• 동의생리병리학회지
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• 제27권2호
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• pp.183-188
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• 2013

Ultraviolet (UV) B irradiation induces the production of matrix metalloproteinases (MMPs), which are responsible for the degradation or synthesis inhibition of collagenous extracellular matrix in connective tissues, causing skin photoaging. In this study, we examined the inhibitory effect of MMP-1 expression of yam extract in tumor necrosis factor-alpha (TNF-${\alpha}$)-stimulated human dermal fibroblast neonatal (HDFn) cell and preventive effect of UVB-induced damage in hairless mice skin. The synthesis of procollagen and the release of MMP-1 in HDFn cells were measured by EIA kit and MMP-1 assay kit, respectively. UVB radiation was applied to the backs of the mice three times a week for 8 weeks. Mice were randomly divided into three groups, and were topical application with the Dioscorea batatas (DB, 6%) or vehicle. Reduction of TNF-${\alpha}$-induced procollagen synthesis was increased by DB (50 ug/ml), which was higher than positive control group (TGF-${\beta}$). Also, pre-treatment of HDFn cells with DB inhibited TNF-${\alpha}$-induced release of MMP-1. In vivo study, we found that preventive effect of DB against UV-induced epidermal thickness. DB suppressed the expression of MMP-3 and MMP-13 induced by UVB irradiation. Our results show that DB have preventive effect of UV-induced skin damage in hairless mice.

• The Plant Pathology Journal
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• 제36권5호
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• pp.468-475
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• 2020

Malva vein clearing virus (MVCV) is a member of the Potyvirus species, and has a negative impact on the aesthetic development of Alcea rosea. It was first reported in Germany in 1957, but its complete genome sequence data are still scarce. In the present work, A. rosea leaves with vein-clearing and mosaic symptoms were sampled and analyzed with small RNA deep sequencing. By denovo assembly the raw sequences of virus-derived small interfering RNAs (vsiRs) and whole genome amplification of malva vein cleaning virus SX strain (MVCV-SX) by specific primers targeting identified contig gaps, the full-length genome sequences (9,645 nucleotides) of MVCV-SX were characterized, constituting of an open reading frame that is long enough to encode 3,096 amino acids. Phylogenetic analysis showed that MVCV-SX was clustered with euphorbia ringspot virus and yam mosaic virus. Further analyses of the vsiR profiles revealed that the most abundant MVCV-vsiRs were between 21 and 22 nucleotides in length and a strong bias was found for "A" and "U" at the 5′-terminal residue. The results of polarity assessment indicated that the amount of sense strand was almost equal to that of the antisense strand in MVCV-vsiRs, and the main hot-spot region in MVCV-SX genome was found at cylindrical inclusion. In conclusion, our findings could provide new insights into the RNA silencing-mediated host defence mechanism in A. rosea infected with MVCV-SX, and offer a basis for the prevention and treatment of this virus disease.

• 대한약침학회지
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• 제19권2호
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• pp.145-154
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• 2016

Objectives: The aim of this paper is to investigate the activities of Malaysian local herbs (Clinacanthus nutans Lindau, Strobilanthes crispus, Murdannia bracteata, Elephantopus scaber Linn., Pereskia bleo, Pereskia grandifolia Haw., Vernonia amygdalina, and Swietenia macrophylla King) for anti-hypertensive and vasorelaxant activity. An infrared (IR) macro-fingerprinting technique consisting of conventional fourier transform IR (FTIR), second-derivative IR (SD-IR), and two-dimensional correlation IR (2D-correlation IR) analyses were used to determine the main constituents and the fingerprints of the Malaysian local herbs. Methods: The herbs were collected, ground into powder form, and then macerated by using three different solvents: distilled water, 50% ethanol, and 95% ethanol, respectively. The potentials of the extracts produced from these herbs for use as vasorelaxants were determined. Additionally, the fingerprints of these herbs were analyzed by using FTIR spectra, SD-IR spectra, and 2D-correlation IR spectra in order to identify their main constituents and to provide useful information for future pharmacodynamics studies. Results: Swietenia macrophylla King has the highest potential in terms of vasorelaxant activity, followed by Vernonia amygdalina, Pereskia bleo, Strobilanthes crispus, Elephantopus scaber Linn., Pereskia grandifolia Haw., Clinacanthus nutans Lindau, and Murdannia bracteata. The tri-step IR macro-fingerprint of the herbs revealed that most of them contained proteins. Pereskia bleo and Pereskia grandifolia Haw. were found to contain calcium oxalate while Swietenia macrophylla King was found to contain large amounts of flavonoids. Conclusion: The flavonoid content of the herbs affects their vasorelaxant activity, and the tri-step IR macro-fingerprint method can be used as an analytical tool to determine the activity of a herbal medicine in terms of its vasorelaxant effect.

