• 한국축산식품학회지
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• 제43권4호
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• pp.703-711
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• 2023

As an initial study to elucidate the molecular mechanism of how probiotics modulate macrophage activity, we monitored mRNA expression patterns in peritoneal macrophages (PMs) treated with two different strains of probiotics. After treatment with either Weissella cibaria WIKIM28 or Latilactobacillus sakei WIKIM50, total RNAs from PMs were isolated and subjected into gene chip analyses. As controls, mRNAs from vehicle (phosphate-buffered saline, PBS)-treated PMs were also subjected to gene chip analysis. Compared to vehicle (PBS)-treated PMs, WIKIM28-treated and WIKIM50-treated PMs exhibited a total of 889 and 432 differentially expressed genes with expression differences of at least 4 folds, respectively. Compared to WIKIM28-treated PMs, WIKIM50-treated PMs showed 25 up-regulated genes and 21 down-regulated genes with expression differences of more than 2 folds. Interestingly, mRNA transcripts of M2 macrophage polarization marker such as anxa1, mafb, and sepp1 were increased in WIKIM50-treated PMs comparing to those in WIKIM28-treated PMs. Reversely, mRNA transcripts of M1 macrophage polarization marker such as hdac9, ptgs2, and socs3 were decreased in WIKIM50-treated PMs comparing to those in WIKIM28-treated PMs. In agreement with these observations, mRNA expression levels of tumor necrosis factor-α and interleukin-1α were significantly reduced in WIKIM50-treated macrophages compared to those in WIKIM28-treated macrophages. These results may indicate that probiotics can be classified as two different types depending on their ability to convert macrophages into M1 or M2 polarization.

• 제어로봇시스템학회논문지
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• 제22권7호
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• pp.513-518
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• 2016

The piezoelectric actuating device is known for its large power density and simple structure. It can generate a larger force than a conventional actuator and has also wide bandwidth with fast response in a compact size. To control the piezoelectric actuator, we need an analog signal conditioning circuit as well as digital microcontrollers. Conventional microcontrollers are not equipped with an analog part and need digital-to-analog converters, which makes the system bulky compared with the small size of piezoelectric devices. To overcome these weaknesses, we are developing a single-chip controller that can handle analog and digital signals simultaneously using mixed-signal FPGA technology. This gives more flexibility than traditional fixed-function microcontrollers, and the control speed can be increased greatly due to the parallel processing characteristics of the FPGA. In this paper, we developed a floating-point multiplier, PWM generator, 80-kHz power control loop, and 1-kHz position feedback control loop using a single mixed-signal FPGA. It takes only 50 ns for single floating-point multiplication. The PWM generator gives two outputs to control the charging and discharging of the high-voltage output capacitor. Through experimentation and simulation, it is demonstrated that the designed control loops work properly in a real environment.

• 한국초전도저온공학회:학술대회논문집
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• 한국초전도저온공학회 2003년도 추계학술대회 논문집
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• pp.127-130
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• 2003

An RSFQ (Rapid Single Flux Quantum) counter can be used as a frequency divider that was an essential part of a programmable voltage standard chip. The voltage standard chip is composed of two circuit parts, a counter and an antenna Analog signal of tens to hundreds ㎓ may be applied to a finline antenna part. This analog signal can be converted to the stream of SFQ voltage pulses by a DC/SFQ circuit. The number of voltage pulses can be reduced by 2n times when they pass through a counter that is composed of n T Flip-Flops (Toggle Flip-Flop). Such a counter can be used not only as a frequency divider, but also to build a programmable voltage standard chip. So, its application range can be telecommunication, high speed RAM, microprocessor, etc. In this work, we have used Xic, WRspice, and L-meter to design an RSFQ counter. After circuit optimization, we could obtain the bias current margins of the T Flip-Flop circuit to be above 31％ Our RSFQ counter circuit designs were based on the 1 ㎄/$\textrm{cm}^2$ niobium trilayer technology.

• 대한전자공학회논문지SD
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• 제37권12호
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• pp.60-69
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• 2000

광대역 무선 디지털 통신 시스템용 파이프라인 적응 결정귀환 등화기(pipelined adaptive decision-feedback equalizer; PADFE)를 0,25-${\mu}m$ CMOS 공정을 사용하여 full custom 단일 칩으로 설계하였다. ADFE의 동작속도를 향상시키기 위해 DLMS(delayed least-mean-square)을 적용한 2-stage 파이프라인 구조로 설계하였다. PADFE의 필터와 계수갱신 블록 등 모든 연산을 redundant binary(RB) 수치계로 처리하였으며, 2의 보수 수치계를 사용하는 기존의 방식에 비해 연산량의 감소와 동작속도의 향상이 얻어졌으며, 또한 전체적인 구조의 단순화에 의해 VLSI 구현이 용이하다는 장점을 갖는다. COSSAP을 이용한 알고리듬 레벨 시뮬레이션을 통해 파이프라인 stage 수, 필터 tap 수, 계수 및 내부 비트 수 등의 설계 파라메터 결정과 bit error rate(BER), 수렴속도 등을 분석하였다. 설계된 PADFE는 약 205,000개의 트랜지스터로 구성되며, 코어의 면적은 41.96\times1.35-mm^2$이다. 시뮬레이션 결과, 2.5-V 전원전압에서 200-MHz의 클록 주파수로 동작 가능할 것으로 예상되며, 평균 전력소모는 약 890-mW로 예측되었다. 제작된 칩의 테스트 결과로부터 기능이 정상적으로 동작함을 확인하였다.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.628-632
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• 2003

