• Knowledge Management Research
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• v.21 no.3
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• pp.105-121
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• 2020

With regard to the development of new drugs, what is most important for a Korean Biotech, where no global sales network has been established, is decision-making related to out-licensing of new drugs. The probability of success for each clinical phase is different, and the licensing amount and its royalty vary depending on which clinical phase the licensing contract is made. Due to the nature of such a licensing contract and Biotech's weak financial status, it is a very important decision-making issue for a Biotech to determine when to license out to a Big Pharma. This study defined a model called 'optimal timing for out-licensing of new drugs' and the results were derived from the decision tree analysis. As a case study, we applied to a Biotech in Korea, which is conducting FDA global clinical trials for a first-in-class new drug. Assuming that the market size and expected market penetration rate of the target disease are known, it has been shown that out-licensing after phase 1 or phase 2 of clinical trials is a best alternative that maximizes Biotech's profits. This study can provide a conceptual framework for the use of management science methodologies in pharmaceutical fields, thus laying the foundation for knowledge and research on out-licensing of new drugs.

• Journal of Korea Water Resources Association
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• v.44 no.12
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• pp.975-990
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• 2011

In this study, to develop an assessment method for spatio-temporal riverbed changes, a 1-dimensional model (HEC-RAS) and a 2-dimensional model (CCHE2D) were built and applied. As for the analysis of a riverbed's long-term change in a real stream, three new assessment methods were developed, which are called the "Sediment section cumulative curve", "Sediment section moment", and "Sediment probability distribution function." These methods were used to assess the characteristics of riverbed changes using a consistent valuation standard and to understand changes in quantities intuitively. From the results of this study, sediment characteristics of cross sections can be detected effectively by applying the "Sediment section cumulative curve" method to determine whether there is any sedimentation or erosion in total emission. The amount of sedimentation or erosion occurring in the right or left banks, which divided by center column, could be presented as one criterion by applying the "Sediment section moment" method. This approach could be utilized as an indicator for sediment predictions. Spatio-temporal sediment variables can be presented quantitatively by determining the mean and uncertain boundaries through the "Sediment probability distribution function", and finally, the results can be illustrated for each cross section to provide intuitive recognition.

• Journal of Wetlands Research
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• v.6 no.3
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• pp.119-126
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• 2004

In recent, the critical rainfall duration concept is widely used but we do not have understandable criteria yet. However, the critical rainfall duration is usually calculated considering concentration time, runoff model using effective rainfall, and unit hydrograph for the estimation of design flood. This study is to derive the regression equations between the critical rainfall duration and hydrologic components such as the basin area, slope, length, CN, and so on. We use a GIS tool which is called the ArcView for the estimation of hydrologic components and the HEC-1 module which is provided in WMS model is used for the runoff computation. As the results, the basin area, basin slope, and basin length had a great influence on the estimations of peak runoff and critical rainfall duration. We also investigated the sensitivities for the peak runoff and critical duration of rainfall from the correlation analysis for the involved components in the runoff estimation.

• Korean Journal of Construction Engineering and Management
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• v.12 no.3
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• pp.73-82
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• 2011

The term 'green' has become an important way of survival for the construction industry in 21th century in accordance with the emergence of the environmental crisis due to the climatic change. Especially the policy of carbon taxation, planed to be introduced from 2012, is expected to be a considerable burden to the construction industry which has abundant carbon emission during the resource transportation due to the complexity of resources and local distribution of the construction sites. In this regard, this study shows an optimizing strategy for delivery frequency, which downsizes the net distribution costs based on the assumption that, despite of its other advantagements, the frequent small lot mode of JIT delivery would take negative effects due to the increase of costs of transportation and carbon emission once the carbon taxation policy carried out. To simulate the efficiency of the management strategies, the System Dynamics modeling has been used. The results show that the frequent small lot transportation strategy is now always efficient method to these changes, and that the frequency of transportation should be re-determinated according to the extent of the imposition of carbon tax. This study provides the conceptual frame for an efficient management of transportation system of the construction industry, showing necessity of change of the resource transportation systems through analysing JIT deliver system in accordance with the global changes in environmental economy.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.12
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• pp.190-199
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• 2019

South Korea has achieved impressive economic growth relatively quickly by focusing on export-driven policies and economies of scale in the process of industrialization. As the country's economic development policy focused on large corporations, however, a power and wealth imbalance developed between SMEs and large corporations. The purpose of this study is to clarify this issue academically and more clearly through theoretical studies and empirical analysis in order to resolve these imbalances and improve the positive relationship between SMEs and large corporations. To this end, a survey was conducted from December 17, 2018 to January 28, 2019, and a total of 378 questionnaires collected from corporate workers were used for the final analysis. The hypotheses confirmed by the study results were as following. First, the factors directly affecting the competitor's orientation were the trust, entrepreneurship, and innovation capability of the entrepreneurial characteristics. Second, when the characteristics of the company were examined from the perspective of cooperative performance, only the innovation capacity factor had a positive effect. Third, the competitor orientation showed a positive effect on cooperative performance. Fourth, competitor orientation had a statistically significant mediating effect on the relationship between trust, entrepreneurship, innovation capability, and cooperative performance.

