• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2613-2617
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• 2015

Radiation induced lung injury has long been considered a treatment limiting factor for patients requiring thoracic radiation. This radiation induced lung injury happens early as well as late. Radiation induced lung injury can occur in two phases viz. early (< 6 months) when it is called radiation pneumonitis and late (>6 months) when it is called radiation induced lung fibrosis. There are multiple factors that can be patient, disease or treatment related that predict the incidence and severity of radiation pneumonitis. Radiation induced damage to the type I pneumocytes is the triggering factor to initiate such reactions. Over the years, radiation therapy has witnessed a paradigm shift in radiation planning and delivery and successfully reduced the incidence of lung injury. Radiation pneumonitis is usually a diagnosis of exclusion. Steroids, ACE inhibitors and pentoxyphylline constitute the cornerstone of therapy. Radiation induced lung fibrosis is another challenging aspect. The pathophysiology of radiation fibrosis includes continuing inflammation and microvascular changes due to pro-angiogenic and profibrogenic stimuli resembling those in adult bronchiectasis. General supportive management, mobilization of airway secretions, anti-inflammatory therapy and management of acute exacerbations remains the treatment option. Radiation induced lung injury is an inevitable accompaniment of thoracic radiation.

• 한국위성정보통신학회논문지
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• 제8권2호
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• pp.36-43
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• 2013

본 논문에서는 고전압에서 동작하는 DDIC(display driver IC) 칩의 정전기 보호소자로 사용되는 GG_EDNMOS 소자의 고전류 특성 및 더블 스냅백 메커니즘이 분석되었다. 이온주입 조건을 달리하는 매트릭스 조합에 의한 수차례의 2차원 시뮬레이션 및 TLP 특성 데이타를 비교한 결과, BJT 트리거링 후에 더블 스냅백 현상이 나타났으나 웰(well) 및 드리프트(drift) 이온주입 조건을 적절히 조절함으로써 안정적인 ESD 보호성능을 얻을 수 있었다. 즉, 최적의 백그라운드 캐리어 밀도를 얻는 것이 고전압 동작용 정전기보호소자의 고전류 특성에 매우 중요한 영향을 주는 임계인자(critical factor)임을 알 수 있었다.

• 한국지반환경공학회 논문집
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• 제16권4호
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• pp.23-32
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• 2015

This paper addresses the effects of extreme rainfall on the stability of cut slopes in Yen Bai city, Northern Viet Nam. In this area, natural slopes are excavated to create places for infrastructures and buildings. Cut slopes are usually made without proper site investigations; the design is mostly based on experience. In recent years, many slope failures have occurred along these cuts especially in rainy seasons, resulting in properties damaged and loss of lives. To explain the reason that slope failure often happens during rainy seasons, this research analyzed the influence of extreme rainfalls, initial ground conditions, and soil permeability on the changes of pore water pressure within the typical slope, thereafter determining the impact of these changes on the slope stability factor of safety. The extreme rainfalls were selected based on all of the rainfalls triggering landslide events that have occurred over the period from 1960 to 2009. The factor of safety (FS) was calculated using Bishop's simplified method. The results show that when the maximum infiltration capacity of the slope top soil is less than the rainfall intensity, slope failures may occur 14 hours after the rain starts. And when this happens, the rainfall duration is the deciding factor that affects the slope FS values. In short, cut slopes in Yen Bai may be stable in normal conditions after the excavation, but under the influence of tropical rain storms, their stability is always questionable.

• Journal of Veterinary Science
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• 제24권1호
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• pp.2.1-2.14
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• 2023

Background: Hypothermia is a crucial environmental factor that elevates the risk of cardiovascular disease, but the underlying effect is unclear. Objectives: This study examined the role of cold stress (CS) in cardiac injury and its underlying mechanisms. Methods: In this study, a chronic CS-induced myocardial injury model was used; mice were subjected to chronic CS (4℃) for three hours per day for three weeks. Results: CS could result in myocardial injury by inducing the levels of heat shock proteins 70 (HSP70), enhancing the generation of creatine phosphokinase-isoenzyme (CKMB) and malondialdehyde (MDA), increasing the contents of tumor necrosis factor-α (TNF-α), high mobility group box 1 (HMGB1) interleukin1b (IL-1β), IL-18, IL-6, and triggering the depletion of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Multiple signaling pathways were activated by cold exposure, including pyroptosis-associated NOD-like receptor 3 (NLRP3)-regulated caspase-1-dependent/Gasdermin D (GSDMD), inflammation-related toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)-mediated nuclear factor kappa B (NF-κB), and mitogen-activated protein kinase (MAPK), as well as oxidative stressinvolved thioredoxin-1/thioredoxin-interacting protein (Txnip) signaling pathways, which play a pivotal role in myocardial injury resulting from hypothermia. Conclusions: These findings provide new insights into the increased risk of cardiovascular disease at extremely low temperatures.

