• Molecules and Cells
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• v.43 no.10
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• pp.880-888
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• 2020

Inherited peripheral neuropathy is a heterogeneous group of peripheral neurodegenerative disorders including Charcot-Marie-Tooth disease. Many peripheral neuropathies often accompany impaired axonal construction and function. To study the molecular and cellular basis of axon-defective peripheral neuropathy, we explore the possibility of using Caenorhabditis elegans, a powerful nematode model equipped with a variety of genetics and imaging tools. In search of potential candidates of C. elegans peripheral neuropathy models, we monitored the movement and the body posture patterns of 26 C. elegans strains with disruption of genes associated with various peripheral neuropathies and compiled a database of their phenotypes. Our assay showed that movement features of the worms with mutations in HSPB1, MFN2, DYNC1H1, and KIF1B human homologues are significantly different from the control strain, suggesting they are viable candidates for C. elegans peripheral neuropathy models.

• International Journal of Automotive Technology
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• v.1 no.1
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• pp.9-16
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• 2000

The growing concerns on environmental protection have been constantly demanding cleaner and more energy efficient vehicles without compromising any conveniences provided by the conventional vehicles. The recent significant advances in proton-exchange-membrane (PEM) fuel cell technology have shown the possibility of developing such vehicles powered by fuel cells. Several prototype fuel cell electric vehicles (FCEV) have been already developed by several major automotive manufactures, and all of the favorable features have been demonstrated in the public roads. FCEV is essentially a zero emission vehicle and allows to overcome the range limitation of the current battery electric vehicles. Being motivated by the laboratory and field demonstrations of the fuel cell technologies, variety of fuel cell alliances between fuel cell developers, automotive manufactures, petroleum companies and government agencies have been formed to expedite the realization of commercially viable FCEV. However, there still remain major issues that need to be overcome before it can be fully accepted by consumers. This paper describes the current fuel cell vehicle development status and the staggering challenges for the successful introduction of consumer acceptable FCEVS.

• Biomolecules & Therapeutics
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• v.23 no.2
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• pp.99-109
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• 2015

Drug development groups are close to discovering another pot of gold-a therapeutic target-similar to the success of imatinib (Gleevec) in the field of cancer biology. Modern molecular biology has improved cancer therapy through the identification of more pharmaceutically viable targets, and yet major problems and risks associated with late-phase cancer therapy remain. Presently, a growing number of reports have initiated a discussion about the benefits of metabolic regulation in cancers. The Warburg effect, a great discovery approximately 70 years ago, addresses the "universality" of cancer characteristics. For instance, most cancer cells prefer aerobic glycolysis instead of mitochondrial respiration. Recently, cancer metabolism has been explained not only by metabolites but also through modern molecular and chemical biological techniques. Scientists are seeking context-dependent universality among cancer types according to metabolic and enzymatic pathway signatures. This review presents current cancer metabolism studies and discusses future directions in cancer therapy targeting bio-energetics, bio-anabolism, and autophagy, emphasizing the important contribution of cancer metabolism in cancer therapy.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.58 no.4
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• pp.568-573
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• 2009

Because of environmental crisis, researchers are seeking and developing a new, clean, safe and renewable energy. Solar cell energy and fuel cell energy have inestimable development potential. The paper introduces hybrid photovoltaic-fuel cell generation systems supplying a remote power load and hybrid system of solar cell and fuel cell considering the advantages of stable and sustainable energy from the economic point of view. Fuel cell power system has been proven a viable technology to back up severe PV power fluctuations under inclement weather conditions. Fuel cell power generation, containing small land us, is able to alleviate the heavy burden for large surface requirement of PV power plants. In addition, the PV-fuel cell hybrid power system shows a very little potential for lifetime $CO_2$ emissions. In this paper shows the I-V characteristics of the solar module which are dependent on the power of the halogen lamp and the I-V characteristics of fuel cells which are connected in parallel. Also, it shows efficiency of the hybrid system.

• Journal of Microbiology and Biotechnology
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• v.16 no.7
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• pp.1010-1016
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• 2006

The effects of the cell viability and integrity of Bifidobacterium on suppression of allergy were investigated. C3H/HeJ mice were sensitized on weeks 3, 4, 6, and 8 with ovalbumin and choleratoxin to induce an allergic reaction. Mice fed 0.2% of live, disrupted, or heat-killed Bifidobacterium bifidum BGN4 in the pellets of their diet for 8 weeks starting 2 weeks before initial sensitization differentially suppressed the allergy response in terms of levels of IgE and IgG1 in their sera, and symptoms on their tails. Viable Bifidobacterium was more effective than disrupted or heat-killed cells in suppressing the allergy. Growth inhibition, which occurred in the sham group at week 4, did not occur in the treated groups. These results show that Bifidobacterium has a suppressive effect on the allergic response of mice, and that the viability and integrity of the Bifidobacterium is required for effective suppression in our experimental model.

