• 제어로봇시스템학회:학술대회논문집
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• 2002.10a
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• pp.44.6-44
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• 2002

$\textbullet$ Introduction $\textbullet$ Dynamical of the quadruple-tank process $\textbullet$ H2x Integral Servo Problems $\textbullet$ Verification via Simulation $\textbullet$ Conclusions

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.4
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• pp.345-356
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• 2023

This study aimed to assess the effects of exogenous hydrogen sulfide (H₂S) on abdominal aorta coarctation (AAC) induced myocardial fibrosis (MF) and autophagy in rats. Forty-four Sprague-Dawley rats were randomly divided into control group, AAC group, AAC + H₂S group, and H₂S control group. After a model of rats with AAC was built surgically, AAC + H₂S group and H₂S group were injected intraperitoneally with H₂S (100 µmol/kg) daily. The rats in the control group and the AAC group were injected with the same amount of PBS. We observed that H₂S can improve left ventricular function and the deposition of myocardial collagen fibers, inhibit pyroptosis, down-regulate the expression of P-eif2α in myocardial tissue, and inhibit cell autophagy by activating the phosphatidylinositol 3-kinase (PI3K)/AKT1 signaling pathway (p < 0.05). In addition, angiotensin II (1 µM) H9c2 cardiomyocytes were injured in vitro experiments, and it was also observed that pyroptosis was inhibited after H₂S (400 µmol/kg) intervention, the expression of P-eif2α in cardiomyocytes was significantly down-regulated, and the PI3K/AKT1 signaling pathway was activated at the same time. Therefore, increasing the expression of P-eif2α reverses the activation of the PI3K/AKT1 signaling pathway by H₂S. In conclusion, these findings suggest that exogenous H₂S can ameliorate MF in rats with AAC by inhibiting pyroptosis, and the mechanism may be associated with inhibiting the phosphorylation of eif2α and activating the PI3K/AKT1 signaling pathway to inhibit excessive cell autophagy.

• Journal of Institute of Control, Robotics and Systems
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• v.4 no.2
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• pp.151-156
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• 1998

This paper presents an $H_{\infty)$ output feedback controller design method for linear systems with delayed state, delayed control input, and delayed masurement output. Using a Lyapunov functional, the stability for delayed systems is discussed independently of delays. Also, sufficient condition for the existence of $H_{\infty)$ controllers of any order is given in terms of three linear matrix inequalities(LMIs). Based on positive definite solutions of their LMIs, we briefly explain the way to construct $H_{\infty)$ controller, which stabilizes time-delay systems independently of delays and guarantees an $H_{\infty)$norm bound.

• Proceedings of the KSAR Conference
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• 2001.03a
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• pp.40-40
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• 2001

Heat stress to bovine oocytes and embryos has suggested a potential role of retardation of their development. Limited study has reported on the effect of heat shock on sperm before using it for IVF. Caudal epididymal sperm cultured in 42$^{\circ}C$ incubator for 0.5, 1 and 2 h compared on sperm viability and oocyte development after its use for IVF to those of control. Oocytes were matured for 22 h and then inseminated with treated or control sperm for 16 h. Embryos were cultured in CRlaa medium, transferred to TCM199＋10% FBS on day 4, and maintained on day 9. A higher proportion (84.1%, 0.5 h; 72%, 1 h: 65%, 2 h) in treated sperm was observed dead and abnormal pattern as 100% of consider as control. In control the rates of cleavage and development into blastocyst were 76% and 22%, respectively, and did not differ the rates between 1 h and 2 h of culture. Significant differences were appeared in the rates between treated for an hour and control (32% and 5% vs. 54% and 10%, respectively). Moreover increased time of culture is more retardation to be cleaved the oocytes. However, the rates of blastocyst from cleaved embryos in treated group similar to control (25% vs. 29%, respectively). The reason for this remains unclear, but male sperm, from preliminary experiment(data un-shown) for sexing of resulting embryos, would be more fragility on heat stress.

• Journal of fish pathology
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• v.20 no.3
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• pp.269-279
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• 2007

This study was conducted to investigate the change of antioxidant enzyme activity (catalase and superoxide dismutase) and variation of blood physiology in olive flounder (Paralyticus olivaceus) by hydrogen peroxide (H2O2) treatment. Blood parameters were measured 1, 3 and 5 hours after H2O2 treatment with 0 (control), 100, 300 and 500 ppm for 1 hr. The value of hematocrit was decreased significantly dependently on treatment concentrate and elapsed time in the treatment of H2O2. Hemoglobin concentration in the test groups were lower than that of the control group. Red blood cell value in the test groups were significantly lower compared to that of the control group, but recovered to the level of the control group after 5 hr. Protein concentration was significantly lower compared to that of the control group at 0 and 1 hr, but recovered after 3 hr in 500 ppm treatment group. The superoxide dismutase (SOD) and catalase (CAT) enzyme activities were observed to be increased. Heat-shock protein 70 (HSP70) was significantly increased compared to that of control group in all of the test groups. HSP70 mRNA groups was highly expressed in 500 ppm treatment.

