• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.2
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• pp.132-139
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• 2009

Purpose: The purpose of this study is to identify the clinical effect of Red Ginseng in the treatment of postmenopausal hot flushes. Methods: We studied 49 women from 45 to 55 years old who complained hot flushes. We randomly divided women into two groups, We treated one group with red ginseng capsule, and treated another group with placebo for 2 months. patients recorded the frequency of the hot flush on an everyday basis. And we measured temperature of patient's face by DITI. Results: Red ginseng and Placebo treated group significantly decreased the frequency of the hot flush. After treatment, the temperature on the cheekbones who treated by red ginseng get lower than before treatment. But there is no statistically difference between red ginseng and placebo. Conclusion: This study shows that both red ginseng and placebo have remarkable effects on patients, but red ginseng is not better than placebo.

• Journal of Life Science
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• v.15 no.6 s.73
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• pp.1022-1027
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• 2005

The aim of this study was to evaluate effects of mulberry cultivars extracts on the collagen content of the connective tissues in ovariectomized rats. From day 2 until day 37 after ovariectomy, Sprague-Dawley female rats were randomly assigned to the following groups : sham-operated rats (Sham), ovariectomized control rats (OVX-control), and ovariectomized rats supplemented with $80\%$ ethyl alcohol extracts from various kinds of Tajikistan mulberry, Korea mulberry and China mulberry at 200 mg/kg bw/day, respectively. The mulberry extracts were orally administrated at 1 mL per day. The OVX rats were significantly heavier than the sham-operated rats were at all time points, but supplementation with the mulberry extracts tended to gain weight less than OVX-control did. The ovariectomy caused a decreasing in the levels of collagen content in bone and cartilage tissues. However, supplementation with mulberry extracts prevented the decrease in the collagen level in bone and cartilage tissues. Therefore, it may be used to possibly improve the quality of life in menopausal women.

• Journal of Acupuncture Research
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• v.22 no.1
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• pp.117-130
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• 2005

Objective : Generation after generation, by Oriental medicine literatures, Soyo-san has been used as a clinical prescription that is important to climacteric syndrome, and also has been used extensively to psyco-neurotic problems, melancholia and stress symptoms. The experimental study of Soyo-san's effect has been reported, but the effect of herbal acupuncture solution by Soyo-san is not reported yet. Thus the purpose of this experiment is to test whether Herbal acupuncture of Soyo-san have anti-stress or antidepressant effects in the menopause or not. Methods : Female Sprague-Dawley(240-260g) rats were used. Temperature controlled within $20-25^{\circ}C$. Water and food not limited, and Manipulated the day and night 12 hours each. In the experiment, enforced Morris water maze after immobilization stress for 5 minutes, and operating Herbal acupuncture of Soyo-san 30 minutes before stress every day during 7 days. Flowed through by 4% paraformaldehyde and fixed brain tissue after test of 7 days. Results : 1) As a result of the acquisition test, Soyo-san group was recognized by significant difference compared to Ovx group and the retention test Soyo-san group increased significantly compared to Sham and Ovx group. 2) Soyo-san group showed that the degree of revealation of Tyrosine hydroxylase decreased comparing to Ovx group in ventral tegmental area and that of Choline acetyltransferase increased comparing to Ovx group in CAI region of Hippocampus. Conclusion : As a result of this experiment to grasp those effects on postmenopausal depression or learing disability and memory disorder, the possibility of Herbal acupunture by Soyo-san is warranted as a suitable treatment to relieve women's monopausal depression and those of stress reaction, improving tearing disability and memory disorder.

• Korean Journal of Health Education and Promotion
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• v.10 no.1
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• pp.72-86
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• 1993

The purpose of this study is to find out the menopausal symptom of middle-aged women and their self-care on it. This study also intended to awaken the relationship of the menopausal symptom and self-care and to provide basic data on the health education of middle-aged women. For this purpose, the study (1) identified respondents background variables, (2) found menopausal symptom and the state of self-care, (3) analyzed relationship between general character, menopausal symptom, and self-care, (4) analyzed the relationship of menopausal symptom and self-care for 543 random sampled women in City of Incheon. The questionnaire consisted of 25 questions on the menopausal symptom interview by Neugarton translated by Jung Hae Ran(1985) and questions of the self-care inventory by Orem reconstructed by Sung Moon Hee(1988). The data were analyzed by using frequency, percentage, t-test, X²-test, pearson's correlation coefficient with SPSS statistical package. The results of this study could be summed up as follows ; 1. The Degree of menopausal symptom were graded from 25 to 75. (x 40.85, s. d. 8. 6.) 2. The test of relationship between the individual background and the menopausal symptom revealed that there seemed to be statistically significant correlation between the sexual life, life-content, the level of education, menstruation(p<0.000). 3. In the test of relationship between the individual background and the self-care process, (1) in case of insight of symptom, there seemed to be statistically significant correlation between the self-content(r=0.1463), sexual life(r= -0.1376), menstruation(r=0.1561), and artificial abortion(r=0.1577), (p<0.001), (2) In case of self-health control, there seemed to be statistical correlation between the states of menstruation and the number of induced abortion. (3) In case of self-health decision, there seemed to be statistically significant correlation between the number of visiting hospitals or clinics and the level of education(r=0.106), the self-content(r=0.1235), induced abortion(r=0.1343) (p<0.0000). And also individual background can show the 40.21 percent of self-health maintenance. 4. The relationship between menopausal symptom and self-care has a significant meaning to the insight of symptom, self-health decision according to the groups of menopausal symptom(p<0.000), but it doesn't have any meaning to self-health control. And self-health maintenance can manifest the 19.88 percent of menopausal symptom.

