• Title/Summary/Keyword: $F_{ST}$

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Allele Frequencies of the Single Nucleotide Polymorphisms Related to the Body Burden of Heavy Metals in the Korean Population and Their Ethnic Differences

  • Eom, Sang-Yong;Lim, Ji-Ae;Kim, Yong-Dae;Choi, Byung-Sun;Hwang, Myung Sil;Park, Jung-Duck;Kim, Heon;Kwon, Ho-Jang
    • Toxicological Research
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    • v.32 no.3
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    • pp.195-205
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    • 2016
  • This study was performed to select single nucleotide polymorphisms (SNPs) related to the body burden of heavy metals in Koreans, to provide Korean allele frequencies of selected SNPs, and to assess the difference in allele frequencies with other ethnicities. The candidate-gene approach method and genome-wide association screening were used to select SNPs related to the body burden of heavy metals. Genotyping analysis of the final 192 SNPs selected was performed on 1,483 subjects using the VeraCode Goldengate assay. Allele frequencies differences and genetic differentiations between the Korean population and Chinese (CHB), Japanese (JPT), Caucasian (CEU), and African (YIR) populations were tested by Fisher's exact test and fixation index ($F_{ST}$), respectively. The Korean population was genetically similar to the CHB and JPT populations ($F_{ST}$ < 0.05, for all SNPs in both populations). However, a significant difference in the allele frequencies between the Korean and CEU and YIR populations were observed in 99 SNPs (60.7%) and 120 SNPs (73.6%), respectively. Ten (6.1%) and 26 (16.0%) SNPs had genetic differentiation ($F_{ST}$ > 0.05) among the Korean-CEU and Korean-YIR comparisons, respectively. The SNP with the largest $F_{ST}$ value between the Korean and African populations was cystathionine-${\beta}$-synthase rs234709 ($F_{ST}$: KOR-YIR, 0.309; KOR-CEU, 0.064). Our study suggests that interethnic differences exist in SNPs associated with heavy metals of Koreans, and it should be considered in future studies that address ethnic differences in heavy-metal concentrations in the body and genetic susceptibility to the body burden of heavy metals.

Genetic Variation of Pinus densiflora Populations in South Korea Based on ESTP Markers (ESTP 표지를 이용한 국내 소나무 집단의 유전변이)

  • Ahn, Ji Young;Hong, Kyung Nak;Lee, Jei Wan;Hong, Yong Pyo;Kang, Hoduck
    • Korean Journal of Plant Resources
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    • v.28 no.2
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    • pp.279-289
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    • 2015
  • Genetic diversity and genetic differentiation of thirteen Pinus densiflora populations in South Korea were estimated using nine ESTP (Expressed Sequence Tag Polymorphism) markers. The numbers of allele and the effective allele were 2.2 and 1.8, respectively. The percentage of polymorphic loci (P) was 98.8%. The observed and the expected heterozygosity were 0.391 and 0.402, respectively, and the eleven populations except for Ahngang and Gangneung population were under Hardy-Weinberg equilibrium state. The level of genetic differentiation (Wright’s FST = 0.057) was higher than those of isozyme or nSSR markers. We could not find out any relationship between the genetic distance and geographic distribution among populations from cluster analysis. Also, the genetic differentiation between populations was not correlated with the geographic distance (r = 0.017 and P = 0.344 from Mantel test). From the result of FST-outlier analysis to identify a locus under selection, six loci were detected at confidence interval of 99% by the frequentist’s method. However, only three loci (sams2+AluⅠ, sams2+RsaⅠ, PtNCS_p14A9+HaeⅢ) were presumed as outliers by Bayesian method. The sams2+AluⅠ and sams2+RsaⅠlocus were originated from the sams2 gene and seemed to be the loci under balancing selection.

Psychological changes in residential treatment for heavy smokers in Seoul Tobacco Control Center (전문치료형 캠프 참가자의 캠프 전 후의 심리변화 (서울금연지원센터 금연캠프 참가자 대상으로))

  • Cheon, Eun-Ju
    • Journal of the Korea Convergence Society
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    • v.11 no.2
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    • pp.315-321
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    • 2020
  • This research explores the change of smoking cessation motivation, maintenance(6months) from the heavy smokers who have experienced residential treatment. Data was collected by the questionnaires about participates motivation from 1st August 2015 to 31st December 2018. Total participates were 1317 that 1248 males (94.8%) and 69 females (31.3%). The most of participants answered their period of smoking was 31-40years as 31.3% (413p) of total participants. Motivation improved after residential treatment, and the 6-month success group had overall cessation of smoking cessation (F=6.52, p=.011), In the subcategories, pre-contemplation(F=5.12, p=.024), contemplation(F=.90, p= .341), preparation-level1(F=5.79, p=.016) and preparation-level2(F=1.33, p=.249) were statistically significant. Thus, this research investigates that the residential program for smoking cessation actually works to the heavy smokers to increased their motivation and that the 6-month success group had stronger.