• Transactions on Control, Automation and Systems Engineering
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• v.2 no.4
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• pp.248-254
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• 2000

This paper presents and output feedback fuzzy H(sup)$\infty$ control problem for a class of nonlinear systems with time-varying delayed state. The Takagi-Sugeno fuzzy model is employed to represent a nonlinear systems with time-varying delayed state. Using a single quadratic Lyapunov function, the globally exponential stability and disturance attenuation of the closed-loop fuzzy control system are discussed. Sufficient conditions for the existence of fuzzy H(sup)$\infty$ controllers are given in terms of matrix inequalities. Constructive algorithm for design of fuzzy H(sup)$\infty$ controller is also developed. A simulation example is given to illustrate the performance of the proposed design method.

• 제어로봇시스템학회:학술대회논문집
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• 1996.10b
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• pp.1304-1307
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• 1996

In this paper, we present a robust Two Degree of Freedom (TDF) $H_{\infty}$ controllers for a missile system. The feedback controller is designed to meet robust stability and disturbance rejection specifications while the prefilter is used to improve the robust model matching properties of the closed loop system. As the perturbed model, we use the normalized coprim factor perturbations. These controllers are designed using $H_{\infty}$ optimization procedures, and applied to a missile model via simulation.

• 제어로봇시스템학회:학술대회논문집
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• 1996.10b
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• pp.754-758
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• 1996

In this paper, a new method of position synchronizing control is proposed for multi-axes driving system. The proposed synchronizing control system is constituted with speed and synchronizing controller. The structure of synchronizing control system is varied by sign of synchronizing error. When a disturbance input becomes added to one axis, this axis becomes slave axis. The other axis is master axis. Therefore, master axis is not influenced by the disturbance. The speed controller of the first axis is designed by $H_{\infty}$ control theory. The speed controller of the second axis is designed by inverse dynamics of speed control system of the first axis. The speed control system designed with $H_{\infty}$ controller guarantees low sensitivity for the disturbance as well as robustness against model uncertainties. Especially, the synchronizing controller is designed to keep position error to minimize by controlling speed of slave axis. The effectiveness of the proposed method is successfully confirmed through several experiments.

• Korean Journal of Plant Resources
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• v.20 no.6
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• pp.548-552
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• 2007

This research is the basic research to develop new anti-inflammatory medicine by feeding Scutellariae Radix extract to lipopolysaccharide(LPS) exposed rats, and analyzed it's effect on inflammatory response by LPS derivation. As a result, Plasma interleukin-$1\beta(IL-1\beta)$ and Plasma interleukin-6(IL-6) concentration showed the highest point at 5h after LPS injection, and in this time, the concentration of $IL-1\beta$ and IL-6 in the Scutellariae Radix extract groups at 200mg/kg and 300mg/kg showed lower values than that of control group. Plasma tumor necrosis $factor-\alpha(TNF-\alpha)$ concentration after LPS injection showed the highest point at 2h and showed similar level till at 5h. $TNF-\alpha$ concentration at 2h after LPS injection showed the low value only in the Scutellariae Radix extract 300mg/kg group compared to others, and in 5h, the all Scutellariae Radix extract groups showed lower value than that of the control group. Plasma interleukin-10(IL-10) concentration increased at 2h after LPS injection and reached the highest at 5h. After LPS injection the IL-10 concentration at 2h, the Scutellariae Radix extract injection group at 300mg/kg showed higher value than that of the others, and in 5h after LPS injection, Scutellariae Radix extract 200mg and 300mg groups showed higher value than the control group. Concluding from the above results, in inflammatory response by LPS derivation, the Scutellariae Radix gives positive effect.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.53 no.7
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• pp.483-490
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• 2004

The descriptor system model has a high ability in representing dynamical systems. It can preserve physical parameters in the coefficient matrices, and describe the dynamic part, static part, and even the improper part of the system in the same form. The design of mixed $H_{2}/H_{\infty}$ controllers for linear time-invariant descriptor systems is considered in this paper. Firstly, an $H_2$ and $H_{\infty}$ synthesis problems fur a descriptor system are presented separately in terms of linear matrix inequalities (LMIs) based on the bounded real lemma. Then, we show that the existence of a mixed $H_2/H_{\infty}$ controller by which the $H_2$ norm of the second channel is minimized while keeping the $H_2$ norm bound of the first channel less than ${\gamma}$, is reduced to the linear objective minimization problem. The class of desired controllers that are assumed to have the same structure as the plant is parameterized by using the linearizing change of variables.