• Journal of Society of Preventive Korean Medicine
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• v.24 no.1
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• pp.1-14
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• 2020

Objectives : The purpose of this systematic review was to investigate the efficacy and safety of Sanjoin-tang (Suanzaoren decoction, SZRD) for insomnia in menopausal syndromes. Method : We searched the following databases: PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Science and Technique Journals Database (VIP), Wanfang, Research Information Service System (RISS), OASIS, Korean studies Information Service System (KISS), and National Digital Science Library (NDSL) databases. Randomized controlled trials (RCTs) or quasi-RCTs that used SZRD for women in menopause were included. The methodological quality of each RCT was assessed using the risk of bias tool. Results : In total, nine RCTs were finally included. The included RCTs had a high risk of bias across their domains. Three RCTs examined the effects of SZRD compared with western medicine (WM) in insomnia. Three RCTs showed favorable effects of SZRD with insomnia. Infrastructure also showed that SZRD resulted in better clinical WM (RR 1.19, 95% CI 1.07 to 1.32, P=0.001, I²=0%). Four RCTs showed favorable effects of Modified SZRD with insomnia. Infrastructure also showed that Modified SZRD resulted in better clinical WM (RR 1.13, 95% CI 1.04 to 1.23, P=0.004, I²=0%). Among the 4 RCTs, three RCTs showed an equivalent effect on the total Pittsburh Sleep Quality Index (PSQI). The meta-analysis also showed that Modified SZRD had a superior effect on the total of PSQI (total of PSQI : MD -2.55, 95% CI -3.72 to -1.37, P<0.0001, I²=85%). Only 2 trials reported adverse events and none reported severe adverse events. Conclusion : SZRD appears to be safe, but there is insufficient evidence to make a definitive conclusion because only a few studies reported adverse events. Due to the poor methodological quality of the included studies and the small number of trials included, the evidence cannot be reproduced and assessed. Well-designed RCTs with a larger sample size are needed in the future.

• Research in Community and Public Health Nursing
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• v.14 no.2
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• pp.323-333
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• 2003

This is a comparative descriptive study conducted for 178 middle-aged women who were residing in Seoul and aged between 41 to 64 (95 in control group, and 83 in experimental group). The study was aimed to examine their climacteric symptoms, degree of fatigue, depression, anxiety and quality of sleep and to examine the differences on the symptoms between the two groups. Data were collected from April 1 to May 15, 2002 through self-statement using structured questionnaires. The collected data were verified with descriptive statistics, ? -test, t-test, ANOVA using SPSS/PC(+). The results are as follows. 1) The average scores of the climacteric symptoms were 1.56 .36 for the control group, and 1.55 .33 for the group taking relexzone massage, showing no significant difference between the groups (t=.15, p=.88). 2) The average scores of the degree of fatigue were 2.17 .65 for the control group, and 2.40 .66 for the group taking relexzone massage, showing a significant difference between the groups. (t=-2.31, p=.02) 3) The average scores of depression were 1.91 .50 for the control group, and 2.05 .42 for the group taking relexzone massage, showing a significant difference between the groups (t=-1.99, p=.05). 4) The average scores of anxiety were 1.54 .60 for the control group, and 1.57 .53 for the group taking relexzone massage, showing no significant difference between the groups (t=-.33, p=.74). 5) The average scores of quality of sleep were 2.97 .49 for the control group, and 2.98 .42 for the group taking relexzone massage, showing no significant difference between the groups(t=-.08, p=.93). Based on these results, the middle-aged women who take relexzone massage are considered to have less fatigue and depression than those who do not. As physiological regression progresses and the structure and role in the family are restructured, middle-aged women are like to experience various climacteric symptoms. As a nursing intervention, relexzone massage can be applied to middle-aged women to reduce their stress, climacteric symptoms and emotional anxiety, ultimately promoting their health. In order to implement relexzone massage as a nursing intervention, further testing on the psycho-neuroimmunologjcal effects of relexzone massage is necessary.

• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.3
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• pp.215-230
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• 2006

Purpose : To evaluate the clinical use of the menopause-specific quality of life questionnaire(MENQOL) for scoring menopausal symptoms by comparison with the conventional Kupperman's index. Methods : A population sample of 66 women was randomly selected from the female patients(aged 45-55) who had visited two oriental medical clinic in Seoul or Woo-Shin-Hwang oriental hospital from 1st April to 15th May in 2006. They completed both the MENQOL and the Kupperman's index and were asked a few additional questions. Results : 1. A degree of the Climacteric symptoms were not significantly related to either an education level or an income level. 2. A comparison of the MENQOL with the Kupperman's index produced a high positive correlation. 3. 41 of subjects (62.1%) answered that the MENQOL was more efficient for explaining their symptoms than the Kupperman's index. 49 (74.2%) of subject thought that both questionnaires are equally not difficult to fill out and 44(66.7%) of subject found no difficult questions to answer in any of questionnaires. Conclusion : The MENQOL is a valuable modern tool for the assessment of climacteric symptoms in place of the Kupperman's index. The MENQOL was excellent in applicability. The MENQOL could serve as an adequate diagnostic instrument for climacteric symptoms.

• Journal of Life Science
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• v.18 no.11
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• pp.1578-1583
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• 2008

The purpose of this study was to investigate the effects of sea tangle (ST) extracts on formation of collagen and collagen cross-link in ovariectomized rats. From day 3 until 42 after the ovariectomy, Sprague-Dawley female rats were randomly assigned to the following groups: sham-operated rats(Sham), ovariectomized control rats (OVX-control), ovariectomized rats supplemented with ST at 50 mg/kg bw/day (OVX-ST50), 200 mg/kg bw/day (OVX-ST200). The ethanol extraxcr of ST was orally administrated at 1 ml/day. The change of collagen content was investigated in bone, cartilage and skin of ovariectomized rats. Effects of ST extract on the amount of collagen was examined by measuring the hydroxyproline, which is a specific amino acid existing in collagen. The ovariectomy resulted in a decrease in the levels of collagen content in bone and cartilage tissues. However, the supplementation with the sea tangle extract prevented the decrease in the collagen level in bone and cartilage tissues. Pyridinoline is pyridinium cross-link formed in the mature form of collagen from lysine and hydroxylysine residues. Although the pyridinoline content in bone collagen declined after ovariectomy, it was recovered to a normal level of Sham group by the supplementation with the ST extracts. In addition, the deoxypyridinoline content in bone collagen, which was reduced after ovariectomy was enhanced to normal level by the supplementation with the ST extract. These results was consistent with the conclusions based on estrogenic activities of ST.

• Korean Journal of Food Science and Technology
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• v.48 no.6
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• pp.604-609
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• 2016

In postmenopausal women, estrogen deficiency can be associated with metabolic diseases, such as obesity, diabetes, and cardiovascular diseases. The purpose of this study was to investigate factors related to lipid, glucose and antioxidnat metabolism. Sprague-Dawley female rats were subjected to either bilateral ovariectomy or sham operation and randomly divided into 3 dietary groups, (n=8) sham-operated fed with normal diet (SHAM), ovariectomized fed with normal diet (OVX), and ovariectomized fed with normal diet supplemented with Eucommia ulmoides extract (OVX-EU). The OVX-EU group showed significantly lower body weight, triacylglycerol, and total cholesterol than that showed by the OVX group. In addition, the OVX-EU group showed improved lipogenesis, glucose-regulating enzyme activities, adipokine and antioxidant enzyme activities. These findings demonstrate that extracts from E. ulmoides extract can be used as a functional food.

• The Journal of Korean Obstetrics and Gynecology
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• v.33 no.1
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• pp.86-103
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• 2020

Objectives: The purpose of this study is to analyse the domestic trends of Traditional Korean Medicine on Hot flush in menopausal women. Methods: We searched six databases and selected relevant papers according to the criteria. Results: 12 papers included case report, literature review, randomized controlled clinical trials (RCTs), Non-RCTs, and retrospective chart analysis study design. 1. The daily diary, Kupperman's Index, Menopause Rating Scale, Menopause-specific Quality of Life Questionnaire, Digital Infrared Thermographic Imaging were used as a measure of the symptoms of hot flush. 2. There were significant correlations between Thermographic images, Pulse energy, Lifestyle Habits, Low frequency power/High frequency power (LF/HF) ratio and certain items of Menopausal Symptoms Measurement. 3. The case report using Er-Xian decoction and Hwangryunhaedoktang-Gamibang showed significant effect. 4. Domestic RCT studies using herbal or acupuncture treatments showed a significant value of 3.4 on average in the quality assessment conducted in the study. However, the number of domestic studies included was five, which is not enough compared to foreign countries. Conclusions: This study examined domestic research trends on hot flushes of menopausal women and found that various evaluation tools and diagnostic methods were applied. It is necessary to conduct various RCT studies in Korea, where the number of studies is insufficient compared to overseas.