• 산업공학
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• 제24권3호
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• pp.196-209
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• 2011

In This Study, New Product Development Activities, Innovation Activities, Technical Cooperation Activities may have an Impact on Competitive Advantage, Development Performance and Business Performance. The aim of Empirical Analyze is to identify the Structural Causal Relationship among the Activities and Performance Factors. We get the Results as Follows : New Product Development Activities have a Positive Impact on Competitive Advantage as well as the Development Performance. Technological Innovation Activities have a Positive Impact on Competitive Advantage, and do not have enough Impact on the Development Performance. Technical Cooperation Activities have a Positive Impact on the Development Performance, and do not have enough Impact on the Competitive Advantage, Competitive Advantage has a Positive Impact on the Development Performance as well as the Business Performance. Development Performance has a Positive Impact on the Business Performance.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2008년도 International Meeting of the Microbiological Society of Korea
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• pp.119-120
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• 2008

• 농촌지도와개발
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• 제7권2호
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• pp.359-376
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• 2000

The purposes of this exploratory study were to interrelate the scholastic discipline of the ‘development communication’ into ‘community development’ and ‘adult education’ in terms of interests, views and theoretical backgrounds of these fields of social sciences; and to draw some implications for developing scholastic interactions among these fields to pursue common social changes of human society. Development communications provide opportunities to set goals, to decide contents, and to utilize communication media in developmental efforts. Contemporary trends of development communication, community development and adult education are concerned with indigenous, two-way, bottom-up and people-centered communication from exogenous, one-way, top-down and institution-centered communication of the past. Multidisciplinary approaches to communication concepts and methodology may increase the potentials of community development and adult education in terms of efficiency and effectiveness. Some of the development communication approaches such as traditional and folk media approach. new media or ICT(information & communication technology) approach, participatory communication for development approach, communication support development approach and mass media approach may be applicable for community development and adult education. Better understanding on development communication approaches will be needed for the adult educators as well as community development practitioners.

• 산업공학
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• 제25권4호
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• pp.393-404
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• 2012

Increasing safety requirements of automobile are asking companies to find out solutions, based on the ISO 26262 which is a functional safety standard. ISO 26262 is an adaptation of the IEC 61508 for automotive electric/electronic systems. ISO 26262 provides a V model for ECU (Electronic Control Unit) development process to secure safety against vehicle. It well describes the requirements, necessary works and their resulting products for each development phase. However, it is difficult to apply to product development for achieving functional safety in the electric/electronic systems of an automobile because it lacks explanation on the working steps to follow and the methodologies and tools to be used in each step. In this paper, we introduce the outline of the ISO 26262 product development process and present a DFSS (Design For Six Sigma) road-map based on the ISO 26262 product development process as a way to operate efficiently the ISO 26262 product development process. The DFSS road-map consists of five phases: Define, Measure, Analyze, Design, and Verify. The detailed activities, tools, inputs, and work products are given for each phase.

• 아동학회지
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• 제30권3호
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• pp.23-36
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• 2009

Relationships between immigrant mothers' Korean language ability and preschoolers' language development in multi-cultural families were studied with 91 mothers and their children. Language capacity of mothers and children was measured by receptive and expressive vocabulary test, sentence comprehension test and two kinds of reading tests. Results showed that mothers' level of comprehension was relatively low but their reading ability was higher than that of elementary school first-grade Korean students. Comprehension of children in multi-cultural families with non-immigrant counterparts showed a lower level of language ability. Mother's level of expressive vocabulary, receptive vocabulary and reading ability correlated with children's language development. These results indicate a relationship between children's delayed language development in multi-cultural families and mother's low proficiency in Korean language.

