• Title/Summary/Keyword: working heart

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Clinical and pharmacological application of multiscale multiphysics heart simulator, UT-Heart

  • Okada, Jun-ichi;Washio, Takumi;Sugiura, Seiryo;Hisada, Toshiaki
    • The Korean Journal of Physiology and Pharmacology
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    • v.23 no.5
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    • pp.295-303
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    • 2019
  • A heart simulator, UT-Heart, is a finite element model of the human heart that can reproduce all the fundamental activities of the working heart, including propagation of excitation, contraction, and relaxation and generation of blood pressure and blood flow, based on the molecular aspects of the cardiac electrophysiology and excitation-contraction coupling. In this paper, we present a brief review of the practical use of UT-Heart. As an example, we focus on its application for predicting the effect of cardiac resynchronization therapy (CRT) and evaluating the proarrhythmic risk of drugs. Patient-specific, multiscale heart simulation successfully predicted the response to CRT by reproducing the complex pathophysiology of the heart. A proarrhythmic risk assessment system combining in vitro channel assays and in silico simulation of cardiac electrophysiology using UT-Heart successfully predicted drug-induced arrhythmogenic risk. The assessment system was found to be reliable and efficient. We also developed a comprehensive hazard map on the various combinations of ion channel inhibitors. This in silico electrocardiogram database (now freely available at http://ut-heart.com/) can facilitate proarrhythmic risk assessment without the need to perform computationally expensive heart simulation. Based on these results, we conclude that the heart simulator, UT-Heart, could be a useful tool in clinical medicine and drug discovery.

Analysis of organizational variables related to nursing between the doctors' strike and normal periods (의료파업시기와 정상시기간의 간호조직 내 제요인 분석)

  • Yee, Jung-Ae;Park, Hyea-Ja;Kim, Jung-Dam;Kim, Hee-Soon;Bang, Hyo-Kyung;Eom, Ok-Ju;Yom, Young-Hee
    • Journal of Korean Academy of Nursing Administration
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    • v.7 no.3
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    • pp.511-529
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    • 2001
  • Purpose : To analyze organization variables related to nursing between the doctors' strike and normal periods. Methods : The sample consisted of 1,220(600 for doctors' strike and 620 for normal periods) nurses working in 5 hospitals. Six instruments were used for data collection including Job Activity Scale(JAS; Laschinger, 1994), Organization Relationship Scale(ORS; Laschinger, 1994), Interpersonal Support Scale(developed by Firth et al., 1986 and revised by Ahn(2000), Self-efficacy Scale(Riggs & Knight, 1994),Job Satisfaction Scale(Slavitts et al., 1978), and Organizational Commitment Questionnaire(OCQ; Mowday et al., 1979). Results : There were significant differences among variables(i.e., formal power, interpersonal support, self-efficacy and organizational commitment)between doctors' strike and normal periods. The formal power was high during the normal period, however interpersonal support, self-efficacy and organizational commitment were high during the doctors' strike. Conclusion : Interpersonal support, self-efficacy and job satisfaction were change by working conditions, but organizational commitment was not changed by working conditions.

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A Study on the Noise by working Process in Dental Laboratory (치과기공실(齒科技工室)의 작업공정별(作業工程別) 소음(騷音)에 관한 연구(硏究))

