Browse > Article
http://dx.doi.org/10.5483/BMBRep.2018.51.5.074

The role of necroptosis in the treatment of diseases  

Cho, Young Sik (Department of Pharmacy, Keimyung University)
Publication Information
BMB Reports / v.51, no.5, 2018 , pp. 219-224 More about this Journal
Abstract
Necroptosis is an emerging form of programmed cell death occurring via active and well-regulated necrosis, distinct from apoptosis morphologically, and biochemically. Necroptosis is mainly unmasked when apoptosis is compromised in response to tumor necrosis factor alpha. Unlike apoptotic cells, which are cleared by macrophages or neighboring cells, necrotic cells release danger signals, triggering inflammation, and exacerbating tissue damage. Evidence increasingly suggests that programmed necrosis is not only associated with pathophysiology of disease, but also induces innate immune response to viral infection. Therefore, necroptotic cell death plays both physiological and pathological roles. Physiologically, necroptosis induce an innate immune response as well as premature assembly of viral particles in cells infected with virus that abrogates host apoptotic machinery. On the other hand, necroptosis per se is detrimental, causing various diseases such as sepsis, neurodegenerative diseases and ischemic reperfusion injury. This review discusses the signaling pathways leading to necroptosis, associated necroptotic proteins with target-specific inhibitors and diseases involved. Several studies currently focus on protective approaches to inhibiting necroptotic cell death. In cancer biology, however, anticancer drug resistance severely hampers the efficacy of chemotherapy based on apoptosis. Pharmacological switch of cell death finds therapeutic application in drug- resistant cancers. Therefore, the possible clinical role of necroptosis in cancer control will be discussed in brief.
Keywords
Apoptosis; Cancer; Necroptosis; Necroptosis modulator; Regulator;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Han W, Li L, Qiu S et al (2007) Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther 6, 1641-1649   DOI
2 Lin Y, Choksi S, Shen HM et al (2004) Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J Biol Chem 279, 10822-10828   DOI
3 Dong W, Li Z, Chen Y et al (2017) NADPH oxidase inhibitor, diphenyleneiodonium prevents necroptosis in HK-2 cells. Biomed Rep 7, 226-230   DOI
4 Fulda S (2016) Regulation of necroptosis signaling and cell death by reactive oxygen species. Biol Chem 397, 657-660
5 Galluzzi L and Kroemer G (2008) Necroptosis: a specialized pathway of programmed necrosis. Cell 135, 1161-1163   DOI
6 Liu C, Zhang K, Shen H, Yao X, Sun Q and Chen G (2018) Necroptosis: A novel manner of cell death, associated with stroke (Review). Int J Mol Med 41, 624-630
7 Benedict CA, Norris PS, Prigozy TI et al (2001) Three adenovirus E3 proteins cooperate to evade apoptosis by tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and -2. J Biol Chem 276, 3270-3278   DOI
8 Nichols DB, De Martini W and Cottrell J (2017) Poxviruses Utilize Multiple Strategies to Inhibit Apoptosis. Viruses 9
9 Jerome KR, Fox R, Chen Z, Sears AE, Lee H and Corey L (1999) Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3. J Virol 73, 8950-8957
10 Lu JV, Weist BM, van Raam BJ et al (2011) Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci U S A 108, 15312-15317   DOI
11 Wang YQ, Wang L, Zhang MY et al (2012) Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model. Neurochem Res 37, 1849-1858   DOI
12 Berger SB, Harris P, Nagilla R et al (2015) Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov 1, 15009
13 Vandenabeele P, Declercq W, Van Herreweghe F and Vanden Berghe T (2010) The role of the kinases RIP1 and RIP3 in TNF-induced necrosis. Sci Signal 3, re4
14 Park SY, Shim JH and Cho YS (2014) Distinctive roles of receptor-interacting protein kinases 1 and 3 in caspase-independent cell death of L929. Cell Biochem Funct 32, 62-69   DOI
15 Fettweis G, Di Valentin E, L'Homme L et al (2017) RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death. Biochim Biophys Acta 1864, 113-124   DOI
16 Stern D, Yan SD, Yan SF and Schmidt AM (2002) Receptor for advanced glycation endproducts: a multiligand receptor magnifying cell stress in diverse pathologic settings. Adv Drug Deliv Rev 54, 1615-1625   DOI
17 Degterev A, Maki JL and Yuan J (2013) Activity and specificity of necrostatin-1, small-molecule inhibitor of RIP1 kinase. Cell Death Differ 20, 366   DOI
18 Liu ZY, Wu B, Guo YS et al (2015) Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice. Am J Cancer Res 5, 3174-3185
19 Nomura M, Ueno A, Saga K, Fukuzawa M and Kaneda Y (2014) Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma. Cancer Res 74, 1056-1066   DOI
20 Roychowdhury S, McMullen MR, Pisano SG, Liu X and Nagy LE (2013) Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury. Hepatology 57, 1773-1783   DOI
21 Wang Y, Wang H, Tao Y, Zhang S, Wang J and Feng X (2014) Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury. Neuroscience 266, 91-101   DOI
22 Najafov A, Chen H and Yuan J (2017) Necroptosis and Cancer. Trends Cancer 3, 294-301   DOI
23 Yang Y, Hu W, Feng S, Ma J and Wu M (2005) RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. Biochem Biophys Res Commun 332, 181-187   DOI