• Journal of Engineering Education Research
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• v.11 no.1
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• pp.85-100
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• 2008

The purpose of this study is development of 'F1 in Schools Program' for elementary school student and validation of the program. Fifteen students were originally chosen from the W elementary school in Cheongju, Chungcheogbuk-Do. The children were tested on their understanding of science and 'F1 in Schools Program'. After developing the 'F1 in Schools Program', it was used in the classroom to evaluate applicability and to examine the responses from students, parents and schools. The program consists of 60 classes and the time of each class is 40 minutes. This study was conducted for 10 days from January 22nd, 2007 to February 2nd, 2007. CAD(Computer Aided Design), CFD(Computation Fluid Dynamics), CAM(Computer Aided manufacturing) and CNC Machine were used in this study and proved to be good materials for students in that they increased the students' participation and imagination. However, the children's cognitive and creative abilities as well as manuals written in English hampered the process. Most students, parents, schools seemed to be satisfied with use of the program. However, the schools showed that there was not enough understanding of the program as a whole. The processes with which students build and inspect using the $CO_2$Model Car not only improves the processing of the model but also enhanced the students scientific understanding related to the car speed.

• Journal of Korean Society of Steel Construction
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• v.9 no.4 s.33
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• pp.697-705
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• 1997

The conventional preflex beams are designed by the method of paritial prestressing and allow the tensile stresses at the lower concrete of beams. As a consequence, most of preflex beams experience the tensile cracks under the service loads. This study was conducted to develop the most effective preflex beams, which do not allow tensile stress under the service load, by introducing additional prestressing called 'represtressing' at the lower concrete of beams. The objective of the study was accomplished by developing a computer analysis and design program and conducting experiments. Using the developed computer program, standard sections of the represtressed preflex beams were determined by computer modeling. In the experiment, two actual size of represtressed beams were tested under the imitated service loads. The results of test have shown that the performance of the represtressed preflex beams is generally excellent. A remarkable improvement was made in the design of preflex composite beams. Since the represtressed preflex beams(RPF) do not experience the tensile cracks under the service loads, the use of this beam for the bridge structures will lead to easy bridge maintenance and management. Furthermore, due to the low beam depth, high clearance and economical design can be realized in the bridge design using RPF.

• Journal of Korean Society of Transportation
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• v.27 no.4
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• pp.195-206
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• 2009

The deregulation of aviation markets in Europe and the United Sates had led airlines to reconfigure their networks into hub-and-spoke systems. Recent trends of "Open Skies" in the Asian aviation market are also expected to prompt the reformation of airlines' networks in the region. A significant connectivity index is a crucial tool for airlines and airport authorities to estimate the degree of hub-and-spoke operations. Therefore, this paper suggests a new index, Continuous Indirect Connectivity Index (CICI), for measuring the coordination of airlines' flight schedules, applying it to the Asian, European and the American aviation markets. CICI consists of three components：(i) temporal connectivity to identify the attractiveness between connection flights, (ii) spatial connectivity to differentiate the attractiveness by de-routing distance with continuous linear function, and (iii) relative intensity to reflect the effect of direct flight frequency on transfer routes. CICI is evaluated to examine a casual relationship through regression analyses with two dependent variables of the number of transfer passengers and transfer rates. Compared with Danesi's index and Doganis' index through evaluation processes, CICI has a higher coefficient value of determination, implying that it explains the relationship between connectivity and transfer passengers more precisely.

• Proceedings of the Korea Water Resources Association Conference
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• 1990.07a
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• pp.49-52
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• 1990

