Antioxidant and Hepatoprotective Effects of Amomum Xanthoides

  • Wang, Jing-Hua (Liver and Immunology Research Center, Institute of Traditional Medicine and Bioscience of Daejeon University) ;
  • Shin, Jang-Woo (Liver and Immunology Research Center, Institute of Traditional Medicine and Bioscience of Daejeon University) ;
  • Son, Chang-Gue (Liver and Immunology Research Center, Institute of Traditional Medicine and Bioscience of Daejeon University)
  • Received : 2010.03.05
  • Accepted : 2010.04.29
  • Published : 2010.05.30


Objective: To examine the in vitro antioxidant and hepatoprotective properties of Amomum xanthoides extract and its fractions. Methods: Methanol extract of Amomum xanthoides was fractionated into three fractions; petroleum ether fraction (PFAX), water fraction (WFAX) and ethyl acetate fraction (AFAX). The antioxidant and hepatoprotective effects of these fractions were compared by in vitro experiments. Results: The total phenols content and DPPH (1 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity was found significant in AFAX when compared with other fractions (PFAX, WFAX). AFAX significantly inhibited NO production by RAW 264.7 cells in LPS-activated condition. In Hep $G_2$ cells, AFAX markedly prevented the leakage of LDH and release of AST against CCl4 challenge. Conclusion: Amomum xanthoides and especially ethyl acetate fraction have potent antioxidative and hepatoprotective properties.



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