• Fisheries and Aquatic Sciences
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• v.3 no.1
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• pp.44-48
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• 2000

In order to utilize chum salmon returned in the east coast of Korea, the changes in the properties of Yeonual-jeot (salted salmon roe) fermented at different temperatures were measured for obtaining the basic data for its commercial production. Moisture content of salted salmon roe was significantly lower than raw salmon roe, while other proximate components were in the reverse. pH was constant for 56 days fermentation at $5^{\circ}C$, but decreased with fermentation Reriod at 10 and $15^{\circ}C$. The contents of amino-nitrogen and VBN were almost in constant at $5^{\circ}C$ up to 28 days of fermentation, but increased very slowly at $10^{\circ}C$ and moderately at $15^{\circ}C$. TBA value, and the numbers of total viable cells and lactic acid bacteria increased over all fermentation periods, more at higher fermentation temperatures.

• Korean Journal of Plant Tissue Culture
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• v.24 no.4
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• pp.189-195
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• 1997

Twenty six per cent of Canada's core biotech companies are Ag-biotechnology, compared with five per cent in the United States. Activities include the use of microorganisms, plant cells to create commercially viable products, and transformation of plants to improve specific qualities. Goals ate to increase the world's food supply, enable crops and animals to resist pests and diseases, increase the nutritional content of food, and improve production efficiency. I believe that there are business opportunities in the agriculture sector for Canada and other countries such as Korea to collaborate. These are research to research : institute to institute: business to business, and combinations of these areas. However, for these opportunities to become a reality we need to increase our awareness of each other's activities and needs. My presentation today was not designed with specifics, but to encourage some strategic thinking by both countries on how we can do business together in agriculture and biotechnology.

• Korean Journal of Plant Tissue Culture
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• v.24 no.4
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• pp.225-231
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• 1997

For genetic engineering to be commercially viable, an efficient transformation system is needed to produce transgenic plane from diverse genotypes ("generalized protocol"). Development of such a system requires optimization of a number of components such as gene transfer agent, plant tissues competent for both regeneration and transformation, and control of transgene expression. Although several novel gene transfer methods have been developed for plane, a majority of stably transformed plane express the introduced genes at low levels. Moreover, silencing of selectable marker genes shortly after their incorporation into plant chromosomes may result in low recovery of transgenic tissues from selection. Matrix attachment regions (MARs) are DNA sequences that bind to the cell's proteinaceous nuclear matrix to form DNA loop domains. MARs have been shown to increase transgene expression in tobacco cells, and reduce position in mature transgenic plants. Flanking an antibiotic resistance transgene with MARs should therefore lead to improved rates of transformation in a diversity of species, and may permit recalcitrant species and genotypes to be successfully transformed. Literature review and recent data from my laboratory suggest that MARs can serve as a transformation booster in recalcitrant plant species.

• Journal of Veterinary Clinics
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• v.22 no.4
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• pp.353-356
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• 2005

This study was performed to examine the antibacterial efecacy of topical agent extracted from Phellodendri cortex, Forsythia fructus and Glycyrrhizae radix as an alternative dermatological agent. Also, the most efficacious concentration of this agent and the skin-contact time inhibiting the vegetation of bacterial cells in various dilutions were determined. Five strains of Staphylococcus intermedius were exposed to various dilutions of this agent. The efficacy was assessed after exposure for time periods varying between 0 and 30 min. The antibacterial efficacy was shown to be the strongest at dilution of 1: 2. The number of viable organisms decreased significantly after 8 minutes of exposure time and was the smallest after 30 minutes of exposure time. This alternative dermatological agent is considered to be effective against Staphylococcus intermedius and has a potential to be a new topical agents far the treatment of pyoderma in dogs.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2000.05a
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• pp.167-168
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• 2000

The potential application of protoplasts useful for studies such as physiology, morphology, genetic engineering, etc has led to the development of suitable methologies for isolation and manupilation of protoplasts from a wide variety of algae (Waaland et al., 1990; Reddy and Fujita, 1991; Chen and Chiang, 1994). Protoplasts technology to seaweeds depends large on the ability to produce viable cells capable of regenerating into whole plantlets (Wakabayashi et al., 1999). Though Capsosiphon fulvescens is one of the important economic seaweeds culturing in Korea, surprisingly protoplasts approach on this species has not been reported so far. Consequently we investigated the various aspects related to the protoplasts of Capsosiphon fulvescens in this study. (omitted)