• Journal of the Korean Society of Food Science and Nutrition
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• v.28 no.2
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• pp.444-451
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• 1999

We performed this study to determine the radioprotective effect of Sam Ryung Baek Chul San (San Ling Bai Shu San), as a prescription of traditional Oriental medicine, and its major ingredients. Jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were investigated in irradiated mice with high and low dose of rays. Sam Ryung Baek Chul San administration before irradiation increased the formation of endogenous spleen colony(p<0.05) and reduced the frequency of radiation induced apoptosis(p<0.05). In the experiment on the effect of ingredients of Sam Ryung Baek Chul San, the result indicated that the extracts of Panax ginseng, Poria cocos and Coix lacryma jabi might have the major radioprotective effects. Although the mechanisms of these inhibitory effects remain to be elucidated, these results indicated that Sam Ryung Baek Chul San might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

• Korean Journal of Agricultural Science
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• v.35 no.2
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• pp.147-153
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• 2008

This experiment was conducted to investigate the feed value of Phellinus linteus meal. The chemical composition and particle size of Phellinus linteus meal was determined, and investigated the effect of partial substitution(0, 5, 10 and 20%) of dried Phellinus linteus meal on metabolizability and serum IgG concentration of layers. Crude fiber content of Phellinus linteus meal was higher, and crude protein and crude fat contents were similar level compare to corn, barley, and wheat. Dry matter metabolizability of Phellinus linteus meal was lower in 10 and 20% treatment than those of 0 and 5% treatment significantly(p<0.05). But, Phellinus linteus meal did not affect concentration of serum IgG.

• The Journal of Korean Obstetrics and Gynecology
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• v.31 no.1
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• pp.122-137
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• 2018

Objectives: This study is to review the effect of Korean medicinal herbs on treatment of polycystic ovary induced rat models reported in domestic & foreign journals. Methods: 7 electronic databases (Pubmed, CNKI, EMBASE, Oasis, RISS, CENTRAL, Koreankt) were searched with term as polycystic ovary, and study reports on polycystic ovary impairment with Korean medicinal herbs. After selecting several studies, the analysis was focused on items reflected in the Rotterdam criteria for diagnosis of polycystic ovary syndrome such as hyperandrogenism (HA), ovarian weight, the number of follicle cysts, estrous cycles, and etc. Results: 15 studies were reviewed. As a polycystic ovary induction material, estradiol valerate (EV) was used in 9 studies, testosterone propionate (TP) in 2 studies and dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), Poretsky's method and letrozole (LE) was used in rest 4 studies, respectively. Tribulus terrestris (TT), Nardostachys jatamansi (NJ), Lycii cortex (LC), Cinnamomum cassia kees (CCK) and Atractylodis macrocephalae koidz (AMK) produced statistically significant results related to hyperandrogenism. In ovarian weight, Silybum marianum (SM), AMK and Alllium sativum (AS) were statistically significant. In the the number of follicle cysts, SM and TT were statistically significant. In estrous cycles, AMK, NJ, TT and Coix lacryma-jobi (CL) were statistically significant. Conclusions: Based on the diagnosis criteria of Rotterdam, TT, NJ, AMK, SM, AS, and CL produced statistically significant results in rat model.

• Feed Journal
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• v.4 no.7 s.35
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• pp.108-115
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• 2006

