• 전자공학회논문지B
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• 제31B권3호
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• pp.132-140
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• 1994

온라인 필기 문자 인식 시스템 'SCRIPT(Symbol/Character Recognition In Pen-based Technology)'는 조합 가능한 모든 한글과 영어 대문자, 숫자, 그리고 키보드 부호 등 자연스럽게 필기되는 정자체 문자를 인식하기 위한 알고리듬이다. 필기 문자는 동일인이 쓰더라도 형태의 변화가 다양해서 정보의 불확실성을 지니게 된다. 그런데 기존의 결정 트리(decision tree)를 이용한 특징 분석 방법(feature analysis approach)은 효율적이지만 필기의 변형에 약하여 잘못된 선택을 하기 쉽기 때문에, 이러한 단점을 보완할 수 있는 방법이 필요하다. 이 논문에서는 패턴의 계층적(hierarchical)특성에 맞추어 획 자체의 형태와 획간의 위치 관계를 파악하기 위한 두 단계의 퍼지 결정 트리(fuzzy decision trees)를 사용하여 문자 패턴의 특징을 분석하는 방법을 제안한다. 이러한 방법은 다양한 가능성을 저장함으로써 형태의 변형에 강하고 이전의 잘못된 선택을 수정하기 쉬우며, 특히 하위 후보 패턴들에 의한 상위 패턴의 인식률 상승 효과가 매우 크다. 실헌 결과, 한글은 약 91%의 인식률과 약 0.33초의 인식 속도를 나타냈으며, 영어 및 기타 문자는 약 95%의 인식률과 약 0.08초의 인식 속도를 보였다. 이는 퍼지 결정 트리를 적용하지 않은 겨우에 비하여 인식률이 8~18% 정도 향상된 것이다.

• 대한한의학회지
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• 제28권3호통권71호
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• pp.1-12
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• 2007

Objectives : The purpose of this study was to explore the perceptions of health promotion programmes using traditional Korean medicine among public health centre staff in charge of running such programmes. To do so, we examined and analysed the current situation of implementing the programmes in the public health centre. Methods : A survey was designed to collect information on perception of the health promotion programmes using traditional Korean medicine by public health centre staff in charge of running such programmes. The survey, using a structured questionnaire designed for this study, was conducted on 161 public health centre staff attending an annual meeting to presenting the results of activity evaluation related to public health programmes using traditional Korean medicine in public health centres. The participants were asked about the most successful programme, the benefits of the programmes, the positive aspects of the programmes, the most desirable outcomes of the programmes and so on. The data were analysed using SPSS system 12.0 for Windows. Results : Of the 161 questionnaires, 121 were analysed. The main findings of this research were as follows. Of the health promotion programmes using traditional Korean medicine implemented in public health centres, qigong and stroke preventive health promotion programmes were perceived as the most successful. The major benefits of the programmes were having merit for health promotion and expecting a positive performance outcome. The major positive aspects of the programmes for health promotion were cultivating community citizen's support and showing consistency between the philosophy of the programmes and the direction of existing health promotion programmes. The most desirable outcomes of the programmes were spreading community understanding of the programme and establishing an effective and unique health promotion model for implementing the programme. Two major causes of implementation difficulties were lack of material resources such as manpower, facility, and equipment, and methods of performance evaluation. One of the most urgent needs for activating the implementation of programmes was continuing financial and technical support from the central government. Conclusions : To promote the role of traditional Korean medicine in the public health sector in order to integrate traditional medicine into the public health system, government should develop some measures for solving the identified causes of implementation difficulties and coping with the most urgent needs for activating the implementation of programmes.

• 재활치료과학
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• 제7권1호
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• pp.27-35
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• 2018