• International Journal of Computer Science & Network Security
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• 제21권8호
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• pp.97-104
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• 2021

The key challenges and problematic aspects of the formation of intellectually and innovation-oriented strategies of regional entities at the present stage of their development are considered. The main tasks that arise in the process of strategizing the potential-forming development of regional economic systems in the context of digitalization are identified. The list of key organizational and economic directions of strategic character of providing intellectual and innovative development of regional economic systems is formed, which includes clustering of centers of high-tech development of regions, creation of creative hubs, development of knowledge infrastructure and improvement of interregional cooperation; a brief description of each of the presented strategic organizational and economic directions is given. Based on the analysis, the key strategic guidelines for the development of regional economic entities in the context of digitalization under the influence of potential-forming determinants, which form the content basis for further processes of strategizing qualitative aspects of development of specific regional entities.

• The Journal of Asian Finance, Economics and Business
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• 제9권7호
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• pp.205-217
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• 2022

The purpose of this study was to explore the relationship between agricultural insurance, agricultural loans, and the agricultural industry and find ways to consolidate and improve the interactive development between these three systems. We collected relevant data from 2009 to 2019 in 15 provinces of China and constructed a coupled coordination model to analyze the data. The results are as follows: First, the eastern part of China was ahead of the central and western parts in terms of agricultural loans and the agricultural industry, while the western part was ahead of the central and eastern parts in terms of agricultural insurance. Second, the coupling degree of the three systems in all 15 provinces reached an extremely high level. Third, all 15 provinces showed an overall continuous rise in coupling coordination degree. In 2019, eight provinces reached the medium-level coupling coordination development, and seven provinces were in a state of barely coupling coordination development. The three systems formed a mutually reinforcing relationship and basically entered a state of coordinated development. Finally, there was a great development gap between different regions of China concerning the coordinated development of the three systems, therefore, innovative development is urgently needed to further promote the coordinated development level.

• Biomolecules & Therapeutics
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• 제30권2호
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• pp.203-211
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• 2022

Melanogenesis is the production of melanin from tyrosine by a series of enzyme-catalyzed reactions, in which tyrosinase and DOPA oxidase play key roles. The melanin content in the skin determines skin pigmentation. Abnormalities in skin pigmentation lead to various skin pigmentation disorders. Recent research has shown that the expression of EMP2 is much lower in melanoma than in normal melanocytes, but its role in melanogenesis has not yet been elucidated. Therefore, we investigated the role of EMP2 in the melanogenesis of MNT1 human melanoma cells. We examined TRP-1, TRP-2, and TYR expression levels during melanogenesis in MNT1 melanoma cells by gene silencing of EMP2. Western blot and RT-PCR results confirmed that the expression levels of TYR and TRP-2 were decreased when EMP2 expression was knocked down by EMP2 siRNA in MNT1 cells, and these changes were reversed when EMP2 was overexpressed. We verified the EMP2 gene was knocked out of the cell line (EMP2 CRISPR/Cas9) by using a CRISPR/Cas9 system and found that the expression levels of TRP-2 and TYR were significantly lower in the EMP2 CRISPR/Cas9 cell lines. Loss of EMP2 also reduced migration and invasion of MNT1 melanoma cells. In addition, the melanosome transfer from the melanocytes to keratinocytes in the EMP2 KO cells cocultured with keratinocytes was reduced compared to the cells in the control coculture group. In conclusion, these results suggest that EMP2 is involved in melanogenesis via the regulation of TRP-2 expression.

• 한국동물학회:학술대회논문집
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• 한국동물학회 1996년도 한국생물과학협회 국제학술대회
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• pp.72.2-72
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• 1996

No Abstract, See Full Text

• Bulletin of the Korean Chemical Society
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• 제30권7호
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• pp.1463-1469
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• 2009

Eleven novel oxiranyl and thiiranyl phenolic compounds were synthesized as potential antitumor agents using epichlorohydrin and epithiohydrin in the presence of $K_2CO_3$. Cytotoxicities were found in range of I$C_{50}$ values of 2.5-14.8 $\mu$M, which was partially attributed to topoisomerase II inhibition. Bis-thiiranyl anthraquinone analog, 19 showed more cytotoxicity against MDA-MB-231 (breast cancer cell) and PC3 (prostate cancer cell) after 24 and/or 48 h and more potent topoisomerase II inhibitory activity than etoposide.