• 한방안이비인후피부과학회지
• /
• 제14권2호
• /
• pp.154-172
• /
• 2001

Major symptoms of al1ergic rhinitis are nasal obstruction, sneezing and watery rhinorrhea. Onpyetang has been used to treat for nasal obstruction, which is one of the symptoms of allergic rhinitis. This Experimental study was done to research effects of Onpyetang and transformed Onpyetang(Allii Radix is deducted from Onpyetang) on the anti-allergic effects. We have studied the vascular permeability response induced by serotonin and histamine, the contact dermatitis response induced by picryl chloride, the delayed type hypersensitivity response to SRC, the mice paw edema induced by carrageenin, the writhing syndrome induced by $0.7\%$ acetic acid, and the rectal temperature in febrile rats induced by yeast. The results were as follows : 1. In the vascular permeability response to intradermal serotonin and histamine. Onpyetang proved significant inhibitory effect(P<0.05, p<0.001) But transformed Onpyetang proved significant inhibitory effect only to histamine(P<0.05) 2. In the contact dermatitis response induced by picryl chloride, Onpyetang and transformed Onpyetang proved significant inhibitory effect.(P<0.05, P<0.05) 3. In the delayed type hypersensitivity response induced by SRC, Onpyetang and transformed Onpyetang proved significant inhibitory effect on mice paw edema.. (P<0.05, P<0.05) 4. In the delayed type hypersensitivity response induced by SRC, Onpyetang proved significant inhibitory effect to serum IgE.(P<0.01) But transformed Onpyetang proved insignificant inhibitory effect on serum Ig E. 5. In the mice paw edema induced by carrageenin, Onpyetang and transformed Onpyetang proved significant anti-inflammatory effect. (P<0.01, P<0.01) 6. In the writhing syndrome induced $0.7\%$ acetic acid, Onpyetang and transformed Onpyetang proved significant analgestic effect. (P<0.01, P<0.01) 7. In the rectal temperature in febrile rats induced by yeast, Onpyetang and transformed Onpyetang proved significant anti-pyretic effect.(P<0.001, P<0.01) according to this result Onpyetang was conclude to be effective on anti-allergic, anti-pyretic, anti-inflammatory and analgestic action. but transformed Onpyetang(Allii Radix is deducted from Onpyetang) was not effective on the vascular permeability response to intradermal serotonin and increasing Ig E of delayed type hypersensitivity response induced by SRC. In addition, transformed Onpyetang is not effective as Onpyetang. More study should be done about the role of Allii Radix.

• International Journal of Ocean Engineering and Technology Speciallssue:Selected Papers
• /
• 제6권1호
• /
• pp.44-50
• /
• 2003

If the accelerometers are used in measuring the response, the absolute values of the velocity and displacement are not usually obtainable because their initial values are not accounted for in the integration of the acceleration response. A new dynamic response conversion algorithm of both the time domain and the frequency domain is proposed for the problem in estimating the displacement data by defining the transformed responses. In this algorithm, the displacement response can be obtained from the measured acceleration records by integration without requiring the knowledge of the initial velocity and displacement information. The applicability of the technique is tested by an example problem using the real bridge's superstructure under several cases of moving load. In the response conversion procedure of the frequency domain, the identified response according to the frequency can be estimated by changing over the limits of integration. If the reliability of the identified responses is ensured, it is expected that the proposed method for estimating the impact factor can be useful in the bridge's dynamic test. This method can be useful in those practical cases when the direct measurement of the displacement is difficult as in the dynamic studies of huge structure.

• 대한기계학회논문집A
• /
• 제28권4호
• /
• pp.467-474
• /
• 2004

A numerical method and algorithms is proposed to perform optimization of non-linear response structures. An analytical and numerical method based finite element method is also proposed for the transformation of non-linear response into linear response. Loads transformed from this method are defined as the equivalent linear loads. With the loads and the transformed response, linear static optimization is performed for nonlinear response structure with geometric and/or material non-linearity. The results of the optimization are compared with them of typical non-linear response optimization using finite difference method. The proposed method is very efficient and derives good solution.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2004년도 춘계학술대회
• /
• pp.999-1004
• /
• 2004

A numerical method and algorithms is proposed to perform optimization of non-linear response structures. An analytical and numerical method based finite element method is also proposed for the transformation of non-linear response into linear response. Loads transformed from this method are defined as the equivalent linear loads. With the loads and the transformed response, linear static optimization is performed for nonlinear response structure with geometric and/or material non-linearity. The results of the optimization are compared with them of typical non-linear response optimization using finite difference method. The proposed method is very efficient and derives good solution.

