• Bulletin of the Korean Chemical Society
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• 제32권9호
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• pp.3251-3254
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• 2011

To probe the chemical constituents of Patrinia scabra, we undertook the phytochemical investigation on its roots, which led to the isolation and elucidation of three new iridoid glucosides, scabroside A-C (1-3), along with three known iridoids, jatamanin J (4), isopatriscabroside I (5) and loganic acid (6) from the aqueous fraction of the ethanolic extract of the roots. The structures and relative configurations of the three new compounds were elucidated by spectroscopic methods including IR, UV, MS, 1D and 2D NMR experiments. Compound 3 was an unusual iridoid with an oxygen bridge connecting C-3 and C-8.

• 디자인학연구
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• 제14권1호
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• pp.167-176
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• 2001

디지털 시대인 21세기는 시각 정보 디자인의 중요성이 과거의 그 어느 때보다 요구되는 시대이며, 정보전달을 위한 가독성 위주의 전통적 개념의 타이포그래픽 디자인과, 전통적 개념에 역행하는 표현위주의 실험적인 타이포그래픽 디자인이 공존하고 있다. 타이포그래피에 관한 실험은 현대미술의 개념정립과 더불어 과거에도 있어 왔지만, 데스크탑 컴퓨터의 상용화된 기술적 발달에 힘입어 1980년대 이후에 더욱 거세게 일어나고 있다. 실험적 타이포그래픽 작업으로 90년대를 대표하는 디자이너 중의 한사람으로 각광받고 있는 데이비드 카슨(David Canon)의 작업의 생성 배경과 작품의 분석을 통해, 그의 전통시각에 역행하는 디지털 시대의 실험적 타이포그래피의 문제점과 전망에 관해 알아본다.

• 동아시아식생활학회지
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• 제18권1호
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• pp.41-48
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• 2008

This study focused on the alcohol fermentability of traditional Nuruk, as well as yeast containing traditional Nuruk, in the production of Yakju. The fermentation performed with 30% Nuruk was effective with regard to alcohol yield. In addition, the fermentation containing 70% Nuruk showed the highest titratable acidity due to increased amounts of organic acids (succinic acid, oxalic acid, malic acid, acetic acid), which, however, negatively influenced the Yakju quality. Moreover, microbiological contamination always occurred in the fermentations using only Nuruk. In contrast, in the experiments with the yeast containing Nuruk, higher alcohol content and lower titrable acidity were obtained, independent of the Nuruk ratio used, positively effected the Yakju taste and flavor. Overall, the fermentation performed using the yeast containing 30% traditional Nuruk showed the best results for Yakju production.

• 한국컴퓨터정보학회논문지
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• 제15권1호
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• pp.103-109
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• 2010

색이란 인간이 조형 활동을 처음 시작할 때부터 사용되어진 조형언어로서 인간이 눈으로 볼 수 있는 모든 현상 세계에 존재하는 것이다. 본 논문에서는 장면 전환 검출에서 추출된 대표 프레임을 대상으로 한국의 전통색 조화를 식별한다. 전통색은 오정색과 오간색으로 분류하여 조화를 이루는지 판별하도록 한다. 빨강, 파랑, 노랑, 검정, 흰색을 오정색이라 부르고 분홍, 하늘색, 보라, 유황색, 초록을오 간색이라 하여 식별한다. 먼저, Canny 알고리즘을 이용하여 경계선을 추출한다. 그리고 경계선을 중심으로 색들을 레이블링 하고 클러스터링 한다. 마지막으로, 전통 색채 조화 식별 방법을 이용하여 전통색을 식별한다. 본 논문에서 제시한 연구는 실험을 통하여 우수성이 입증 되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4453-4458
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• 2012

Angiogenesis plays a significant role in colorectal cancer (CRC) and cyclooxygenase-2 (COX-2) appears to be involved with multiple aspects of CRC angiogenesis. Our aim was to investigate the inhibitory effects of Tan II-A (Tanshinone II-A, Tan II-A) on tumor growth in mice, as well as alteration of expression of COX-2 and VEGF in CRC. We established the mice xenograft model of C26 CRC cell line, and injected 0.5, 1, 2mg/kg of Tan II-A and 1mg/kg of 5-FU in respectively in vivo. Then, we assayed tumor weight and volume, and evaluated microvascular density and expression of VEGF. COX-2 promoter and COX-2 plasmids were transfected into HCT-116 cells, followed by detection of COX-2 promoter activity by chemiluminescence, and detection of COX-2 mRNA expression by fluorescence quantitative PCR. Taken together, the results showed Tan II-A could inhibit tumor growth and suppress the VEGF level in vivo. HCT-116 cell experiments showed marked inhibitory effects of Tan II-A on COX-2 and VEGF in a dose-dependent manner. The results indicate that Tan II-A can effectively inhibit tumor growth and angiogenesis of human colorectal cancer via inhibiting the expression level of COX-2 and VEGF.

