• The Journal of the Korea institute of electronic communication sciences
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• v.11 no.3
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• pp.339-344
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• 2016

This study is conducted for analysis of distribution of macrobenthic by using satellite image and in-situ data in the intertidal zone of Suncheon bay. The satellite images on low tide on July 7, 2010 and high tide on Sept. 25, 2010, respectively, are classified into sea water, tidal flat and land. It is to extract for intertidal zone overlaying at low tide and high tide image from previously classified image. Total number of species emergence are 196 species in the intertidal zone, and most species are emergence in the right part of the subtidal zone. The Sigambra tentaculata is the dominant species and emergence the Mediomastus californiensis, Magelona japonica, etc. It is noticed that many kind of macrobenthic distribution in the subtidal zone more than the supralittoral zone. It find out that contamination due to organic through the macrobenthic distribution with a strong resistance to organic in the subtidal zone of Suncheon Bay.

• Clinical and Experimental Pediatrics
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• v.63 no.8
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• pp.301-309
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• 2020

Human breast milk (HBM) is essential for the infant's growth and development right after birth and is an irreplaceable source of nutrition for early human survival. Various infant formulas have many similarities to HBM in many components, but there is no perfect substitute for HBM. Recently, various breast milk components and their roles have been studied according to the development of various analysis techniques. As is already well known, HBM contains about 87%-88% water, and 124-g/L solid components as macronutrients, including about 7% (60-70 g/L) carbohydrates, 1% (8-10 g/L) protein, and 3.8% (35-40 g/L) fat. The composition may vary depending on the environmental factors, including maternal diet. Colostrum is low in fat but high in protein and relatively rich in immuneprotective components. Although HBM contains enough vitamins to ensure normal growth of the infant, vitamins D and K may be insufficient, and the infant may require their supplementation. Growth factors in HBM also serve as various bioactive proteins and peptides on the intestinal tract, vasculature, nervous system, and endocrine system. In the past, HBM of a healthy mother was thought to be sterile. However, several subsequent studies have confirmed the presence of rich and diverse microbial communities in HBM. Some studies suggested that the genera Staphylococcus and Streptococcus may be universally predominant in HBM, but the origin of microbiota still remains controversial. Lastly, milk is the one of most abundant body fluid of microRNAs, which are known to play a role in various functions, such as immunoprotection and developmental programming, through delivering from HBM and absorption by intestinal epithelial cells. In conclusion, HBM is the most important source of nutrition for infants and includes microbiomes and miRNAs for growth, development, and immunity.

• Journal of Korean Neurosurgical Society
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• v.63 no.6
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• pp.689-697
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• 2020

Objective : Cerebral edema is the predominant mechanism of secondary inflammation after intracerebral hemorrhage (ICH). Pioglitazone, peroxisome proliferator-activated receptor gamma agonist has been shown to play a role in regulation of central nervous system inflammation. Here, we examined the pharmacological effects of pioglitazone in an ICH mouse model and investigated its regulation on NLRP3 inflammasome and glucose metabolism. Methods : The ICH model was established in C57 BL/6 mice by the stereotactical inoculation of blood (30 µL) into the right frontal lobe. The treatment group was administered i.p. pioglitazone (20 mg/kg) for 1, 3, and 6 days. The control group was administered i.p. phosphate-buffered saline for 1, 3, and 6 days. We investigated brain water contents, NLRP3 expression, and changes in the metabolites in the ICH model using liquid chromatography-tandem mass spectrometry. Results : On day 3, brain edema in the mice treated with pioglitazone was decreased more than that in the control group. Expression levels of NLRP3 in the ICH model treated with pioglitazone were decreased more than those of the control mice on days 3 and 7. The pioglitazone group showed higher levels of glycolytic metabolites than those in the ICH mice. Lactate production was increased in the ICH mice treated with pioglitazone. Conclusion : Our results demonstrated less brain swelling following ICH in mice treated with pioglitazone. Pioglitazone decreased NLRP3-related brain edema and increased anaerobic glycolysis, resulting in the production of lactate in the ICH mice model. NLRP3 might be a therapeutic target for ICH recovery.

