• Title/Summary/Keyword: 기초의학

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An Analysis of the Research Trend of the Participants in Emotional Science in Korea (한국의 감성과학 연구참여분야 동향 분석)

  • Park, Seong-Bae
    • Science of Emotion and Sensibility
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    • v.15 no.1
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    • pp.29-36
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    • 2012
  • This study aims to analyse the research trend of the participants in Emotional Science in Korea and to suggest a desirable direction of research. I analysed the 1,262 articles published in Korean Journal of the Science of Emotion and Sensibility from 2000 to 2011 according to fields of study and keywords. The findings from the study are as follows. In the fields of study regarding Clothing Design, Psychology, Medicine, Visual Media, Brain Science they are still the top rated categories amongst participants. With the participation of Industrial Engineering and Ergonomics they have shown a meaningful difference depending on governmental support such as G7 Project. The problem with Industrial Design is that the majority of studies have been performed alone, and they have many keywords which are not related with Emotional Science. However, 31 new fields of study have been added to the research making the findings more desirable considering that Emotional Science is typical interdisciplinary filed of study. I hope that this study will provide basic data which can be used to promote the interdisciplinary research between the different fields of study in order to generate significant synergy.

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Genetic variance of Tuchomonns uaginclis isolates by Southern hybridization (Southern hybridization에 의한 질편모충의 유전학적 다양성)

  • 류재숙;민득영
    • Parasites, Hosts and Diseases
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    • v.36 no.3
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    • pp.207-212
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    • 1998
  • In the present study, genomic DNAs were purified from Korean isolates (KT8, KT6, KT-Kim and KT-Lee) and foreign strains (CDC85, IR78 and NYH 286) of 1Trichomonas voslnalis, and hybridized with a probe based on the repetitive sequence cloned from T. uqfinolis to observe the genetic differences. By Southern hybridization, all isolates of T. uoSinoLis except the NYH386 strain had 11 bands. Therefore all isolates examined were distinguishable into 3 groups according to their banding patterns; i) KT8, KT6 and KT-Kim isolates had 11 identical bands such as 1 kb, 1.2 kb, 1.6 kb, 1.9 kb, 2.3 kb. 27 kb, 3.2 kb, 2.4 kb, 3.8 kb, 4.9 kb and 6.0 kb, ii) The metronidazole-resistant IR78 strain had the some bands as KT-Lee isolate at bands of 1 kb, 1.2 kb, 1.6 kb. 1.8 kb, 2.1 kb, 2.5 kb, 2.7 kb, 2.9 kb, 3.4 kb, 5.0 kb and 6.0 kb, Bands of CDC85, metronidazole-resistant strain, were similar to those of IR78 and KT-Lee, except that 3.2 kb replaced 2.9 kb. iii) NYH286 particularly had 12 bands and bun patterns were similar to IR78 with a few exceptions as follows; i) 6.2 kb in place of 6.0 kb, ii) 2.0 kb and 2.2 kb instead of 2.1 kb. Through the results obtained, genetic variance of T. uoginnlis isolates was demonstrated by Southern hybridization.

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Isolation and identification of Cyuptosporidium from various animals in Korea (한국산 동물로부터 크립토스포리디움의 분리 및 동정 III. 닭으로부터 Cryptosporidium baileyi의 분리)

