• 한국신뢰성학회:학술대회논문집
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• 한국신뢰성학회 2005년도 학술발표대회 논문집
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• pp.385-392
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• 2005

The restriction of the use of hazardous substances in electrical and electronic equipment legislation mandates the substitution of lead and other hazardous substances in electronics products by July 2006. Due to this legislative pressure, the electronics industry is moving to adoption of lead free solders. In this paper, we investigated a flux to restrict generating electrochemical migration in lead-free solder. The lead-free solders used in this study were Sn-0.7Cu-0.01P and Sn-3.0Ag-0.5Cu. To measure the resistance of electrochemical migration, the dew-cycle test and water drop test were adopted. As the result, now flux having high durable of electrochemical migration was developed.

• 전자공학회논문지SC
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• 제41권6호
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• pp.17-25
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• 2004

본 논문에서는, 저전력 소비를 위한 새로운 저전압 스윙 도미노 로직 회로를 제안한다. 전력 소비를 줄이기 위해, 도미노 로직의 예비충전(precharge) 노드와 출력 노드가 0V부터 V/sub REF/-V/sub TH/까지의 범위에서 스윙하도록 설계하였다. 여기서, V/sub REF/=VDD-nV/sub TH/ (n=0, 1, 2, 3)로 정의되며 설계자는 요구되는 속도와 전력 소비 특성을 감안하여 n 값을 설정할 수 있다. 이와 같은 특성은 누설 전류 없이 저전압 입력을 받을 수 있는 인버터의 구조에 의해 얻어진다. 제안된 도미노 로직을 적용하여 4×4 Braun 곱셈기를 설계하였고 공급전압 3.3V를 갖는 0.35㎛ n-well CMOS 공정으로 제작하였다. 제작된 칩은 기존 회로들과 비교할 때, 30% 이상의 전력 감소효과를 나타내며 전력-지연 곱에서도 우수한 성능을 나타내었다.

• 한국운동역학회지
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• 제17권3호
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• pp.61-68
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• 2007

When an active muscle is stretched, its steady-state isometric force following stretch is greater than that of a purely isometric contraction as the corresponding muscle length, referred to as force enhancement (FE). The purpose of this study was to investigate possible effects of muscle architecture on the FE. While subject performed maximal isometric dorsiflexion (REF) and isometric-stretch-isometric dorsiflexion (ECC) contractions, ankle joint angle and dorsiflexion torque using a dynamometer and electromyography of the tibialis anterior and the medical gastrocnemius muscles were measure. Simultaneously, real-time ultrasound images of the tibialis anterior were acquired. Regardless of the speed of stretch of the ECC contractions. the torques produced during the isometric phase following stretch ($37.3{\pm}1.5\;Nm$ ($10{\pm}3%$ FE) and $38.3{\pm}1.5$ ($12{\pm}3%$ FE) for the ECC contractions with $15^{\circ}$/s and $45^{\circ}$/s stretch speeds, respectively) were greater than those of the REF contractions ($34.5{\pm}2.5\;Nm$). Moreover, the amount of FE was found to be stretch speed dependent. Angles of pennation ($\alpha$) during the isometric phase following stretch were the same for the REF ($15{\pm}1^{\circ}$) and the ECC ($14{\pm}1^{\circ}$(LS), $15{\pm}1^{\circ}$(LF)). During the same phase, muscle thicknesses were the same ($14.9{\pm}0.6$, and $14.9{\pm}0.5\;mm$ for the REF and the ECC contractions, respectively). For a large limb muscle, the tibialis anterior muscle, a similar amount of force enhancement was observed as did for other human skeletal muscles. Architectural variables, pennation angle and thickness, were not systematically different between the REF and ECC contractions when FE occurred. Therefore, the results of this study suggest that muscle architecture may have little influence on the production of FE.

