• Title/Summary/Keyword: 기초의학

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Development of a Methodology for Oxygen Partial Pressure Increase : Example of Veterinary Hyperbaric Chambers (고압산소챔버 내의 산소분압 적정 증가 방안 개발 : 동물실험용 챔버 대상)

  • Wang, Soon-Joo;Kim, Eun;Kang, Pooreun
    • Proceedings of the Korean Society of Disaster Information Conference
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    • 2023.11a
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    • pp.351-352
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    • 2023
  • 동물용 고압산소치료 시 산소를 통한 가압은 이미 있는 공기를 제거하고 산소로 대치시키는데 효율성이 떨어져서 100%에 가까운 산소분압을 구현하는데 어려움이 있고, 그 방법도 표준화되지 않았다. 따라서 어떠한 방식의 산소가압이 신속하고 효율적으로 100%에 가까운 산소분압을 구현할 수 있는지에 대한 방안을 개발하고 표준화할 필요가 있다. 동물용 고압산소치료를 활용한 동물실험이나 동물의 치료 중 가압 단계에서 간헐적 환기 방법이 더 신속하게 100%에 가까운 산소 분압을 보이므로 향후 표준 지침 개발을 위한 중요한 기반 연구와 제안으로 활용 가능하다. 이는 재난 기반으로의 고압산소챔버의 활용을 위한 기초 자료가 될 것이다.

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Analysis of research trends in mushroom science in North Korean journals (1978-2023) (북한 학술지에 게재된 버섯과학 연구동향 분석(1978~2023))

  • Woo-Sik Jo
    • Journal of Mushroom
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    • v.21 no.3
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    • pp.93-100
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    • 2023
  • In this study, research trends in mushroom science were examined using North Korean journal articles published in 1978-2023. Researchers in each field reviewed 450 papers and finally selected 429 papers, excluding 21 papers classified in different fields. The number of researchers was 872, and the number of authors per paper was 2.03. Kim Cheol-Hak published the most academic papers in the field of mushroom science in North Korea, with 12 papers. The number of research articles increased annually, from 7 in 1985, 12 in 1998, 11 in 2008, and 27 in 2020, and has especially increased rapidly since the mid-2010s. The study by mushroom type was as follows: 42 pine mushrooms (17.8 %), 25 oyster mushrooms (10.6 %), 23 Ganoderma sp. (9.8 %), 19 shiitake mushrooms (8.1 %), 17 button mushrooms (7.2 %), and 16 manna lichens (6.8 %). This study is considered meaningful in reviewing the research status and technology level in North Korea through analyzing North Korean academic journals in the field of mushroom science for the first time.

Technological Convergence Trend through Patent Network Analysis: Focusing on Patent Data in Korea, U.S., Europe, and Japan (특허 네트워크 분석을 통한 융합 기술 트렌드 분석: 한국.미국.유럽.일본의 특허데이터를 중심으로)

  • Baek, Hyun Mi;Kim, Myung Seuk
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.8 no.2
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    • pp.11-19
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    • 2013
  • Many companies are developing a numerous number of new products and business models for their sustainable growth. First, their unique technological capability needs to be obtained to develop new products and services. However, as the applicable period of a technology into its industrialization becomes shorter and shorter, the necessity of technological convergence is increasing. Therefore, this study aims to look at the patent status in Korea for the last ten years to analyze in which direction technological convergence had advanced and further compare the patent status in Korea with that in U.S., Europe, and Japan. In addition, this study looks at the impact of converged patent technology on the sales in relevant industries. To this end, this study collected 5,000 patents applied from 2000 to 2009 for the last ten years in Korea, U.S., and Europe every year and conducted network analysis by using UCINET, social network analysis program. In this study, we drew our research findings as follows: First, we could find that technological convergence increased over time and what technology was in the center of fusion. Second, our correlation analysis found that as we had more technological convergence, it was more related to the sales in relevant industries.

