• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5069-5074
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• 2012

Objectives: The purpose of this study was to determine the relationship between methylation status of the Dact1 gene and MTHFR a1298c polymorphic forms in transitional cell carcinoma tissues in a Chinese population. Methods: Polymorphisms of folate metabolism enzyme gene MTHFR were assessed by restrictive fragment length polymorphism (RFLP) methods and PCR-based DNA methylation analysis was used to determine the CpG island methylation status of the Dact1 gene. Associations between the methylation status of the Dact1 gene and clinical characteristics, as well as MTHFR a1298c polymorphisms, were analyzed. Results: aberrant methylation of the Dact1 gene was found in 68.3% of cancer tissues and 12.4% of normal tissues,. The methylation rate of the Dact1 gene in cancer tissues was significantly higher in patients with lymph node metastasis than in those without lymph node metastasis (46.3% vs. 17.2%, P = 0.018). No association was found between aberrant DNA methylation and selected factors including sex, age, tobacco smoking, alcohol consumption and green tea consumption. After adjusting for potential confounding variables, variant allele of MTHFR a1298c was found to be associated with methylation of the Dact1 gene. Compared with wild type CC, the odds ratio was 4.33 (95% CI: 1.06-10.59) for AC and 4.95 (95% CI: 1.18-12.74) for AA. The N stage in TNM staging and the occurrence of lymph node metastasis were associated with an MTHFR 1298 AA+AC genotype (P<0.05). Conclusion: MTHFR 1298 AC and AA genotypes might help maintain a normal methylation status of the Dact1 gene, aberrant CpG island methylation of which is closely related to the genesis and progression of transitional cell carcinoma.

• Journal of The Korean Association of Information Education
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• v.8 no.3
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• pp.385-394
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• 2004

The process for the information society centered on the internet supplied us a space of another life, cyber space. In the reality that the cyber space exercised its influence on the our society outstandingly, this researcher think that it needs to have to discuss about the cyber school in the elementary schools by making use of experience the soft landing of cyber university. This study suggested the model of cyber elementary school applicable to the elementary schools, and discussed with the operational plan by the model. Also, it examined the field teachers' opinions about the model classification and operation through the questionnaire, and analyzed the result. It was divided into the four sorts of cyber elementary schools like the school support type, school associated type, and independent type, and transitional period type. This study researched the concept by the model each, the object and purpose of major education, the operational system, curriculum and contents. As a result of collecting their opinions through the questionnaire, it is desirable to be operated as the transitional period type and the school support type in case of the introduction of cyber elementary schools in the present elementary schools.

• Journal of Korean Neurosurgical Society
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• v.29 no.9
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• pp.1215-1221
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• 2000

Objective : The clinical prognosis and biological behavior of atypical and especially malignant meningiomas are well known to be worse than benign meningioma, but the degree of biological aggressiveness in each classical subtypes of benign meningioma is controversy. This study was performed to see whether there is a difference in the proliferative activity between each different histological subtypes of benign meningioma as well as atypical meningioma. Methods : Paraffin-embedded surgical specimens of 27 meningiomas, including two recurrent tumors, were studied to evaluate proliferative activity by immunohistochemical method with monoclonal antibodies to proliferating cell nuclear antigen(PCNA) and MIB-1. The specimens consisted of 8 cases of meningothelial, 9 cases of transitional, 5 cases of fibroblastic subtypes and 5 cases of atypical meningiomas. Results : Mean PCNA labeling indices of meningothelial, transitional and fibroblastic meningiomas were $4.82{\pm}5.10%$, $9.01{\pm}4.25%$ and $5.66{\pm}5.32%$, but that of atypical meningiomas was $27.62{\pm}19.67%$, noting a higher value compared to all three subtypes of benign meningiomas. Mean Ki-67 labeling indices of the above 3 subtypes were $0.43{\pm}0.85%$, $0.44{\pm}1.08%$ and $0.24{\pm}0.18%$, and that of atypical meningiomas was also revealed to be of higher value ($0.84{\pm}0.59%$). PCNA and Ki-67 labeling indices were not statistically different between histological subtypes of benign meningioma(p>0.05), but the differences of both immunolabeling between benign and atypical meningiomas were statistically significant(p<0.05). Conclusion : Immunolabeling of PCNA and Ki-67 in intracranial meningiomas reveals no prognostic difference between meningothelial, transitional and fibroblastic subtypes in classical benign meningiomas by measuring expression of PCNA and Ki-67, but it seems to be helpful in differentiating benign and atypical meningioma, later showing more proliferative activity and biological aggressiveness.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.12 no.3
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• pp.25-39
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• 2004

An experimental study was quantitatively carried out in order to investigate the influence of flow conditions on a boundary layer in the near-wake of a flat plate. Tripping wires attached at various positions were selected to change flow conditions of a boundary layer in the vicinity of trailing edge. The flows such as laminar, transitional, and turbulent boundary layer at 0.98C from the leading edge are imposed to investigate the evolution of symmetric and asymmetric wake. Measurements were made at freestream velocity of 6.0m/s, and the corresponding Reynolds number is $2.8{\times}10^5$. An x-type hot-wire probe(55P61) was employed to measure at 8 stations in the near-wake region. Test results show that the near-wake of the flat plate for the case of a laminar and transitional boundary layer is sensitive to mean flow shear generated after separation but for the case of turbulent boundary layer is insensitive.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.22 no.12
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• pp.1078-1083
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• 2009

Generally Lighting system consists of lamp and luminaire. When a fluorescent lamp is installed in luminaire, power and light output is changed by ambient temperature. Particularly electrodeless lamp depends on the changes that are mercury pressure with amalgam temperature and magnetic properties with ferrite temperature. It has finally influence on optical efficiency. In this study, the temperature change of ferrite and cold spot, vessel are measured at transitional state and then same characteristics are measured with increase of ambient temperature. At transitional state, luminous flux is related to temperature change of cold spot that compare with behavior of mercury pressure and light output. At increase of ambient temperature, we analyzed change that efficiency and electrical, optical characteristics of elecrodeless lamp are related to ferrite core and cold spot temperature.