목적 : 본 연구는 편측 공간무시 환자의 평가도구 중 KF-NAP (Kessler Foundation - Neglect Assessment Process)과 지필검사 (직선이분검사, 글자소거검사, 알버트 검사) 사이의 상관관계와 편측 공간무시에 대한 민감도가 높은 평가도구를 알아보고자 한다. 연구방법 : 2014년 9월부터 2015년 9월까지 서울 소재의 병원 재활의학과에 입원한 32명의 뇌졸중 환자를 대상으로 하였다 (남성 19명, 여성 13명, 평균연령 61.8세). KF-NAP과 지필평가는 입원 7일 이내에 시행하였으며, 각 평가도구의 결과 값으로 편측 공간무시 정도를 비교하였다. 결과 : 편측 공간무시 정도는 KF-NAP 93.8%, 직선이분검사 53.1%, 글자지우기 53.1%, 알버트 검사 37.5%로 편측 공간무시에 대한 민감도가 가장 높은 평가도구는 KF-NAP이었다. KF-NAP은 직선이분검사(r=.430), 글자 지우기(r=.641), 알버트 검사(r=.398) 모두에서 유의한 상관관계가 있었다 (p<0.05). 결론 : KF-NAP은 환자의 일상생활 동안 편측 공간무시를 평가하는 도구로써 지필검사에 비해 편측 공간무시의 진단에 더 민감할 뿐 아니라 편측 공간무시의 중증도에 대한 평가가 가능하다. 따라서 편측 공간무시의 평가에 KF-NAP이 유용하게 사용되어져야 한다.

• Biomolecules & Therapeutics
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• 제15권1호
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• pp.16-26
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• 2007

Tissue plasminogen activator (tPA) is a serine protease catalyzing the proteolytic conversion of plasminogen into plasmin, which is involved in thrombolysis. During last two decades, the role of tPA in brain physiology and pathology has been extensively investigated. tPA is expressed in brain regions such as cortex, hippocampus, amygdala and cerebellum, and major neural cell types such as neuron, astrocyte, microglia and endothelial cells express tPA in basal status. After strong neural stimulation such as seizure, tPA behaves as an immediate early gene increasing the expression level within an hour. Neural activity and/or postsynaptic stimulation increased the release of tPA from axonal terminal and presumably from dendritic compartment. Neuronal tPA regulates plastic changes in neuronal function and structure mediating key neurologic processes such as visual cortex plasticity, seizure spreading, cerebellar motor learning, long term potentiation and addictive or withdrawal behavior after morphine discontinuance. In addition to these physiological roles, tPA mediates excitotoxicity leading to the neurodegeneration in several pathological conditions including ischemic stroke. Increasing amount of evidence also suggest the role of tPA in neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis even though beneficial effects was also reported in case of Alzheimer's disease based on the observation of tPA-induced degradation of $A{\beta}$ aggregates. Target proteins of tPA action include extracellular matrix protein laminin, proteoglycans and NMDA receptor. In addition, several receptors (or binding partners) for tPA has been reported such as low-density lipoprotein receptor-related protein (LRP) and annexin II, even though intracellular signaling mechanism underlying tPA action is not clear yet. Interestingly, the action of tPA comprises both proteolytic and non-proteolytic mechanism. In case of microglial activation, tPA showed non-proteolytic cytokine-like function. The search for exact target proteins and receptor molecules for tPA along with the identification of the mechanism regulating tPA expression and release in the nervous system will enable us to better understand several key neurological processes like teaming and memory as well as to obtain therapeutic tools against neurodegenerative diseases.

• The Korean Journal of Physiology and Pharmacology
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• 제9권2호
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• pp.87-94
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• 2005

It is not clear whether $Ca^{2+}-induced$ $Ca^{2+}$ release from the sarcoplasmic reticulum (SR) is involved in the regulation of atrial natriuretic peptide (ANP) release. Previously, we have shown that nifedipine increased ANP release, indicating that $Ca^{2+}$ entry via voltage-gated L-type $Ca^{2+}$ channel activation decreases ANP release. The purpose of the present study was two-fold: to define the role of SR $Ca^{2+}$ release in the regulation of ANP release and whether $Ca^{2+}$ entry via L-type $Ca^{2+}$ channel is prerequisite for the SR-related effect on ANP release. Experiments were performed in perfused beating rabbit atria. Ryanodine, an inhibitor of SR $Ca^{2+}$ release, increased atrial myocytic ANP release ($8.69{\pm}3.05$, $19.55{\pm}1.09$, $27.31{\pm}3.51$, and $18.91{\pm}4.76$% for 1, 2, 3, and $6{\mu}M$ ryanodine, respectively; all P<0.01) with concomitant decrease in atrial stroke volume and pulse pressure in a dose-dependent manner. In the presence of thapsigargin, an inhibitor of SR $Ca^{2+}$ pump, ryanodine-induced increase in ANP release was not observed. Thapsigargin attenuated ryanodine-induced decrease in atrial dynamic changes. Blockade of L-type $Ca^{2+}$ channel with nifedipine abolished ryanodine-induced increase in ANP release ($0.69{\pm}5.58$% vs. $27.31{\pm}3.51$%; P＜0.001). In the presence of thapsigargin and ryanodine, nifedipine increased ANP release and decreased atrial dynamics. These data suggest that $Ca^{2+}$-induced $Ca^{2+}$ release from the SR is inversely involved in the regulation of atrial myocytic ANP release.

