• Journal of the Korean Society of Systems Engineering
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• v.17 no.1
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• pp.65-75
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• 2021

When the decommissioning of South Korea nuclear power plants is promoted in earnest with the permanent shutdown of Kori Unit 1 in 2017, a large amount of various types of radioactive waste will be generated. For minimal generation and safe management of decommissioning waste, the waste should be made by appropriate classification of the dismantling waste characteristics in accordance with physical, chemical and radiological characteristics to meet the acceptance criteria of disposal facilities. Replacing the preliminary inspection at the site for the compliance of the waste acceptance criteria (WAC) of medium and low-level radioactive waste with the generator's own radioactive waste certification program (WCP), from the perspective of disposal, the optimization of waste management at the national level contributes to the efficient availability of disposal, such as the processing of non-conforming radioactive wastes at the site. To this end, it is important to evaluate radioactivity in each system and area such as nuclear reactors before decommissioning is carried out in earnest, and the prior removal of harmful wastes is important. From waste collection to waste disposal, decommissioning waste should be managed at each stage in consideration of the acceptance criteria of disposal facilities to minimize the generation of non-conforming waste.

• Journal of Korean Neurosurgical Society
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• v.64 no.4
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• pp.534-542
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• 2021

Objective : While balanced crystalloid (BC) could be a relevant fluid regimen with buffer system compared with normal saline (NS), there have been no studies on the optimal fluid for surgery of an unruptured intracranial aneurysm (UIA). This study aimed to compare the effects of fluid regimens between NS and BC on the metabolic and clinical outcomes of patients who underwent surgery for UIA. Methods : This study was designed as a propensity score matched retrospective comparative study and included adult patients who underwent UIA clipping. Patient groups were categorized as NS and BC groups based on the types of pre-operative fluid and the amount of fluid administered during surgery. The primary outcomes were defined as electrolyte imbalance and acidosis immediately after surgery. The secondary outcomes were the length of stay in the intensive care unit (ICU) and duration from the end of the operation to extubation. Results : A total of 586 patients were enrolled in this study, with each of 293 patients assigned to the NS and BC groups, respectively. Immediately after surgery, serum chloride levels were significantly higher in the NS group. Compared to the NS group, the BC group had lower incidence rates of acidemia (6.5% vs. 11.6%, p=0.043) and metabolic acidosis (0.7% vs. 4.4%, p=0.007). As compared to NS group, BC group had significantly shorter duration from the end of the operation to extubation (250±824 vs. 122±372 minutes, p=0.016) and length of stay in ICU (1.37±1.11 vs. 1.12±0.61 days, p=0.001). Throughout multivariable analysis, use of BC was found to be significant factor for favorable post-operative results. Conclusion : This study showed that the patients who received BC during UIA clipping had lower incidence of metabolic acidosis, earlier extubation and shorter ICU stay compared to those who received NS. Therefore, using BC as a peri-operative fluid can be recommended for patients who undergo surgery for UIA.

• Journal of Korean Society of Forest Science
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• v.100 no.3
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• pp.466-475
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• 2011

This study purposed to analyze the spatial pattern and the amount of carbon emission at the deforestation area based on the administrative and GIS data. The total size of deforestation area in last nine years (2000-2008) was about 649 ha, and it was occurred annually about 72 ha. The occurrence rate of deforestation per administrative area in Wonju was about 0.74%. It was 0.34% higher than that of Kwangwondo, and 0.06% less than that of National rate. On the other hand, the forms of deforestation by purpose were not related to the administrative district unit. The number of deforestation forms was highest at settlements. second most frequent form is other land. Grassland showed the lowest score. In addition, the deforestations were more occurred which is closed to the existing housing and building rather than roads. The number of deforestation was 1.2 times higher based on 300m. Seventy percent of deforestation was occurred which is less than 0.5 ha in size, and it increased to 91% when the size is less than 1ha. The total size of theoretical carbon emission based on deforestation area was estimated at 23,424 tc, and average annual carbon emission was estimated by 2,603 tc. Carbon emission per ha was 36.1 tC/ha. This study results will be useful to construct the greenhouse gas statistical verification system against the Post-2012 by GIS.

