• BMB Reports
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• v.57 no.3
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• pp.155-160
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• 2024

Lung cancer carries one of the highest mortality rates among all cancers. It is often diagnosed at more advanced stages with limited treatment options compared to other malignancies. This study focuses on calnexin as a potential biomarker for diagnosis and treatment of lung cancer. Calnexin, a molecular chaperone integral to N-linked glycoprotein synthesis, has shown some associations with cancer. However, targeted therapeutic or diagnostic methods using calnexin have been proposed. Through 1D-LCMSMS, we identified calnexin as a biomarker for lung cancer and substantiated its expression in human lung cancer cell membranes using Western blotting, flow cytometry, and immunocytochemistry. Anti-calnexin antibodies exhibited complement-dependent cytotoxicity to lung cancer cell lines, resulting in a notable reduction in tumor growth in a subcutaneous xenograft model. Additionally, we verified the feasibility of labeling tumors through in vivo imaging using antibodies against calnexin. Furthermore, exosomal detection of calnexin suggested the potential utility of liquid biopsy for diagnostic purposes. In conclusion, this study establishes calnexin as a promising target for antibody-based lung cancer diagnosis and therapy, unlocking novel avenues for early detection and treatment.

• Proceedings of the KIPE Conference
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• 2011.11a
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• pp.207-208
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• 2011

중요부하를 갖는 계통연계 인버터에서 계통이상시 독립운전으로 전환하여 중요부하에 지속적인 전력을 공급하여야 한다. 기존의 제어 방식은 독립운전시 전압제어를 계통연계시 전류제어를 하기 때문에 모드전환시 과도상태가 발생하고 단독운전 검출전에도 부하의 전압과 주파수가 변동하여 중요부하에 심각한 영향을 줄 수 있다. 본 논문에서는 모드 전환시 과도상태를 최소화하면서 단독운전 검출전에도 부하 전압과 주파수가 일정하게 유지하는 간접전류제어 기반의 계통연계 인버터에서 전압 고조파를 주입함으로써 NDZ(Non-Detection Zone)를 갖지 않는 단독운전방지 기법을 제안한다.

• Biomedical Science Letters
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• v.10 no.2
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• pp.75-84
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• 2004

Massive identification of differentially expressed patterns has been used as a tool to detect genes that are involved in disease related process. We employed circular single stranded sense molecules as probe DNA for a DNA chip. The circular single stranded DNAs derived from 1,152 unigene cDNA clones were purified in a high throughput mode from the culture supernatant of bacterial transformants containing recombinant phagemids and arrayed onto silanized slide glasses. The DNA chip was examined for its utility in detection of differential expression profile by using cDNA hybridization. Hybridization of the single stranded probe DNA were performed with Cy3- or Cy5-labeled target cDNA preparations at $60^\circ$C. Dot scanning performed with the hybridized slide showed 29 up-regulated and 6 down-regulated genes in a cancerous liver tissue when compared to those of adjacent noncancerous liver tissue. These results indicate that the circular single stranded sense molecules can be employed as probe DNA of arrays in order to obtain a precious panel of differentially expressed genes.

• Journal of Environmental Science International
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• v.16 no.12
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• pp.1325-1335
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• 2007

The utility of soil-gas surveys is directly proportional to their accuracy in reflecting and representing changes in the subsurface concentrations of source compounds. Passive soil-gas vapor-phase is merely a fractional trace of the source, so, as a matter of convenience, the units used in reporting detection values from EMFLUX surveys are smaller than those employed for source-compound concentrations. According to the Leaking Underground Storage Tank(LUST) Program Annual Report, approximately 16 U.S. million dollars were spent for environmental site investigations at over 1,600 Underground Storage Tank(UST) sites and approximately over 1,000 acres of land was characterized and remediated in the State of Illinois in the year of 2003 alone. The main purpose of this study is to propose an idea to significantly reduce the site investigation cost by utilizing a passive soil-gas survey and conventional intrusive drilling method and to fully define the three dimensional characteristics of subsurface contamination from two industrial drycleaning facilities.

