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The Hyperthermic Effect of Nitric Oxide in Central Nervous System

  • Jung, Jae-Kyung;Sohn, Uy-Dong;Lee, Seok-Yong
    • The Korean Journal of Physiology and Pharmacology
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    • v.5 no.1
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    • pp.93-98
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    • 2001
  • The precise mechanism of set-point regulation in hypothalamus was not elucidated. Nitric oxide synthases(NOS) were detected in hypothalamus, however, the roles of NO in hypothalamus was not fully studied. So, we tested the effects of NO on body temperature because preoptic-anterior hypothalamus was known as the presumptive primary fever-producing site. NO donor sodium nitroprusside (SNP, 4 nmol, i.c.v.) elicited marked febrile response, and this febrile response was completely blocked by indomethacin (a cyclooxygenase inhibitor). But, ODQ (selective guanylate cyclase inhibitor, $50\;{\mu}g,$ i.c.v.) did not inhibit fever induced by SNP. The cyclic GMP analogue dibutyryl-cGMP $(100\;{\mu}g,\;i.c.v.)$ induced significant pyreses, which is blocked by indomethacin. $N^G-nitro-L-arginine$ methyl ester (L-NAME, non selective NOS inhibitor) inhibited fever induced by $interleukin-1{\beta}\;(IL-1{\bata},\;10\;ng,\;i.c.v.),$ one of endogenous pyrogens. These results indicate that NO may have an important role, not related to stimulation of soluble guanylate cyclase, in the signal pathway of thermoregulation in hypothalamus.

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Atomic Force Microscopy Study of Conducting Layered Transition Metal Ditellurides

  • Kim Sung-Jin;Park So-Jung;Oh Hoon-Jung;Jeon, Il Cheol;Song Sunae
    • Bulletin of the Korean Chemical Society
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    • v.15 no.12
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    • pp.1098-1103
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    • 1994
  • Atomic force microscopy (AFM) images of two conducting layered transition-metal ditellurides, $TaTe_2$ and $Ta_{0.5}$$V_{0.5}$$Te_2$, were examined and their surface and bulk structural features were compared. All the measured unit cell parameters from AFM image were consistent and in complete agreement with the results of the X-ray diffraction. The microscopic structures of corrugated surface tellurium sheets were strongly affected by the modification of metal double zig-zag chains underneath Te surface. Large difference in the height amplitudes of AFM images in $TaTe_2$ and $Ta_{0.5}$$V_{0.5}$$Te_2$ phases was observed and this reflects large difference in the surface electron densities of two phases. On surface, the shorter intralayer Te…Te contacts in $TaTe_2$ induce more electron transfer from Te p-block bands to Ta d-block bands, thus electron density on surface observed in $TaTe_2$ is much lower than that of $Ta_{0.5}$$V_{0.5}$$Te_2$. However, in bulk, interlayer Te…Te contacts in V substituted phase are shorter than those in $TaTe_2$ phase, thus tellurium-to-metal electron transfer occurs more easily in $Ta_{0.5}$$V_{0.5}$$Te_2$ phase.

Insulation Characteristics of Dry-air Insulated Switchgear for 72.5 kV Wind Power Generation (72.5 kV 풍력 발전용 Dry-air Switchgear의 절연 특성)

  • Chan-Hee Yang;Jin-Seok Oh;Hee-Tae Park;Young-il Kim
    • Journal of Wind Energy
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    • v.15 no.2
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    • pp.5-9
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    • 2024
  • This paper describes the insulation breakdown characteristics of 72.5 kV dry-air insulated switchgear under development for installation in a wind power generator when a lightning impulse voltage is applied. For this study, the weak point of insulation due to the electric field concentration of the switchgear's internal shape was identified by finite element method (FEM) analysis, and the shape was actually simulated to measure and analyze the polarity of the lightning impulse voltage and the insulation breakdown characteristics according to the gas pressure at dry-air pressures of 0.1 Mpa to 0.45 Mpa. This study derives the maximum electric field with a 50 % discharge probability for each switchgear internal insulation vulnerable point based on the actual test and electrical simulation, which will be useful as reference data for supplementing and changing insulation design in the future.