  • Lee, Jae-Gu;Seo, Yeong-Seok;Park, Bae-Geun
    • Parasites, Hosts and Diseases
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    • v.29 no.4
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    • pp.315-324
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    • 1991
  • Each of SPF chicken(Hi-Line strain, 2-day-old males) was inoculated with 2.5 or $5\times10^4$ oocysts by stomach tube. The oocyst was the medium type of Cryptosporidium previously isolated from Korean chicken origin, and passed in 2-day-old SPF chicken. The patterns of oocyst discharge were monitored daily, and in order to observe the ultrastructure of the developmental stages, the bursa of Fabricius of the chicken was examined by transmission electron microscopy (TEM) on the 12th day postinoculation. The prepatent period for 8 chicken was 5.9 days postinoculation on the average, and the patent period was 12.9 days. The number of oocysts discharged per day for the chicken was reached peak on day 12 postinoculation on the average. A large number of oocysts was found in fecal samples obtained from inoculated chicken on days 8~14 postinoculation. The ultrastructural feature of almost every developmental stage of the medium type from chicken was very similar to that of Cryptosporidium previously isolated from mammalia including human and birds except for the attachment site of C. tsuris to the mucus cell from mammalia, but dimension of the oocysts from fecal samples of the medium type was different from those of C. meleagridis and mammalia origin. The above results reveal that the medium type of Cryptosporidium of Korean chicken origin is identified as Cryptosporidium baileyi.

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The Recurrent Pregnancy Loss Associated with a Female Carrier of a Structural Chromosome Rearrangement (염색체 구조적 이상을 가진 산모의 재조합에 의한 태아의 비정상 핵형분석결과의 증례보고)

  • Lee, Soo-Min;Go, Sang-Hee;Jo, Soo-Kyung;Park, So-Hyun;Moon, Soo-Jin;Lee, Dong-Suk;Kim, Ki-Chul;Hwang, Do-Yeong
    • Journal of Genetic Medicine
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    • v.7 no.2
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    • pp.156-159
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    • 2010
  • Inversion, one of the balanced rearrangements, usually does not lead to phenotypic abnormalities; all genetic information exists in the proper amount, merely in a different order or in an abnormal location. However, offspring of an inversion carrier is at risk of chromosomal imbalance because an inversion loop can be formed during crossing-over of the paternal and the maternal chromosomes in meiosis. We report a 38-year-old woman with inversion and balanced translocation and her fetus with unusual rearrangement causing chromosomal imbalance. We performed conventional cytogenetic analysis, MLPA, and subtelomeric FISH in the cells of the embryo. The results showed that the distal portion of chromosome 13q was added to the terminal portion of chromosome 9p during crossing-over. Therefore, the final karyotype of the fetus was 46,XY,rec(9)t(9;13)(p22;q32)inv(9)(p12q13)mat, confirmed using molecular-cytogenetic analyzing tools.

About Streptococcosis of Cultured Olive Flounder, Paralichthys olivaceus in South Korea (국내 양식 넙치에서 발생하는 연쇄구균병에 관하여)

  • Lee, Nam-Sil;Min, Eunyoung;Kim, Kwang Il;Choi, Hye Sung;Jung, Sung-hee;Cho, Miyoung
    • Journal of Marine Life Science
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    • v.5 no.1
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    • pp.1-8
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    • 2020
  • This review is about current Streptococcosis of cultured olive flounder, Paralichthys olivaceus, in South Korea. The main bacterial species are Streptococcus iniae, S. parauberis and Lactococcus garvieae. The occurrence trend has been arranged with published data and seed bank (NIFS) data that was examined with deposited strains and the number from 2002 to 2017. S. iniae and L. garvieae were collected until 2012 and 2002, respectively, but not collected any more after that year. In recent years, the dominant strain of Streptococcosis of cultured olive flounder is S. parauberis. The phenotypic and genetic characteristics of standard strains and isolated strains were examined with published paper. Notably, we describe about distinguishing gross signs and histological signs of 3 types of Streptococcosis in this report. White turbidity of eye, hemorrhage, enteritis and ascites are main signs of S. iniae infection. Darkness of body surface, hemorrhage in somatic muscle and pericarditis are predominant in occasion S. parauberis infection. In occasion of L. garvieae infection, common signs of Streptococcosis are revealed, but these are weak tendency compared with the previous two cases.

