• Journal of Embryo Transfer
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• v.29 no.3
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• pp.297-303
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• 2014

The objective of this study was to determine the breed differences in the 3'-untranslated region (UTR) of MC1R mRNA, which may be used to distinguish Korean brindle cattle (Chikso) from other breeds. We investigated the relationship between the variation of 3'-UTR of the MC1R mRNA and coat color among different breeds and the Korean brindle cattle with different coat colors. MC1R mRNA expression levels were determined in accordance with the coat color and hair colors of the tail. Total cellular RNA was extracted from the hair follicles of the tails in Hanwoo, Korean brindle cattle, Holstein and $Hanwoo{\times}Holstein$ crossbred cattle. After cDNA synthesis, PCR was performed. Sequences of the 3'-UTR of MC1R mRNA were analyzed. The 3'-UTR of the MC1R mRNA from different breeds of cattle did not show any variations. There were no variations in the 3'-UTR of the MC1R mRNA in Korean brindle cattle with different coat colors. The levels of MC1R mRNA expression in hair follicles of the tail varied substantially among the Korean brindle cattle with different coat colors, except yellow coat color. Correlation between the MC1R mRNA expression in the hair follicles of the tail and coat color may be present in the Korean brindle cattle, but not between the variations of 3'-UTR of MC1R mRNA and coat color. Further studies to determine the regulation of MC1R mRNA expression from the hair follicles of different coat colors will be beneficial in clarifying the role of MC1R in the coat colors of the Korean brindle cattle.

• Korean Journal of Digital Imaging in Medicine
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• v.9 no.1
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• pp.37-43
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• 2007

1. Purpose : This study is to present effective exposure conditions to acquire the best image of simple abdomen in Film Screen (F.S) system and Computed Radiography (C.R) system. 2. Method : In the F.S system, while an exposure condition was fixed as 70kVp, images of a patients simple abdomen were taken under the different mAs exposure conditions. Among these images, the best one was chosen by radiologists and radiological technologists. In the C.R system, the best image of the same patient was acquired with the same method from the F.S system. Both characteristic curves from F.S system and C.R system were analyzed. 3. Results : In the F.S system, the best exposure condition of simple abdomen was 70kVp and 20mAs. In the CR system, with the fixed condition at 70kVp, the image densities of human organs, such as liver, kidney, spleen, psoas muscle, lumbar spine body and iliac crest, were almost same despite different environments (3.2mAs, 8mAs, 12mAs, 16mAs and 20mAs). However, when the exposure conditions were over or under (below) 12mAs, the images between the abdominal wall and the directly exposed part became blurred because the gap of density was decreased. In the C.R system, while the volume of mAs was decreased, an artifact of quantum mottle was increased. 4. Conclusion : This study shows that the exposure condition in the C.R system can be reduced 40% than in the F.S system. This paper concluded that when the exposure conditions are set in CR environment, after the analysis of equipment character, such as image processing system(EDR : Exposure Data Recognition processing), PACS and so on, the high quality of image with maximum information can be acquired with a minimum exposure dose.

• Toxicological Research
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• v.21 no.3
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• pp.209-218
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• 2005

We investigated effects of recombinant human erythropoietin (rHuEPO) on profiles of mRNA transcripts in 6 male cynomolgus (M. fascicularis) monkey's spleen for 4 weeks. Six monkeys, composed of control and treatment group (Control : M1, M2, M3: Treatment : M4, M5, M6) were intravenously administered 3 times per week without or with a dose of rHuEPO 2730 IU/0.1 ml/kg. After 4 weeks rHuEPO treatment, spleen was removed for RNA isolation. Splenic gene expression was assessed using Affymetrix U133A 2.0 arrays containing 18,400 transcripts and variants, including 14,500 well-characterized human genes. Gene expression pattern was very different between individuals even in same treatment. In rHuEPO treated groups showed number of genes were up- or down-regulated (M4: 79: M5: 48; M6: 73 genes). Six genes (epidermal growth factor receptor, calgranulin A, estrogen receptor binding site associated antigen, matrix metalloproteinase 19, zinc finger and BTB domain containing 16, progestin and adipoQ receptor) were commonly expressed in rHuEPO treated group. The different individual response could be major considering factor in monkey experiment. Further study is needed to clarify the different individual response to rHuEPO in molecular level. This study will be valuable in the fundamental understanding and validation of molecular toxicology for bio-generic drugs including rHuEPO in cynomolgus monkey.

• East Asian mathematical journal
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• v.16 no.1
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• pp.111-123
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• 2000

Northcott and McKerrow proved that if R is a left noetherian ring and E is an injective left R-module, then $E[x^{-1}]$ is an injective left R[xl-module. Park generalize Northcott and McKerrow's result so that if R is a left noetherian ring and E is an injective left R-module, then $E[x^{-S}]$ is an injective left $R[x^s]$-module, where S is a submonoid of N(N is the set of all natural numbers). In this paper we show $$Hom_{R[x^S]}(M[x^{-S}],\;N[x^{-S}]){\cong}Hom_R(M,\;N)[[x^S]]$$ and using the above result and this isomorphism, finally we show that $$Ext^i_{R[x^S]}(M[x^{-S}],\;N[x^{-S}]){\cong}Ext^i_R(M,\;N)[[x^S]]$$.