THE EFFECT OF IRRADIATION MODES ON POLYMERIZATION AND MICROLEAKAGE OF COMPOSITE RESIN (광조사 방식이 복합레진의 중합과 누출에 미치는 영향)

  • Park, Jong-Jin;Park, Jeong-Won;Park, Sung-Ho;Park, Ju-Myong;Kwon, Tae-Kyung;Kim, Sung-Kyo
    • Restorative Dentistry and Endodontics
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    • v.27 no.2
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    • pp.158-174
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    • 2002
  • The aim of this study was to investigate the effect of light irradiation modes on polymerization shrinkage, degree of cure and microleakage of a composite resin. VIP$^{TM}$ (Bisco Dental Products, Schaumburg, IL, USA) and Optilux 501$^{TM}$ (Demetron/Kerr, Danbury, CT, USA) were used for curing Filtek$^{TM}$ Z-250 (3M Dental Products, St. Paul., MN, USA) composite resin using following irradiation modes: VIP$^{TM}$ (Bisco) 200mW/$\textrm{cm}^2$ (V2), 400mW/$\textrm{cm}^2$ (V4), 600mW/$\textrm{cm}^2$ (V6), Pulse-delay (200 mW/$\textrm{cm}^2$ 3 seconds, 5 minutes wait, 600mW/$\textrm{cm}^2$ 30seconds, VPD) and Optilux 501$^{TM}$ (Demetron/Kerr) C-mode (OC), R-mode (OR). Linear polymerization shrinkage of the composite specimens were measured using Linometer (R&B, Daejeon, Korea) for 90 seconds for V2, V4, V6, OC, OR groups and for up to 363 seconds for VPD group (n=10, each). Degree of conversion was measured using FTIR spectrometer (IFS 120 HR, Bruker Karlsruhe, Germany) at the bottom surface of 2 mm thick composite specimens V2, Y4, V6, OC groups were measured separately at five irradiation times (5, 10, 20, 40, 60 seconds) and OR, VPD groups were measured in the above mentioned irradiation modes (n=5 each). Microhardness was measured using Digital microhardness tester (FM7, Future-Tech Co., Tokyo, Japan) at the top and bottom surfaces of 2mm thick composite specimens after exposure to the same irradiation modes as the test of degree of conversion(n=3, each). For the microleakage test, class V cavities were prepared on the distal surface of the ninety extracted human third molars. The cavities were restored with one of the following irradiation modes : V2/60 seconds, V4/40 seconds, V6/30 seconds, VPD , OC and OR. Microleakage was assessed by dye penetration along enamel and dentin margins of cavities. Mean polymerization shrinkage, mean degree of conversion and mean microhardness values for all groups at each time were analyzed using one-way ANOVA and Duncan's multiple range test, and using chi-square test far microleakage values. The results were as follows : . Polymerization shrinkage was increased with higher light intensity in groups using VIP$^{TM}$ (Bisco) : the highest with 600mW/$\textrm{cm}^2$, followed by Pulse-delay, 400mW/$\textrm{cm}^2$ and 200mW/$\textrm{cm}^2$ groups, The degree of polymerization shrinkage was higher with Continuous mode than with Ramp mode in groups using Optilux 501$^{TM}$ (Demetron/Kerr). . Degree of conversion and microhardness values were higher with higher light intensity. The final degree of conversion was in the range of 44.7 to 54.98% and the final microhardness value in the range of 34.10 to 56.30. . Microleakage was greater in dentin margin than in enamel margin. Higher light intensity showed more microleakage in dentin margin in groups using VIP$^{TM}$ (Bisco). The microleakage was the lowest with Continuous mode in enamel margin and with Ramp mode in dentin margin when Optilux 501$^{TM}$ (Demetron/Kerr) was used.

How to Evaluate the Combined Dust Removal Efficiency of Fine Dust in the Dust Collector (집진기 미세먼지의 복합제진효율 평가방법)

  • Kang, Il-Seo;Lee, Young-su;Kim, Dong-Hyun
    • Journal of Digital Convergence
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    • v.20 no.2
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    • pp.339-344
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    • 2022
  • It is about how much fine dust can be efficiently removed with respect to the electric dust collector used in factories and large facilities. The results of evaluating the fine dust removal efficiency are as follows. At 10,000 V, Efficiency method I showed 68.1 %, and Efficiency method II was 58.6 %, which was lower than that of Efficiency method I. At 5,000 V, Efficiency method I showed 57.6%, and Efficiency method II showed 51.6%, which was lower than Efficiency method I. At 2,500 V, Efficiency method I showed 50.3%, and Efficiency method II showed 24.4%, which was lower than Efficiency method I. In case of Efficiency method I, it is the efficiency calculated by using the dust concentration before and after passing through the filter. Efficiency method II calculated Efficiency method II to measure the efficiency a little more accurately in the environment where the air after the filter and the polluted air are mixed. Efficiency method II showed lower efficiency than Efficiency method I. As a result of the electrostatic precipitator test, the dust collecting performance was highest at 10,000 V, followed by 5,000 V and 2,500 V in that order.