24 Wu W, Liu P and Li J (2012) Necroptosis: an emerging form of programmed cell death. Crit Rev Oncol Hematol 82, 249-258   DOI
25 Oliver Metzig M, Fuchs D, Tagscherer KE, Grone HJ, Schirmacher P and Roth W (2016) Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-alpha-dependent necroptosis driven by RIP1 kinase and NF-kappaB. Oncogene 35, 3399-3409   DOI
26 Wu W, Zhu H, Fu Y et al (2014) Clinical significance of down-regulated cylindromatosis gene in chronic lymphocytic leukemia. Leuk Lymphoma 55, 588-594   DOI
27 Feng X, Song Q, Yu A, Tang H, Peng Z and Wang X (2015) Receptor-interacting protein kinase 3 is a predictor of survival and plays a tumor suppressive role in colorectal cancer. Neoplasma 62, 592-601   DOI
28 Ruan J, Mei L, Zhu Q, Shi G and Wang H (2015) Mixed lineage kinase domain-like protein is a prognostic biomarker for cervical squamous cell cancer. Int J Clin Exp Pathol 8, 15035-15038
29 Yan B, Liu L, Huang S et al (2017) Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineage kinase domain-like protein. Chem Commun (Camb) 53, 3637-3640   DOI
30 Mandal P, Berger SB, Pillay S et al (2014) RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell 56, 481-495   DOI
31 Fauster A, Rebsamen M, Huber KV et al (2015) A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis. Cell Death Dis 6, e1767   DOI
32 Feldmann F, Schenk B, Martens S, Vandenabeele P and Fulda S (2017) Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells. Oncotarget 8, 68208-68220
33 Sosna J, Voigt S, Mathieu S et al (2013) The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis. Cell Commun Signal 11, 76   DOI
34 Janko C, Filipovic M, Munoz LE et al (2014) Redox modulation of HMGB1-related signaling. Antioxid Redox Signal 20, 1075-1085   DOI
35 Harris PA, Bandyopadhyay D, Berger SB et al (2013) Discovery of small molecule RIP1 kinase inhibitors for the treatment of pathologies associated with necroptosis. ACS Med Chem Lett 4, 1238-1243   DOI
36 Jouan-Lanhouet S, Arshad MI, Piquet-Pellorce C et al (2012) TRAIL induces necroptosis involving RIPK1/RIPK3- dependent PARP-1 activation. Cell Death Differ 19, 2003-2014   DOI
37 Ardestani S, Deskins DL and Young PP (2013) Membrane TNF-alpha-activated programmed necrosis is mediated by ceramide-induced reactive oxygen species. J Mol Signal 8, 12   DOI
38 Frank S, Gaume B, Bergmann-Leitner ES et al (2001) The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 1, 515-525   DOI
39 Vanlangenakker N, Vanden Berghe T, Krysko DV, Festjens N and Vandenabeele P (2008) Molecular mechanisms and pathophysiology of necrotic cell death. Curr Mol Med 8, 207-220   DOI
40 Moriwaki K, Bertin J, Gough PJ, Orlowski GM and Chan FK (2015) Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agentinduced cell death. Cell Death Dis 6, e1636   DOI
41 Miao B and Degterev A (2009) Methods to analyze cellular necroptosis. Methods Mol Biol 559, 79-93
42 Hitomi J, Christofferson DE, Ng A et al (2008) Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 135, 1311-1323   DOI
43 Degterev A, Hitomi J, Germscheid M et al (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 4, 313-321   DOI
44 Cho YS, Challa S, Moquin D et al (2009) Phosphorylationdriven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137, 1112-1123   DOI
45 Sun L, Wang H, Wang Z et al (2012) Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148, 213-227   DOI
46 Wang Z, Jiang H, Chen S, Du F and Wang X (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148, 228-243   DOI
47 Feoktistova M and Leverkus M (2015) Programmed necrosis and necroptosis signalling. FEBS J 282, 19-31   DOI
48 Xu X, Chua CC, Kong J et al (2007) Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. J Neurochem 103, 2004-2014   DOI
49 Belizario J, Vieira-Cordeiro L and Enns S (2015) Necroptotic Cell Death Signaling and Execution Pathway: Lessons from Knockout Mice. Mediators Inflamm 2015, 128076
50 Alameda JP, Moreno-Maldonado R, Navarro M et al (2010) An inactivating CYLD mutation promotes skin tumor progression by conferring enhanced proliferative, survival and angiogenic properties to epidermal cancer cells. Oncogene 29, 6522-6532   DOI
51 Zhu S, Zhang Y, Bai G and Li H (2011) Necrostatin-1 ameliorates symptoms in R6/2 transgenic mouse model of Huntington's disease. Cell Death Dis 2, e115   DOI
52 Re DB, Le Verche V, Yu C et al (2014) Necroptosis drives motor neuron death in models of both sporadic and familial ALS. Neuron 81, 1001-1008   DOI
53 Murakami Y, Matsumoto H, Roh M et al (2014) Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNAinduced retinal degeneration. Cell Death Differ 21, 270-277   DOI
54 Veyer DL, Carrara G, Maluquer de Motes C and Smith GL (2017) Vaccinia virus evasion of regulated cell death. Immunol Lett 186, 68-80   DOI
55 Robinson N, McComb S, Mulligan R, Dudani R, Krishnan L and Sad S (2012) Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium. Nat Immunol 13, 954-962   DOI
56 Sridharan H and Upton JW (2014) Programmed necrosis in microbial pathogenesis. Trends Microbiol 22, 199-207   DOI
57 Kaminskyy V and Zhivotovsky B (2010) To kill or be killed: how viruses interact with the cell death machinery. J Intern Med 267, 473-482   DOI
58 Lin J, Li H, Yang M et al (2013) A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep 3, 200-210   DOI