The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Effects of the Korean Medicinal Herbs for Treatment of Polycystic Ovary induced Rat Models: a Review

다낭성 난소 유발 rat에 단미 한약제가 미치는 영향에 관한 연구분석

  • Bae, In-Suk (Dept. of Korean Internal Medicine, Dong-Guk University Bundang Korean Medicine Hospital) ;
  • Kim, Eun-Seo (Dept. of Korean Internal Medicine, Dong-Guk University Bundang Korean Medicine Hospital) ;
  • Nam, Eun-Young (Dept of Korean Obstetrics & Gynecology, Dong-Incheon Gachon University Gil Korean Medicine Hospital) ;
  • Jung, Seung-Hyun (Dept. of Korean Internal Medicine, Dong-Guk University Bundang Korean Medicine Hospital)
  • 배인숙 (동국대학교 분당한방병원 한방내과) ;
  • 김은서 (동국대학교 분당한방병원 한방내과) ;
  • 남은영 (가천대학교 동인천부속길한방병원 한방부인과) ;
  • 정승현 (동국대학교 분당한방병원 한방내과)
  • Received : 2018.01.26
  • Accepted : 2018.02.14
  • Published : 2018.02.23
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Abstract

Objectives: This study is to review the effect of Korean medicinal herbs on treatment of polycystic ovary induced rat models reported in domestic & foreign journals. Methods: 7 electronic databases (Pubmed, CNKI, EMBASE, Oasis, RISS, CENTRAL, Koreankt) were searched with term as polycystic ovary, and study reports on polycystic ovary impairment with Korean medicinal herbs. After selecting several studies, the analysis was focused on items reflected in the Rotterdam criteria for diagnosis of polycystic ovary syndrome such as hyperandrogenism (HA), ovarian weight, the number of follicle cysts, estrous cycles, and etc. Results: 15 studies were reviewed. As a polycystic ovary induction material, estradiol valerate (EV) was used in 9 studies, testosterone propionate (TP) in 2 studies and dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), Poretsky's method and letrozole (LE) was used in rest 4 studies, respectively. Tribulus terrestris (TT), Nardostachys jatamansi (NJ), Lycii cortex (LC), Cinnamomum cassia kees (CCK) and Atractylodis macrocephalae koidz (AMK) produced statistically significant results related to hyperandrogenism. In ovarian weight, Silybum marianum (SM), AMK and Alllium sativum (AS) were statistically significant. In the the number of follicle cysts, SM and TT were statistically significant. In estrous cycles, AMK, NJ, TT and Coix lacryma-jobi (CL) were statistically significant. Conclusions: Based on the diagnosis criteria of Rotterdam, TT, NJ, AMK, SM, AS, and CL produced statistically significant results in rat model.

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References

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