• Bulletin of the Korean Mathematical Society
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• v.59 no.1
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• pp.213-226
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• 2022

Let R be a ring and M an R-module. Then M is said to be regular w-flat provided that the natural homomorphism I ⊗_R M → R ⊗_R M is a w-monomorphism for any regular ideal I. We distinguish regular w-flat modules from regular flat modules and w-flat modules by idealization constructions. Then we give some characterizations of total quotient rings and Prüfer v-multiplication rings (PvMRs for short) utilizing the homological properties of regular w-flat modules.

• Bulletin of the Korean Mathematical Society
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• v.22 no.2
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• pp.117-119
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• 1985

Let R be a commutative noetherian ring with 1.neq.0, denoting by .nu.(I) the cardinality of a minimal basis of the ideal I. Let A be a polynomial ring in n>0 variables with coefficients in R, and let M be a maximal ideal of A. Generally it is shown that .nu.(M $A_{M}$).leq..nu.(M).leq..nu.(M $A_{M}$)+1. It is well known that the lower bound is not always satisfied, and the most classical examples occur in nonfactional Dedekind domains. But in many cases, (e.g., A is a polynomial ring whose coefficient ring is a field) the lower bound is attained. In [2] and [3], the conditions when the lower bound is satisfied is investigated. Especially in [3], it is shown that .nu.(M)=.nu.(M $A_{M}$) if M.cap.R=p is a maximal ideal or $A_{M}$ (equivalently $R_{p}$) is not regular or n>1. Hence the problem of determining whether .nu.(M)=.nu.(M $A_{M}$) can be studied when p is not maximal, $A_{M}$ is regular and n=1. The purpose of this note is to provide some conditions in which the lower bound is satisfied, when n=1 and R is a regular local ring (hence $A_{M}$ is regular)./ is regular).

• Journal of the Korean Mathematical Society
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• v.54 no.4
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• pp.1099-1108
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• 2017

Let R be a commutative ring with non-zero identity and M be a unitary R-module. Let S(M) be the set of all submodules of M and ${\phi}:S(M){\rightarrow}S(M){\cup}\{{\emptyset}\}$ be a function. We say that a proper submodule P of M is a ${\phi}$-semiprime submodule if $r{\in}R$ and $x{\in}M$ with $r^2x{\in}P{\setminus}{\phi}(P)$ implies that $rx{\in}P$. In this paper, we investigate some properties of this class of sub-modules. Also, some characterizations of ${\phi}$-semiprime submodules are given.

• The Korean Journal of Physiology and Pharmacology
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• v.20 no.6
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• pp.557-564
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• 2016

Metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD), a type of synaptic plasticity, is characterized by a reduction in the synaptic response, mainly at the excitatory synapses of the neurons. The hippocampus and the cerebellum have been the most extensively studied regions in mGluR-dependent LTD, and Group 1 mGluR has been reported to be mainly involved in this synaptic LTD at excitatory synapses. However, mGluR-dependent LTD in other brain regions may be involved in the specific behaviors or diseases. In this paper, we focus on five cortical regions and review the literature that implicates their contribution to the pathogenesis of several behaviors and specific conditions associated with mGluR-dependent LTD.

• IE interfaces
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• v.21 no.3
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• pp.254-261
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• 2008

Connected-(r,s)-out of-(m,n) : F system is an important topic in redundancy design of the complex system reliability and it's maintenance policy. Previous studies applied Monte Carlo simulation and genetic, simulated annealing algorithms to tackle the difficulty of maintenance policy problem. These algorithms suggested most suitable maintenance cycle to optimize maintenance pattern of connected-(r,s)-out of-(m,n) : F system. However, genetic algorithm is required long execution time relatively and simulated annealing has improved computational time but rather poor solutions. In this paper, we propose the ant colony optimization approach for connected-(r,s)-out of-(m,n) : F system that determines maintenance cycle and minimum unit cost. Computational results prove that ant colony optimization algorithm is superior to genetic algorithm, simulated annealing and tabu search in both execution time and quality of solution.

• The Journal of the Acoustical Society of Korea
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• v.13 no.1
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• pp.93-98
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• 1994

This study aims to find the theoretical consideration of the basic simularity rule between scale model experiment and real building as a results ; 1. In the case of room acoustics, $f_m=n\cdot{f_r}\;T_m=T_r/n\; \alpha_m(f_m)=\alpha_r(f_r)$ 2. That of sound Insulation : $TL_m(f_m)=TL_r(f_r)$