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http://dx.doi.org/10.15204/jkobgy.2018.31.1.122

Effects of the Korean Medicinal Herbs for Treatment of Polycystic Ovary induced Rat Models: a Review  

Bae, In-Suk (Dept. of Korean Internal Medicine, Dong-Guk University Bundang Korean Medicine Hospital)
Kim, Eun-Seo (Dept. of Korean Internal Medicine, Dong-Guk University Bundang Korean Medicine Hospital)
Nam, Eun-Young (Dept of Korean Obstetrics & Gynecology, Dong-Incheon Gachon University Gil Korean Medicine Hospital)
Jung, Seung-Hyun (Dept. of Korean Internal Medicine, Dong-Guk University Bundang Korean Medicine Hospital)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.31, no.1, 2018 , pp. 122-137 More about this Journal
Abstract
Objectives: This study is to review the effect of Korean medicinal herbs on treatment of polycystic ovary induced rat models reported in domestic & foreign journals. Methods: 7 electronic databases (Pubmed, CNKI, EMBASE, Oasis, RISS, CENTRAL, Koreankt) were searched with term as polycystic ovary, and study reports on polycystic ovary impairment with Korean medicinal herbs. After selecting several studies, the analysis was focused on items reflected in the Rotterdam criteria for diagnosis of polycystic ovary syndrome such as hyperandrogenism (HA), ovarian weight, the number of follicle cysts, estrous cycles, and etc. Results: 15 studies were reviewed. As a polycystic ovary induction material, estradiol valerate (EV) was used in 9 studies, testosterone propionate (TP) in 2 studies and dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), Poretsky's method and letrozole (LE) was used in rest 4 studies, respectively. Tribulus terrestris (TT), Nardostachys jatamansi (NJ), Lycii cortex (LC), Cinnamomum cassia kees (CCK) and Atractylodis macrocephalae koidz (AMK) produced statistically significant results related to hyperandrogenism. In ovarian weight, Silybum marianum (SM), AMK and Alllium sativum (AS) were statistically significant. In the the number of follicle cysts, SM and TT were statistically significant. In estrous cycles, AMK, NJ, TT and Coix lacryma-jobi (CL) were statistically significant. Conclusions: Based on the diagnosis criteria of Rotterdam, TT, NJ, AMK, SM, AS, and CL produced statistically significant results in rat model.
Keywords
Polycystic Ovary Syndrome; Korean Medicinal Herbs; Rat Model; Review;
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