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The Association of Asthma and Osteoporosis in the Residents of the Local Community (지역사회 주민을 대상으로 한 천식과 골다공증과의 연관성)

  • Park, Kyung-Yong;Lee, Sok-Goo
    • Journal of agricultural medicine and community health
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    • v.34 no.3
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    • pp.316-323
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    • 2009
  • Objectives: Corticosteroids, usually as an inhaled form, are usually used to treat narrowed airway in the treatment of asthma. However, the use of corticosteroid commonly associated with the development of osteoporosis. In this study, we studied the association of asthma and osteoporosis in the residents of the local community. Methods: As a part of the Local Community Health Study Chungnam 2008, the residents are surveyed with the formal questionnaire. We analyzed the association between asthma and osteoporosis data with the questionnaire. Results: We analyzed total 6,348 data from the residents in Chungnam province. Of them, 203(3.2%) were asthma patients and 465(7.3%) were osteoporosis patients. Patients with asthma have more advanced age(p<0.001), higher incidence of hypertension(p<0.001) and diabetes(p=0.001), lower incidence of exercise(p=0.002) and economic activity(p<0.001). Patients with osteoporosis have more advanced age (p<0.001), female predominance(p<0.001), higher incidence of hypertension (p<0.001), diabetes(p=0.001), and fractures (p<0.001), lower incidence of exercise (p=0.002) and economic activity (p<0.001). In total population, asthma is associated with the increased incidence of osteoporosis, especially in patients treated with anti-asthmatic medications. Conclusions: Through this study, we demonstrated the presence of asthma is closely associated with the increased incidence of osteoporosis, especially in patients treated with anti-asthmatic medications. Therefore, further and broad study will be needed to evaluate the association of asthma and the types of anti-asthmatic medications in the development of osteoporosis.

The Basic Study on the Preventive Measures against Medical Accident Induced by Acupuncture and Moxibustion Therapy I. A Literature Research on the Essence of Prohibitive Acupuncture Point, Jīn-Zhėn-Xué-Gė (禁鍼穴歌) (침구 의료행위에 기인하는 의료사고 예방에 관한 기초적 연구 (I) - 금침혈가에 관한 문헌적 고찰 -)

  • Moon, Jin-Young
    • The Journal of Dong Guk Oriental Medicine
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    • v.8 no.2
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    • pp.175-199
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    • 2000
  • Acupuncture and moxibustion play an important role not only in the medical service and health care of Korea, China and japan but also in those of many western countries such as Germany, France, United States of America. An unexpected results induced by careless acupuncture and moxibustion treatments may be mild or severe, and are due to practitioner's mistake and particular body condition of a patient. This study was performed to establish a preventive measures against medical accident induced by acupuncture therapy. Total 23 acupuncture points which are included in a J${\bar{l}}$n-Zh${\dot{e}}$n-Xu${\acute{e}}$-G${\dot{e}}$ were selected as prohibited acupuncture points. Although the records in J${\bar{l}}$n-Zh${\dot{e}}$n-Xu${\acute{e}}$-G${\dot{e}}$ are an important data historically which show dangerous acupuncture points, there are few a full investigation on J${\bar{l}}$n-Zh${\dot{e}}$n-Xu${\acute{e}}$-G${\dot{e}}$ up to the present. So present study was done for literature review to understand a feasibility of the records in J${\bar{l}}$n-Zh${\dot{e}}$n-Xu${\acute{e}}$-G${\dot{e}}$ in association with dangerous acupuncture points. Based upon the locations of these acupuncture points, the dangerous region were classified three categories, head, soma and limb. And abnormal signs related to the improperly performed acupuncture treatment on each point were investigated by using historical reference books on acupuncture and moxibustion. And then names, locations, depth of insertion, operation methods and side effects of each point were investigated.

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Public perception of environmental health due to small-scale industries in a rural community (일개 농촌지역 주민의 소규모 공장으로 인한 보건생활환경에 관한 인식도 조사)

  • Kim, Jeong-Youn;Jung, Yun-Jae;Sung, Yu-Mi;Ha, Eun-Hee;Wie, Cha-Hyung
    • Journal of agricultural medicine and community health
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    • v.25 no.1
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    • pp.1-9
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    • 2000
  • A public perception survey of environmental health due to small-scale industries was conducted in Sudong Myun, Namyangju City, Kyungki Do, recently being changed to industrialized rural community. This survey had the purpose to ascertain public interest, to identify public needs, and to assess participation for environmental health programs of rural community. The results of survey were as follows: 1. The rate of the respondents with factory worker 19.4% and half(53.1%) of respondents had lived nearby the factory. 2. Some respondents were not favor their neighboring factories(30.1%) and have discussed about its environmental problems in community meeting(14.4%) especially in neighborhood adjacent factories. 3. The respondents have perceived that: (1) major problems were water contamination, air pollution, nasty odor, dust, and noise (2) health problems were more serious in employees than in other residents (3) the employers were responsible for environmental problems (4) the health service should provided by public health center channel and participated by the residents (5) most important service for workers was improvement of working conditions. We hope the community environmental and/or occupational health delivery system for the employees and residents will be developed true public health center channel in a rural community on the basis of this result.

