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http://dx.doi.org/10.25153/spkom.2020.24.1.001

Sanjoin-tang (Suanzaoren decoction) for Insomnia in Menopausal Syndromes: A Systematic Review and Meta-analysis  

Jun, Ji Hee (Department of Preventive Medicine, College of Korean Medicine, Daejeon University)
Choi, Tae-Young (Clinical Medicine Division, Korea Institute of Oriental Medicine)
Lee, Myeong Soo (Clinical Medicine Division, Korea Institute of Oriental Medicine)
Song, Eunhye (Department of Preventive Medicine, College of Korean Medicine, Daejeon University)
Ang, Lin (Korea University of Science and Technology, Korean Convergence Medicine)
Park, Sunju (Department of Preventive Medicine, College of Korean Medicine, Daejeon University)
Publication Information
Journal of Society of Preventive Korean Medicine / v.24, no.1, 2020 , pp. 1-14 More about this Journal
Abstract
Objectives : The purpose of this systematic review was to investigate the efficacy and safety of Sanjoin-tang (Suanzaoren decoction, SZRD) for insomnia in menopausal syndromes. Method : We searched the following databases: PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure (CNKI), Chinese Science and Technique Journals Database (VIP), Wanfang, Research Information Service System (RISS), OASIS, Korean studies Information Service System (KISS), and National Digital Science Library (NDSL) databases. Randomized controlled trials (RCTs) or quasi-RCTs that used SZRD for women in menopause were included. The methodological quality of each RCT was assessed using the risk of bias tool. Results : In total, nine RCTs were finally included. The included RCTs had a high risk of bias across their domains. Three RCTs examined the effects of SZRD compared with western medicine (WM) in insomnia. Three RCTs showed favorable effects of SZRD with insomnia. Infrastructure also showed that SZRD resulted in better clinical WM (RR 1.19, 95% CI 1.07 to 1.32, P=0.001, I2=0%). Four RCTs showed favorable effects of Modified SZRD with insomnia. Infrastructure also showed that Modified SZRD resulted in better clinical WM (RR 1.13, 95% CI 1.04 to 1.23, P=0.004, I2=0%). Among the 4 RCTs, three RCTs showed an equivalent effect on the total Pittsburh Sleep Quality Index (PSQI). The meta-analysis also showed that Modified SZRD had a superior effect on the total of PSQI (total of PSQI : MD -2.55, 95% CI -3.72 to -1.37, P<0.0001, I2=85%). Only 2 trials reported adverse events and none reported severe adverse events. Conclusion : SZRD appears to be safe, but there is insufficient evidence to make a definitive conclusion because only a few studies reported adverse events. Due to the poor methodological quality of the included studies and the small number of trials included, the evidence cannot be reproduced and assessed. Well-designed RCTs with a larger sample size are needed in the future.
Keywords
Sanjoin-tang; Suanzaoren decoction; systematic review; menopausal syndromes;
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