• 감성과학
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• 제5권3호
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• pp.61-66
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• 2002

최근 고감성 PET 사를 이용하여 생산한 PET 직물은 고감성 의류용 직물로서 많이 사용되고 있다. 이러한 고감성 의류용 PET 직물은 다양한 공정을 거치면서 장력이나 열 등의 영향을 받음으로서 사의 물성의 변화를 초래하여 감성 의류용도의 PET 직물에 많은 결점을 유발시킴으로서 직물 생산시 공정조건 설정 등의 어려움에 직면하고 있다. 이러한 고감성 의류에 치명적인 문제를 유발하는 문제점에 관한 감성사 제조시의 공정조건 변화와 관련된 연구논문은 많이 발표가 되지 못하고 있다. 따라서 본 연구에서는 국내 7개 원사 Maker의 cake내의 Denier 별 PET 사의 물성을 균일한 길이의 Layer를 설정하여 분석, 조사하고 Layer 별 물성 차이와 습·건열 열처리 온도에 따른 사의 수축률 등을 비교함으로서 감성 의류용 직물 생산에 필요한 기초 물성 Data를 제공하고 PET 사의 품질향상을 도모함으로서 최종 감성 의류용 직물 소재 개발에 기여할 수 있는 기초자료를 제공하고자 한다.

• 한국약용작물학회지
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• 제6권1호
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• pp.33-37
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• 1998

마의 껍질을 제거하거나 상처가 생겼을 때 발생하는 갈변현상을 억제할 수 있는 방법을 개발코자 실험을 수행한 결과는 다음과 같다. 1. 마는 박피후 시간이 경과할수록 갈변지수가 높아지는 경향를 보여 박피 후 15시간에 갈변지수가 장마는 38까지 증가한 반면 단마는 13이 었으며 이로서 장마가 단마보다 갈변이 빠르게 진행됨을 알 수 있었다. 2. 장마의 경우 NaCl 2M 처리시 갈변억제율이 48시간에 48%로 가장 높았고 특히 $80^{\circ}C$ 온탕처리의 경우 24시간까지 높은 억제율을 보였으나 이후 급격히 감소하는 경향을 보였다. 3. NaCl 1M 처리시 단마의 갈변은 43% 정도 억제 되었으나 NaCl 0.5M과 $70^{\circ}C$ 온탕처리는 비슷한 억제현상을 보였다. 그러나 $60^{\circ}C$ 온탕처리는 무처리보다 더 높은 갈변지수를 나타내었다.