• 한국지반환경공학회 논문집
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• 제8권2호
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• pp.11-18
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• 2007

철도 연변 사면의 활동은 열차 노선의 사용성과 안전성에 상당한 영향을 미치고 있다. 따라서 사면안정 문제는 철도 노선 운용에 있어 큰 관심사항이다. 본 연구에서는 철도연변 사면의 활동이 발생하는 조건에서의 강우정보를 분석하였으며 침투해석과 한계평형해석을 통하여 강우를 고려한 사면의 안정성 분석 기법을 제시하고자 한다. 강우량 분석결과 사면활동이 발생하기까지 누적강우량은 150~500mm 사이에 분포하고 있었고 강우지속시간은 3~24시간으로 나타났다. 분석된 강우량을 바탕으로 무한사면 조건에서의 침투해석과 강체거동 분석을 수행하고 무한사면의 심도는 2m를 가정하였으며 다중의 파괴면은 2m 심도로부터 16.7cm 간격으로 모델링이 되었다. 한계파괴심도인 2m는 안전율이 수렴하는 심도이다. 해석결과 기존의 사면안정성 평가 기준에서 고려하고 있는 우기시 해석조건의 결과보다 현실적인 안전율을 보였다. 또한 누적강우량, 강우지속시간, 안전율을 축으로 하는 3차원 공간상에 안전율 변화 추이를 도시한 결과 강우를 고려한 사면의 안전성 분석 시 일반적으로 고려하는 강우강도 뿐만 아니라 누적강우량(강우지속시간) 또한 고려되어야 할 것으로 판단되었다.

• 지질공학
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• 제10권2호
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• pp.18-35
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• 2000

우리나라에서 가장 흔히 발생하는 산사태는 쇄설성유동(debris flow)이며 이는 집중호우 시기인 6월-8월 사이에 대부분 발생한다. 조사통계에 의하면 2일간의 강우량이 200mm 이상일 때 발생하기 시작한다. 이들은 산사면의 노두 발달이 양호한 지역에서는 발생하지 않으면 노두가 없는 지역에서만 발생한다. 초기에는 전이형슬라이드(translational slide)로 시작되며 파괴물질이 산사면의 계곡으로 유동되면서 쇄설성유동으로 전이된다. 쇄설성유동의 원인이 되고있는 전이형 슬라이드의 발생인자는 강우와 인위적 조건을 제외하면 암석의 종류, 지형고도, 사면경사, 입도분표, 투수계수, 건조밀도, 공극율 등이다. 이들 발생인자들의 통계처리, 특히 로지스틱 회귀분석에 의하여 인자들의 정량적 가중치를 구하여 산사태 발생 확률을 정량화 하였다. 암반포행(rock mass creep)은 대부분 경상계 퇴적암지역에서 발생되면 직접원인은 거의 사면 하단 부의 절토 때문이다. 전단전이는 적은 편으로 1m 내외이나 포행암반의 규모가 크기 때문에 매우 위험하다. 칠곡, 부산 황룡산 터널입구, 사천 산사태 등이 이 범주에 속한다. 포행의 원인이 되는 상부 전단대는 대부분 주변에 발달되어있는 단층이나 대규모 전달절리와 연과되어 있어 사면설계 조사시 지질구조에 주의를 요한다. 회전형 슬라이드(rotational slide)는 토양층이 두껍거나 기반암이 심히 풍화된 연약층에서 발생하여 이들도 흔히 사면 하단부의 절토와 연관되어있다. 이 산사태는 원호 또는 반원호형으？ 진행되는 특징이 있으며 우리나라에서는 제 3기 응회암 지역이 취약하다. 이는 화산재와 화산쇄설 물질이 흔재된 제3기 응회암의 절리가 매우 잘 발달되어있어 팽윤과 흡수율이 높고 이로 인하여 심부까지 풍화에 취약하기 때문으로 경주 산사태와 포함-구릉포간 국도면의 산사태가 이 종류의 산사태에 속한다.

