In this paper, it is intended to introduce a method to solve multi-objective optimization problems and to evaluate its performance. In order to verify the performance of this method it is applied for a vertical roller mill for Portland cement. A design process is defined with the compromise decision support problem concept and a design process consists of two steps: the design of experiments and mathematical programming. In this process, a designer decides an object that the objective function is going to pursuit and a non-linear optimization is performed composing objective constraints with practical constraints. In this method, response surfaces are used to model objectives (stress, deflection and weight) and the optimization is performed for each of the objectives while handling the remaining ones as constraints. The response surfaces are constructed using orthogonal polynomials, and orthogonal array as design of experiment, with analysis of variance for variable selection. In addition, it establishes the relative influence of the design variables in the objectives variability. The constrained optimization problems are solved using sequential quadratic programming. From the results, it is found that the method in this paper is a very effective and powerful for the multi-objective optimization of various practical design problems. It provides, moreover, a reference of design to judge the amount of excess or shortage from the final object.