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Apoptotic Effects of Curcumin on the Epstein-Barr Virus-Transformed Human B Lymphoma Cells Activated by PWM  

Ryu, Sang-Chae (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
Lee, Jang-Suk (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University)
Chong, Myong-Soo (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University)
Lee, Ki-Nam (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.26, no.3, 2012 , pp. 287-292 More about this Journal
Abstract
The results of this study intended to clarify the apoptotic effects of curcumin on Epstein-Barr virus transformed human B lymphoma (EBV-B) cells are summarized as follows: It was found that curcumin induced endoplasmic reticulum(ER) stress as well as apoptotic cell death in EBV-B cells, although the magnitude of action was insignificant. When EBV-B cells activated by pokeweed mitogen (PWM) were treated with the same concentrations of curcumin, it was found that higher ER stress (GRP78, P-PERK, XBP-1, ATF6, and CHOP expressed) increased unfold protein response (UPR) and thus, apoptosis attributed to ER stress, compared to non-activated EBV-B cells In conclusion, it is expected that curcumin will play an important role for leukemia treatment.
Keywords
curcumin; epstein-barr virus transformed human B lymphoma; PWM (Pokeweed mitogen); endoplasmic reticulum stress response; apoptotic cell death;
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