• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.4
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• pp.866-874
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• 2006

Atopic dermitiis(AD) is a chronic inflammatory skin disease, which requires safe and effective medicinal therapy. Over production of Th2 cytokines and chemokines as well as IgE, which are mediated by highly activated immune cells, have been considered as pathologic factors in this disease. We found that Gamipaidok-san(GPDS), which is a traditional herbal medicine clinically prescribing for atopic dermitis patients in the hospital, has suppressive effects on the development of DNC8 induced dermatitis in Nc/Nga atopic model. Oral administration of GPDS at the concentration of 250 mg/Kg for 12 weeks significantly suppressed the clinical severity of the dermatitis including pruities, edema, eczematous and dryness. Histological examination revealed that thickness of dermis and epidermis were considerably reduced, and the number of infiltrated inflammatory immune cells including mast cells, CCR3+, and CD4+ T cells were decreased in the affected skin and ear, and consistantly, the number of CD3+/CCR3+ cells in Iymph nodes were decreased. The levels of Th2 cytokines produced by activated splenocyte from atopic mice were also down-regulated by GPDS. Furthermore, the serum levels of IgE were considerably reduced, which accompanied by a decrease in the number of B220+IgE+ B cells in the Iymph nodes. Taken together, these results suggested that oral administration of GPDS, a traditional herbal medicine, has suppressive effects on atopic dermitis of Nc/Nga mouse by the modulation of the immune system, therefore GPDS has potential as a natural therapeutic for treatment of atopic dermatitis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.3
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• pp.382-388
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• 2011

Traditional Korean Medicine and Taoism think of the importance of a life nurturing for one's health and longevity. However, for a life nurturing, Traditional Korean Medicine aims at a person living up to one's natural life span. Taoism lays importance on ascending up to the sky to be a Taoist hermit with supernatural powers. Therefore, they both differ in the pursuit of their goals and their methods in doing respectively. In this study we have shown similarities and differences in the meaning and ways to practice su-seung-hwa-gang (body water rising and heat falling) which Traditional Korean Medicine and Taoism regard highly as a means of the practice of a life nurturing. Su-seung-hwa-gang is a concept that both Traditional Korean Medicine and Taoism set a high value on and at the same time it is a concrete method of a life nurturing demonstrating the possibility of 'non-disease treatment' through the active efforts of Traditional Korean Medicine.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.6
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• pp.1427-1432
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• 2003

This study was carried out to investigate the antimicrobial and anticancer effects of Galla Rhois (GR) on pathogens isolated from oral and KB human oral epidermoid carcinoma cells. Their antimicrobial activities were tested against Streptococcus mutans (S. mutans), Staphylococcus aureus (S. aureus), Enterobacter aerogenes (E. aerogenes), Escherichia coli (E. coil) and Candida albicans (C. albicans). GR powder has the antimicrobial activity against C. albicans, S. mutans and S. aureus. The extracts of water and ethanol have the antimicrobial activity against S. sureus and C. albicans. The water extract showed inhibitory activity against the growth and pH of above mentioned reference microorganisms. The water extract of GR declined cell viability in a dose dependent manner. DNA flow cytometric analysis showed that population of sub-G/sub 0//G₁, phase of cell cycle was increased by GR extract treatment in a dose dependent manner. Western blot analysis revealed that Caspase-3 was reduced by GR extract treatment. These result suggested that GR has the effect of antimicrobial on pathogens isolated from oral, and also, has anticancer effect that associated with the induction of apoptosis in a dose dependent manner in KB human oral epidermoid carcinoma cells. It may be GR-induced apoptosis was mediated via activation of Caspase-3.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.3
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• pp.322-329
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• 2014

The purpose of this study was to investigate the quality of two different commercial Bangpungtongseong-san (BTS) extract granules (BTS-2 and BTS-3) by comparing with BTS decoction (BTS-1). The contents of characterizing components and biological activities of two different commercial BTS extract granules were compared with those of the BTS decoction. The contents of characterizing components were analyzed with HPLC. The antioxidative effects were determined by measuring 2,2-diphenyl-1-picrylhygrazyl (DPPH) radical scavenging and superoxide dismutase (SOD)-like activity. Also, we compared the effects on lipid accumulation and reactive oxygen species (ROS) production during differentiation of 3T3-L1 preadipocytes. The contents of five components except liquiritin and sennoside A were higher in BTS-1. The DPPH radical scavenging and SOD-like activity were higher in BTS-1. BTS-1 significantly inhibited lipid accumulation during differentiation of 3T3-L1 preadipocytes and showed stronger effects than BTS-2, BTS-3. In addition BTS-1 showed stronger inhibition effects on ROS production during differentiation of 3T3-L1 preadipocytes than BTS-2, BTS-3. These results indicate that BTS decoction has strong biological activities than commercial BTS extract granules. It is also consistent with the contents of characterizing components.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.6
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• pp.1383-1389
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• 2008

