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Antioxidant and Hepatoprotective Effects of Amomum Xanthoides  

Wang, Jing-Hua (Liver and Immunology Research Center, Institute of Traditional Medicine and Bioscience of Daejeon University)
Shin, Jang-Woo (Liver and Immunology Research Center, Institute of Traditional Medicine and Bioscience of Daejeon University)
Son, Chang-Gue (Liver and Immunology Research Center, Institute of Traditional Medicine and Bioscience of Daejeon University)
Publication Information
The Journal of Korean Medicine / v.31, no.3, 2010 , pp. 98-106 More about this Journal
Abstract
Objective: To examine the in vitro antioxidant and hepatoprotective properties of Amomum xanthoides extract and its fractions. Methods: Methanol extract of Amomum xanthoides was fractionated into three fractions; petroleum ether fraction (PFAX), water fraction (WFAX) and ethyl acetate fraction (AFAX). The antioxidant and hepatoprotective effects of these fractions were compared by in vitro experiments. Results: The total phenols content and DPPH (1 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity was found significant in AFAX when compared with other fractions (PFAX, WFAX). AFAX significantly inhibited NO production by RAW 264.7 cells in LPS-activated condition. In Hep $G_2$ cells, AFAX markedly prevented the leakage of LDH and release of AST against CCl4 challenge. Conclusion: Amomum xanthoides and especially ethyl acetate fraction have potent antioxidative and hepatoprotective properties.
Keywords
herb; Amomum xanthoides; phenol; antioxidant; hepatoprotective;
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