  • Nam, Sang-Yong
    • Journal of Technologic Dentistry
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    • v.15 no.1
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    • pp.27-41
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    • 1993
  • Degree of noise by personal dental laboratory working process and degree of noise by complex dental laboratory working process were measured separtely. The time of exposure to noise greater than 70dB was analyzed. Then, the whole degree of noise in dental laboratory was estimated on the basis of afore-mentioned information. Questionaire were employed to investigate the mental, emotional and physiological effects of noise in dental technicians, The purpose of this study was to provide basic information on keeping dental techneicans who are exposed to noise pollution in good working condition and good health. Results obtained are as follows ; 1. Polishing process in each working part showed high degree of noise greater than 70dB in terms of degree of noise by personal working. 2. Degree of noise by complex working process in each working part was greater than that of personal working process. 3. Time of exposure to noise complex working process the part of porcelain 150min, partial denture 120 min, crown and bridge 100 min, full denture 80 min. 4. Degree of noise by time in dental laboratory was 80dB in general for polishing process and below 75dB for waxing process. 5. Effects of noise on mental and emotional state of dental technicians showed that they felt irritated every day(14%), irritated once in a while(29%) and easily ger mad(19%). 6. Effects of noise on heart and stomach were hyper-gastric acid(38%), gastric ulcer(11%), gastritis(5%), deuodenal ulcer(3%) and weak heart function(32%). 7. Effects of noise in the hearing ability were weak(39%), moderate(33%) and normal(14%) Data presented in this study demonstrated that noise in the dental laboratory exerts profound effect on dental technicians mentally, physiologically and emotionally, in light of the above results, therefore, it appears advisable to devots substantial on the management of working condition and put further(continuing) efforts in the investigation for reducing noise problem.

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A Research on Oxygen Uptake and Heart Rate in Static Working Postures (정적 자세에 있어서의 산소 흡입량과 맥박에 관한 연구)

  • Im, Hyeon-Gyo;Park, Gyeong-Su
    • Journal of the Ergonomics Society of Korea
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    • v.3 no.1
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    • pp.19-24
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    • 1984
  • As in dynamic muscular activity, to support one's body may be regarded as the static workload. An examination is made of the relationship between heart rate and oxygen uptake of three male graduate students in static working postures (sitting, squatting and standing). Though it has been believed that there exists a linear relationship between heart rate and oxygen uptake, this thesis shows that both have no relationship in the case of static postures, and that they may depend upon the characteristics of postures rather than the static workload. These results are discussed analytically. The additivity between static body postures and holding up one's hands at his maximum height is tested. Compared with the sum of energy expenditure in balancing one's body and holding up hands, the net rate of energy expenditure in performing them simultaneously is equivalent. In the case of static postures, the importance of the awareness of the characteristics and relevance of the measures is discussed.

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A Study for Farmers to Reduce Work Load on the Different Working Conditions (part II) - Cultivating Welsh Onion in the Summer Ground - (농민의 작업환경별 노동부담경감방안에 관한 연구(II) - 여름철 노지에서 대파재배 작업을 중심으로 -)

  • 김명주;최정화
    • Korean Journal of Rural Living Science
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    • v.8 no.2
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    • pp.119-124
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    • 1997
  • In this study we tried to give a decision on propriety of working conditions, to present ideas on reducing work loads, and to grope for efficiency of agricultural works. For this we examined the actual working conditions of cultivating welsh onion in the summer ground. And we improved harmful factors that affect farmer's health by considering results of previous study and farmer's subjective sensation. And we measured. compared, and analyzed the farmer's work loads before and after improvement. The results of this study are as follows ; 1. According to examine the actual working conditions of cultivating welsh onion in the summer ground, farmers have experienced physical and mental chronic fatigue on the basis of farmer's appel to eye - fatigue and sun - burned skin on hot working environment including excessive ultraviolet rays, the rough ground condition, inconsistent arrangement of working stand and sorter, heavy - weared habits, and unsuitable working posture. 2. When we improved harmful factors that affect farmer's health, conformed the effects on important work efficiency index such as heart rate, electromyovolume, body temperature, and microclimate inside clothing and work loads were decreased by eliminating the hillock and obstacles of ground, decreasing the clothing weight, using proper clothing appliances such as hat and sunglasses, controlling height of working stand and sorter suitably, improving the working postures and methods as using assistant appliances, alloting the working time and sequence effectively and presenting the light gymnastic exercises and rest for fatigue restoration.

