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검색결과 6,126건 처리시간 0.033초

Inhibition of Collagenase by Naturally-Occurring Flavonoids

  • Sin, Bo-Young;Kim, Hyun-Pyo
    • Archives of Pharmacal Research
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    • 제28권10호
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    • pp.1152-1155
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    • 2005
  • We examined the inhibitory activities of various flavonoids, including the flavanones, flavones/isoflavones and flavonols, on collagenase from Clostridium histolyticum to establish their therapeutic potential against skin inflammation and photoaging. In general, the flavonols were stronger inhibitors than the flavones/isoflavones, and this indicated the importance of the C-3 hydroxyl substitution. Quercetin was the most active flavonoid among those tested, and it showed an $IC_{50}$ of 286 ${\mu}M$. These novel results suggest that certain flavonoids, particularly the flavonols, may prevent collagen breakdown by inhibiting collagenase in inflamed skin as well as photoaged skin.

Development of Planetary Reduction Motor with Mechanical Power Monitoring and Network Capability

  • Jang In-Hun;Sim Kwee-Bo
    • International Journal of Control, Automation, and Systems
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    • 제4권3호
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    • pp.359-364
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    • 2006
  • This article describes the useful way to measure the torque and RPM of the geared motor. For this we have made the planetary geared reduction motor including 2 Hall sensors in it and the monitoring system. The monitoring system displays the sensing values (torque, rpm) and the calculated value (power) and it also has the network capability using the Bluetooth protocol. We will show that our solution is much more inexpensive and simple method to measure torque and rpm than before.

Tris(2-methoxyphenyl)phosphine as a Highly Active Ligand for the Synthesis of Biaryls by Suzuki Coupling Reaction

  • Kang, Pill-Seong;Ko, Sung-Bo;Ko, Jang-Myoun;Park, Jeong-Ho
    • Bulletin of the Korean Chemical Society
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    • 제30권11호
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    • pp.2697-2700
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    • 2009
  • A $Pd(OAc)_2/(o-MeOPh)_3P$ system has been developed for the catalytic Suzuki coupling of aryl bromides with arylboronic acids. Our catalyst system covers a broad spectrum of commonly available arylboronic acids and aryl bromides to provide biaryls in very good yields. The catalyst system works very well in the synthesis of sterically hindered biaryls.

한국산(韓國産) Aristolochia속(屬) 식물의 성분 연구(I) (Studies on the Components of the Genus Aristolochia Plants in Korea(I))

  • 정보섭
    • 생약학회지
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    • 제5권3호
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    • pp.167-172
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    • 1974
  • The stems of Aristolochia manshuriensis $K_{OMAROV}$ collected in Kang-won-do, Korea, have been shown to contain aristolochic acids I and II and debilic acid. ${\beta}-Sitosterol$ and the ester of linolic acid were isolated from the petroleum ether: ether(1 : 1) extracts of the stem by using column chromatography.

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인간 심실모델에서의 혈류역학 해석 (Computational analysis of hemodynamics in a human ventricular model)

  • 심은보;권순성;김유석;전형민
    • 대한기계학회:학술대회논문집
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    • 대한기계학회 2007년도 춘계학술대회B
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    • pp.2947-2950
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    • 2007
  • A 3D human ventricular model is proposed to simulate an integrative analysis of heart physiology and blood hemodynamics. This consists of the models of electrophysiology of human cells, electric wave propagation of tissue, heart solid mechanics, and 3D blood hemodynamics. The 3D geometry of human heart is discretized to a finite element mesh for the simulation of electric wave propagation and mechanics of heart. In cellular level, excitations by action potential are simulated using the existing human model. Then the contraction mechanics of a whole cell is incorporated to the excitation model. The excitation propagation to ventricular cells are transiently computed in the 3D cardiac tissue using a mono-domain method of electric wave propagation in cardiac tissue. Blood hemodynamics in heart is also considered and incorporated with muscle contraction. We use a PISO type finite element method to simulate the blood hemodynmaics in the human ventricular model.

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Quality Evaluation of Modified Bo-Yang-Hwan-O-Tang by Capillary Electrophoresis and High-performance Liquid Chromatography