• 복식
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• 제36권
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• pp.53-75
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• 1998

The kind, the structure, and the motif of the Chosun dynasty's fabrics found mainfy within the Buddhist statues were studied. The total of 62 pieces of fabrice can be classified chronologically as follows ; 27 pieces in the year of 1431, 20 pieces of 1550, 9 pieces of 1664, and 6 pieces of 1735. These 62 fabrics also categorized by the weaving method as follows; 27 plain weaved, 17 twill weaved, 10 pieces of satine weaved, 7 pieces of Leno weaved, and 1 piece of double weaved fabrics. Most of the studied fabrics were silk, the rest were 2 pieces of yam and 1 piece of cotton, Kyun, Chu, and Cho were the plain weaved silk as Nung and Ki were the twill weaved silk, Satine weaved silk was called as Dan and double weaved silk was called Chikum in the Chosun dynasty. 1. The antique fabrics were composed of mainly silk. This is believed due to the utmost devotion to the buddhist statue as an object of worship. 2. In the fabric's structural point of view, th ecrossed 4-ply threads of warp yarn which is one of Leno weaved can be observed fre-quently in the period of Korea dynasty's fabrics. But it started to disappear in the beginning of Chosun dynasty, since only one piece of Ra could be found in the 1431's fabrics. Keum, one of the double weaved structure is assumed to be extinct from the Korea dynasty. Satin weaved fabrics started to be woven from the latter period of Korea dynasty and was very popular in Chosun dynasty. 3. The widths of fabrics in the Chosun dynasty gradually decreased compared with those of Korea dynasty.

• 대한예방한의학회지
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• 제4권1호
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• pp.144-151
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• 2000

This study was carried out to evaluate cytotoxic effects of Houttuynia cordata Thunberg extracts on murine leukemia tumor cell lines. Disruptions in cell organelles were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazol iumbromide (MMT) assay. The comparison of $IC_{50}$ values of Houttuynia cordata Thunberg extracts on $L1210,\;P388D_1$ and Vero cell lines showed that the methanol extract of Houttuynia cordata Thunberg indicated the most antitumor activity in the MTT assay. In order to develop a antimicrobial agent, dried Houttuynia cordata Thunberg was extracted with several solvents, and then antimicrobial activity was investigated. The minimal inhibitory concentration (MIC) of the extracted substance against microorganisms were also examined. Antimicrobial activity of amocla and ketoconazole as references was compared to those of other solvent extracts such as $H_2O$, n-hexane, chloroform, ethyl acetate ethanol and methanol. The antimicrobial activity of all extracts from the sample had growth inhibition activity against gram-negative bacteria, yam-positive bacteria and fungi $(MIC,\;>\;200\;{\mu} g/ml)$. These results suggest that the methanol soluble extract of Houttuynia cordata Thunberg may be a valuable choice for the studies on the treaeent of murine leukemia tumor cell lines and antimicrobial agents.

• 한국의류학회지
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• 제30권2호
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• pp.255-265
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• 2006

The purpose of this study was to examine the dyeing properties of four kinds of composite yams that were twisted in different processes. The composite yarns consist of acetate and functional polyester in ratio of 70 : 30. The composite yams were dyed at 100$^{circ}C$ and 125$^{circ}C$ using three types of dyes, disperse dyes for acetate fiber, PET fiber and PET-acetate blended fiber, in the three primary colors. The exhaustion($\%$) and K/S value were observed for each case. Also the effects of four different twisting processes to dyeing properties and physical properties were examined. Regardless of twisting methods, the composite yarns that were dyed at 125$^{circ}C$ had higher exhaustion($\%$) than those were dyed at 100$^{circ}C$ with all three types of dyes; However, tendency of the K/S value after reduction cleaning process was measured at 100$^{circ}C$ and the value measured 125$^{circ}C$ had a great difference with disperse dyes for acetate and dyes for PET. The difference of the K/S values of composite yarns, when dyed at 100$^{circ}C$ and 125$^{circ}C$ with disperse dyes for PET-acetate blended fiber, was almost negligible. According to twisting methods K/S values were in the following order: AP1 > AP3 > AP4> AP2. This means that AP1, treated at 220$^{circ}C$, had the highest K/S value and K/S value becomes higher as the yam is higher twisted and becomes lower as lower twisted. On the other hand, the dry shrinkage and wet shrinkage showed low shrinkage rate when the twist was high and steam setting temperature was high.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 1995년도 추계학술대회논문집; 한국종합전시장, 24 Nov. 1995
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• pp.39-43
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• 1995