• Fisheries and Aquatic Sciences
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• v.14 no.2
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• pp.111-117
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• 2011

The population dynamics of Pandalus gracilis was investigated in the southeastern coastal area of Korea between May 1998 and April 2000. Of the 4,127 specimens, 57% were identified as females, 39% as males, and 4% as transitional hermaphrodites. The number of females was greater than that of males and transexuals. A significant correlation was observed between the number of transitional hermaphrodites and ambient seawater temperature. Growth parameters were estimated using the modified von Bertalanffy growth function model incorporating seasonal variation in growth using the program ELEFAN. Females grew faster and reached a larger size-at-age than males (K=0.65/y and $L_{\infty}$=17.86 mm carapace length [CL] for females; K=0.51/y and $L_{\infty}$=14.70 mm CL for males). Mean size and age (95% confidence limits) at sex transition, calculated from growth parameters, were 7.07 mm carapace length and 1.05 years, respectively. The reproductive strategies of pandalid shrimps are discussed in terms of the type of sex transition.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.7
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• pp.518-528
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• 2016

It seems like many songs have the tonality of one key in jazz standards, but there are many cases in which more than one new key could be formed, despite being a short moment. Moreover, some songs contain keys of temporary changes many times in the event that keys are changed transitionally with the sequencing of cords many times, which is called 'Transitional Modulation with Sequences. The proceeding II-V-I of the major and minor keys are used as the sequencing of cords, and the most popular type in this sequencing pattern is the downward modulation in whole-steps or half-steps. The downward modulation in the interval of whole-steps is a useful technique; for example, there should be three compositions in the adjacency circumstances when it is used twice. We could express effectively a phenomenon that feelings go up to the climax and rapidly fall down. The downward modulation in half-steps must be more dramatic because a higher comparative aspect is made between the adjacent two keys.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4539-4543
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• 2013

Background: Transitional cell carcinoma (TCC) is the most predominant type of urinary bladder tumor. As cyclooxygenase (COX)-2 is recently introduced as an attractive target molecule in bladder TCC, we evaluated the immunohistochemical expression of this marker and its association with several clinicopathological characteristics. Materials and Methods: This cross-sectional study was performed in the Pathology department of Sina Hospital in Tehran, Iran during 2006-2011. Ninety-two paraffin embedded blocks were selected from patients with urinary bladder TCC who underwent cystectomy or transurethral resection (TUR). Then, we assessed COX-2 expression by immunohistochemical staining using antibody against COX-2. Staining in more than 5% of tumor cells was considered as positive expression. Results: COX-2 was expressed in 50 % of our patients. This marker was markedly expressed in high grade bladder TCC (62.1%) versus other grades and there was statistically a significant difference in COX-2 expression between various grades (p=0.008). In addition, patients' age, lymphatic and perineurial invasion were associated with the expression of COX-2 (p=0.001, 0.015 and 0.039, respectively). However, other parameters such as stage, tumor size, venous invasion and lymph node metastasis did not show any significant relationship with this marker (all, p>0.05). Conclusions: COX-2 was expressed in urinary bladder TCC especially in high grade forms, advocating its probable role in the differentiation of this tumor. Accordingly, COX-2 could be a valuable biological target molecule in the evaluation and treatment of patients with bladder TCC.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.04a
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• pp.65-69
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• 2009

Generally Lighting system consists of lamp and luminaire. When a fluorescent lamp is installed in luminaire, power and light output is changed by ambient temperature. Particularly electrodeless lamp depends on the changes that are mercury pressure with amalgam temperature and magnetic properties with ferrite temperature. It has finally influence on optical efficiency. In this study, the temperature change of ferrite and cold spot, vessel are measured at transitional state and then same characteristics are measured with increase of ambient temperature. At transitional state, luminous flux is related to temperature change of cold spot that compare with behavior of mercury pressure and light output. At increase of ambient temperature, we analyzed change that efficiency and electrical, optical characteristics of electrodeless lamp are related to ferrite core and cold spot temperature.

• Journal of the Korean housing association
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• v.20 no.5
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• pp.61-72
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• 2009

The purpose of this study was to examine how the interface between "place of work" and "place of living" in the housing sphere has changed, and to understand its social background. During the korean modernization period, changes in economic structure toward industry has an influence on many aspects of modem life in addition to occupations. The traditional mixing of heterogeneous activities in the home-such as between reproduction and household affairs, first changed into a coexistence of two spaces with different functions within the boundaries of home, and finally into a spatial separation between functions in an urban dimension. As a result of this process, the primary role of the modem home is as a place for relaxation without work. One important kind of home, in which a retail shop is integrated with it, was researched as a transitional form. Its spatial layout showed a various combined usage of both spaces. In conclusion, changes in relevant macro-social aspects are very concretely reflected m the function and spatial organization of the home.