• Nutrition Research and Practice
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• 제9권6호
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• pp.586-591
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• 2015

BACKGROUND/OBJECTIVES: Reactive oxygen species (ROS) formation is closely related to miconazole-induced heart dysfunction. Although rhamnetin has antioxidant effects, it remained unknown whether it can protect against miconazole-induced cardiomyocyte apoptosis. Thus, we investigated the effects of rhamnetin on miconazole-stimulated H9c2 cell apoptosis. MATERIALS/METHODS: Cell morphology was observed by inverted microscope and cell viability was determined using a WelCount$^{TM}$ cell proliferation assay kit. Miconazole-induced ROS production was evaluated by fluorescence-activated cell sorting with 6-carboxy-2',7'-dichlorofluoroscein diacetate ($H_2DCF$-DA) stain. Immunoblot analysis was used to determine apurinic/apyrimidinic endonuclease 1 (APE/Ref-1) and cleaved cysteine-aspartic protease (caspase) 3 expression. NADPH oxidase levels were measured using real-time polymerase chain reaction. RESULTS: Miconazole (3 and $10{\mu}M$) induced abnormal morphological changes and cell death in H9c2 cells. Rhamnetin enhanced the viability of miconazole ($3{\mu}M$)-treated cells in a dose-dependent manner. Rhamnetin (1 and $3{\mu}M$) treatment downregulated cleaved caspase 3 and upregulated APE/Ref-1 expression in miconazole-stimulated cells. Additionally, rhamnetin significantly reduced ROS generation. CONCLUSIONS: Our data suggest that rhamnetin may have cytoprotective effects in miconazole-stimulated H9c2 cardiomyocytes via ROS inhibition. This effect most likely occurs through the upregulation of APE/Ref-1 and attenuation of hydrogen peroxide levels.

• Korean Journal of Mathematics
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• 제12권1호
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• pp.67-75
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• 2004

Paul Turan observed that the Legendre polynomials satisfy the inequality $P_n(x)^2-P_{n-1}(x)P_{n+1}(x)$ > 0, $-1{\leq}x{\leq}1$. And G. Gasper(ref. [6], ref. [7]) proved such an inequality for Jacobi polynomials and J. Bustoz and N. Savage (ref. [2]) proved $P^{\alpha}_n(x)P^{\beta}_{n+1}(x)-P^{\alpha}_{n+1}(x)P{\beta}_n(x)$ > 0, $\frac{1}{2}{\leq}{\alpha}$ < ${\beta}{\leq}{\alpha}+2.0$ < $x$ < 1, for the ultraspherical polynomials (respectively, Laguerre ploynomials). The Bustoz-Savage inequalities hold for Laguerre and ultraspherical polynomials which are symmetric. In this paper, we prove some similar inequalities for non-symmetric Jacobi polynomials.

• The Korean Journal of Physiology and Pharmacology
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• 제14권3호
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• pp.139-144
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• 2010

In this study, we evaluated the role of apurinic/apyrimidinic endonuclease1/redox factor-1 (Ref-1) on the tumor necrosis factor-$\alpha$ (TNF-$\alpha$) induced cyclooxygenase-2 (COX-2) expression using A549 lung adenocarcinoma cells. TNF-$\alpha$ induced the expression of COX-2 in A549 cells, but did not induce BEAS-2B expression. The expression of COX-2 in A549 cells was TNF-$\alpha$ dose-dependent (5~100 ng/ml). TNF-$\alpha$-stimulated A549 cells evidenced increased Ref-1 expression in a dose-dependent manner. The adenoviral transfection of cells with AdRef-1 inhibited TNF-$\alpha$-induced COX-2 expression relative to that seen in the control cells ($Ad{\beta}gal$). Pretreatment with $10\;{\mu}M$ of SB203580 suppressed TNF-$\alpha$-induced COX-2 expression, thereby suggesting that p38 MAPK might be involved in COX-2 expression in A549 cells. The phosphorylation of p38 MAPK was increased significantly after 5 minutes of treatment with TNF-$\alpha$, reaching a maximum level at 10 min which persisted for up to 60 min. However, p38MAPK phosphorylation was markedly suppressed in the Ref-1-overexpressed A549 cells. Taken together, our results appear to indicate that Ref-1 negatively regulates COX-2 expression in response to cytokine stimulation via the inhibition of p38 MAPK phosphorylation. In the lung cancer cell lines, Ref-1 may be involved as an important negative regulator of inflammatory gene expression.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1996년도 추계학술대회 논문집 학회본부
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• pp.91-94
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• 1996

A simulation procedure was developed for identifying Yungnam unit 2 excitation model parameters to improve the accuracy of stability simulation of KEPCO. First, generator model parameters are derived by using modified load rejection technique from measured load rejection test. For identifying excitation model parameters, switch was changed from MVR mode to AVR mode in Yungnam unit 2 excitation system instead of applying to a small step to the voltage reference($V_{ref}$) because of saving time and efforts, assuming the test result would show coincided result with applying to a small step to the $V_{ref}$. However, it was found that the response of switching from MVR to AVR is greatly different from it of applying small signal to the $V_{ref}$. A simulation procedure was needed to take into accounts of real AVR component status before and after switching from MVR to AVR. This paper reports the procedure which duplicated the measured response and addresses the merits of this test on conventional AVR step test.