대형 상용차용 내연기관에서 방출되는 소음의 음압 레벨은 경우에 따라 140dBA 이상으로 환경소음 배출규제에 부합되는 배출 소음을 위하여는 소음기의 적절한 설계가 필요하다 하겠다. 소음기는 방출 소음을 저감시키는 기본적인 작용 이외에 엔진의 효율을 저하시키는 배압(back-pressure) 상승의 효과를 동반할 뿐만 아니라 차체에의 장착을 위하여 크기와 무게의 제약을 받는다. 따라서 소음기는 설계자의 경험과 과거에 사용되어 온 소음기에 대한 이해, 소음기를 구성하는 단위 요소에 대한 음향학적 해석이론, 제작 과정에서의 경험과 튜닝 등에 바탕을 두고 설계되어져 왔다. 본 연구에서는 대형 상용차에 장착되는 기존 소음기 구성요소의 투과 손실(Transmission Loss: TL)을 전달 행렬법으로 해석하여 음향학적 특성을 규명하고 개별 소음기 요소에 대한 기존의 연구 결과를 바탕으로 공명기와 다공 요소를 이용하여 기존 소음기를 재설계함으로써 배출 소음의 저감을 이루어 나간 과정을 소개하고 이를 적용 사례를 중심으로 살펴보고 있다. 소음기의 설계를 위하여 고려할 수 있는 음향학적 요소는 그 기능과 형태면에서 다양하나 본 연구에서는 대형 상용차용 소음기에 주로 사용 가능한 공명기와 다공관을 주된 설계요소로 생각하였다. 공명기는 공명 주파수 대역의 소음을 저감하는 역할을 하므로 일정한 엔진 회전수 하에서 엔진의 방출 소음중 폭발 성분에 의한 소음을 줄이는데 효과적으로 사용될 수 있지만 가속 주행시에는 회전수(rpm)의 변화에 따라 폭발 주기가 변화하게 되므로 공명기의 설계에 주의를 기울여야 한다. 내연 기관용 소음기에 빈번하게 쓰이는 다공 요소의 해석 방법으로는 Sullivan[1], Kim and Yoon[2] 등의 분할 접근 방법(Segmentation approach)과 Jayaraman and Yam[3], Munjal[4], Peat[5] 등의 연성 제거 방법(Decoupling Approach)등이 제시되었고 평면파 영역에 한하여 해서되어져 왔다. 본 논문에서는 분할 접근 방법(Segmentation Approach)을 이용하여 다공 요소로 이루어진 소음기를 해석하는데 적용하였다.

• 한국의류산업학회지
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• 제4권3호
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• pp.248-253
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• 2002

The purpose of this study was to improve consumer sleeping life in quality and to suggest producers meet new consumer needs and demands, by examining the nationwide use of bedding, analyzing consumer sleeping life by category and age group, comparing the results with the findings of the nationwide studies by Sung Su-kwang (1992) and Lee Song ja (1995), and identifying the major trend of consumer sleeping life. Results and Discussion The findings of this study were as below: 1. The General Characteristics of the Subjects : Most of the housewives investigated were in their 30s and 40s, with 41.7% and 50.8% respectively. 2. Bedroom : When it comes to bedroom style, 47.8% put beds in their rooms with the Korean under-floor heating system, and 45.4% didn't place beds in their rooms with the same heating system. 3. The Purchase of Bedding : 49.0%, approximately half the homemakers, bought their current bed-clothes at bedding shops, and just 3.2% made them on their own at home. 4. The Use of Bedclothes : In summer, yam (flax, ramie fabric) and a single-layer bed sheet (41.9%) were in use most, followed by a single-layer quilt (34.5%). 5. Bedding Management The most common frequency of bedding disinfection by sunning was once a month (29.4%), followed by once per two weeks (23.9%) and once a week (19.0%) in the order named.