• Advances in Traditional Medicine
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• v.7 no.3
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• pp.261-273
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• 2007

We investigated the antihypertensive effect of Pet ether extract (PE) of ginger rhizome; its toluene fraction (TF) and Korean ginseng extract (KGE) in deoxycorticosterone acetate (DOCA) - salt induced and fructose induced hypertensive rats. In DOCA model, DOCA (25 mg/kg, once a week; s.c) was administered in uninephrectomised animals for 4 w. PE (50 mg/kg/day; p.o), TF (10 mg/kg/day; p.o) and KGE (30 mg/kg/day; p.o) were evaluated for their antihypertensive effect. In the fructose model, drinking water was replaced with fructose (10%) for five weeks to induce hypertension. PE (50 mg/kg/day; p.o) and KGE (30 mg/kg/day; p.o) were assessed for its antihypertensive effect in fructose model. After completion of the treatment schedule, vascular reactivity to various agonists like 5-HT, noradrenaline, adrenaline, phenylbiguanide and acetylcholine were recorded in rats of both the models. A cumulative dose response curve (CDRC) of 5-HT was carried out in isolated rat fundus strip of the fructose induced hypertensive rats. Chronic administration of PE (50 mg/kg/day; p.o), TF (10 mg/kg/day; p.o), and KGE (30 mg/kg/day; p.o) significantly reduced the blood pressure in DOCA salt whereas PE (50 mg/kg/day; p.o) and KGE (30 mg/kg/day; p.o) reduced the blood pressure in fructose induced hypertensive rats. Treatment with PE (50 mg/kg/day; p.o) and KGE (30 mg/kg/day; p.o) in fructose model for five weeks shifted the CDRC towards the right on rat fundus. The mechanism of action may partly involve the serotonergic antagonistic property.

• The Korean Journal of Physiology
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• v.16 no.2
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• pp.165-175
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• 1982

Changes in handling of $Li^+$ by contralateral kidney during acute $Li^+$ loading were investigated immediately after unilateral ureteral obstruction. Carotid artery, jugular vein, renal vein and ureter of experimental animal were catheterized and renal venous flow was shunted to .external jugular vein. In experimental group right ureter was ligated. One to two hours after operation a single shot of LiCl solution (2 mEq/kg) was intravenously injected and then .arterial, renal venous blood and urine samples were taken sequentially for 1 to $1{\frac{1}{2}}$ hours. Urine volume, plasma and urinary concentrations of $Li^+$, $Na^+$ and $K^+$ were measured and urinary excretion of them were calculated. Results obtained were as follows: 1) In experimental group urine volume, urinary excretion of $Na^+$, and $K^+$ by contralateral kidney after unilateral ureteral obstruction were slightly larger than mean value of both kidney in control group. 2) During acute $Li^+$ loading contralateral kidney in experimental group showed limited $K^+$ excretion, but urinary flow and $Na^+$ excretion were comparable to mean value of both kidney in control group. 3) Urinary osmolar concentration in experimental group was much lower than that in control group, and it was maintained at low level even after Li loading. 4) In experimental group plasma$Li^+$ concentration decreased more slowly than in control group after a single shot of LiCl solution. 5) Urinary excretion of $Li^+$ in experimental group was markedly decreased, even lesseer than mean of both kidney in control group. 6) From the above results it was concluded that immediately after unilateral ureteral obstruction contralateral kidney showed normal water and $Na^+$ diuretic response to Li load but urinay $Li^+$ excretion was decreased and reclaimed $Li^+$ to systemic circulation.

• The Korean Journal of Quaternary Research
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• v.16 no.1
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• pp.17-27
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• 2002

Analysis of No. 199∼145 cross-sections set up by the Ministry of Construction (1978) in the middle reaches of the Sumjin River around Sunchang, Daegang, and Goksung areas have been done for delineating the changes In fluvial geomorphic features. The entire river-bed in the study area has been considerably degraded since 1978. In some cross-sections, the thalweg shillings are observed. Two aspects are responsible for the erosion-dominant environment. First, flow velocity has been increased. Human activities including wetland destruction, ex-channel destruction and artificial levee construction reduced the channel width, and fixed the channel geometry. This has resulted in increase of the water velocity. Pebble and granule∼coarse sand are prevailing on the river-bed, indicate the high speed of the currents. Second, aggregate has been intensively mined during 1980s∼1990s around the areas. Especially, in the right side of the cross-sections No. 188∼187 and the left side of the cross-section No. 155, erosion toward under the artificial levee is remarkable. This can be led to bank failure in case of heavy rainfall.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.3
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• pp.805-812
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• 2014

This study investigates the impact of morphological change on the physical habitat simulation. For this, CCHE2D model is used for the hydraulic analysis including the morphological change, and the physical habitat suitability is assessed with habitat suitability curves. The model is applied to a 2.5km long reach downstream of the Goesan Dam, from Sujeon Bridge to Daesu Weir. Flow data of discharge and stage in July, 2006 are used in the computation. The numerical model is verified by means of comparison with the measured water surface elevation data, and the variation of the river bed is not verified in this study. Adult Zacco platypus is chosen for the dominant species. Physical habitat simulations result in composite habitat suitability and weighted usable area for drought, low, normal, and averaged-wet flows. The simulation results indicate that the composite suitability index increased at reaches right downstream of the Sujeon Bridge and around the bend. This also increased weighted usable area by 5.4-11.3%.