• Journal of the Korean Physical Society
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• 제73권12호
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• pp.1814-1820
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• 2018

With the publication of TRS-483 in late 2017 the IAEA has established an international code of practice for reference dosimetry in small and non-standard fields based on a formalism first suggested by Alfonso et al. in 2008. However, data on beam quality correction factors ($k^{f_{msr},f_{ref}}_{Q_{msr},Q_0}$) for the Leksell Gamma $Knife^{(R)}$ $Perfexion^{TM}$ is scarce and what little data is available was obtained under conditions not necessarily in accordance with the IAEA's recommendations. This study constitutes the first systematic attempt to calculate those correction factors by applying the new code of practice to Monte Carlo simulation using the GEANT4 toolkit. $k^{f_{msr},f_{ref}}_{Q_{msr},Q_0}$ values were determined for three common ionization chamber detectors and five different phantom materials, with results indicating that in most phantom materials, all chambers were well suited for reference dosimetry with the Gamma $Knife^{(R)}$. Similarities and differences between the results of this study and previous ones were also analyzed and it was found that the results obtained herein were generally in good agreement with earlier PENELOPE and EGSnrc studies.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 추계 학술발표회 제20권2호
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• pp.241-244
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• 2008

본 연구의 필자는 우리나라 철근콘크리트(RC) 건물의 대다수를 차지하고 있는 중 저층 RC 건물, 특히 전단 및 휨파괴형 부재가 혼합된 중.저층 RC 건물의 성능지정이 가능한 내진성능평가법을 제안하였다$^{1)}$. 문헌[1]에서는 중 저층 RC 건물의 전단 및 휨파괴형 부재 내력과 연성능력 사이의 상관관계를 파악함과 동시에, 전단 및 휨파괴형 부재의 각각의 피해 정도가 건물 전체의 피해 상황에 어떻게 영향을 미치는가를 검토 및 검증하여 내진성능 평가법을 제안하였으며, 또한 실제 지진에서 피해를 입은 중 저층 RC 건물에 적용하여 제안한 평가법의 신뢰성을 검증하였다. 문헌[1]에서 제안한 평가법은 기존의 내력 중심의 내진성능 평가법(일본 내진진단법)에 비하여 보다 효율적으로 내진성능이 우수한 건물을 선별 가능하다고 사료되며, 이에 제안한 평가법을 토대로 본 연구에서는 국내 현존 저층 RC 건물을 대상으로 그 내진안정성을 평가 및 검토하였다.

• Transactions on Electrical and Electronic Materials
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• 제5권2호
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• pp.71-75
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• 2004

This paper proposes a new bandgap reference (BGR) circuit which takes advantage of a cascode current mirror biasing to reduce the V$\_$ref/ variation, and sizing technique, which utilizes two related ratio numbers k and N, to reduce the PNP BJT area. The proposed BGR is designed and fabricated on a test chip with a goal to provide a reference voltage to the 10 bit A/D(4-4-4 pipeline architecture) converter of the CMOS Active Pixel Sensor (APS) imager to be used in X-ray imaging. The basic temperature variation effect on V$\_$ref/ of the BGR has a maximum delta of 6 mV over the temperature range of 25$^{\circ}C$ to 70$^{\circ}C$. To verify that the proposed BGR has radiation hardness for the X-ray imaging application, total ionization dose (TID) effect under Co-60 exposure conditions has been evaluated. The measured V$\_$ref/ variation under the radiation condition has a maximum delta of 33 mV over the range of 0 krad to 100 krad. For the given voltage, temperature, and radiation, the BGR has been satisfied well within the requirement of the target 10 bit A/D converter.