• Structural Engineering and Mechanics
• /
• 제15권6호
• /
• pp.717-733
• /
• 2003

A time domain method is presented for soil-structure interaction analysis under seismic excitations. It is based on the finite element formulation incorporating infinite elements for the far field soil region. Equivalent earthquake input forces are calculated based on the free field responses along the interface between the near and far field soil regions utilizing the fixed exterior boundary method in the frequency domain. Then, the input forces are transformed into the time domain by using inverse Fourier transform. The dynamic stiffness matrices of the far field soil region formulated using the analytical frequency-dependent infinite elements in the frequency domain can be easily transformed into the corresponding matrices in the time domain. Hence, the response can be analytically computed in the time domain. A recursive procedure is proposed to compute the interaction forces along the interface and the responses of the soil-structure system in the time domain. Earthquake response analyses have been carried out on a multi-layered half-space and a tunnel embedded in a layered half-space with the assumption of the linearity of the near and far field soil region, and results are compared with those obtained by the conventional method in the frequency domain.

• 동의생리병리학회지
• /
• 제26권3호
• /
• pp.287-292
• /
• 2012

The results of this study intended to clarify the apoptotic effects of curcumin on Epstein-Barr virus transformed human B lymphoma (EBV-B) cells are summarized as follows: It was found that curcumin induced endoplasmic reticulum(ER) stress as well as apoptotic cell death in EBV-B cells, although the magnitude of action was insignificant. When EBV-B cells activated by pokeweed mitogen (PWM) were treated with the same concentrations of curcumin, it was found that higher ER stress (GRP78, P-PERK, XBP-1, ATF6, and CHOP expressed) increased unfold protein response (UPR) and thus, apoptosis attributed to ER stress, compared to non-activated EBV-B cells In conclusion, it is expected that curcumin will play an important role for leukemia treatment.

• 한국독성학회:학술대회논문집
• /
• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
• /
• pp.154-155
• /
• 2001

Cyclooxygenase-2 (COX-2) is an inducible enzyme expressed in response to a variety of proinflammatory agents and cytokines. COX-2 expression has been shown to be elevated in several different types of human cancer. The presence of oncogenic ras has been associated with constitutive induction of COX-2 in certain H-ras transformed cells, and COX-2 overexpression confers resistance to apoptosis.(omitted)

• 한국해양공학회지
• /
• 제17권2호
• /
• pp.27-33
• /
• 2003

본 논문에서는 측정된 가속도신호만을 사용하여 변위응답을 추정하는 시간영역과 주파수영역에서의 동적 응답변환 알고리즘을 제시하였다. 본 알고리즘에서 사용되는 변환변위응답은 속도와 변위성분의 초기조건에 대한 정보 없이 측정된 가속도신호의 적분에 의하여 계산되며 실제 변위응답과 상관관계를 갖는다. 이에 측정된 구조물의 동적응답이 무재하부분과 자유진동부분을 포함하고 있을 때 변환응답을 보정하여 초기치 문제를 해결할 수 방법을 제시함으로써 가속도신호만을 사용하여 실제 변위응답을 추정할 수 있도록 하였다. 제시된 응답변환 알고리즘의 타당성을 평가하기위해 실교량에 대한 현장시험자료를 적용하여 변위응답을 추정하고 실측된 동적 변위와 비교하였다. 또한, 주파수영역에서의 응답변환에서 적분구간을 상이하게 사용함으로써 동적성분과 정적성분으로 분리된 추정응답을 평가할 수 있었으며 이에 따른 충격계수의 계산은 신뢰성 있는 평가방법임을 확인하였다.

• 대한음성학회:학술대회논문집
• /
• 대한음성학회 2006년도 추계학술대회 발표논문집
• /
• pp.88-91
• /
• 2006

Steered response power(SRP) based algorithm uses a focused beamformer which steers the array to various locations and searches for a peak in output power to localize sound sources. SRP-PHAT, a phase transformed SRP, shows high accuracy, but requires a large amount of computation time. This paper proposes an algorithm that clusters search spaces in advance to reduce computation time of SRP based algorithms.

• 한국전산구조공학회:학술대회논문집
• /
• 한국전산구조공학회 1999년도 봄 학술발표회 논문집
• /
• pp.121-128
• /
• 1999

This paper presents a time domain method for soil-structure interaction analysis for seismic loadings. It is based on the finite element formulation incorporating analytical frequency-dependent infinite elements for the far field soil. The dynamic stiffness matrices of the far field region formulated using the present method in frequency domain can be easily transformed into the corresponding matrices in time domain. At first, the equivalent earthquake forces are evaluated along the interface between the near and the far fields from the free-field response analysis carried out in frequency domain, and the results are transformed into the time domain. An efficient procedure is developed for the convolution integrals to evaluate the interaction force along the interface, which depends on the response on the interface at the past time instances as well as the concurrent instance. Then, the dynamic responses are obtained for the equivalent earthquake force and the interaction force using Newmark direct integration technique. Since the response analysis is carried out in time domain, it can be easily extended to the nonlinear analysis. Example analysis has been carried out to verify the present method in a multi-layered half-space.