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Transverse buckling analysis of spatial diamond-shaped pylon cable-stayed bridge based on energy approach

  • Zheng, Xing;Huang, Qiao;Zheng, Qing-gang;Li, Zhen
    • Structural Engineering and Mechanics
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    • v.83 no.1
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    • pp.123-134
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    • 2022
  • The stability of cable-stayed bridges is an important factor considered during design. In recent years, the novel spatial diamond-shaped bridge pylon has shown its advantages in various aspects, including the static response and the stability performance with the development of cable-stayed bridge towards long-span and heavy-load. Based on the energy approach, this paper presents a practical calculation method of the completed state stability of a cable-stayed bridge with two spatial diamond-shaped pylons. In the analysis, the possible transverse buckling of the girder, the top pylon column, and the mid pylon columns are considered simultaneously. The total potential energy of the spatial diamond-shaped pylon cable-stayed bridge is calculated. And based on the principle of stationary potential energy, the transverse buckling coefficients and corresponding buckling modes are obtained. Furthermore, an example is calculated using the design parameters of the Changtai Yangtze River Bridge, a 1176 m cable-stayed bridge under construction in China, to verify the effectiveness and accuracy of the proposed method in practical engineering. The critical loads and the buckling modes derived by the proposed method are in good agreement with the results of the finite element method. Finally, cable-stayed bridges varying pylon and girder stiffness ratios and pylon geometric dimensions are calculated to discuss the applicability and advantages of the proposed method. And a further discussion on the degrees of the polynomial functions when assuming buckling modes are presented.

miR-340 Reverses Cisplatin Resistance of Hepatocellular Carcinoma Cell Lines by Targeting Nrf2-dependent Antioxidant Pathway

  • Shi, Liang;Chen, Zhan-Guo;Wu, Li-li;Zheng, Jian-Jian;Yang, Jian-Rong;Chen, Xiao-Fei;Chen, Zeng-Qiang;Liu, Cun-Li;Chi, Sheng-Ying;Zheng, Jia-Ying;Huang, Hai-Xia;Lin, Xiang-Yang;Zheng, Fang
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.23
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    • pp.10439-10444
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    • 2015
  • Many chemotherapeutic agents have been successfully used to treat hepatocellular carcinoma (HCC); however, the development of chemoresistance in liver cancer cells usually results in a relapse and worsening of prognosis. It has been demonstrated that DNA methylation and histone modification play crucial roles in chemotherapy resistance. Currently, extensive research has shown that there is another potential mechanism of gene expression control, which is mediated through the function of short noncoding RNAs, especially for microRNAs (miRNAs), but little is known about their roles in cancer cell drug resistance. In present study, by taking advantage of miRNA effects on the resistance of human hepatocellular carcinoma cells line to cisplatin, it has been demonstrated that miR-340 were significantly downregulated whereas Nrf2 was upregulated in HepG2/CDDP (cisplatin) cells, compared with parental HepG2 cells. Bioinformatics analysis and luciferase assays of Nrf2-3'-untranslated region-based reporter constructor indicated that Nrf2 was the direct target gene of miR-340, miR-340 mimics suppressing Nrf2-dependent antioxidant pathway and enhancing the sensitivity of HepG2/CDDP cells to cisplatin. Interestingly, transfection with miR-340 mimics combined with miR-340 inhibitors reactivated the Nrf2 related pathway and restored the resistance of HepG2/CDDP cells to CDDP. Collectively, the results first suggested that lower expression of miR-340 is involved in the development of CDDP resistance in hepatocellular carcinoma cell line, at least partly due to regulating Nrf2-dependent antioxidant pathway.

An Analysis of the Prevalence and Pattern Identification of Korean Medicine for Acute Stress Disorder and Post Traumatic Stress Disorder in Patients with Traffic Injuries (교통사고 상해증후군 환자의 급성 스트레스 장애와 외상 후 스트레스 장애의 유병률과 한의변증유형 분석)

