• Title/Summary/Keyword: 경남대학교

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Inhibition of Tyrosinase by Metabolites Originating from Thrichoderma atroviride (Thrichoderma atroviride 배양액의 tyrosinase 억제제에 관한 연구)

  • Kang, Dong Woo;Kim, Kyu-Min;Kim, Ye-Seong;Seo, Yu-Jin;Song, Da-Yeong;Oh, Da-Yun;Choi, Si-On;Hwang, Ju-Hyeon;Kim, Sam Woong;Bang, Kyu Ho;Gal, Sang Wan
    • Journal of Life Science
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    • v.31 no.1
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    • pp.47-51
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    • 2021
  • In today's society, functional whitening cosmetics are important to beauty. Fungi are known to produce a variety of whitening-related metabolites. In this study, we searched for tyrosinase inhibitors with metabolic products derived from Trichoderma atroviride supernatant in order to apply a material for whitening functional cosmetics. In addition, the inhibitory effect was compared to arbutin, which has already been approved as a whitening raw material by the Korea Ministry of Food and Drug Safety (KMFDS). The metabolites from the T. atroviride supernatant showed higher tyrosinase inhibitory activity than that of arbutin. Some of the tyrosinase inhibitors were stable to heat, whereas some were unstable. The heat unstable material was exhibited in the case of samples treated with little amounts, such as 0.02~0.2%. They were very unstable in acidic and alkali pHs, especially under acidic conditions. However, it was found that a weakly-acidic to neutral pH range was the optimal working pH, especially neutral pH. Since the activity of the inhibitory substances in the T. atroviride supernatant was maintained regardless of proteinase K treatment, it was assumed that the metabolites, but not the bioactive peptides, were involved in the activity. In summary, we propose that the metabolites derived from T. atroviride supernatant have strong potential as whitening raw material.

Development of Micro-chip Removal Equipment Using Bubble (버블을 이용한 미세칩 제거장치의 개발)

  • Choi, Sung-Yun;Kwon, Dae-Gyu;Lee, Sea-Han;Park, Tae-hyun;Wang, Duck Hyun
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.20 no.10
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    • pp.88-94
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    • 2021
  • Machining operations require the removal of chips to keep the water-soluble cutting oil clean and fresh throughout the operation time. Water-soluble cutting oil for metal processing is diluted using a 3-8% solution in water which is generally replaced every three to six months. This study aims to develop multiple purification devices to efficiently remove fine contaminating particles from water-soluble cutting oil. The 2D concept designs were created using AutoCAD. The designs were drawn using the 3D modelling feature of CATIA. Flow analysis was performed in a bubble purifier using Ansys computational fluid dynamics (CFD). This analysis has aided in improving the design and structure of the device to create the final prototype. Experiments were conducted to check the prototype's performance. Comparisons of the effects of each process variable on the experiment was carried out using ANOVA.

Study on Upward Machining of Inclined Surface by Ball-End Milling (볼 엔드밀에 의한 경사면 상방향 절삭가공에 관한 연구)

  • Jeong, Jin-Woo;Bae, Eun-Jin;Kim, Sang Hyun;Wang, Duck Hyun
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.20 no.4
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    • pp.87-93
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    • 2021
  • The mold industry is competitive, and mold should be processed under optimal conditions for efficient processing. However, the cutting conditions of the ball-end mill, which are a major factor in mold processing, are mostly set empirically, and considerable research is required for increasing the tool life and processing accuracy. In this study, a tool dynamometer and an eddy current sensor were used along with NI-DAQ, a data acquisition device, to obtain characteristic values of the cutting force and tool deformation during the ball end-mill machining of inclined surfaces at a machining center. The cutting force and tool deformation were measured in an experiment. It was found that the tool received the greatest cutting force at the end of the machining process, and the deformation of the tool increased rapidly. Furthermore, the cutting force tended to increase with the angle and number of rotations. The deformation increased rapidly during the machining of a 45° inclined surface.