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A Study on the Perceived Symptoms of Fatigue of the Workers in the Textile Industry (일부 섬유 제조업 근로자의 피로자각 증상에 관한 연구)

  • Suh In Sun;Ahn Ok Hee
    • Journal of Korean Public Health Nursing
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    • v.7 no.1
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    • pp.81-97
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    • 1993
  • This study was carried out to analyze the factors of the perieved symptoms of fatigue of the industrial workers, to examine the inter-relatisnship of the above factors with their general charactenstics and the environments of working area for the examination of their health status and the effective health management of them. This study was undertaken from December 1 to December 20, 1990. The subjets were 495 workers who had worked at the Industrial complex located in Chonbuk Province. The result of this study were as follows: 1. The worker's percieved symptoms of fatigue were classified to the following seven factors; A) Musculo-Skeletal Symptoms, B) Neuro-Psychial Symptoms, C) Optical Symptoms, D) Heart Symptoms, E) Head Symptoms, F) Respiratory Symptoms, G) Genital Symptoms 2. Analysis of the inter-relationship of their percieved symptoms of fatigue with general characteristics; 1) The difference of distribution to their percieved symptoms of fatigue according to sexuality was significant; Female were higher than Male $(p{\leqq}0.001$, p<0.005) 2) The difference of distribution to their percieved symptoms of fatigue according to age was significant; Age group under 24 years of age were higher than the other's group (p<0.001). 3) The difference of distribution to their percieved symptoms of fatigue according to the level of education was significant; Workers who stand on a low intellectual were higher than workers on a high intellectual level. 4) The difference of distribution to their percieved symptoms of fatigue for a week was the highest when worked at sunday. 5) The difference of distribution to their percieved symptoms of fatigue for seasons was high at spring. 3. Analysis of the inter-relationship of their percieved symptoms of fatigue with the environments of working area. 1) The difference of distribution of their percieved symptoms of fatigue according to the working department was significant; Production workers were higher than office workers. 2) The difference of distribution of their percieved symptoms of fatigue related with working posture was significant; Sitting: Musculo-Skeletal symptoms (p<0.05), Optical symptoms (p<0.005) 3) The more dissatisfied with their's own duty they were, the higher became the distribution of their percieved symptoms of fatigue (p<0.001. p<0.005, p<0.05) 4) The more dissatisfied with their working condition they were, the higher became the degree of their percieved symptoms of fatigue (p<0.001. P<0.05) 5) The difference of distribution of their percieved symptoms of fatigue according to kinds of job was significant: Workers who has handled heavy materials were higher than who had not handled $(p{\leqq}0.001$, p<0.05). Workers who has handled chemical materials: Optical, symptoms $(p{\leqq}0.001)$. Workers who has handled dusty materials: Respiratory symptoms (p<0.01) 6) The environment of working area was significantly affected to the distribution of their percieved symptoms of fatigue: Workers complains of a illumination problem; Optical symptoms (p<0.005), Heart symptoms (p<0.005) Workers complains of a ventilation problem: Heart symptoms (p<0.05), Optical symptoms, Heart symptoms (p<0.01) Musculo-skeletal symptoms ($p{\leqq}0.001$)

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An Exploratory Study of Factors associated with the Health Behavior of Working Elderly with Chronic Diseases (만성질환이 있는 일하는 노인의 건강행위 관련요인에 관한 탐색적 연구)

  • Kim, Dong Ok;Yun, Soon-Nyung
    • Research in Community and Public Health Nursing
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    • v.23 no.4
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    • pp.395-404
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    • 2012
  • Purpose: This study aimed to identify the health behaviors of working elderly Koreans aged 65 over and examined the socio-demographic and disease-related factors by health behaviors. Methods: This study used data obtained from the 2nd basic survey of the 2008 Korean Longitudinal Study of Ageing. We selected 381 working elderly having one or more of the diseases hypertension, diabetes, heart disease or cerebrovascular disease. Results: 78.9% out of the subjects have hypertension, 31.2% have diabetes, 12.3% have heart disease, and 6.3% have cerebrovascular disease. Compared to the health behaviors of the general elderly, the rate of the practice of regular exercise among the subjects was lower, but the smoking and drinking rate were higher. The significant variables associated with health behavior practice rates were gender, type of work, subjective health status and chronic diseases. Conclusion: The type of work of the elderly with chronic diseases was significantly associated with health behaviors. Consequently, this study found that continuous care programs for the working elderly with chronic diseases should be developed and provided as an occupational health service when the jobs are offered to them.