Study on Sensory Papillae of Metagonimus yokogawai Cercaria (Metagonimus yokogawai 세르카리아의 감각유두에 관한 연구)

  • 김재진;민득영소진탁
    • Parasites, Hosts and Diseases
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    • v.22 no.1
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    • pp.11-20
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    • 1984
  • A number of studies on the papillae of cercariae of trematodes reported that the papillar patterns (or chaetotaxy) of cercariae might be an excellent method to attain better understanding of the digenetic trematodes (Richard, 1971 ; Short and Cartrett, 1973; Bayssade-Dufour, 1979) . The present study was aimed to determine the number, distribution pattern and structure of the sensory papillae of Metagonimus yokogawai cercariae, and to elucidate the chaetotaxy of this digenetic trematode. M. yokogawai cercariae were pipetted from a vial in which infected snails (Semisulcospira libertina) had been kept for 3 hours. The snails were collected from an endemic area of M. yokogawai, Boseong river in west-southern part of Korea. Observations of papillae were based on light microscopy of those stained with silver nitrate, and on scanning electron microscopy The results are summarized as follows: 1, All papillae observed were uniciliated. 2. Cilia in anterior tip were shorter than the others in other portions. 3. The body papillae were arranged in essentially symmetrical patterns, Total number of the papillae was 126(63 pairs) in average; anterior tip 40(20 pairs), ventral 20(10 pairs), lateral 42(21 pairs), and caudal 8(4 pairs). 4. The chaetotany of M. yokogawai cercaria was: Ci cycle ($3+3C_{I}V,{\;}2+2C_{I}L,{\;}2+3C_{I}D),{\;}C_{II}{\;}cycle(2C_{II}V,{\;}1C_{II}L,{\;}2C_{II}D),{\;}C_{lll}{\;}cycle{\;}(1+lC_{III}V,{\;}1C_{IlI}L),{\;}C_{IV}{\;}cycle{\;}(1C_{IV}V,{\;}IC_{lV}L){\;}in{\;}cephalic{\;}region:{\;}A_I(1A_{IV}V,{\;}1+2A_{I}L,{\;}1A_{I}D),{\;}A_{II}(1A_{II}V,{\;}1+3A_{II}L,{\;}1A_{II}D),{\;}A_{III}(1A_{III}V,{\;}1+1A_{III}L,{\;}1A_{III}D){\;}and{\;}A_{IV}(1A_{IV}V,{\;}2A_{IV}L)$ in antacetabular region: $1M_{I}V{\;}and{\;}2M_{I}L$ in median: $1+1P_{I}L,{\;}1P_{II}L,{\;}1P_{II}D,{\;}1P_{III}L,{\;}1P_{IV}L{\;}and{\;}1P_{IV}D$ in postacetabular region: 2-2-2-2 in caudal region.

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Medullary Sponge Kidney Detected in the Pediatric Age (소아 연령에서 발견된 medullary sponge kidney)

  • Chung, Woo Yeong;Cho, Min Hyun;Gu, Young-Ran;Leem, Sun-Hee;Cheong, Hae Il
    • Childhood Kidney Diseases
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    • v.16 no.2
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    • pp.109-114
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    • 2012
  • Purpose: Medullary sponge kidney (MSK) is a rare congenital disease characterized by diffuse ectasia or dilatation of precalyceal collecting tubules. MSK incidence and prevalence in the general population is uncertain and only a few patients are reported especially in the pediatric age. There has been increasing reports of patients with MSK who have other malformative disorders. Also several case reports concerning about etiological association of some genes. Methods: Collaborative study through nation-wide survey was done to investigate the incidence and etiological association of some genes such as GDNF gene, ATP6V1B1, ATP6V0A4 gene in developing MSK in Korean children. Results: Four cases of MSK who have various other malformative disorders were collected. There are no mutations of GDNF gene, ATP6V1B1, ATP6V0A4 gene in all patients. Conclusion: MSK is one of the very rare diseases in pediatric age. The etiological association of GDNF gene, ATP6V1B1, ATP6V0A4 gene in developing MSK in Korean children is not proved.