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Effects of a Health Diary Program on Fall-Related Outcomes in Low-Income Elderly Women with Osteoarthritis (건강다이어리 프로그램이 저소득 관절염 여성노인의 낙상관련 심리적 변수에 미치는 효과)

  • Lee, Myung-Suk
    • Journal of agricultural medicine and community health
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    • v.36 no.3
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    • pp.167-178
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    • 2011
  • Purpose: This study was done to identify the effects of a health diary program on fall related outcomes the low-income elderly women. Methods: The study was carried out with a nonequivalent control group with pretest-posttest design. The study was composed of two groups, each made up of 24 subjects: experimental group and control group. The subjects were low-income women aged over 65 years with osteoarthritis and both the experimental and control groups were made up of subjects with the same age profiles. The independent variable was the health diary program, and the dependent variables were fall related outcomes (fear of falling, fall-efficacy, knowledge of fall) difficulty of performing activity, and mood state. The health diary program was performed for 50 minutes each session and twice a week for 8 weeks. Data were collected before the health diary program 10 weeks after the beginning of the program. Results: The experimental group showed significant differences in knowledge of fall, fear of falling, and mood state compared to the control group. However there was no significant differences in difficulty of performing activity and fall efficacy. Conclusion: The results of this study may be used as part of an education to prevent falls for low-income elderly women with osteoarthritis.

The Current Research Status of Complementary and Integrative Medicine in Practice-Based Research Networks: A Systematic Review (개원의중심연구망에서 수행된 보완통합의학 관련 연구 현황: 체계적 문헌고찰)

  • Won, Jiyoon;Han, Gajin;Kim, Yejin;Park, Jae Rang;Noh, Eunyoung;Ji, Yu-jin;Adams, Jon;Lee, Hyangsook
    • Korean Journal of Acupuncture
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    • v.37 no.4
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    • pp.209-230
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    • 2020
  • Objectives : Practice-Based Research Networks (PBRNs), collaborations of practitioners and academic researchers, have provided platforms for conducting research to address clinical questions generated from daily routine care. This review aimed to critically analyse articles from PBRNs that are related to complementary and integrative medicine (CIM) and to suggest future directions for a PBRN which is appropriate for Korean Medicine (KM). Methods : PubMed, PBRN registries in Agency for Healthcare Research and Quality and relevant PBRN websites were searched up to November 2019 for research articles from PBRNs that focused on CIM regardless of study design. Methodological quality of the included studies was assessed. The included studies were read in full, classified and summarised according to their topics. Results : A total of 51 articles published from 1998 through 2020 were included in this review. They were categorised into three principal themes based on research questions and findings: health services research (embracing researches examining characteristics of patients and CIM practitioners/practices, and communication between patients and practitioners); effectiveness and safety of CIM practices/interventions; and feasibility studies of instruments and interventions in PBRN settings. The study designs varied including surveys (n=30), prospective observational studies (n=6), 2ndary analyses of existing studies (n=7), protocols (n=7), retrospective chart review (n=1) and qualitative study (n=1). Quality of the included studies greatly varied. Conclusions : PBRNs can serve as a feasible platform for conducting practice-relevant research on KM and CIM. Considering growing demands on evidence-base for routine practice of KM amid various stakeholders, a PBRN in KM community and further researches nested within PBRN designs are warranted.

