• The Korean Journal of Medicine
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• 제93권6호
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• pp.538-547
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• 2018

목적: 급성 심근경색증 환자에서 좌심실 이완 기능과 좌심실 충만압은 환자의 예후와 관련되어 있다고 알려져 있다. 이 연구의 목적은 젊은 급성 심근경색증 환자에서 좌심실 이완 기능 저하 및 충만압 상승에 따른 임상 경과의 차이를 파악하고자 하였다. 방법: 2011년 1월부터 2015년 8월까지 Korea Acute Myocardial Infarction Registry-National Institute of Health (KAMIR-NIH)에 등록된 환자 중 젊은 급성 심근경색증(남 < 45세, 여 < 55세)으로 전남대학교병원에 입원한 환자 240명중에서 관상동맥중재술을 시술받고 2년 동안 임상 추적 관찰이 되어 분석 가능한 환자 200명(남 : 여 = 160명 : 40명)을 대상으로 하였다. 200명의 환자를 좌심실 이완 기능이 정상인 군(46명, $39.5{\pm}5.3$세)과 비정상군(154명, $43.5{\pm}5.1$세)으로 나누었다. 좌심실 충만압을 측정하였으며, 좌심실 충만압 상승을 E/e' ratio 15 이상으로 정의하였다. 좌심실 이완 기능 정상군과 비정상군으로 나누었고 정상 좌심실 충만압군과 좌심실 충만압 상승군으로 나누어 각각 주요 심장 사건을 분석하였다. 주요 심장 사건은 사망, 심근경색증의 재발 및 재관류술로 정의하였다. 결과: 연구 대상자를 평균 $40.9{\pm}11.6$개월 동안 임상적으로 추적 관찰한 결과, 이 중 26명(13%)에서 사망, 심근경색증재발 및 재관류등의 주요 심장 사건이 발생하였고, 좌심실이완 기능 정상군과 비정상군 간의 유의한 차이는 없었다(p = 0.810). 또한 좌심실 이완 기능을 정상군과 1도 이완기기능 장애군과 2도 이완기 기능 장애군으로 나누어서 추가 분석하였다. 2도 이완기 기능 장애군에서 심근경색증 재발은 유의한 차이를 보였지만(p = 0.006), 주요 심장 사건과 유의한 차이는 없었다(p = 0.081). 그러나 좌심실 충만압 상승군에서 정상 좌심실 충만압을 가진 환자군에 비하여 주요 심장 사건의 발생률은 유의한 차이가 있었다(p < 0.001). 다변량 분석 결과 주요 심장 사건 발생의 독립적인 인자는 E/e' ratio 15 이상 환자로 파악되었다(p = 0.019). Kaplan-Meier 생존 곡선을 이용한 사망률을 추적한 결과 좌심실 수축 기능 40% 미만인 환자(p < 0.001)와 E/e' ratio 15 이상 환자(p = 0.004)에서 유의하게 생존율이 낮았다. 결론: 높은 좌심실 충만압은 젊은 급성 심근경색증 환자의 예후에 대한 독립적 예측 인자였으며, 좌심실 충만압의 측정은 젊은 급성 심근경색증 환자에서 심근경색증 후 고위험 환자군 분류에 유용할 것으로 기대된다.

• 충청수학회지
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• 제19권1호
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• pp.79-99
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• 2006

In this paper, we define a class of functional defined on a very general function space $C_{a,b}[0,T]$ like a Fresnel class of an abstract Wiener space. We then define the multiple $L_p$ analytic generalized Fourier-Feynman transform and the generalized convolution product of functionals on function space $C_{a,b}[0,T]$. Finally, we establish some relationships between the multiple $L_p$ analytic generalized Fourier-Feynman transform and the generalized convolution product for functionals in $\mathcal{F}(C_{a,b}[0,T])$.

• 대한수학회논문집
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• 제19권1호
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• pp.93-111
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• 2004

In this paper, we use a generalized Brownian motion process to define a generalized Feynman integral and a generalized Fourier-Feynman transform. We also define the concepts of the multiple Lp analytic generalized Fourier-Feynman transform and the generalized convolution product of functional on function space $C_{a,\;b}[0,\;T]$. We then verify the existence of the multiple $L_{p}$ analytic generalized Fourier-Feynman transform for functional on function space that belong to a Banach algebra $S({L_{a,\;b}}^{2}[0, T])$. Finally we establish some relationships between the multiple $L_{p}$ analytic generalized Fourier-Feynman transform and the generalized convolution product for functionals in $S({L_{a,\;b}}^{2}[0, T])$.

