopsy of animal revealed no abnormal gross finding. Therefore, $LD_{50}$ value of YJT for ICR mice was more than 5000 mg/kg on oral route. Conclusions : These results suggest that no toxic dose level of YJT in mice is considered to be more than 5000 mg/kg. Consequently, it was concluded that YJT have no effect on acute toxicity and side effect in ICR mice.

• Environmental and Resource Economics Review
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• v.25 no.4
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• pp.495-516
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• 2016

This study empirically examines how asymmetric price adjustment of the retail gas price happens differently for various oil products, such as high-grade gasoline, regular gasoline, and diesel, by employing asymmetric error correction model within weekly data set from 2010~2015. Our estimation results show that the price adjustment, across the all oil types, predicated on shifting crude oil and wholesale oil prices is asymmetric. In addition, the duration of asymmetry was shorter in high-grade gasoline case than in other oil types. This took place by rapid price adjustment of high-grade gasoline price when faced with both cost increases and decreases, in comparison with regular gasoline and diesel cases. There results were attributed by characteristics of the consumer group and a high retail-wholesale margin of high-grade gasoline.

• Journal of Distribution Research
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• v.12 no.3
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• pp.91-109
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• 2007

This paper intends to examine the antecedents to the ex-post supply price cut which is typical retailer's unfair trade practices from three perspectives such as market power, efficiency, and retailer's tendency. For the empirical research, we analyzed manufacturer's 79 key account managers who have traded with domestic discount stores. As a result, the harder a retailer tries to increase sales and margin simultaneously, the more the retailer tends to use the ex-post supply price cut against manufacturers. In addition, the most frequent pattern of ex-post supply price cut occurs after retailer's discount at discretion. Finally, we suggest this research's implications, limitations of this research with future research directions.