• CELLMED
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• v.11 no.1
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• pp.4.1-4.8
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• 2021

Background: The Unani system of medicine has been practised since centuries for the treatment of a range of diseases. In spite of their efficacy they have been widely criticised due to the lack of standardization and poor quality control. Standardization of Unani medicine is a valuable issue at the present because they are very prone to contamination, deterioration, adulteration and variation in composition due to biodiversity as well as careless collection. Objective: To Standardize and Development of HPTLC Fingerprinting of a polyherbal Unani formulation Qurs-e-Safa. Materials and methods: The conventional and modern analytical techniques were used to standardise Qurs-e-Safa. The study was carried into three different batches of Qurs-e-Safa prepared with its ingredients. The parameters studied are organoleptic, microscopic, physicochemical parameters, phytochemical screening, TLC, HPTLC profile, aflatoxin, microbial load and heavy metal analysis. Results and conclusion: Qurṣ-e-Sa'fa is dark yellow in colour and aromatic smell. Uniformity of diameter and weight variation were found to be 13 ± 0, and 524.7 ± 1.72 mg. friability, hardness and disintegration time of all 3 batches were found to be (0.0615 ± 0.004, 0.0885 ± 0.0047 and 0.0725 ± 0.0058), (3.5 ± 0.2886, 3.67 ± 0.1674 and 3.67 ± 0.1674) and (16 to 17 minutes). Extractive value were found to be maximum in distilled water (38.488 ± 0.20, 37.3824 ± 0.38 and 39.8177 ± 0.13) followed by alcohol (27.5406 ± 0.54, 27.5656 ± 0.32 and 26.9229 ± 0.25). Loss of weight on drying, pH, total ash, acid insoluble ash, qualitative test was set in. Phytochemical screening revealed the presence of Carbohydrates, Phenols, Resins, Proteins, Steroids, fixed oil and Flavonoids. The microbial load was found absent and heavy metals were within permissible limits. The data evolved from the study may serve as a reference to validate and also help in the quality control of other finished products in future research.

• Journal of Korean Society on Water Environment
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• v.37 no.3
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• pp.217-228
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• 2021

This paper discusses a methodology where an integrated modelling framework is used to quantify the risk derived from anthropic activities on habitats and species. To achieve this purpose, a tool comprising the Delft3D and HABITAT model, was applied in the Yeongsan river. Delft3D effectively simulated the operational condition and flow of weirs in river. In accuracy evaluation of the Delft3D-FLOW, the Bias, Pbias, Mean Absolute Error (MAE), Nash-Sutcliffe Efficiency (NSE), and Index of Agreement (IOA) were used, and the result was evaluated as grade above 'Satisfactory'. The HABITAT calculated Habitat Suitability Value (HSV) for the following eight species: mammal, fish, aquatic plant, and benthic macroinvertebrate. An Area was defined as a suitable habitat if the HSV was larger than 0.5. HABITAT was judged accurately by measuring the Correct Classification rate (CCR) and the area under the ROC curve (AUC). For benthic macroinvertebrate, the CCR and AUC were 77% and 0.834, respectively, at thresholds of 0.017 and 4 inds/m² for HSV and individuals per unit area. This meant that the HABITAT model accurately predicted the appearance of the benthic macroinvertebrates by approximately 77% and that the probability of false alarms was also very low. As a result of evaluating the suitability of habitats, in the Yeongsan river, if the annual "lowest level" (Seungchon weir: 2.5 EL.m/ Juksan weir: -1.35 EL.m) was maintained, the average habitat improvement effect of 6.5%P compared to the 'reference' scenario was predicted. Consequently, it was demonstrated that the integrated modelling framework for habitat suitability assessment is able to support the remedy aquatic ecological management.

