The tread pattern of tire is represented by a great number of design factors, such as groove breadth of circumference direction, breadth direction, rib breadth, block length, kerfs, tread breadth and tread radius, etc. It is not efficient in time and cost to analyze the rolling resistance for a great number of real tread pattern, because It requires lots of pattern forming handwork. In order to optimize tread pattern for rolling resistance, the experiment is planed and analyzed by Taguchi's robust design methods. We identified the important design factors for Rolling Resistance, determined the optimal condition and calculated prediction value which is related. Using the experiment data and the analyzed data, we developed the program which could predict Rolling Resistance. It is expected that time and cost may be reduced in designing and developing new tire tread pattern.