Effectiveness Evalution of 18F-FDG Auto Dispenser (RIID: Radiopharmaceutical Intelligent Dispenser) (18F-FDG 자동분주기 사용에 따른 유용성 평가)

  • Yoo, Moon-Gon;Moon, Jae-Seung;Kim, Su-Geun;Shin, Min-Yong;Kim, Seung-Chul;Lee, Tea-hun;An, Sung-Hyeun
    • The Korean Journal of Nuclear Medicine Technology
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    • v.22 no.2
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    • pp.79-83
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    • 2018
  • Purpose $^{18}F-FDG$, which is commonly used in PET-CT examinations, is low in capacity and it is difficult to keep the amount of radioactivity busy when the specific activity is high, increasing the amount of space dose and radioactive contamination in the distribution room. Therefore, while evaluating the actual dose administered to patients during the manual dispense process, the medical institution intends to assess the usefulness of the auto dispenser by comparing the differences from the actual dose administered to the patient using the new automatic dispense. Materials and Methods From July 2016 to December 2016, 846 patients were manually administered by workers using $^{18}F-FDG$ and $^{18}F-FDG$ 906 patients were using auto dispenser from July 2017 to December 2017. Results Capacity administered to patients during the manual dispense averaged $35.41{\pm}27.79%$ compared to the recommended dose, and the auto dispenser process showed a small difference of $-2.15{\pm}3.99%$ compared to the recommended dose(p<0.05). Conclusion Working people did not have to touch radioactive medicines directly while they were busy in the auto dispenser, and because of the availability of other tasks far away, the time and distance to receive the exposure were also advantageous. It is believed that future use by many medical institutions will not only reduce the dose to patients but also help reduce the exposure dose to workers.

Genetic diversity assessment of wild populations of Paeonia lactiflora Pall. in Gyeongju National Park, Korea (경주국립공원 내 야생 작약(Paeonia lactiflora Pall.) 집단의 유전다양성 분석)

  • Won, Hyosig;Lim, Chang Kun;Choi, Sun Ah;Kim, Mi-Jin
    • Korean Journal of Plant Taxonomy
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    • v.43 no.4
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    • pp.245-251
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    • 2013
  • Paeonia lactiflora is a valuable natural resource for horticulture and traditional Chinese medicine. To propose conservation strategy and future utility of the wild Paeonia lactiflora populations recently found around the Gyeongju National Park, genetic diversity analysis using microsatellite markers were performed. Three populations in and near the Gyeongju N.P. and one population from Jilin, China were analyzed for five microsatellite markers, producing 61 alleles with mean observed heterozygosity($H_o$) of 0.452. $F_{ST}$ value (0.11642) suggested moderate level of genetic differentiation among the populations, and hierarchical AMOVA suggested most of the genetic variation resides within/among the individuals rather than among-population. While AMOVA with $F_{ST}$ suggested lack of genetic differentiation between the regional (Korean vs. Chinese) populations, AMOVA with $R_{ST}$, which incorporates the allele sizes, suggested considerable differentiation between them, but without significant statistical support. STRUCTURE analysis also suggested segregation of regional populations with presence of gene flow among the three Gyeongju N.P. populations. Considering small population size and scarcity of mature individuals, further protection and long-term monitoring are needed.

CONVOLUTION PROPERTIES FOR GENERALIZED PARTIAL SUMS

  • Silberman, Herb
    • Journal of the Korean Mathematical Society
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    • v.33 no.3
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    • pp.601-607
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    • 1996
  • For functions $f(z) = \sum_{n = 0}^{\infty}a_n z^n$ and $g(z) = \sum_{n = 0}^{\infty} b_n z^n$ analytic in the unit disk $\Delta = {z : $\mid$z$\mid$ < 1}$, the convolution $f * g$ is defined by $(f * g)(z) = \sum_{n = 0}^{\infty}a_n b_n z^n$. Let S denote the family of functions $f(z) = z + \cdots$ analytic and univalent in $\Delta$ and K, St, C the subfamilies that are respectively convex, starlike, and close-to-convex.

