Regarding the green environment, it is important to boost the spread of environmentally friendly vending machines and to operate the vehicles for their inventory replenishments while minimizing emissions of greenhouse gases. In general, the vending machine management company lacks capability to operate the supply chain effectively in an integrated way under the dynamic, complex, and stochastic environment. This paper presents a decision support system, termed DSSVM, for the operations of the general and smart vending machine supply chains with stock-out-based, one stage item substitution in a green logistics environment. The DSSVM supports the estimation of item demand and substitution probabilities, determination of operation parameters, supply chain analysis, what-if analysis, and $CO_2$ analysis for which various analytical models are employed.