• 대한의용생체공학회:의공학회지
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• 제34권3호
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• pp.148-155
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• 2013

This study is about the development of the wrist rehabilitation system for the patient who has limited capability of movement after stroke. Electromyography triggered training system (ETTS) can play the role between complete passive training and patient activating training system. Surface EMG was measured on pronator teres muscle and biceps brachii muscle for wrist pronation and supination. Our system detects whether the subject makes muscular effort for pronation or supination or nothing in every 50 ms. When the effort level exceeds the preset percentage of maximal voluntary contraction, the motor rotates according to the direction of the intention of the subject. EMG triggers the motor rotation for the wrist rehabilitation training until the preset angle. To evaluate its performance, the maximum voluntary contraction level was measured for 4 subjects at first. With the audio-visual instruction to rotate the wrist (pronation or supination) the subjects made effort to follow the instruction. After calculating root mean square (RMS) for 50 ms, the controller determines whether there was muscular effort to rotate while holding the motor. When there was an effort to rotate, the controller rotates the motor 0.8 degree. By comparing the RMS values from two channels of EMG, the controller determines the rotational direction. The onset delay is $0.76{\pm}0.24$ s and offset delay is $0.65{\pm}0.22$ s for pronation. For supination the onset delay is $1.24{\pm}0.41$ s and offset delay is $0.77{\pm}0.22$ s. The system responded fast enough to be used for rehabilitation training. The controller perceived the direction of rotation 100% correctly for the pronation and 97.5% correctly for supination. ETTS was developed and the fundamental functions were validated for normal subjects. The clinical validation should be done with patients for real world application. With ETTS, the subjects can train voluntarily over the limitation of the range of motion which increases the effectiveness of the rehabilitation training.

• 한국산학기술학회논문지
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• 제17권12호
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• pp.371-380
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• 2016

본 연구의 목적은 성인 신체장애인을 부양하는 배우자의 부양스트레스, 우울, 장애인의 일상생활활동능력을 살펴보고, 각 영역들의 상관관계 및 장애인의 일상생활활동능력이 배우자의 부양스트레스와 우울에 미치는 영향을 알아보고자 하는 것이다. 2016년 7월부터 8월까지 S시와 K도에 소재한 2개의 병원에서 재활치료를 받고 있는 장애인들의 배우자 86명을 대상으로 연구를 진행하였다. 연구결과 부양스트레스 총점은 $71.43{\pm}17.78$점 이었으며, 부양스트레스 하위항목 중 경제적 스트레스와 심리적 스트레스가 다른 항목보다 높았다. 우울총점은 $50.34{\pm}26.41$점으로, 일반 정상 성인들의 평균점수보다 다소 높았다. 대상자의 일반적 특성에 따른 부양스트레스와 우울을 살펴본 결과, 연령이 많은 여성의 경우, 부양비에 대한 지출이 많고 부양시간이 많은 경우, 장애인의 연령이 젊고, 병명이 뇌졸중인 경우 부양스트레스와 우울지수가 높았다. 부양스트레스에 영향을 미치는 요인으로는 장애인의 연령, 장애기간으로 나타났으며, 장애인의 일상생활활동능력은 부양스트레스에 영향을 미치지 못하였다. 우울에는 장애인의 연령, 장애유형 및 등급, 장애인의 일상생활활동능력 모두 영향을 미치는 것으로 나타났다. 부양가족들의 스트레스 및 우울을 감소시키기 위하여 경제적, 신체적 혹은 심리적으로 도움을 줄 수 있는 실질적인 정책적 지원이 마련되어야 할 것이다.