Characterization of Hot Electron Transistors Using Graphene at Base (그래핀을 베이스로 사용한 열전자 트랜지스터의 특성)

  • Lee, Hyung Gyoo;Kim, Sung Jin;Kang, Il-Suk;Lee, Gi Sung;Kim, Ki Nam;Koh, Jin Won
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.29 no.3
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    • pp.147-151
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    • 2016
  • Graphene has a monolayer crystal structure formed with C-atoms and has been used as a base layer of HETs (hot electron transistors). Graphene HETs have exhibited the operation at THz frequencies and higher current on/off ratio than that of Graphene FETs. In this article, we report on the preliminary results of current characteristics from the HETs which are fabricated utilizing highly doped Si collector, graphene base, and 5 nm thin $Al_2O_3$ tunnel layers between the base and Ti emitter. We have observed E-B forward currents are inherited to tunneling through $Al_2O_3$ layers, but have not noticed the Schottky barrier blocking effect on B-C forward current at the base/collector interface. At the common-emitter configuration, under a constant $V_{BE}$ between 0~1.2V, $I_C$ has increased linearly with $V_{CE}$ for $V_{CE}$ < $V_{BE}$ indicating the saturation region. As the $V_{CE}$ increases further, a plateau of $I_C$ vs. $V_{CE}$ has appeared slightly at $V_{CE}{\simeq}V_{BE}$, denoting forward-active region. With further increase of $V_{CE}$, $I_C$ has kept increasing probably due to tunneling through thin Schottky barrier between B/C. Thus the current on/off ration has exhibited to be 50. To improve hot electron effects, we propose the usage of low doped Si substrate, insertion of barrier layer between B/C, or substrates with low electron affinity.

Synthesis and Electrolyte Characterization of 1-Benzyl-3-butylimidazolium Hydroxide Ionic Liquid (1-Benzyl-3-butylimidazolium Hydroxide 이온성액체 합성 및 전해질 특성 조사)

  • Salman, Muhammad;Lee, Hye Jin
    • Applied Chemistry for Engineering
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    • v.31 no.6
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    • pp.603-606
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    • 2020
  • A hydrophilic alkaline room temperature ionic liquid electrolyte (RT-IL) carrying hydroxide ion as an anion and 1-benzyl-3-butylimidazolium as a cation was synthesized. Electrochemical, physical and structural properties of the synthesized RT-IL were characterized using cyclic voltammetry, ionic conductivity, viscosity, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), FT-IR, and 1H-NMR measurements. High ionic conductivity and low viscosity characteristics comparable to 0.1 M KCl electrolyte solution were achieved for the RT-IL in addition to a wide electrochemical potential window of about 4.4 V. The results indicate that the RT-IL is promising for future applications as an alternative electrolyte to energy and environmental research fields.

Vibrios Isolated from Diseased Marine Culturing Fishes in Korea (질병의 증상을 보이는 해수 양식 어류에서 분리한 비브리오속 세균)

  • Kim, Su-Mi;Won, Kyung-Mi;Woo, Sung-Ho;Li, Hua;Kim, Eun-Jeon;Choi, Kwang-Jin;Cho, Mi-Young;Kim, Myung-Suk;Park, Soo-Il
    • Journal of fish pathology
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    • v.18 no.2
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    • pp.133-146
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    • 2005
  • A bacteriological survey in maricultured fish farms was conducted in Korea from 2002 to 2004. A total number of 166 Vibrio isolates were collected from diseased fishes, including olive flounder (133 isolates), black rock fish (8 isolates), red sea bream (6 isolates), shrimp (5 isolates), black sea bream (4 isolates), abalone (3 isolates) and other fishes (7 isolates). All isolates were phenotypically characterized and then groups were obtained using the traditional biochemical test. Representative isolates of each group were genotypically characterized with sequencing the 16S rRNA genes or 16S-23S intergenic space genes. Above 14 species of Vibrio were identified as V. ichthyoenteri (45 strains), V. alginolyticus (34 strains), V. harveyi (32 strains), Ph. damselae subsp. damselae (Formerly V. damsela, 10 strains), V. campbellii (6 strains), V. costicola-like (6 strains), V. fisheri (5 stains), V. fluvialis (4 strains) and others Vibrio sp. (24 strains) by combining of biochemial and genetic characteristics.