• 한국실내디자인학회논문집
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• 제21권2호
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• pp.74-83
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• 2012

This study is an historical consideration about the modern discourse of Japanese spacial tradition driven from cultural background. The purpose of this study is to establish a cartographic map of historical progress, and to shed light on the forming of identity in Japanese traditional space design on the schizo-analytical aspect. It adopts F. Guattari's psychoanalytic theory to the structural analysis of Japanese traditional space design. The process of this study is illustrated as follows: At first, it mentions Guattari's theory of Mechanical Unconscious, Schizo-analysis, Cartography, and Abstract machine as theoretical background. And, it considers the identity of Japanese traditional space constructed by various cultural sign over a long period of time as the statement of apriority. Secondly, it clarifies semiologic generation of Japanese traditional space design based on the analysis of spacial morphemes about each design stemmed from modernization process of Japan. Thirdly, it ascertains semiologic topography the representamens draw, i.e. schizo-analytic cartography from synchronic and diachronic point of view. Fourthly, it analyses traditional discourse structure in terms of generative schizo-analysis and transformational schizo-analysis with four categories- object, style, concept, strategy. Through this process, it studies the reproduction of Japanese tradition in terms of the 'social organization', and explores the way vitalized on the space-time coordinate system by the schizo-analysis of the mechanical unconscious. In conclusion, it clarifies Generative-schizo is accomplished in the level of formulating representamen, and Transformational-Schizo involves experimental mind that induce implantation of the heteromorphic elements and avant-garde experiments of abstract mechanical operation in the schizo-analysis of Japanese traditional space design. The significance of this study is to arrange an opportunity of introspection on Korean-ness seriously from inspecting logic of Japan-ness closely in traditional space design.

• 대한한의학회지
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• 제30권5호
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• pp.127-136
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• 2009

Objective: This study aimed to analyze the current status of treatments and patients with diabetic peripheral neuropathy, and then map out of a strategy for development of generalized-treatments for diabetic peripheral neuropathy in Traditional Korean Medicine. Methods: We selected research materials from various databases such as PubMed, Google, KStudy, KoreanTK, OIM, KOMS and books. Also, to understand current tendencies of medical examination and treatment related with diabetic peripheral neuropathy, we requested Health Insurance Review and Assessment Service clinical data from 2003 to 2007. Results: It is reported that the incidence of diabetic peripheral neuropathy is increasing in an aging society. The medical fees of National Health Insurance related with diabetic peripheral neuropathy show a year-on-year increase. There are no particularly effective therapies for diabetic peripheral neuropathy in Western medicine, and in some papers, it was reported that treatment of diabetic peripheral neuropathy using Traditional Korean Medicine was effective. However, patients usually visit on Western medical center rather than seek Traditional Korean Medicine. To take charge of clinical fields related with diabetic peripheral neuropathy by Traditional Korean Medicine, we need more studies and experiments of diabetic peripheral neuropathy using Traditional Korean Medicine and should make a standardized protocol. Conclusion: Various studies related with diabetic peripheral neuropathy using Traditional Korean Medicine will have to be undertaken hereafter. We expect that Traditional Korean Medicine will play a vital role in treating of diabetic peripheral neuropathy.

• 교육시설 논문지
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• 제19권5호
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• pp.37-43
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• 2012

Results of experiments conducted in university-based design studio suggests that Building information Modeling invites the adoption of a dramatically different design process, traditional design process and BIM-aided design process. Experiment method is used the actual experiment by students. In contrast to traditional design process rooted in successive refinement of abstractions and dependence on tacit knowledge, the studio BIM-aided design process depends on a complete and comprehensive date base and alterative solutions by complete analysis for helping choice of finial result. BIM viewed as provocateur of design education provides great potential for the critical analysis of how architectural design is taught. The results reflect new ways of teaching and addressing BIM methods and process in the design studio project.

• 한국멀티미디어학회논문지
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• 제21권3호
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• pp.423-431
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• 2018

In this paper, we try to verify a normative module based house design procedure consisted of several sequential steps. The first step is to suggest formalization of designing so that we could clarify each phase and operation we are adopting in our design process. The second step is the clearing up the conceptual schema of traditional skills that we adopt and utilize from traditional Hanok framing techniques. The third step is to formulate adequate modular kits for the assembly of house design solutions for the schematic, conceptual and preliminary phases of designing. The fourth step is to implementing our ideas and methods to a proper computational platform such as Unity3D. The final step is to verify our symbolic descriptions of design formalization with the output of our experiments so that we have better understanding of design reasoning characteristics such as in house design.

• 대한한의학회지
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• 제31권3호
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• pp.98-106
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• 2010

Objective: To examine the in vitro antioxidant and hepatoprotective properties of Amomum xanthoides extract and its fractions. Methods: Methanol extract of Amomum xanthoides was fractionated into three fractions; petroleum ether fraction (PFAX), water fraction (WFAX) and ethyl acetate fraction (AFAX). The antioxidant and hepatoprotective effects of these fractions were compared by in vitro experiments. Results: The total phenols content and DPPH (1 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity was found significant in AFAX when compared with other fractions (PFAX, WFAX). AFAX significantly inhibited NO production by RAW 264.7 cells in LPS-activated condition. In Hep $G_2$ cells, AFAX markedly prevented the leakage of LDH and release of AST against CCl4 challenge. Conclusion: Amomum xanthoides and especially ethyl acetate fraction have potent antioxidative and hepatoprotective properties.