• 대한기계학회논문집A
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• 제34권8호
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• pp.1119-1127
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• 2010

본 논문에서는 작동 평면상의 네 위치에서 사중안정점을 가지는 신개념 전자기형 마이크로 액추에이터의 구조체와 전자기 로렌츠력을 이용하는 구동 방식을 제시하고, 이의 타당성을 비선형 구조해석 및 전기-열해석을 통하여 검증하였다. 사중안정성 액추에이터의 구현을 위해서 관련 분야에서 널리 연구되고 있는 쌍안정성 액추에 이터의 개념을 확장 응용하였다. 비선형 유한요소해석을 이용하여 사중안정성 미소 구조체의 정적 해석과 과도동 적 해석을 수행함으로써 액추에이터 구조체의 다중안정성 유무를 파악하고 이 결과를 분석하여 구조체 설계에 반영하였다. 사중안정성 미소 구조체를 도체화하여 자기장 내에서 구조체에 전류를 통할 때에 발생하는 로렌츠력으로 평면상의 네 안정점으로 구조체를 구동할 수 있도록 고안하고, 그 때 필요한 구동전류의 크기 및 전자기 구동에 의한 주울열에 의한 온도분포를 계산하여 전반적인 타당성을 검토하였다. 본 논문은 지금까지의 관심 대상인 쌍안정성의 이용이 아니라 더욱 확장된 다중안정성을 가진 미소 액추에이터의 구조체와 전자기 구동방법을 제안하여 향후에 다중안정성을 필요로 하는 마이크로 시스템에 활용될 수 있도록 하는데 그 의미가 있다.

• 대한한방내과학회지
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• 제37권1호
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• pp.47-64
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• 2016

Objectives: In the present study, a genetic analysis was conducted to investigate the association of the expression of SNPs of EDN1 gene polymorphism with the clinical phenotype in bronchial asthma patients with either excess or deficiency syndrome.Methods: Ninety-four healthy control subjects and 52 asthma patients were included in this study. The asthma patients were divided into two groups: those with deficiency syndrome and those with excess syndrome. We searched the exonic and promoter areas of the EDN1 gene in the NCBI website SNPs with <0.01 minor allele frequency (MAF) and <0.01 heterozygosity. Pro programs were performed to obtain the odds ratio, 95% confidence interval, and p-value. Multiple logistic regression models were conducted to analyze the genetic data.Results: In our genotype and allele analyses, there were significant differences in the codominant 2 model of the rs3087459 SNP genotype and also in the CGG haplotype between the control group and the asthma group. Genotype and allele analyses were conducted between the deficiency and excess syndrome group. There were significant differences in the dominant and log-additive model and also in the frequency of C-alleles of rs3087459 SNP genotype. There were significant differences in codominant 1, dominant and log-additive model and T-allele of rs5370 SNP genotype. The AGG haplotype also revealed significant differences.Conclusions: EDN1 SNPs (rs3087459, rs5370) showed a significant association with symptomatic excess syndrome in Korean asthmatic patients.

• 대한한방내과학회지
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• 제33권3호
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• pp.243-256
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• 2012

Objectives : This clinical study was done to examine metabolic syndrome (MS) and plasma homocysteine (HCY) level in patients with silent lacunar infarction (SLI) and in normal controls. Methods : A total of 154 patients, who were over 20 years of age and visited the stroke prevention check-up center of a university hospital from December 2006 to December 2010, were examined by brain CT or brain MRI, and classified into two groups. We compared the components of MS and HCY levels between patients with SLI (n=74) and normal controls (n=80). Modified ATP III definition was used for diagnosis of MS while Korean standard for waist circumference was used. Results : Prevalence of MS was significantly higher in the SLI group than the normal group. HCY was also significantly higher in the SLI group than the noraml, and the odds ratio (OR) for SLI, comparing high HCY level (${\geq}10{\mu}mol/L$) with low HCY level ($<10{\mu}mol/L$), was 3.64 (95% confidence interval (CI); 1.81-7.29, p<.0001). However, there was no correlation between MS and HCY in the SLI group. Prevalence of diabetes and hypertension (HT) was higher in the SLI group than the normal group, but there was no significant difference in blood lipids level between the SLI and normal groups. Of note, HT itself was enough to be an independent risk factor for SLI (OR; 4.58, 95% CI; 1.91-11.01, p=0.001). Body mass index, waist circumference, waist-hip ratio and visceral fat area were significantly higher in the SLI than normal group, and visceral fat area was enough to be an independent risk factor for SLI (OR; 2.41, 95% CI; 1.04-5.59, p=0.040). Conclusions : SLI is shown to have significant correlation with HCY and prevalence of MS, however there is no relationship between HCY and prevalence of MS in patients with SLI.