  • Chen, Jianbo;Wu, Enqi;Zhu, Hongmei;Lee, Kwan-Jun;Chu, Van Men;Cho, Cheong-Weon;Kim, Young-Ho;Park, Yong-Ki;Lee, Won-Jae;Kang, Jong-Seong
    • Bulletin of the Korean Chemical Society
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    • 제32권8호
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    • pp.2666-2670
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    • 2011
  • High-performance liquid chromatography (HPLC) and capillary electrophoresis (CE) were used to identify five active components in the modified herbal decoction Bo-Yang-Hwan-O-Tang (mBHT), i.e., amygdalin, decursin, paeoniflorin, salvianolic acid B, and calycosin-7-O-${\beta}$-D-glycoside. These components were identified by comparing their retention times and mass spectra with those of reference compounds. The conditions of both analytical methods were optimized and validated. Sufficient separation of target analytes was achieved using a buffer consisting of 40 mM sodium borate and 60 mM sodium dodecylsulfate (SDS) containing 10% methanol (pH 9.5) at 250 nm for CE analysis and gradient elution with a water-methanol mobile phase and ultraviolet (UV) photodiode array detector (DAD) at 250 nm for HPLC analysis. The mBHT components were determined within 65 min by HPLC and 16 min by CE. All calibration curves showed high linearity (R > 0.999) within the ranges tested. Intra-day and inter-day precision were less than 1.6% and 1.8% for HPLC and 2.5% and 4.8% for CE, respectively. The accuracy of the methods ranged from 98.8% to 102.3% for HPLC and from 95.9% to 108.2% for CE.

새로운 비스-크라운 에테르의 합성(제 2보) : 실옥산 사슬에 연결된 비스-크라운 에테르 (Synthesis of New Bis-Crown Ether (Ⅱ) : Bis-Crown Ether with Siloxane Moiety)

  • 장승현;김재용;정광보
    • 대한화학회지
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    • 제40권9호
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    • pp.635-639
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    • 1996
  • 실옥산 사슬에 크라운 에테르가 연결된 유연성이 큰 새로운 비스-크라운 에테르를 합성하였다. 1, 3-Bis(trimethylsiloxy)-1, 3-dimethyl-1, 3-di(4'-ethylbenz-o-18-crown-6) disiloxane(1)은 백금촉매 존재하에서 1, 3-bis(trimethylsiloxy)-1, 3-dimethyl-1, 3-disiloxane과 4'-vinylbenzo-18-crown-6의 반응에 의해 합성하였다.

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리튬황전지의 임피던스 특성 (Impedance Properties of Lithium Sulfur Batteries)

  • 김파;김종욱;구할본
    • 한국전기전자재료학회:학술대회논문집
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    • 한국전기전자재료학회 2002년도 추계학술대회 논문집 Vol.15
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    • pp.444-447
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    • 2002
  • The Jig cells are fabricated in the drying room, and consisted of elemental sulfur used as a cathode active material, lithium metal used as a anode material and 1M $LiCF_{3}SO_{3}$ dissolved in TG (Tetraglyme)/DIOX (1,3-Dioxolane) used as a electrolyte. The four kinds of electrolytes with different content of TG and DIOX are prepared. The electrochemical properties of the foregoing electrolytes-based lithium sulfur batteries are analyzed by AC impedance experiments. The conductivity of four different electrolytes is investigated. The conductivity of electrolyte [1M $LiCF_3SO_3$ dissolved in TG/DIOX (50:50, vol.)] is higher than that of other three kinds of electrolytes with different volume ratio (70:30, 30:70) and single solvent (TG).

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3D Object Picking in Web-based Design System

  • Kim, Dong-Hyun;Yun, Bo-Yeul;Kim, Eung-Kon
    • Journal of information and communication convergence engineering
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    • 제1권2호
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    • pp.82-87
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    • 2003
  • We are able to work on the shared virtual space in Web-based Collaborative Design System using only Internet and Web browser. Then the users will share 3D objects and must be able to pick the objects effectively which they want to manipulate. In this paper, picking is implemented not only by computing intersection of mouse pointer with the objects of the virtual world, but also by using capabilities and attributes of scene graph node, by setting bounds intersection testing instead of geometric intersection testing, by limiting the scope of the pick testing, using Java 3D. These methods can reduce the computation of picking and can pick 3D objects effectively and easily using the system of hierarchy.

Photo reflectance Measurement in Si$_{3}$N$_{4}$/ Al$_{0.21}$Ga$_{0.79}$ As/GaAs Heterostructure

  • Yu Jae-In;Park Hun-Bo;Choi Sang-Su;Kim Ki-Hong;Baet In-Ho
    • KIEE International Transactions on Electrophysics and Applications
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    • 제5C권2호
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    • pp.54-57
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    • 2005
  • Photoreflectance (PR) has been measured to investigate the characterization of the Si$_{3}$N$_{4}$Al$_{0.21}$ Ga$_{0.79}$As/GaAs and Al$_{0.21}$Ga$_{0.79}$As/GaAs heterostructures. In the PR spectrum, the caplayer thickness was 170 nm and Si$_{3}$N$_{4}$ was utilized as the capping material. The C peak is confirmed as the carbon defect with residual impurity originating from the growth process. After annealing, in the presence of the Si$_{2}$N$_{4}$ cap layer, band gap energy was low shifted. This result indicates that the Si$_{3}$N$_{4}$ cap layer controlled evaporation of the As atom.