A Study on the Real-Tim Path Control of Robot for Transfer Automation of Forging Parts in Manufacturing Process for Smart Factory (스마트 팩토리를 위한 제조공정 내에서 단조 부품의 이송자동화를 위한 로봇의 실시간 경로제어에 관한 연구)

  • Kang, Jung-Seok;Noh, Sung-Hoon;Kim, Du-Beum;Bae, Ho-Yuong;Kim, Sang-Hyun;Im, O-Duck;Han, Sung-Hyun
    • Journal of the Korean Society of Industry Convergence
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    • v.22 no.3
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    • pp.281-292
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    • 2019
  • This paper proposed a new technology to control a path forging parts in limited narrow space of manufacturing process automation for smart factory. In the motion control, we adapted the obstacle avoidance technology based on ultrasonic sensors. The new motion control performance test for a mobile robot is experimented in narrow space environments. The travelling path control is performed by a fuzzy control logic. which plays a role for selecting an appropriate behavior in accordance with the situation in the vicinity of the mobile robot. Ultrasonic sensors installed at the front face of the mobile robot are used. In order to update the current position and heading angle of the mobile robot, a new approch is adapted. The reliability is illustrated by simulation and experiments.

A Study on Obstacle Avoidance and Autonomous Travelling of Mobile Robot in Manufacturing Precess for Smart Factory (스마트 팩토리를 위한 제조공정내에서 모바일 로봇의 장애물 회피 및 자율주행에 관한 연구)

  • Kim, D.B.;Kim, H.J.;Moon, J.C.;Bae, H.Y;Han, S.H.
    • Journal of the Korean Society of Industry Convergence
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    • v.21 no.6
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    • pp.379-388
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    • 2018
  • In this study, we propose a new approach to impliment autonomous travelling of mobile robot based on obstacle avoidance and voice command. Obstacle Avoidance technology of mobile robpot. It has been used in wide range of different robotics areas to minimize the risk of collisions. Obstacle avoidance of mobile robots are mostly applied in transportation systems such as aircraft traffic control, autonomous cars etc. Collision avoidance is a important requirement in mobile robot systems where they all featured some kind of obstacle detection techniques in order to avoid colliding. In this paper it was illustrated the reliability of voice command and obstacle avoidance for autonomous travelling of mobile robot with two wheels as the purpose of application to the manufacturing process by simulation and experiments.

Cutting Force Characteristics and Tool Deflection When Machining Rectangular Shapes with a Ball End Mill (볼엔드밀 공구에 의한 사각형상 가공시 공구 휨에 따른 절삭력 특성)

  • Kim, In Soo;Kim, Sang Hyun;Lee, Dong Sup;Wang, Duck Hyun
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.18 no.6
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    • pp.26-32
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    • 2019
  • Ball end mills used for high-speed and high-precision machining require longer machining time than flat end mills or face cutters, since the tool diameter is limited and the rigidity is reduced by the characteristics of the tool's cutting edge: at the top end of the tool, the cutting speed approaches zero and hardly removes any material. Because there is little material removal at the top end of the ball end mill, the outer cutting edge performs the majority of the work; this irregular cutting force deforms the tool and shortens its life. In this study, we attached an eddy-current sensor to a tool to measure the deformation from the cutting force and we used a tool dynamometer to measure the cutting force. We found that the change in cutting force is dependent on the change in feed rate during square-shaped processing and, as the feed rate is accelerated, the cutting force also increases. Higher cutting forces increase tool deformation.

Knowledge and Attitude about Drugs and the Current Status of Self-medication of Nursing Students (간호대학생의 의약품 자가투약 실태, 약물에 대한 지식 및 태도에 관한 연구)

  • Kim, Hae-Ok;Lee, Eun-Joo;Sung, Min;Kim, Min-Kyeong
    • Health Communication
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    • v.13 no.2
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    • pp.185-193
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    • 2018
  • Background: Nursing college students are exposed to information about diseases or drugs, and are likely to have a distorted perception of drug knowledge or behavior. The study aimed to identify knowledge and attitude about drugs and current status of self-medication among nursing students. Methods: The subjects were 172 nursing students from a university in Busan. Data were collected with structured questionnaires and analyzed using descriptive analysis, t-test, and one-way ANOVA using SPSS 23.0. Results: Nursing students had a high level of knowledge about drugs, but attitudes toward drugs were relatively low. 83.7% of patients had experience of self-medication. The methods to acquire information for self-administration were 29.9% by smart phone and 27.1% by internet. The use of nonsteroidal anti-inflammatory drugs (NSAIDs) among self-medication drugs was the highest. The most common reason for self-medication was 'I thought it to be a mild disease', and the pharmacists were the most affected by choice of self-medication. The knowledge about drugs was statistically significant according to grade, school life satisfaction and subjective health status. The attitudes about medication were statistically significant according to grade and self-medication experience. Conclusion: Nursing college students need drug safety education to improve awareness and practice of correct drug use.