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Inhibition of Collagenase by Naturally-Occurring Flavonoids  

Sin, Bo-Young (College of Pharmacy, Kangwon National University)
Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University)
Publication Information
Archives of Pharmacal Research / v.28, no.10, 2005 , pp. 1152-1155 More about this Journal
Abstract
We examined the inhibitory activities of various flavonoids, including the flavanones, flavones/isoflavones and flavonols, on collagenase from Clostridium histolyticum to establish their therapeutic potential against skin inflammation and photoaging. In general, the flavonols were stronger inhibitors than the flavones/isoflavones, and this indicated the importance of the C-3 hydroxyl substitution. Quercetin was the most active flavonoid among those tested, and it showed an $IC_{50}$ of 286 ${\mu}M$. These novel results suggest that certain flavonoids, particularly the flavonols, may prevent collagen breakdown by inhibiting collagenase in inflamed skin as well as photoaged skin.
Keywords
Flavonoid; Quercetin; Collagenase; Skin inflammation;
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Times Cited By Web Of Science : 12  (Related Records In Web of Science)
Times Cited By SCOPUS : 10
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