Background: The purpose of this study was to effect of the manual therapy and pelvic floor muscle exercise interventions in patient with acute lumbar sprain. Based on this, proceed to present an effective physical treatments. Methods: Subject was 55 year old female patient with acute lumbar sprain. Subject was damaged, wash in the morning. Subject was hoping to return to work and Activity daily living (ADL) without pain. I proceed in order screening, evaluation, diagnosis, prognosis, treatment planning and intervention, re-screening. To solving problem, was conducted in parallel to a manual therapy and therapeutic exercise. Results: To investigate changes in body functions and activities was measured, Visual analog scale (VAS) and Oswestry disability index (ODI), changes in posture, maintain in posture, 10m walk test. The improved results were compared before and three weeks after mediation interventions. Conclusions: Frequency manual therapy and pelvic floor muscle exercise is thought to be an efficient way of patients with acute lumbar sprain.