• Korean Journal of Remote Sensing
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• v.36 no.6_3
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• pp.1721-1732
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• 2020

Elementary school students spend a lot of time in a school and are more exposed to indoor air pollution. Also the students are physically growing and have a relatively high respiratory rate per unit weight compared to adults, so it is known that there is a high sensitivity to indoor air pollution. Therefore, indoor air quality in a school is becoming an important factor for the student's health. In this study, a correlation analysis using levels of indoor and outdoor Particulate Matter (PM) measured from five elementary schools in Seoul was performed to evaluate the effect of outdoor PM on indoor PM. PM ratio and indoor/outdoor (I/O) ratio were also analyzed to investigate the actual condition of indoor air quality and effect of outdoor PM on indoor PM. As a result, the correlation between indoor and outdoor PM in elementary school was more significant in PM2.5 and PM1 than PM10. In the case of I/O ratio, the I/O ratio of PM10 was higher than that of 1 in four elementary schools except SD (BB:2.21, NS: 1.67, IS: 1.73, SI: 1.17). This indicates that the activity of students has a great effect on the concentration of indoor PM10.

• Biomolecules & Therapeutics
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• v.29 no.5
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• pp.465-482
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• 2021

Lipids, which along with carbohydrates and proteins are among the most important nutrients for the living organism, have a variety of biological functions that can be applied widely in biomedicine. A fatty acid, the most fundamental biological lipid, may be classified by length of its aliphatic chain, and the short-, medium-, and long-chain fatty acids and each have distinct biological activities with therapeutic relevance. For example, short-chain fatty acids have immune regulatory activities and could be useful against autoimmune disease; medium-chain fatty acids generate ketogenic metabolites and may be used to control seizure; and some metabolites oxidized from long-chain fatty acids could be used to treat metabolic disorders. Glycerolipids play important roles in pathological environments, such as those of cancers or metabolic disorders, and thus are regarded as a potential therapeutic target. Phospholipids represent the main building unit of the plasma membrane of cells, and play key roles in cellular signaling. Due to their physical properties, glycerophospholipids are frequently used as pharmaceutical ingredients, in addition to being potential novel drug targets for treating disease. Sphingolipids, which comprise another component of the plasma membrane, have their own distinct biological functions and have been investigated in nanotechnological applications such as drug delivery systems. Saccharolipids, which are derived from bacteria, have endotoxin effects that stimulate the immune system. Chemically modified saccharolipids might be useful for cancer immunotherapy or as vaccine adjuvants. This review will address the important biological function of several key lipids and offer critical insights into their potential therapeutic applications.

• CELLMED
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• v.11 no.3
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• pp.13.1-13.9
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• 2021

Background and Objective: Nux-vomica based traditional Unani formulation, Habb-e-Azaraqi (HAZ) is an important drug used by Unani physicians since several decades. It possesses Muqawwi-i-A'sab (nervine tonic), Muharrik-i-A'sab (nervine stimulant) properties and is an effective treatment option for diseases like Laqwa (facial palsy), Falij (paralysis), Niqris (gout) and Waja'al-Mafasil (arthritis) etc. The aim of the study is to access and provide information of HAZ for its TLC, HPTLC Fingerprinting defining its clear qualitative perspective and acute oral toxicity evaluation for its safety assessment which was not done earlier, thus contributing in the field of research. Materials and Methods: The chief ingredient, nux-vomica was detoxified as per method mentioned in Unani Pharmacopeia before its use in formulation. TLC and HPTLC was developed under four detection system i.e., UV 366nm, UV 254nm, exposure to iodine vapours and after derivatization with anisaldehyde sulphuric acid. Acute toxicity studies were performed as per OECD Guidelines 425 at a limit dose of 2000 mg/kg. Observations were done for signs of toxicity, body weight, and feed consumption at regular intervals followed by haematological and biochemistry evaluation. Results: The generated data proved the authenticity and established the TLC and HPTLC profile of the formulation. Acute toxicity revealed no significant differences in HAZ-treated animals with respect to body weight gain, feed consumption, haematology, clinical biochemistry evaluation. No significant gross pathological observation was noticed in necropsy. Conclusion: Data of the present study is substantial and scientific proof of HAZ in terms of standardization and toxicity study that can be utilize in future research activities.