강우강도가 큰 집중호우가 지표면에 도달하게 되면 강우량중 상당 부분이 수문학적 손실성분인 침수, 증발산, 차단 및 저류등으로 시간에 따라 분포된다. 이 가운데 지표면에 분포된 식생계 및 낙엽등에 의한 차단(canopy interception effect)과, 지표가 포화시의 증발산(wetted environmental evapotranspiration) 및 각종 저류, 즉 지표면 저류(depression storage), 지표토양층에의 저류(retention storage) 성분 등을 들 수 있으며 이들 각 손실성분은 직접유출로 나타나는 초과우량의 발생시간을 지체시켜 주는 역할을 하나 차단성분 및 저류성분은 시간이 경과함에 따라 결국은 증발산 또는 침투성분으로 흡수된다. 따라서 침투성분은 초과우량 추정에 매우 큰 영향을 줄 뿐 아니라 지표면 아래의 흙의 변형을 야기시키며, 중간유출 및 지하수유출에 기여 한다. 대부분의 호우사상은 강우초기에 강우강도가 지표 흙의 침수계수(hydraulic conductivity)보다 작기 때문에 모두 각 손실성분에 의해 손실되며, 강우강도가 점차 커져 침수능을 초과하면 지표면에 순간적으로 물이 고이게 되는데 이것을 지표심수(surface ponding)라하고, 강우시작부터 이 때까지가 침수시간(ponding time)이 된다. 이 지표침수가 나타나는 순간이 곧 직접유출 시작 시간으로 볼 수 있을 뿐 아니라, 침수시간은 지표면의 물수지면에서 볼 때 초기손실량 및 침수율 결정에 중요한 인자가 된다. 본 연구에서는 각 손실 성분별로 유역의 제반 특성을 고려하여 구한 매개변수로부터 시간에 대한 손실율을 결정하여 산지 하천유역에 발생하는 부정강우사상(unsteady rainfall)의 초과우량을 추정하는 모델을 유도하였다. 대상유역으로는 현재 건설부에서 수행하고 있는 국제수문개발계획(IHP) 대표시험유역 가운데 평창강 수계내의 장평유역으로서, 본 유역은 자기 우량계 및 자기 수위계가 운용되고 있고, 인접 대관령 측후소로부터 기상자료를 획득, 이용할 수 있는 비교적 분석에 양호한 조건을 지닌 유역이다. 모델의 유도 과정은 대상유역 식생계로 피복된 산지유역임으로, 식생차단 저류효과를 고려해서 지표면의 흙에 도달되는 순강우주상도를 얻고 이로부터 침수시간 및 침투율을 결정해서 초과우량을 산정하는 모델을 유도하였다. 강우 지속시간내 즉, 유역이 완전 포화시의 증발산율의 결정은 Morton 모델로부터, 침수시간 및 침투율 결정은 Green-Ampt 방정식을 부정강우사상에 적용할 수 있도록 수정된 모델을 사용하였으며, 분석에 이용된 호우는 1986 ~ 1987년도 발생된 호우사상 가운데 강우강도 및 총 강우량이 비교적 큰 7개 강우사상을 선정하였다. 각 호우사상별로 손실율울 지표면에서 물수지개념을 이용하여 계산하고 산술지상에 구성시킨 결과는 다음 그림과 같다. 이 그림에서 굵은 실선으로 나타낸 곡선(B. L. R)은 각 손실을 곡선을 시간축에 따라 산술평균한 대표손실율곡선이다. 이 대표손실율곡선은 역지수함수형으로서 곡선식의 유도는 회기분석을 이용하였다. 초과우량 주상도를 얻기 위하여 이 대표손실을 곡선을 관측 강우주상도에 적용시켜 본 결과 식생계에 의한 차단 저류율은 약 6mm/hr 정도인 것으로 나타났으며, 이로 인한 침수시간 지체효과는 1~3시간 정도로서 비교적 그 영향이 큼을 알았다. 또한 각 호우사상별 침수시간 계산 결과 그 변동이 큰 것으로 나타났는데 이는 초기 강우강도에 민감하기 때문인 것으로 판단되낟. 한편 유역 포화시의 증발산율은 우기의 기상자료를 이용하여 구한 결과 0.05 - 0.10 mm/hr 의 범위로서 이로 인한 강우손실량은 큰 의미가 없음을 알았다.

• Journal of Korea Water Resources Association
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• v.49 no.8
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• pp.685-692
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• 2016

This study aimed to develop the indicator-based approach to assess water use vulnerability in watersheds and applied to the unit watershed within the Han River watershed. Vulnerability indices were comprised of three sub-components (exposure, sensitivity, adaptive capacity) with respect to water use. The indicators were made up of 16 water use indicators. Then we estimated vulnerability indices using the Technique for Order of Preference by Similarity to Ideal Solution approach (TOPSIS). We collected environmental and socio-economic data from national statistics database, and used them for simulated results by the Soil and Water Assessment Tool (SWAT) model. For estimating the weighted values for each indicator, expert surveys for subjective weight and data-based Shannon's entropy method for objective weight were utilized. With comparing the vulnerability ranks and analyzing rank correlation between two methods, we evaluated the vulnerabilities for the Han River watershed. For water use, vulnerable watersheds showed high water use and the water leakage ratio. The indices from both weighting methods showed similar spatial distribution in general. Such results suggests that the approach to consider different weighting methods would be important for reliably assessing the water use vulnerability in watersheds.