• Proceedings of the KIEE Conference
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• 1999.07c
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• pp.1407-1409
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• 1999

Distance relay is being used for transmission line protection. Recently, current differential relay is used with high reliability in power system. This kind of relay is reported that it has a reliable detection ability, even so high impedance faults take place in transmission line. Therefore it is expected to use and expand widely in many utilities. Tripping of the relay is decided according to the difference between differential and restraint current. However the tripping criterion can be changed by the manufacturers. This paper presents an operational scheme of current differential relay for transmission line protection with graphical model. It is developed for educational purpose for students interesting in power system and protection engineer in utility. MATLAB is used to establish the models.

• Proceedings of the KSME Conference
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• 2001.11a
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• pp.240-245
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• 2001

Ultrasonic inspection system is consisted of the operator, equipment and procedure. The reliability of results in ultrasonic inspection is affected by its ability. Furthermore, the reliability of nondestructive testing is influenced by the inspection environment, other materials and types of defect. Therefore, it is very difficult to estimate the reliability of NDT due to various factors. In this study, the probability of detection, used logistic probability model and Monte Carlo simulation, estimated the reliability of ultrasonic inspection. The utility of the NDT reliability assesment is verified by the analysis of the data from round robin test applied these models.

• Proceedings of the KIPE Conference
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• 2006.06a
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• pp.213-215
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• 2006

Islanding phenomenon is undesirable because it lead to a safety hazard to utility service personnel and may cause damage to power generation and power supply facilities as a result of unsynchronized reclosure. In order to prevent the phenomenon, various anti-islanding methods have been studied. This paper proposes the variation method of inverter output current magnitude to prevent the islanding phenomenon as a novel method, which causes the large frequency variation of inverter output voltage after islanding. Unlike most active anti-islanding method deteriorating power quality, this novel method will have high performance of islanding detection and good power quality. For the verification of the proposed method, the simulated result and analyses are presented.

• KSBB Journal
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• v.17 no.2
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• pp.121-136
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• 2002

Immunosensors are of great interest because of their potential utility as specific, simple, label-free, direct detection means and provision of reduction in size, cost and time of analysis comparing with conventional immunoassay. In the last two decades, many reports have been published on the use of immunosensors for a wide range of applications to clinical diagnostics, pharmaceutical chemistry, environmental monitoring, biotechnology and food industries. There are also numerous transduction techniques developed such as electrochemical techniques, piezoelectric crystal, and surface plasmon resonance receiving much attention for the direct monitoring of immune reactions at solid surfaces. In this article, the principles, characteristics, structures, fonctions and clinical applications of immunosensors were reviewed

• International Journal of Reliability and Applications
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• v.5 no.1
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• pp.25-36
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• 2004

Ultrasonic inspection system consist of the examination procedures, equipment, and operators. The reliability of nondestructive testing is influenced by the inspection environment, materials and types of defect. It is very difficult to estimate the reliability of NDT due to the various factors. Piping inspection round robin was conducted to quantify the capability of ultrasonic inspection during in-service. In this study, the models for predicting the ultrasonic NDE reliability by logistic model and linear regression model are discussed. The utility of the NDT reliability assessment is verified by the analysis of the data from round robin test with these models.

• Plant Resources
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• v.7 no.2
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• pp.136-140
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• 2004

Co-segregation of male fertility with DNA markers selected by RAPD analysis as being potentially linked to the restorer gene (Rf) for Cytoplasmic male sterility (CMS) was analyzed using segregating F2 population. One RAPD marker directly linked to the Rf locus was identified. Amplification of OPT-02/570 using the STS primers generated a monomorphic band of each fertile plants randomly selected F2 progenies. From these results, this specific marker would be strongly linked to be restoring gene. The use of STS marker is effective in overcoming the reliability of the RAPD phenotype and improving their utility for MAS, co-dominant STS markers are especially very useful.