This paper investigates the attitudes of medical users toward Korean oriental medicine and traditional Chinese medicine and their future demand. The subjects are 404 university students both in Korea and in China. The items that were questioned in this paper were the attitudes toward Korean oriental medicine and traditional Chinese medicine, the experience of using the medicine, the reason they used the traditional medicine, the factors that made them satisfied with the medicine, and the future plan for using the traditional medicine. The reason the university students were selected as subjects was that they have more possibilities as future users of the traditional medicine. This paper show that Chinese students have more positive attitude toward the traditional medicine than Korean students. The Koreans' experience rate of using the traditional medicine was comparatively high and the subjects in both the countries used the western medicine for the symptoms of a cold and dental problems. For the illness of stomach, Korean and Chinese subjects used the traditional medicine and the western medicine half and half. This paper presented the subjects with the common 14 diseases that they can have and asked which medicine they will use when they have the diseases. The results of analysis indicate that the subjects tend to use different medical institution according to the diseases. The subjects in Korea and China selected different medical institution for the same disease. From the analysis of the questionnaire, it can be seen that there are some differences between Koreans and Chinese in using the medical institution, which results from the difference in medical culture and the relationship between the traditional medicine and medical users could be figured out.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.1-8
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• 2010

They have brought many inconsistencies by making much of Wang Sukhwa's six-meridian-transmutation-theory based on Yeollon, Somun in Oriental traditional medicine. On this many medical men such like Hwa Ta have raised objections to that or insisted on its repeal. Wang Geungdang and Yang Soi posed the problem of editing tables of contents, Bang Yujip and Ga Geum etc. gave explanations of fields of six-meridian, Un Cheolcho and Jang Gyeongak etc. presented cause and direction of transmutation. And Gilik Dongdong insisted on its repeal. Sanghannon was the theory that was arranged various experiences of acute epidemic diseases. But they didn't recognize the differences between analogous epidemic diseases, regarded as the same things in Oriental traditional medicine, and this made many inconsistencies. This is the reason why many medical men raised objections to Wang Sukhwa's six-meridian-transmutation-theory.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.4
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• pp.580-585
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• 2010

To develop a new traditional rice liquor by using Mulberry leaves, the optimal condition of fermentation was investigated by addition of different concentrations (1%, 3%, and 5%) of Mulberry leaves powder in the raw rice mash. The efficiency of ethanol production of all conditioned groups were not inhibited by addition Mulberry leaves. The acceptability and antimicrobial activity of the Mulberry leaves liquor with different concentrations of Mulberry leaves powder were tested. The 3% Mulberry leaves liquor showed the best acceptability in the sensory evaluation test and color test. The antimicrobial activity against Helicobacter pylori were increased according to added amount of Mulberry leaves. It was supposed that the antimicrobial activity were affected by phenolic compound extracted from Mulberry leaves with ethanol produced during the fermentation period. The results suggested that the Mulberry leaves can be useful source to develop a new traditional rice liquor.

• Journal of Physiology & Pathology in Korean Medicine
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• v.25 no.6
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• pp.1102-1107
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• 2011

This study was case report to show the good effects of korean traditional medical treatment and breathing meditation. The methods were applied to lung cancer patients. We treated one patient who scored 27 point at Beck's depression inventory(BDI) and 28 point at Hamilton rating scale for depression(HRSD) and 22 point at Beck's anxiety inventory(BAI) and 20 point at Anxiety status inventory(ASI) by korean traditional medical treatment and breathing meditation. After treatment, the clinical symptoms were improved and the score of BDI, HRSD, BAI, ASI were decreased. According to this study korean traditional medical treatment is effective for the cure of depression and anxiety disorder and breathing meditation forifies the korean traditional medical treatment.

• Journal of Physiology & Pathology in Korean Medicine
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• v.27 no.1
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• pp.107-111
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• 2013

To investigate the possible usage as probiotics, we isolated and identified one strain of bacillus from Korean traditional food, Jeotgal. The isolate was identified as Bacillus megaterium KS12 by examining its biochemical properties and 16S rRNA sequence analysis (99% similarity). B. megaterium KS12 exhibited high viability in artificial gastric juice for 3 h and in artificial bile salts for 24 h, about 14.4 and 14%, respectively. The herbal digestive medicine containing the isolate showed high starch hydrolytic activity and proteolytic activities (about 6-fold) compared to traditional herbal digestive medicine. The viable cells in the herbal digestive medicine containing the isolate were higher than those of traditional herbal digestive medicine.

• Journal of Physiology & Pathology in Korean Medicine
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• v.29 no.6
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• pp.443-450
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• 2015

The purpose of this study was is to understand how the network pharmacology databases of traditional medicine in China are established and provide suggestion for successful implementation in Traditional Korean Medicine. We searched for network-pharmacology-related TCM Databases provided on the internet, and analysed their contents. Then, we compared herbs related to Sasang with herbs of the TCM Databases. We chose 8 network-pharmacology-related TCM Databases. They shared information about compounds, herbs, formulae, drugs, targets and diseases, and provided interaction networks between these components. In comparison with herbs related to Sasang, TCMSP Database did not have information about 99 herbs in total, and 25 herbs included in major Sasang formulae. The implications and recommendations for Traditional Korean Medicine researches were discussed. Based on the results of this primary study, more related studies should be carried out in the future.