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Differences in Conflict Management Style according to MBTI Indicators of Nursing Students (간호대학생의 MBTI 지표에 따른 갈등해결유형의 차이)

  • Su Jeong Shin
    • The Journal of the Convergence on Culture Technology
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    • v.9 no.6
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    • pp.479-486
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    • 2023
  • This study is a descriptive research study to determine differences in conflict management types according to MBTI preference indicators among nursing students. Data collection was from August 30 to September 30, 2023. Data analysis was performed using independent t-test, one-way ANOVA, and Scheffe's. As a result of the study, among the MBTI indicators showing significant differences in conflict management types, 'i' had higher avoidance than 'E' in the energy direction (t=-3.776, <0.01). In the case of decision-making function, F had higher concession (t=-3.478, <0.01) and avoidance (t=-3.389, <0.01) than T, and T had higher dominance than F (t=2.070, <0.5). In terms of external life coping style, J had higher cooperation (t=2.756, <0.01) and compromise (t=2.044, <0.5) than P. In MBTI's psychological function types, the NF type had higher concessions than the ST type (F=4.174, <0.05), and the SF type had higher avoidance than the ST type (F=4.202, <0.05). The results of analyzing the differences in conflict management types by combining the MBTI decision-making function type and external life coping style showed that the FJ type was more cooperative than the FP type (F=2.907, <0.05), and the FJ type was more cooperative than the TP type (F =4.662, <0.01), and the FJ type had higher avoidance than the TJ type (F=3.327, <0.05). MBTI's attitude index showed that the EJ type had higher cooperation than the EP type (F=2.817, <0.05), and the IP type had significantly higher avoidance than the EP type (F=4.551, <0.01). This study is significant in confirming differences in conflict management types by combining MBTI decision-making function types (F, T) and external life coping styles (J, P), which have not been studied in Korea to date. In the follow-up study, we propose research on conflict management types by MBTI personality type by reflecting the results of this study and expanding the number of subjects, development of conflict management programs by MBTI indicators and personality types, and analysis of program effectiveness.

The Study on the Excitation Lasers for NO Planar Laser-Induced Fluorescence Imaging (NO PLIF용 excitation 레이저에 관한 연구)

  • Kang, Kyung-Tae
    • 한국연소학회:학술대회논문집
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    • 1997.06a
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    • pp.13-21
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    • 1997
  • Excitations of eight pumping transitions for nitric oxide fluorescence imaging are analyzed under equivalent experimental conditions to determine the detection. Frequency mixed dye laser pumping, 1st anti-Stokes $H_2$ Raman of KrF excimer laser pumping and ArF excimer laser pumping show good sensitivities.

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Recommendation of P and K Fertilizers for Crops Based on Soil Testing (토양분석치(土壤分析値)에 의(依)한 작물별(作物別) 인산(燐酸) 및 가리시비량(加里施肥量) 결정법(決定法))

  • Hong, Chong Woon;Kim, Yung Sup;Kim, Yung Koo
    • Korean Journal of Soil Science and Fertilizer
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    • v.6 no.1
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    • pp.29-31
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    • 1973
  • Upon the assumption that the available components in the soil evaluated by present analytical procedures, are as effective as the components applied to the soil as fertilizer, some formulas for the calculation of fertilizer requirements (F. R) for crops are suggested. Basically, the formulas are derived by combining the country average values of soil test data(${\overline{ST}}$) and of the optimum rate of fertilizers (ORF) for crops obtained from N.P.K. trials in farmer's field, as following. $$F.R(kg/10a)={\overline{ST}}(kg/10a)+ORFkg/10a-ST(kg/10a)$$ where, ST denotes the available components tested in the soil under question. Although this formula can be used both for P and K fertilizers, considering the significance of the potassium saturation rate of the soil for the availability of K, for the calculation of K fertilizer requirement, following formula is suggested. $$F.R(kg/10a)=(C.E.C.{\times}B.S.R.K.-KST(me/100g){\times}CF$$ where, B. S. R. K. is the basic potassium saturation rate of the soil and CF is conversion factor for the conversion of K me/100g into $K_2O$ kg/10a. The B. S. R. K. for different crops are obtained from the country average values of soil exchangeable K (${\overline{KST}}$), cation exchange capacity (CEC) and the optimum rates of K fertilizers for crops (ORF $K_2O$). $$B.S.R.K.=\frac{{\overline{KST}}{\times}CF+ORF(K_2O)}{CEC{\times}CF}$$ Using these formulas, equations for P and K fertilizer requirements for rice, barley, wheat, corn, italian millet, soy bean, sweet potato, potato and rape are derived.

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