Needs for Community Health Promotion Courses of the Traditional Korean Medicine among One Metropolitan Citizens (일개 광역시민의 지역사회 한의약 건강증진 강좌에 대한 수요)

  • Kim, Ae-Ran;Lee, Sang-Hun;Lee, Moo-Sik
    • Journal of the Korea Convergence Society
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    • v.10 no.3
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    • pp.105-113
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    • 2019
  • This study was conducted with 500 citizens of one metropolitan city to prepare foundational data for the opening of health promotion course of traditional korean medicine. A questionnaire examined participants' general characteristics and their experience with and awareness of oriental treatment and a survey on the need for health promotion course of traditional korean medicine were used as the research tools. Results showed that 56.8% of respondents had an experience with oriental treatment over the last year. Participants who responded that oriental treatment was effective accounted for 72.3%. Respondents selected "subject and contents of class" (59.1%) as the important factor in attending the oriental health promotion course, and cardiovascular disease (23.7%) as the disease they wanted to learn about. They considered "self-health care method for diseases" (69.0%) as what they expected most from the class. The results of this study will be useful when planning health promotion course of traditional korean medicine to satisfy the participants' needs.

Investigation of Microbial Communities in Sulculus diversicolor supertexta Through 16S rRNA Sequencing and Antibacterial Monitoring of Harmful Strains (16S rRNA 염기서열 분석을 통한 오분자기(Sulculus diversicolor supertexta)내 미생물 군집 조사 및 인체유해 질병세균에 대한 항균활성 모니터링)

  • Kim, Min-Seon;Lee, Seung-Jong;Heo, Moon-Soo
    • Journal of Life Science
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    • v.28 no.12
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    • pp.1477-1488
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    • 2018
  • This study investigated the muscles, intestines, and gonads of Sulculus diversicolor supertexta to examine the diversity of microbial communities within examples collected from the Jeju Coast. Using different media, initial pure isolation in MA, 1% BHIA, and 1% TSA indicated that the muscles, intestines, and gonads supported more communities, respectively. In analysis of relative similarity with 16s rRNA sequencing, 190 pure colonies were isolated, and further analysis with NBLAST identified 71 species, 39 genera, 25 families, and five phyla. Homogeny with the reference strain was 91-100%. Microbial communities in S. supertexta consisted of gamma and alpha Proteobacteria (48%), Actinobacteria (32.5%), Firmicutes (16.9%), Deinococcus-Thermus (1.3%), and Bacteroides (1.3%). In all tissue, Psychrobacter cibarius in Moraxellaceae was dominant. Alteromonadaceae, Enterobacteriaceae, Pasturellaceae, Moraxellaceae, Rhodobacteraceae, Geminicoccaceae, Dietziaceae, Intrasporangiaceae, Microbacteriaceae, Micrococcaceae, Micromonosporaceae, Streptomycetaceae, Aerococcaceae, Bacillaceae, Paenibacillaceae, Planococcaceae, and Staphylcoccaceae were commonly isolated across all tissues, and Flavobacteriaceae, Corynebacteriaceae, Yesiniaceae, Vibrionaceae, Hahellaceae, Pseudomonadaceae were also identified from the intestines. In microbial monitoring of four harmful bacteria, Streptomyces albus (96%) showed antibacterial activity against all four strains, and Agrococcus baldri (99%) and Psychrobacter nivimaris (99%) presented against E. Coli and E. aerogens. In addition, some strains with low homogeny were isolated and further experiments are therefore required, for example to refine the antimicrobial substances including new strain investigations. These additional experiments would aim to establish generic resources for the microbial communities in S. Supertexta and provide basic data for applied microbiological research.

