• Archives of Pharmacal Research
• /
• v.19 no.3
• /
• pp.201-206
• /
• 1996

Nitric oxide (NO) is thought to be a second messenger involved in secretion. Upon stimulating pancreatic acinar cells with cholecystokinin-pancreozymin (CCK-PZ), NO formation has been shown to be associated with increased levels of cGMP (Seo et al., 1995). To elucidate the signaling pathway of VIP-induced enzyme secretion, we investigated the NO and cGMP synthesis steps as potential steps where two signal pathways triggered by CCK-PZ and VIP interact. The results obtained in this work provide evidence that increase in pancreatic enzyme secretion by treatment with VIP has no relationship with NOS activity and cGMP level. This conclusion was derived from the following findings that VIP treatment of rat pancreatic tissue increased amylase release as well as protein output in a dose- and time-dependent manner, whereas NOS activity and cGMP synthesis were not affected by VIP treatment as monitored by NOS activity assay and determining cGMP level, which was further confirmed by a NOS-inhibitor study. Consequently, CCK-PZ or VIP increases enzyme secretion in rat pancreatic tissue, but the two hormones are different in their mode of action. Together the results suggest that signaling pathway of VIP-induced enzyme secretion might either bypass the NO and cGMP synthesis steps or lie on a distinct pathway from CCK-PZ-induced pathway.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.10 no.6
• /
• pp.1101-1105
• /
• 2006

Ubiquitous computing network comprises a variety of distributed service devices. Today Web services technology enables the heterogeneous devices to provide their own services and interact with each other via well-defined Internet protocol. Nevertheless, service devices in ubiquitous environments require more event-driven, autonomous interaction beyond rather passive service-oriented architecture of the present time. This paper presents an ECA (Event-Condition-Action) rule description language in an attempt to support capability for autonomous interactions among service-oriented devices in ubiquitous computing network. Specifically, the proposed WS-ECA is an XML-based ECA rule description language for web service-enabled devices. The rules are embedded in distributed devices which invoke appropriate services in the network if the rules are triggered by some internal or external events. The presented ECA-based device coordination approach is expected to facilitate seamless inter-operation among the web service-enabled devices in the emerging ubiquitous computing environment.

• Proceedings of the KIEE Conference
• /
• 2005.07b
• /
• pp.1228-1230
• /
• 2005

This paper deals with design of heater trigger switching in a persistent current system(PCS) by finite element method(FEM) analysis of YBCO coated conductor(CC) tape. Most promising superconducting wire is YBCO coated conductor tape in these days for its high n value and critical current independency from external magnetic field. It is expected to be used many superconducting application such as fault current limiter and cable etc. The superconducting magnet which is operated in persistent current mode in SMES, NMR, MRI and MAGLEV has many advantages such as a high uniformity of a magnetic field and reducing a thermal loss. A PCS system consists of magnet power supply (MPS) which energized current to a magnet, heater, a coated conductor tape for switching, and superconducting magnet. In this paper, the characteristic of thermal quench of the YBCO CC tape and BSCCO tape by heater trigger analyzed by FEM. And optimal length of heater is calculated by temperature and time analysis. This heater trigger analysis is expected to be a basic concept of PCS application design.

• The Journal of the Korea Contents Association
• /
• v.21 no.2
• /
• pp.631-640
• /
• 2021

The purpose of this study focuses on and explain the policy-determining factors that emerged in the process of revising customized wages for the National Basic Livelihood Security Act on December 30, 2014. This is an analysis of the reasons why the rapid revision of the welfare system could have been made at a certain time in a situation that did not progress despite the specific demand for revision of the law surrounding the blind spot. To this end, using Kingdon's policy flow model, which emphasizes the contingency of policy decisions, the flow of problems, political flows, and policy alternatives were reviewed respectively. In the course of each of these flows, the suicide incident of mother and 2 daughters in Songpa served as a major medium that played a large role in the policy-making process and the window of policy could be opened. As a result, This incident triggered social and policy interest in the issue of the National Basic Livelihood Security Act. It was found that the law was revised quickly, causing a great wave of waves as a social issue.

• Journal of Microbiology and Biotechnology
• /
• v.30 no.12
• /
• pp.1885-1895
• /
• 2020

Rumex japonicus Houtt (RJH) is a valuable plant used in traditional medicine to treat several diseases, such as scabies and jaundice. In this study, Jurkat cell growth inhibitory extracts of R. japonicus roots were subjected to bioassay-guided fractionation, resulting in the isolation of three naphthalene derivatives (3-5) along with one anthraquinone (6) and two phenolic compounds (1 and 2). Among these compounds, 2-methoxystypandrone (5) exhibited potent anti-proliferative effects on Jurkat cells. Analysis by flow cytometry confirmed that 2-methoxystypandrone (5) could significantly reduce mitochondrial membrane potential and promote increased levels of mitochondrial reactive oxygen species (ROS), suggesting a strong mitochondrial depolarization effect. Real-time quantitative polymerase chain reaction (qPCR) analysis was also performed, and the results revealed that the accumulation of ROS was caused by reduced mRNA expression levels of heme oxygenase (HO-1), catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD). In addition, 2-methoxystypandrone (5) triggered strong apoptosis that was mediated by the arrest of the G0/G1 phase of the cell cycle. Furthermore, 2-methoxystypandrone (5) downregulated p-IκB-α, p-NF-κB p65, Bcl2, and Bcl-xl and upregulated BAX proteins. Taken together, these findings revealed that 2-methoxystypandrone (5) isolated from RJH could potentially serve as an early lead compound for leukemia treatment involving intracellular signaling by increasing mitochondrial ROS and exerting anti-proliferative effects.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.25 no.2
• /
• pp.119-143
• /
• 2021

Selecting liquid methane as fuel is a prevailing trend for recent rocket engine developments around the world, triggered by its affordability, reusability, storability for deep space exploration, and prospect for in-situ resource utilization. Given years of time required for acquiring a new rocket engine, a national-level R&D program to develop a methane engine is highly desirable at the earliest opportunity in order to catch up with this worldwide trend towards reusing launch vehicles for competitiveness and mission flexibility. In light of the monumental cost associated with development, fabrication, and testing of a booster stage engine, it is strategically a prudent choice to start with a low-thrust engine and build up space application cases.