우리나라는 사계절이 뚜렷한 기후적 환경으로 여름철 한낮의 외부온도가 35℃ 이상이 되는 날이 계속되고, 야간에도 25℃ 이상인 열대야가 지속되는 날이 많다. 이러한 조건하에서 양돈 생산성 향상을 위해서는 돼지의 사육환경과 성장단계별 적절한 사양기술을 투입하여야만 한다. 돼지는 생리적으로 추위에 의한 영향보다는 여름철 더위에 의한 영향을 쉬게 받으며, 이로 인해 자돈의 쇠약, 압사,수태율 저하, 번식장애 등으로 생산성 저하의 원인이 되며, 사육기간 중에 일시적인 고온스트레스가 돼지가 생존하는 동안 능력의 저하를 초래하게 된다. 특히 하절기 양돈장은 우기와 무더위로 인한 돈사내 온도의 급상승과 더불어 습도의 불균형에 의한 환경적 스트레스로 번식능력과 생산성에 크게 영향을 미칠 수 있으며,돼지에 일시적인 고온 스트레스 피해는 장기간 계속되며, 생존하는 동안 능력저하를 초래하기 때문에 농장별 사육여건에 따른 성장저해 요인을 제거하는 안목이 필요한 계절이다. 즉,5~9월 모돈에 고온스트레스가 가해지면 11~12월, 다음해 1월 모돈의 분만율은 최저가 되고 , 이 시기에 생산된 자돈은 추운겨울을 이겨내야 함으로 육성률도 낮아지며, 이로 인해 4~7월의 출하성적은 최저가 되는 것이다. 따라서 모돈 관리는 5~9월이 집중관리가 필요한 시기이기도 하다. 고온 다습한 환경 하에서 어미돼지는 영양불균형과 생체리듬의 파괴로 인하여 신생자돈의 폐사가 증가할 수도 있고,이유 후 1주일 이내 발정 재귀율이 약 30%정도 감소하고 무발정돈이 많이 발생되며, 수태가 되어도 조기 배아사멸 및 흡수로 인하여 수태율이 25%까지 감소될 수 있다. 현재 국내 양돈농가에는 예년과 같이 돼지 조모성질환의 발생이 늘어나고 있고, 어려움을 겪고 있는 농장이 많은 것으로 조사 보고되어지고 있는데, 이는 농장에 사육되는 돈군이 외부환경에 대한 적응능력과 질병에 저항력이 부족하여 쉽게 질병에 노출되어 발생함으로 농장에는 돼지가 스트레스를 받지 않게 외부 환경과 사양관리 측면에 심혈을 기울려 강건한 축군을 유지하려는 노력이 무엇보다 우선되어져야 한다고 생각된다. 따라서 본고에서는 여름철에 돼지 스트레스를 줄이고 생산성을 향상시키기 위해 돼지의 생리변화와 돈사 급수설비와 사료관리 및 사육관리에 대해 알아보고자 한다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.28 no.3
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• pp.698-704
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• 1999

In this study, we evaluated the radioprotective effects of Kuei Pi Tang and its ingredients, as a prescription of traditional Oriental medicine. The jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were investigated in mice irradiated with high and low dose of ${\gamma}$ rays. In the mice administered with Kuei Pi Tang extract before irradiation, the jejunal crypts were protected significantly(p<0.005) and the frequency of radiation induced apoptosis was reduced(p<0.05). In the experiment on the effects of the ingredients of Kuei Pi Tang, the results indicated that the extract of Dangui(Angelica sinensis), Suanzaoren(Zizyphus valgaris), Rensan (Panax ginseng), Fuling(Poria cocos) and Muxiang(Saussurea lappa) might have a major radioprotective effect. Although the mechanisms of this inhibitory effect remain to be elucidated, these results indi cated that Kuei Pi Tang might be a useful radioprotector, especially since it is a relatively nontoxic natural product.

• Restorative Dentistry and Endodontics
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• v.36 no.2
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• pp.114-118
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• 2011

Objectives: This study was aimed to examine the patients' perception and satisfaction with the results of endodontic microsurgery which was apicoectomy with retrofilling. Materials and Methods: A questionnaire was given to 109 patients, who were recalled after a minimum of 3 months upon endodontic microsurgery in the Department of Conservative Dentistry, Yonsei University. A contingency table and correlation analysis were used to determine if there were any correlations between age/gender and the patients' responses (p = 0.05). Results: Approximately 60% of respondents answered they had never heard of surgical endodontic procedures. 63.3% of respondents chose the surgical option because they wanted to keep their natural teeth. If the patient required the same procedure on another tooth later, 100 out of 109 respondents answered they would choose microsurgery instead of extraction. Most patients (82.57%) appeared to be satisfied with the surgical procedure. Conclusions: Endodontic microsurgery consisting of apicoectomy and retrofilling seems to appeal to majority of patients as a satisfactory and valuable treatment choice.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.32 no.5
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• pp.637-641
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• 1999