Residue level and pharmacokinetics of trichlorfon in the Japanese eel (Anguilla japonica) after bath treatment (Trichlorfon (TCF)의 약욕 투여에 따른 뱀장어 체내 약물 잔류량 및 약물동태학 연구)

  • Jo, Hyun Ho;Chung, Joon Ki
    • Journal of fish pathology
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    • v.35 no.1
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    • pp.93-102
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    • 2022
  • This study performed a trichlorfon (TCF) residue and pharmacokinetic analysis with Japanese eels, Anguilla japonica, to obtain baseline data to establish the maximum residue level (MRL) of TCF in A. japonica. After dipping A. japonica in 30 ppm and 150 ppm of TCF at 28℃ and 18℃, drug residue in the body was analyzed with LC-MS/MS, and these results were further analyzed with the PK solver program to obtain the pharmacokinetic parameters of TCF in the serum, muscles, and liver. The maximum concentrations (Cmax) in the serum, muscles, and liver were 25.87-357.42, 129.91-1043.73, and 40.47-375.20, respectively, and the time to maximum concentration (Tmax) was 0.13-1.32h, 1.17-3.34h, and 0.14-5.40h, respectively. The terminal elimination half-life (T1/2) was 2.13-3.92h, 5.30-10.35h, and 0.65-13.81h, respectively. In the 30 mg/L concentration group, TCF was not detected in the serum of eels 96 hours after bathing, and was below the detection limit after 336 hours in muscle and liver. On the other hand, in the 150 mg/L concentration group, TCF was not detected in the serum of eels 336 hours after bathing, but was detected in muscle and liver at 336 hours. In conclusion, the results of this study would be useful in establishing the MRL of TCF in farmed A. japonica.

폐암 세기변조방사선치료 시 최적화된 조사계획 설정과 가상 장기 설정에 관한 연구

  • Lee, Seok;Lee, Chang-Geol;Cho, Sam-Ju;Chu, Sung-Sil;Lee, Sang-Hoon;Choi, Myung-Sun;Kim, Chul-Yong
    • Proceedings of the Korean Society of Medical Physics Conference
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    • 2003.09a
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    • pp.34-34
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    • 2003
  • 목적 : 폐암 환자 세기변조방사선치료 과정을 소개하고, 방사선치료계획의 최적화를 위한 빔 수와 방향, 가상장기 설정 (virtual organ delineation, VOD) 및 선량 제한 인자들의 이용에 대해 평가함으로써 폐, 심장 등에 조사되는 선량을 최소화하는데 사용하는 세기변조방사선치료 (intensity modulated radiotherapy, IMRT) 기술의 유용성을 평가하고자한다. 대상 및 방법 : 종양이 종격동을 침범하여 상대적으로 장기움직임에 의한 오차가 적은 폐암환자 5 명을 대상으로 하였다. 환자고정장치는 상반신을 편안하게 유지함과 동시에 팔의 위치를 고정시킴으로써 기대할 수 있는 환자고정효과와 벨트를 이용하여 환자 상복부를 압박해줌으로써 호흡운동에 의한 장기 움직임을 감소시킬 수 있는 형태로 고안하였다. 치료계획시 빔 수와 방향은 5,7,9 문 (from 200 to 160, equispaced field, arbitrary field), 4 문 (anterior, posterior, bilateral posterior oblique field) 과 비등방 7, 9 문 (non-equispaced field, arbitrary field) 등을 사용하였다. 선량제한 ($V_{20}V_{25}$)은 문헌에 기초하여 설정하였으며, 가상장기를 적절히 사용하여 최적화된 치료계획 결과를 얻었다. 방사선치료계획 평가는 선량-체적간 히스토그람 (DVH), 등선량곡선 및 선량통계 등을 이용하여 수행하였다. 특히 가상장기 설정 전, 후의 결과 값을 분석함으로써 그 유용성을 확인하였다. 결과 : 9문 등방-IMRT와 7문 비등방-IMRT 방법이 치료계획용적의 선량균질성 (PTV dose homogeneity), 평균 폐선량 (mean lung dose) 및 $V_{20}V_{25}$ 모두에서 20% 이내의 좋은 결과를 얻을 수 있었고, 가상 장기를 설정함으로써 같은 결과를 가져옴을 알 수 있었다. 또한 폐암 세기변조방사선치료 프로토콜을 작성하여 임상에 사용함으로써 치료과정 중 발생할 수 있는 오류를 보완할 수 있음을 알 수 있었다. 결론 : 폐암 세기변조방사선치료 시 사용할 수 있는 프로토콜을 작성하였고, 적절한 가상 장기 및 조사계획 설정으로 치료계획의 최적화를 얻을 수 있음을 알 수 있었다.

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