• Journal of Korean Society of Rural Planning
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• v.24 no.1
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• pp.113-127
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• 2018

This study comprehends that the landscape of Ipsan Village is the accumulated output of the landscape management and social behavior by the historic personages through the reference research and field surveys. And the study sorted out the over-layered landscape characteristics of Ipsan Village by analyzing the dispersed landscape elements as follows. First, right before the start of Japanese invasions to Korea(1592-98), Tamjin(耽津) An(安) Family moved into Ipsan and started establishing the a single clan village. At a site with mountain background and facing the water(背山臨水), the village used to be a typical farming one with an organically planned road-system and housing area following the traditional order. However, the landscape has changed drastically since the 20th century with the construction of banks, roads and readjustment of arable land etc. Second, the original landscape, which can be figured out through the 'Gosanjaesibyukgyeong(高山齋十六景)' in the 18th century, shows its harmony with natural landscape: mountain & valley, stream & field, traditional trees, etc, cultural landscape: village, well, spring, etc, and momentary landscape: seasons, time, weather phenomena, sound, behavior, etc. Third, based on the second, 16 natural landscape elements: mountain & stream, planting, etc. and 25 cultural landscape elements: housing spaces, self-cultivation & ceremony spaces, community spaces and modern education & enlightenment spaces were selected and interpreted as landscaping meanings. Fourth, the over-layered landscape which stems from the compositive functions and inter-connectivity of landscape elements which consists Ipsan Village is regarded as 'Natural geographical and Fungsu landscape', 'Rural production and livelihood landscape', 'Confucian ceremony and symbolic landscape' and 'Modern education and enlightenment landscape.'

• Journal of Environmental Impact Assessment
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• v.9 no.2
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• pp.127-142
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• 2000

This research was performed for analyzing the transport of suspended solids during the harbor construction. In behalf of the research, we have analyzes the characteristics of suspended solids movement in sand reclamation of breakwater according to age of tide and tidal period at the construction spot of Pusan new harbor. In the process of sand reclamation, soil was dumped by a dumping device which direct soil from the barge to the bottom of the sea. According to the results from this research, suspended solid concentration was very high in the range of 5m from the dumping point right after the dumping. However these suspended solids settled very quickly and the solids concentration was very beyond 10m from the dumping point. It is deduced that the movement of solids dumped from barge has the tendencies as following; 1) Most of the dumped solids precipitated quickly after the dumping 2) The rest of the suspended solids are diffused slowly toward the bottom of the water being figured smoothing curve 3) The diffusion movement of suspended solids tend to proceed toward the shore line in a parallel motion with tidal current at the sea-bottom That is to say, most of the suspended solids precipitated very quickly even though highly concentrated solids produced at the bottom of the solids which did not precipitated spread with the tidal current horizontally along the bottom of the sea.

• Parasites, Hosts and Diseases
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• v.51 no.3
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• pp.335-341
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• 2013

Balamuthia mandrillaris is one of the 4 amebas in fresh water and soil that cause diseases in humans. Granulomatous amebic encephalitis (GAE), caused by B. mandrillaris, is a rare but life-threatening condition. A 4-year-old, previously healthy, Thai girl presented with progressive headache and ataxia for over a month. Neuroimaging studies showed an infiltrative mass at the right cerebellar hemisphere mimicking a malignant cerebellar tumor. The pathological finding after total mass removal revealed severe necrotizing inflammation, with presence of scattered amebic trophozoites. Cerebrospinal fluid (CSF) obtained from lumbar puncture showed evidence of non-specific inflammation without identifiable organisms. A combination of pentamidine, sulfasalazine, fluconazole, and clarithromycin had been initiated promptly before PCR confirmed the diagnosis of Balamuthia amebic encephalitis (BAE). The patient showed initial improvement after the surgery and combined medical treatment, but gradually deteriorated and died of multiple organ failure within 46 days upon admission despite early diagnosis and treatment. In addition to the case, 10 survivors of BAE reported in the PubMed database were briefly reviewed in an attempt to identify the possible factors leading to survival of the patients diagnosed with this rare disease.