This study was carried out to understand feeding ecology of black rockfish, Sebastes inermis in the coastal waters off Shinsudo, Sachon. The specimens were collected by angling, gill net, small danish seine, and long-bag net from February 1984 to May 1985. The fish consisted of 5 age groups from 0 to 4. Feeding activity was more intensive in the early morning and late afternoon in spring and summer, but the fish showed intermittent feeding activities in autumn and winter. Although the food items of the fish changed slightly by seasons and with growth of the fish, main food items were cope pods, gammarids, caprellids, carideans, polychaetes, and brachyurans. Of these food items, cope pods were major preys for the fish of age group 0, and gammarids over age group 1. Evenness and diversity of the food items increased as the fish grew. In consideration of feeding organs, digestive organs and stomach contents of the fish, S. inermis seemed to be not only carnivore but also visual feeder consuming mainly small crustaceans.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.25 no.4
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• pp.12-34
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• 2012

Objective : The purpose of this study is to survey the experimental studies for herbal simplexes of Anti-inflammatory Effects by reviewing oriental medicine journals since 2001. Methods : We collected 65 research papers on Oriental herbal simplexes medicines (herbs and Pharmacopunctures) of Anti-inflammatory effects in the internet site OASIS using the keyword 'Anti-inflammation'. Then we analyzed them according to published journals, years, and research methods, etc. Results : 65 papers in relation to Oriental herbal medicines of anti-inflammatory effects have been published in many kinds of journals and shows a tendency to increase recently. There are 60 cases of using herbal simplexes and 5 cases of Pharmacopuncture. Conclusions : This result will provide useful information of field of Oriental herbal medicine for the development and clinical use of anti-inflammatory related herb simplexes. In the future, we have to perform more studies such as clinical trial and research papers on developed design and herb-combined prescription study for anti-inflammatory effects.

• Journal of Physiology & Pathology in Korean Medicine
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• v.33 no.1
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• pp.39-47
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• 2019

Galgeun-tang (GGT) is a traditional herbal medicine generally used to treat cold, fever, headache, migraine and convulsion. To investigate the difference of ingredient and efficacy of GGT according to production method, mix extract powder and decoction, the quantities of index components, antioxidant and anti-inflammatory effects of two kinds of GGT formulation were compared. The contents of ten index components were simultaneously analyzed with HPLC. A HPLC method was developed and validated for the simultaneous determination. The GGT mix extract powder contained higher puerarin and daidzin content than the decoction, while the GGT decoction contained higher cinnamic acid and glycyrrhizic acid content than the mix extract powder. But ingredient of GGT mix extract powder and decoction was statistically very similar (r=0.8335). GGT decoction showed higher antioxidant effect than GGT mix extract powder, but the difference was low. The patterns of productions for NO, iNOS, COX-2, TNF-${\alpha}$, IL-$1{\beta}$ and IL-6 were decreased along the increasing dose of GGT formulation in LPS-induced RAW 264.7 macrophages. The inhibitory effects on NO, iNOS, COX-2, IL-$1{\beta}$ and IL-6 in Raw 264.7 cell were very similar to each other. The results obtained in this study could be used as fundamental data for verifying the equivalence and effectiveness of the herbal medicines.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.6
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• pp.235-241
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• 2021

Sogunjung-tang (SGJT) is traditional herbal prescriptions used to treat abdominal pain. In this study, we evaluated the effect on inflammation and gastritis through SGJT formulation development. SGJT composition herbal medicine was boiled in water at 95~100℃ for 3 hours and then concentrated. Sogunjung-tang mix soft extract (STM) was prepared using pharmaceutical excipients such as purified water, sodium benzoate, β-cyclodextrin and CMC-Na. Anti-inflammatory experiment was conducted using STM and lipopolysaccharide (LPS) in RAW 264.7 cells. Cell survival was measured by MTT method. Nitric oxide (NO) was measured using griess reagents, and pro inflammatory cytokines were measured by enzyme-linked immunosorbent assay and RT-PCR. Also, we verified STM validity in acute gastritis using the ICR mouse. STM was administered oral for three days. And 150 mM HCl in 60% ethanol was oral administered 0.5 mL one hour after the last drug administration. Mice were sacrificed 1 hour after 150 mM HCl in 60% ethanol administration. The gastric mucosa was visually observed. STM were not toxic in RAW 264.7 cells. Treatment of STM inhibited the production of NO and inflammatory cytokine at the protein and mRNA levels. Also, in the acute gastritis model with the mouse, the treatment of STM improved gastric mucosal bleeding and edema. In summary, it was confirmed that the treatment of STM exerts anti-inflammatory and anti-gastritis effects. Therefore, we suggest that STM may provide a preclinical evidence for the prevention and treatment of inflammatory and gastritis diseases.