Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Comparative Study of Characterizing Components and Biological Activities of Bangpungtongseong-san Formulation

방풍통성산 제제의 성분 및 생리활성 비교 연구

  • Kim, Jung Ok (Korean Traditional Medicine Agency, Korea Promotion Institute for Traditional Medicine Industry) ;
  • Choi, Hye Min (Korean Traditional Medicine Agency, Korea Promotion Institute for Traditional Medicine Industry) ;
  • Lee, Hee Hyun (Korean Traditional Medicine Agency, Korea Promotion Institute for Traditional Medicine Industry) ;
  • Moon, Sung Ok (Korean Traditional Medicine Agency, Korea Promotion Institute for Traditional Medicine Industry) ;
  • Kim, Jong Bum (Korean Traditional Medicine Agency, Korea Promotion Institute for Traditional Medicine Industry) ;
  • Lee, Hwa Dong (Korean Traditional Medicine Agency, Korea Promotion Institute for Traditional Medicine Industry)
  • 김정옥 ((재)한국한방산업진흥원 한약제제사업단) ;
  • 최혜민 ((재)한국한방산업진흥원 한약제제사업단) ;
  • 이희현 ((재)한국한방산업진흥원 한약제제사업단) ;
  • 문성옥 ((재)한국한방산업진흥원 한약제제사업단) ;
  • 김종범 ((재)한국한방산업진흥원 한약제제사업단) ;
  • 이화동 ((재)한국한방산업진흥원 한약제제사업단)
  • Received : 2014.03.07
  • Accepted : 2014.05.20
  • Published : 2014.06.25
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Abstract

The purpose of this study was to investigate the quality of two different commercial Bangpungtongseong-san (BTS) extract granules (BTS-2 and BTS-3) by comparing with BTS decoction (BTS-1). The contents of characterizing components and biological activities of two different commercial BTS extract granules were compared with those of the BTS decoction. The contents of characterizing components were analyzed with HPLC. The antioxidative effects were determined by measuring 2,2-diphenyl-1-picrylhygrazyl (DPPH) radical scavenging and superoxide dismutase (SOD)-like activity. Also, we compared the effects on lipid accumulation and reactive oxygen species (ROS) production during differentiation of 3T3-L1 preadipocytes. The contents of five components except liquiritin and sennoside A were higher in BTS-1. The DPPH radical scavenging and SOD-like activity were higher in BTS-1. BTS-1 significantly inhibited lipid accumulation during differentiation of 3T3-L1 preadipocytes and showed stronger effects than BTS-2, BTS-3. In addition BTS-1 showed stronger inhibition effects on ROS production during differentiation of 3T3-L1 preadipocytes than BTS-2, BTS-3. These results indicate that BTS decoction has strong biological activities than commercial BTS extract granules. It is also consistent with the contents of characterizing components.

Keywords

References

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