A Corpus-Based Study of the Use of HEART and HEAD in English

  • Oh, Sang-suk
    • Language and Information
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    • v.18 no.2
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    • pp.81-102
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    • 2014
  • The purpose of this paper is to provide corpus-based quantitative analyses of HEART and HEAD in order to examine their actual usage status and to consider some cognitive linguistic aspects associated with their use. The two corpora COCA and COHA are used for analysis in this study. The analysis of COCA corpus reveals that the total frequency of HEAD is much higher than that of HEART, and that the figurative use of HEART (60%) is two times higher than its literal use (32%); by contrast, the figurative use of HEAD (41%) is a bit higher than its literal use (38%). Among all four genres, both lexemes occur most frequently in fictions and then in magazines. Over the past two centuries, the use of HEART has been steadily decreasing; by contrast, that the use of HEAD has been steadily increasing. It is assumed that the decreasing use of HEART has partially to do with the decrease in its figurative use and that the increasing use of HEAD is attributable to its diverse meanings, the increase of its lexical use, and the partial increase in its figurative use. The analysis of the collocation of verbs and adjectives preceding HEART and HEAD, as well the modifying and predicating forms of HEART and HEAD also provides some relevant information of the usage of the two lexemes. This paper showcases that the quantitative information helps understanding not only of the actual usage of the two lexemes but also of the cognitive forces working behind it.

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A Study of Workload Change at Varying Working Posture, Work/Pest Ration and Task Type in an Automobile Assembly Task (자동차 조립작업 시 작업자세, 작업/휴식비율, 작업형태에 따른 작업부하의 변화에 관한 연구)

  • 이준엽;김철홍
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.24 no.69
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    • pp.51-64
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    • 2001
  • A laboratory experiment was conducted to investigate the effects of working posture. work/rest ration, and task type on the physical workload in automobile assembly jobs. Ten healthy male university students participated as subjects in the experiment. East subject performed 18 experimental session with combination of 3 working posture 3 work/rest ratio and 2 task types. To examine the effect of various working conditions on workload, DMG analysis was performed on 4 different muscles in the neck an arm area, Also RPE scale and heart rate were taken as response variables. The result showed that all working conditions considered in the experiment had significant effects on the workload concluding that labor intensity in auto assembly jobs should be adjusted with respect to different levels of working posture, work/rest ratio, and task type. Detailed analysis are presented in the paper.

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The Study on the Moving Rail-chair and Electromotive Scissors for Preventing of the Musculoskeletal Disorders (근골격계 질환 예방을 위한 이동형 레의자와 전동가위에 관한 연구)

  • Chae, Hye-Seon;Kim, Kwan-Woo;Lee, Kyung-Suk;Kim, Chang-Han;Lee, Kyoung-Mi;Choi, Youn-Woo;Park, Keun-Sang
    • Journal of the Ergonomics Society of Korea
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    • v.29 no.1
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    • pp.139-144
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    • 2010
  • Grape weeding work requires Ergonomics improvement, because it performs motion likely to cause Musculoskeletal disorders (MSDs) repeatedly and continuously. The object of this study was to reject workload in Grape weeding works raised MSDs with the Moving Rail-chair and Electromotive Scissors. As objective method of analysis, we used heart rate, EMG, RULA, REBA. As subjective method of analysis, we used questionnaire that indicate lethargy area of body, pain of muscle and bone. As a result, working with Moving Rail-Chair and Electromotive Scissors is lower heart rate and EMG than typical working. Also for the subjective evaluation, reducing of neck and shoulder movement makes improve workload.