• 대한수학회논문집
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• 제21권2호
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• pp.261-272
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• 2006

In this paper, we define the sequence spaces: $[V,{\lambda},f,p]_0({\Delta}^r,E,u),\;[V,{\lambda},f,p]_1({\Delta}^r,E,u),\;[V,{\lambda},f,p]_{\infty}({\Delta}^r,E,u),\;S_{\lambda}({\Delta}^r,E,u),\;and\;S_{{\lambda}0}({\Delta}^r,E,u)$, where E is any Banach space, and u = ($u_k$) be any sequence such that $u_k\;{\neq}\;0$ for any k , examine them and give various properties and inclusion relations on these spaces. We also show that the space $S_{\lambda}({\Delta}^r, E, u)$ may be represented as a $[V,{\lambda}, f, p]_1({\Delta}^r, E, u)$ space. These are generalizations of those defined and studied by M. Et., Y. Altin and H. Altinok [7].

• 대한수학회지
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• 제34권1호
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• pp.135-147
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• 1997

Let k be an infinite field and let $X = {P_1, \cdots, P_s}$ be a set of s-distinct points in $P^n$. We denote by $I(X)$ the defining ideal of $X$ in the polynomial ring $R = k[x_0, \cdots, x_n]$ and by A the homogeneous coordinate ring of $X, A = \sum_{t = 0}^{\infty} A_t$.

• 대한수학회보
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• 제36권2호
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• pp.287-303
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• 1999

The general solution of the functional equation f1(pr, qs) + f2(ps, qr) = g(p,q) + h(r,s) for p, q, r, s $\in$] 0, 1[will be investigated without any regularity assumptions on the unknown functions f1, f2, g, h:]0.1[->R.

• 대한핵의학회지
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• 제25권2호
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• pp.227-236
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• 1991

Background: The evaluation of individual renal function is important to diagnosis and follow-up of various diseases. Ureteral catheterization of each kidney has been widely used for this purpose, but this method had some technical difficulty, frequent complications and much restriction in reapplication. Therefore we tried to applicate radiopharmaceuticals for the evaluation of individual renal function. Methods: We measured 2 hour, 4 hour and 24 hour relative renal uptake of $^{99m}Tc-DMSA$ and relative glomerular filteration rate of $^{99m}Tc-DTPA$ with 59 patients with various renal diseases to determine their usefulness for assessment of individual renal function and to compare correlations between every renal uptake of $^{99m}Tc-DMSA$ and relative glomerular filteration rate. Results: The correlations between 2 hour-, 4 hour- and 24 hour- relative renal uptake of $^{99m}Tc-DMSA$ and relative glomerular filteration rate of $^{99m}Tc-DTPA$ were R=0.9190 (p < 0.001), R: 0.9229 (p<0.001) and R=0.9917 (p<0.001). In acute obstructive uropathy, the correlations at 2 hour and 4 houre were poor as R=0.1812 (p<0.05) and R=0.4923 (p < 0.05), but the correlation at 24 hour was good as R=0.9942 (p<0.001). Conclusions: We concluded that relative renal uptake at 2 hour and 4 hour had good correlation with relative DTPA uptake ratio in the cases without chronic renal failure and obstructive uropathy. Delayed image with 24 hour relative renal uptake $^{99m}Tc-DTPA$ had the best correlation with relative glomerular filteration rate of $^{99m}Tc-DTPA$ and that might be useful in evaluation of chronic renal disease in which showed increased beckground activity or acute obstructive uropathy.