  • Lee, Yu Jin;Lee, Sung Joon;Cheong, Moon Joo;Lim, Jung Hwa;Jo, Hee Geun;Kim, Bo Min;Chung, Sun-Yong;Kwak, Hui-Yong;Park, Bo Ra;Park, Tae-Yong;Shin, Byung-Cheul;Kang, Hyung Won
    • Journal of Oriental Neuropsychiatry
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    • v.32 no.1
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    • pp.1-11
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    • 2021
  • Objectives: To investigate the prevalence of acute stress disorder (ASD) and post-traumatic stress disorder (PTSD) in patients with traffic injuries. In addition, PTSD patients was classified using 'pattern identification for jing ji and zheng chong'. Methods: Questionnaires such as the primary care PTSD screen for DSM-5(PC-PTSD-5), Korean version of PTSD checklist-5 (PCL-5-K), and the instrument of pattern identification for jing ji and zheng chong were conducted on 195 patients within 3 days to 1 year after traffic accidents. Patients were recruited from six medical institutions. Collected data were used to determine the prevalence of acute stress disorder and post-traumatic stress disorder. Results: On PC-PTSD-5, the prevalence was 39.1% for ASD and 50% for PTSD. On PCL-5-K, the prevalence was 20.4% for ASD and 29.3% for PTSD. Satisfying both PC-PTSD-5 and PCL-5-K, the prevalence was 18.2% for ASD and 25.8% for PTSD. As a result of pattern identification for jing ji and zheng chong, 'weakness of heart and gall bladder type' accounted for the highest proportions in both ASD and PTSD groups. Conclusions: In this study, the prevalence was 39.1% for ASD and 50% for PTSD by PC-PTSD-5. Satisfying both PC-PTSD-5 and PCL-5-K, the prevalence was 18.2% for ASD and 25.8% for PTSD. Further large-scale prospective studies are needed to analyze the prevalence of ASD and PTSD, the rate of progression from ASD to PTSD, and the type of pattern identification.

FORWARD ORDER LAW FOR THE GENERALIZED INVERSES OF MULTIPLE MATRIX PRODUCT

  • Xiong, Zhipin;Zheng, Bing
    • Journal of applied mathematics & informatics
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    • v.25 no.1_2
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    • pp.415-424
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    • 2007
  • The generalized inverses have many important applications in the aspects of theoretic research and numerical computations and therefore they were studied by many authors. In this paper we get some necessary and sufficient conditions of the forward order law for {1}-inverse of multiple matrices products $A\;=\;A_1A_2{\cdots}A_n$ by using the maximal rank of generalized Schur complement.

MEAN DISTANCE OF BROWNIAN MOTION ON A RIEMANNIAN MANIFOLD

  • Kim, Yoon-Tae;Park, Hyun-Suk
    • Proceedings of the Korean Statistical Society Conference
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    • 2002.05a
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    • pp.45-48
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    • 2002
  • Consider the mean distance of Brownian motion on Riemannian manifolds. We obtain the first three terms of the asymptotic expansion of the mean distance by means of Stochastic Differential Equation(SDE) for Brownian motion on Riemannian manifold. This method proves to be much simpler for further expansion than the methods developed by Liao and Zheng(1995). Our expansion gives the same characterizations as the mean exit time from a small geodesic ball with regard to Euclidean space and the rank 1 symmetric spaces.

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Workload Allocation Methods in Discrete Manufacturing Systems:Model and Optimization

  • Yingwen, Zheng
    • 제어로봇시스템학회:학술대회논문집
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    • 2003.10a
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    • pp.1362-1366
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    • 2003
  • Workload programming is allocating suitable workloads of production process according to the needs of products, which would minimize the total cost of both work and stock under some constraint conditions. In this paper, a production process flow chart of discrete manufacturing is presented by a Petri net, and the optimization model of workload-stock is established. An approach of the optimal workloads is provided by means of the integer matrix theory. An example is given to verify this method.

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About Global Avalanche Characteristics Balanced Boolean functions (균등함수들의 GAC에 관해서)

  • 손중제;김희진;김종덕;임종인
    • Proceedings of the Korea Institutes of Information Security and Cryptology Conference
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    • 1997.11a
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    • pp.196-202
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    • 1997
  • [6]에서 Zhang과 Zheng은 부울함수의 암호학적인 전역상관계수의 특성을 계산하기 위해서 GAC(Global Avalanche Characteristic)이라는 새로운 개념을 제시하였다. 그들은 GAC의 값들에 대한 측적을 위해서 2개의 단위를 제시했고 2개의 단위의 상한과 하한에 대해서 계산했다. 그러나 그들은 균등함수의 GAC의 하한은 향후의 연구과제로 남겨놓았다. 본 논문에서는 균등함수의 GAC의 하한에 대해서 계산했고, 연접의 방법에 의한 좋은 GAC 의 특성을 가지는 함수의 생성방법을 제시하였다.

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Electrospinning of poly(vinylidene fluoride) with carbon nanotubes (Carbon nanotube를 포함한 PVDF/DMF 용액의 전기방사)

  • Kim, Yong-Tae;Chang Seoul;Zheng, Hai-Lan
    • Proceedings of the Korean Fiber Society Conference
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    • 2002.04a
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    • pp.183-186
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    • 2002
  • Polymer composites with carbon nanotubes have recently been investigated for improving certain properties i.e., electrical, optical and mechanical properties[1-3]. Kymakis et. al. have reported the electrical and optical properties of single wall carbon nanotube-poly(3-octylthiophene) composites[4]. Polyurethane dissolved in dimethylformanide (DMF) were electrospun by Demir et. al.[5]. (omitted)

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