Clinical Usefulness of Ultrasonography in the Diagnosis of Fatty Liver (지방간 진단에 있어 초음파 검사의 임상적 유용성 연구)

  • An, Hyun;Lee, Hyo Yeong
    • Journal of the Korean Society of Radiology
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    • v.13 no.3
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    • pp.349-357
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    • 2019
  • The purpose of this study was to evaluate the clinical significance of ultrasonographic classification of fatty liver in three grades. From June 2018 to April 2019, 1047 patients (818 males and 229 females) diagnosed as fatty liver among 3607 patients who underwent abdominal ultrasonography at Busan screening center. Ultrasonography was classified into three grades: Grade I (mild fatty liver), Grade II (moderate fatty liver), and Grade III (severe fatty liver) according to the degree of parenchyma texture, acoustic attenuation, Obesity index, hematological test, and metabolic syndrome. The average age of men in each sex increased with the increase of the fatty liver. Body mass index (BMI) and waist circumference were significantly increased in both men and women (p=.000). hematological analysis showed that AST, ALT, ${\gamma}-GTP$, TG, fasting blood sugar, and glycated hemoglobin were significantly different from each other (p<.05). In women, ALT, ${\gamma}-GTP$ and TG showed a significant difference with increasing fatty liver (p<.05). The prevalence of metabolic syndrome was significantly increased in both sexes as the grade of fatty liver increased (p=.000). Based on the results of this study, it is suggested that the use of ultrasound - guided fatty liver according to severity may be useful for the treatment and follow - up of fatty liver if the liver grade is divided in consideration of hematological variables and metabolic syndrome.

Classical testing based on B-splines in functional linear models (함수형 선형모형에서의 B-스플라인에 기초한 검정)

  • Sohn, Jihoon;Lee, Eun Ryung
    • The Korean Journal of Applied Statistics
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    • v.32 no.4
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    • pp.607-618
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    • 2019
  • A new and interesting task in statistics is to effectively analyze functional data that frequently comes from advances in modern science and technology in areas such as meteorology and biomedical sciences. Functional linear regression with scalar response is a popular functional data analysis technique and it is often a common problem to determine a functional association if a functional predictor variable affects the scalar response in the models. Recently, Kong et al. (Journal of Nonparametric Statistics, 28, 813-838, 2016) established classical testing methods for this based on functional principal component analysis (of the functional predictor), that is, the resulting eigenfunctions (as a basis). However, the eigenbasis functions are not generally suitable for regression purpose because they are only concerned with the variability of the functional predictor, not the functional association of interest in testing problems. Additionally, eigenfunctions are to be estimated from data so that estimation errors might be involved in the performance of testing procedures. To circumvent these issues, we propose a testing method based on fixed basis such as B-splines and show that it works well via simulations. It is also illustrated via simulated and real data examples that the proposed testing method provides more effective and intuitive results due to the localization properties of B-splines.

Influences of the Global Deterioration Scale according to Routine Blood Chemistry Results (통상적 혈액화학 결과에서 전반적 퇴화 척도의 영향성)

  • Kim, Sun-Gyu;Park, Chang-Eun
    • Korean Journal of Clinical Laboratory Science
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    • v.51 no.3
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    • pp.351-359
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    • 2019
  • Neurocognitive testing commonly uses the MMSE (Mini-Mental State Examination) to evaluate the overall cognitive function of patients at outpatient clinics, but the MMSE has recently been extensively used in the SNSB II (Seoul Neuropsychological Screening Battery II) for making diagnoses. We retrospectively investigated the results of routine neurocognitive tests and the results of the blood tests of 120 elderly patients who had been referred to a South Central Medical Center from 2017 to 2018 and who had been examined at a public health center. These subjects' space-time capability was high on the sub-region of the global deterioration scale (GDS). GDS showed a significant increase as the Na decreased on the electrolyte analysis. The subjects' concentration, their language-based orientation for space and time, their memory, and their scores for the frontal lobe function on GDS showed statistically significant reductions (P<0.001) For the normal and abnormal groups according to the ALT and creatinine levels, the frontal/execute function areas showed statistically significant differences (P<0.001) as well as negative correlation between GDS and ALT (P<0.01). In conclusion, this study provides basic information to develop test items that are important for patient screening and diagnosis, and several routine blood chemistry factors provide basic information for diagnosing and assessing the status and progress of cognitively impaired patients.