• Asian-Australasian Journal of Animal Sciences
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• 제32권2호
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• pp.217-223
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• 2019

Objective: An experiment was conducted to investigate the effects of feed intake restriction during late pregnancy on the function, anti-oxidation capability and acute phase protein synthesis of ovine liver. Methods: Eighteen time-mated ewes with singleton fetuses were allocated to three groups: restricted group 1 (RG1, 0.18 MJ ME/kg $W^{0.75}$ d, n = 6), restricted group 2 (RG2, 0.33 MJ ME/kg $W^{0.75}$ d), n = 6) and a control group (CG, ad libitum, 0.67 MJ ME/kg $W^{0.75}$ d, n = 6). The feed restriction period was from 90 days to 140 days of pregnancy. Results: The ewe's body weight, liver weights, water, and protein content of liver in the restricted groups were reduced compared with the CG group (p<0.05), but the liver fat contents in the RG1 group were higher than those of the CG group (p<0.05). The increased hepatic collagen fibers and reticular fibers were observed in the restricted groups with the reduction of energy intake. The concentrations of nonesterified free fatty acids in the RG1 and RG2 groups were higher than those of the CG group with the reduction of energy intake (p<0.05), but there were decreased concentrations of lipoprotein lipase and hepatic lipase in both restricted groups compared with the CG group (p<0.05). In addition, the increased concentrations of ${\beta}$-hydroxybutyric acid, triglycerides, malondialdehyde, total antioxidant capacity and activities of superoxide dismutase activity and catalase were found in the RG1 group, and the concentrations of cholinesterase in the RG1 group were reduced compared with the CG group (p<0.05). For the concentrations of acute phase proteins, the C-reactive protein (CRP) in the RG1 group were reduced compared with the CG group, but there were no differences in haptoglobin relative to the controls (p>0.05). Conclusion: The fat accumulation, increased hepatic fibrosis, antioxidant imbalance and modified synthesis of acute phase proteins were induced in ewe's liver by maternal malnutrition during late pregnancy, which were detrimental for liver function to accommodate pregnancy.

• PNF and Movement
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• 제19권1호
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• pp.57-65
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• 2021

Purpose: This study investigated the effects of proprioceptive neuromuscular facilitation (PNF) respiratory muscle strengthening exercise on the pulmonary function, back pain, and disability level of patients with chronic low back pain (CLBP). Methods: There were 24 CLBP patients randomly divided into the experimental group (n = 12) who took part in PNF respiratory muscle strengthening exercise and the control group (n = 12) who performed a mock treatment. Both groups performed their respective interventions for 15 min five times per week for four weeks. The pulmonary function was measured using a portable spirometer. The back pain of the participants was assessed using a visual analogue scale. The Oswestry disability index was conducted to measure disability level. A paired t-test was performed to compare within-group changes before and after the PNF respiratory muscle strengthening exercise. Differences between the experimental and the control groups were analyzed using an independent t-test. For all tests, the level of statistical significance was α = 0.05. Results: The within-group change in pulmonary function was significantly different in the experimental group (p < 0.05), and the levels of back pain and disability were significantly different between the groups (p < 0.05). There was also a significant between-group difference in pulmonary function, back pain, and disability level after intervention (p < 0.05). Conclusion: These results suggest that PNF respiratory muscle strengthening exercise enhances pulmonary function and reduces levels of back pain and disability in patients with CLBP.

• 대한수학회지
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• 제59권5호
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• pp.911-926
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• 2022

Let u be a function on a locally finite graph G = (V, E) and Ω be a bounded subset of V. Let 𝜀 > 0, p > 2 and 0 ≤ λ < λ₁(Ω) be constants, where λ₁(Ω) is the first eigenvalue of the discrete Laplacian, and h : V → ℝ be a function satisfying h ≥ 0 and $h{\not\equiv}0$. We consider a perturbed Yamabe equation, say $$\{\begin{array}{lll}-{\Delta}u-{\lambda}u={\mid}u{\mid}^{p-2}u+{\varepsilon}h,&&\text{ in }{\Omega},\\u=0,&&\text{ on }{\partial}{\Omega},\end{array}$$ where Ω and ∂Ω denote the interior and the boundary of Ω, respectively. Using variational methods, we prove that there exists some positive constant 𝜀₀ > 0 such that for all 𝜀 ∈ (0, 𝜀₀), the above equation has two distinct solutions. Moreover, we consider a more general nonlinear equation $$\{\begin{array}{lll}-{\Delta}u=f(u)+{\varepsilon}h,&&\text{ in }{\Omega},\\u=0,&&\text{ on }{\partial}{\Omega},\end{array}$$ and prove similar result for certain nonlinear term f(u).