• Journal of Korea Entertainment Industry Association
• /
• v.14 no.6
• /
• pp.201-208
• /
• 2020

The purpose of this study was to analyze the claim data of Health Insurance Review & Assessment Service to determine what factors affected the length of stay in patients aged 65 and older and undergoing total knee arthroplasty due to the principal diagnosis of gonarthrosis by the type of medical institutions. As a result of making an analysis, gender, age, medical security type, severity, residential area and the number of sickbeds were identified as the factors that influenced the length of stay in each type of medical institutions. At this point in time when an increase in the elderly population triggered by population aging and another subsequent increase in medical expenses put a heavy strain on household and national economy, it's necessary to consider how to shorten the length of stay and how to ensure the efficient management of sickbeds based on the findings of this study. In addition, this study is of significance in that it could be used as basic data on quality life-care for elderly patients by the introduction of a systematic management system geared toward lessening patient burden for medical expenses.

• International Journal of Advanced Culture Technology
• /
• v.11 no.3
• /
• pp.99-105
• /
• 2023

This thesis discusses a performer's unpredictability and immediacy as a prerequisite quality and/or ability to facilitate his/her professional identity as a doer on stage. To examine the key principles and approaches, this research focuses on addressing a specific aspect of the performer's transformative experience from those, directors, and practitioners' concepts that inform and enhance the performer's passive readiness on stage. To be precise, this research attempt to interrogate and articulate the place and role of a performer's internal readiness and/or that of inner looking. The performer's inner intensity as seed of action signifies that his/her body is being in a state of listening to every tiny moment with his/her heightened awareness which in turn lead the performer's body to meet the demands of theatre, the whole-body engagement. Here, this thesis argues that the key principles of acting/training underlies the importance of a performer's ethical attitude and at the same time his/her responsibility for what the performer's choices and experiences within the performative involvement, that is, a process of preparation, are not technical matter but rather, the concepts, and/or approaches from those theatre artists' practical assumptions highlight a process of thorough encountering and/or listening to his/her body. Inhabiting and/or obtaining the principles through the performer's body means being free from his/her unnecessary trait(s) which in turn initiate and then move the whole body according to what is happening in the series of moment(s) on stage. What is more, such an appropriate psychophysical order reminds us of the significance of the nature of human/performer's body, namely, to being in a state of one's 'own' body as oneness. From this perspective, this thesis further argues that the performer's body necessarily need to be affected and/or triggered in a sense of responding to the given circumstance where the performer is working on in the here and now.

• Journal of the Korean Geotechnical Society
• /
• v.22 no.7
• /
• pp.55-64
• /
• 2006

Shallow failures of slopes in weathered soils are caused by infiltration caused by prolonged rainfall. These failures are mainly triggered by the deepening of the wetting band accompanied by a decrease in suction induced by the water infiltration. In this paper, hysteresis on soil-water characteristic curve (SWCC) of granite and gneiss weathered soils is investigated using transient flow analysis respectively. Each case was subjected to artificial rainfall intensities and time duration depending on the laboratory-based drying and wetting processes. The results show that the unsaturated seepage on weathered slopes are very much affected by the initial suction of soils and unsaturated permeability of the soils. In addition, a granite weathered soil has a lower air-entry value, residual matric suction, and wetting front suction and less hysteresis loop than a gneiss weathered soil.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.22 no.1
• /
• pp.53-78
• /
• 2009

Purpose: In this study, we investigated the anti-thrombotic and antiinflammatory efficacy of "Gamijoukyungtang(GJKT)". Methods: We studied inhibitory effects of platelet aggregation, FXa activation, $TXB_2$ and $PGE_2$ biosynthesis and suppressive effects of GPIIb/IIIa activity and oxidative damage, pro-inflammatory cytokine reduction effects of 'GJKT(by press extractor)/GJKT-1(by pressless extractor)' in vitro. Also, we studied suppression of pulmonary embolism, AV shunt model in rats and shortening of Rat tail bleeding time in vivo. Results: GJKT/GJKT-1 extract showed inhibitory effects on GPIIb/IIIaactivities and platelet aggregation induced by ADP, epinephrine, collagen and arachidonic acid. They suppressed biosynthesis of $PGE_2$ but GJKT-1 only supressed biosynthesis of $TXB_2$. In FXa assay, they inhibited activation of FXa. they suppressed pulmonary embolism triggered by collagen and epinephrine. In AV shunt model, they decreased the weights of AV shunt thrombus. they inhibited pro-inflammatory cytokines and decreased oxidative damages caused by DPPH. Conclusion: We confirmed the anti-thrombosis, and ant-inflammatory efficacy of 'GJKT(by press extractor)/GJKT-1(by pressless extractor)'.