An intelligent miniature humanoid robot system is designed and implemented as a platform for researching walking algorithm. The robot system consists of a mechanical robot body, a control system, a sensor system, and a human interface system. The robot has 6 dofs per leg, 3 dofs per arm, and 2 dofs for a neck, so it has total of 20 dofs to have dexterous motion capability. For the control system, a supervisory controller runs on a remote host computer to plan high level robot actions based on the vision sensor data, a main controller implemented with a DSP chip generates walking trajectories for the robot to perform the commanded action, and an auxiliary controller implemented with an FPGA chip controls 20 actuators. The robot has three types of sensors. A two-axis acceleration sensor and eight force sensing resistors for acquiring information on walking status of the robot, and a color CCD camera for acquiring information on the surroundings. As an example of an intelligent robot action, some experiments on playing soccer are performed.

• 센서학회지
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• 제13권2호
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• pp.85-89
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• 2004

This paper represents the development of high sensitivity photo-sensor for the fluorescence detection in the integrated biological analysis system. The finger-type PIN photodiodes were fabricated as the photo-sensor, and had a high sensitivity ($I_{light}/I_{dark}$ = 8720). The interference filter consisted of $TiO_{2}$ and $SiO_{2}$ was directly deposited on the photodiodes. Deposited filter with 95.5% reflection under 532 nm and 98% transmission over 580 nm exceedingly decreased the magnitude of background signal in the detection. The PDMS micro-fluidic channels are bonded on the photodiode by $O_{2}$ plasma treatment. The detection current was proportional to two primary parameters (light intensity, concentration), and the on-chip detection system could detect fluorescence signals down to 100 nM concentration (LOD = Limit of detection of rhodamine).

• 센서학회지
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• 제10권5호
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• pp.337-342
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• 2001

1차원 또는 2차원 배열을 갖는 적외선 센서는 흔히 Si CMOS 신호 처리 회로에 인듐 범프를 이용하여 접합된다. 이러한 방식을 취함으로 해서 적외선의 감지와 신호 처리가 초점면에서 이루어지게 되어 신호의 잡음을 크게 줄일 수 있고 적외선 검출기 자체도 훨씬 작게 만들 수 있다. 본 논문에서는 적외선 센서와 신호 처리 회로를 서로 자동으로 평행이 되도록 하면서 인듐범프 접합을 하는 방법을 연구하였다. 이에 의해서 개발된 플립 칩 본더는 구조가 간단하면서도 칩 간의 평행을 유지할 수 있고 작동 방법 또한 간단하여 접합의 신뢰성을 향상시킬 것으로 기대된다.

• JSTS:Journal of Semiconductor Technology and Science
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• 제2권1호
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• pp.30-40
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• 2002

A 2.45GHz double-balanced modified Gilbert-type CMOS up-conversion mixer design is introduced, where the PMOS current-reuse bleeding technique is demonstrated to be efficient in improving conversion gain, linearity, and noise performance. An LO buffer is included in the mixer design to perform single-ended to differential conversion of the LO signal on chip. Simulation results of the design based on careful modeling of all active and passive components are examined to explain in detail about the characteristic improvement and degradation provided by the proposed design. Two kinds of chips were fabricated using a standard $0.35\mu\textrm$ CMOS process, one of which is the mixer chip without the LO buffer and the other is the one with it. The measured characteristics of the fabricated chips are quite excellent in terms of conversion gain, linearity, and noise, and they are in close match to the simulation results, which demonstrates the adequacy of the modeling approach based on the macro models for all the active and passive devices used in the design. Above all the benefits provided by the current-reuse bleeding technique, the improvement in noise performance seems most valuable.

• JSTS:Journal of Semiconductor Technology and Science
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• 제14권1호
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• pp.70-82
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• 2014

A nano-power CMOS voltage reference is proposed in this paper. Through a combination of switched-capacitor technology with the body effect in MOSFETs, the output voltage is defined as the difference between two gate-source voltages using only a single PMOS transistor operated in the subthreshold region, which has low sensitivity to the temperature and supply voltage. A low output, which breaks the threshold restriction, is produced without any subdivision of the components, and flexible trimming capability can be achieved with a composite transistor, such that the chip area is saved. The chip is implemented in $0.18{\mu}m$ standard CMOS technology. Measurements show that the output voltage is approximately 123.3 mV, the temperature coefficient is $17.6ppm/^{\circ}C$, and the line sensitivity is 0.15 %/V. When the supply voltage is 1 V, the supply current is less than 90 nA at room temperature. The area occupation is approximately $0.03mm^2$.

• Transactions on Electrical and Electronic Materials
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• 제18권2호
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• pp.59-61
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• 2017

This research was analyzed thermal characteristics that was appointed disadvantage when smart LED driver ICs was packaged and we applied extracted thermal characteristics for optimal layout design. We confirmed reliability of smart LED driver ICs package without additional heat sink. If the package is not heat sink, we are possible to minimize package. For extracting thermal loss due to overshoot current, we increased driver current by two and three times. As a result of experiment, we obtained 22 mW and 49.5 mW thermal loss. And we obtained optimal data of 350 mA driver current. It is important to distance between power MOSFET and driver ICs. If the distance was increased, the temperature of package was decreased. And so we obtained optimal data of 3.7 mm distance between power MOSFET and driver ICs. Finally, we fabricated real package and we analyzed the electrical characteristics. We obtained constant 35 V output voltage and 80% efficiency.