• Journal of the Korean Geosynthetics Society
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• v.20 no.4
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• pp.19-32
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• 2021

In this study, evaluation and consideration of domestic/overseas design, construction, and quality control performed by the authors on the deep cement mixing method were performed, and improvements for the development of the DCM method were suggested in the future. As a result of this study, it was found that the cross-sectional area correction for strength is required during the laboratory test of mix proportion, and caution is required because the extrapolation method may lead to different results from the actual one. Applicable design methods should be selected in consideration of both the improvement ratio and the type of improvement during design, and it was confirmed that the allowable compressive strength to which the safety factor was applied refers to the standard value for stability review and not the design parameters. In the case of the stress concentration ratio, rather than applying a conventional value, it was possible to perform economical design by calculating the experimental and theoretical stress concentration ratio reflecting the design conditions. In the case where pre-boring is expected during construction, if the increased water content is not large compared to the original, there were cases where a major problem did not occur even if the result that did not consider the increase in water content was used. In addition, it was confirmed that when the ratio of the top treatment length to the improved length is high, a small amount of design cement contents per unit length can be injected during construction. In the case of quality control, it was evaluated that D/4~2D/4 for single-axis and D/4 point for multi-axis were optimal for coring of grouting mixtures. As an item for quality control, it is judged that the standard that considers the TCR along with the unconfined compressive strength of grouting mixtures is more suitable for the domestic situation.

• Investigative Magnetic Resonance Imaging
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• v.25 no.4
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• pp.313-322
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• 2021

Purpose: To find diagnostic image features, to compare diagnostic performance of multiphase CT versus gadoxetic acid disodium-enhanced MRI (GAD-MRI), and to evaluate the impact of analyzing Liver Imaging Reporting and Data System (LI-RADS) imaging features, for distinguishing combined hepatocellular-cholangiocarcinoma (CHC) from hepatocellular carcinoma (HCC). Materials and Methods: Ninety-six patients with pathologically proven CHC (n = 48) or HCC (n = 48), diagnosed June 2008 to May 2018 were retrospectively analyzed in random order by three radiologists with different experience levels. In the first analysis, the readers independently determined the probability of CHC based on their own knowledge and experiences. In the second analysis, they evaluated imaging features defined in LI-RADS 2018. Area under the curve (AUC) values for CHC diagnosis were compared between CT and MRI, and between the first and second analyses. Interobserver agreement was assessed using Cohen's weighted κ values. Results: Targetoid LR-M image features showed better specificities and positive predictive values (PPV) than the others. Among them, rim arterial phase hyperenhancement had the highest specificity and PPV. Average sensitivity, specificity, and AUC values were higher for MRI than for CT in both the first (P = 0.008, 0.005, 0.002, respectively) and second (P = 0.017, 0.026, 0.036) analyses. Interobserver agreements were higher for MRI in both analyses (κ = 0.307 for CT, κ = 0.332 for MRI in the first analysis; κ = 0.467 for CT, κ = 0.531 for MRI in the second analysis), with greater agreement in the second analysis for both CT (P = 0.001) and MRI (P < 0.001). Conclusion: Rim arterial phase hyperenhancement on GAD-MRI can be a good indicator suggesting CHC more than HCC. GAD-MRI may provide greater accuracy than CT for distinguishing CHC from HCC. Interobserver agreement can be improved for both CT and MRI by analyzing LI-RADS imaging features.