• Journal of Plant Biotechnology
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• 제44권2호
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• pp.142-148
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• 2017

Drought stress is one of the important factors that restrict the expansion of Hevea brasiliensis cultivation to non-traditional regions experiencing extreme weather conditions. Plants respond to drought stress by triggering expression of several drought responsive genes including transcription factors which in turn trigger expression of various downstream signalling pathways and adaptive networks. Expression of such drought responsive genes may revert back to their original level upon re-watering. However, no reports are available on such phenomenon in Hevea and hence, this study was initiated. For this purpose, NAC transcription factor (NAC tf) was chosen as candidate gene. Its expression levels were monitored under intermittent drought as well as irrigated conditions in two clones (RRII 105 and RRIM 600) of H. brasiliensis with contrasting tolerance level. Copy number of NAC tf was found similar in both the clones. Expression of NAC tf was found highly up-regulated in RRIM 600 (a relatively drought tolerant clone) than in RRII 105 (a relatively drought susceptible clone) throughout the drought incidences which upon re-watering, reached back to its original levels in both the clones. The study indicated the existence of an association between expression of NAC tf and drought tolerance trait exhibited by the tolerant clone RRIM 600. The study also proves the influence of drought and re-watering on the leaf photosynthesis and expression of NAC tf in H. brasiliensis.

• BMB Reports
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• 제51권5호
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• pp.219-224
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• 2018

Necroptosis is an emerging form of programmed cell death occurring via active and well-regulated necrosis, distinct from apoptosis morphologically, and biochemically. Necroptosis is mainly unmasked when apoptosis is compromised in response to tumor necrosis factor alpha. Unlike apoptotic cells, which are cleared by macrophages or neighboring cells, necrotic cells release danger signals, triggering inflammation, and exacerbating tissue damage. Evidence increasingly suggests that programmed necrosis is not only associated with pathophysiology of disease, but also induces innate immune response to viral infection. Therefore, necroptotic cell death plays both physiological and pathological roles. Physiologically, necroptosis induce an innate immune response as well as premature assembly of viral particles in cells infected with virus that abrogates host apoptotic machinery. On the other hand, necroptosis per se is detrimental, causing various diseases such as sepsis, neurodegenerative diseases and ischemic reperfusion injury. This review discusses the signaling pathways leading to necroptosis, associated necroptotic proteins with target-specific inhibitors and diseases involved. Several studies currently focus on protective approaches to inhibiting necroptotic cell death. In cancer biology, however, anticancer drug resistance severely hampers the efficacy of chemotherapy based on apoptosis. Pharmacological switch of cell death finds therapeutic application in drug- resistant cancers. Therefore, the possible clinical role of necroptosis in cancer control will be discussed in brief.

• Molecules and Cells
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• 제43권4호
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• pp.313-322
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• 2020

Eukaryotes transport biomolecules between intracellular organelles and between cells and the environment via vesicle trafficking. Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNARE proteins) play pivotal roles in vesicle and membrane trafficking. These proteins are categorized as Qa, Qb, Qc, and R SNAREs and form a complex that induces vesicle fusion for targeting of vesicle cargos. As the core components of the SNARE complex, the SNAP25 Qbc SNAREs perform various functions related to cellular homeostasis. The Arabidopsis thaliana SNAP25 homolog AtSNAP33 interacts with Qa and R SNAREs and plays a key role in cytokinesis and in triggering innate immune responses. However, other Arabidopsis SNAP25 homologs, such as AtSNAP29 and AtSNAP30, are not well studied; this includes their localization, interactions, structures, and functions. Here, we discuss three biological functions of plant SNAP25 orthologs in the context of AtSNAP33 and highlight recent findings on SNAP25 orthologs in various plants. We propose future directions for determining the roles of the less well-characterized AtSNAP29 and AtSNAP30 proteins.

• 말소리와 음성과학
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• 제11권4호
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• pp.35-43
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• 2019

This study examines the voice onset times (VOTs) of Korean stops produced by Korean learners of English with high language proficiency and long L2 exposure (i.e., Korean-English bilinguals) to assess whether the VOTs of their lax and aspirated stops are merging and, if so, which types of stops are being changed. Thirteen Korean speakers (six female and seven male) who had studied in the USA for more than three to ten years participated. The results show that the speakers in this study with long L2 exposure are participating in the VOT merger, in which VOTs for aspirated stops are reduced while those for lax stops are increased. In other words, change in VOT affects not only aspirated stops but also lax stops. The results indicate that L1 phonetic drift may not be primarily affected by the amount of L2 exposure, and language contact may not be the primary factor triggering a sound change in the Korean stop system. Further study is necessary focusing on the phonetic shift of the "lax" category because it may play a pivotal role in a tonogenetic-like sound change in present-day Korean.