• 한국국방경영분석학회지
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• 제22권2호
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• pp.166-181
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• 1996

Aircraft survivability is determined by the susceptibility and the vulnerability. The aircraft susceptibility and vulnerability depend upon the hardware and software factors. Each of the hardware and software factors consisted of the qualitative and quantitative attributes varies according to the time of the mission. In order to establish the mathermatical model to analyze and evaluate the aircraft survivability, qualitative factors have to be transformed into quantitative factors. Even if many researches in the area of dynamic concept analysis and conversion of qualitative factors into the quantitative factors has been insufficient. This research enhances these insufficient area by developing a reliable aircarft survivability analysis method. The major areas of this research are as follows. First, a method for the conversion of the qualitative factors into the quantitative factors is developed by combining the Fuzzy Set Theory concept and the Delphi Technique. Second, by using the stochastic network diagram for the dynamic survivability analysis, the aircraft survivability and the probability of kill are calculated from the state probability for the situation during mission. The advantage of the analysis technique developed in this research includes ease of use and flexibility. In other words, in any given aircraft's mission execution under any variable probability density function, the developed computer program is able to analyze and evaluate the aircraft survivability.

• 미생물학회지
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• 제5권2호
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• pp.97-101
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• 1967

Up to the present time, there are only three methods by which we can obtain bacteria free crown gall tissue. According to some papers related to this field, the first method is based on the works of Braun(53') who maintained infected plants at 46-47'c for several days. But the method has a problem that very few plants can tolerate this temperature. The second method is based on the well known observation that old tumors appear to be bacteria free at least 1 or 2% of the explants. Also this method is known to us as laborious and time consuming. The third method is the one we were using that was attempting to kill the bacteria with bacteriacidal agent such as Antibiotics. In fact., it is reported that almost complete control of crown gall of tomato was obtained by Blanchard('51) when plants were grown in a nutrient containing Aureomycin(20${\mu}g$/ml) following needle puncture with the gall bacteria. We have been engaged in making the experiment by applying solution of Penicillin, Streptomycin and of Chloramphenicol(Succinate free) to find the strong bacteriacidal agent through the method of disc plate, and to confirm the effect of antimicrobial action through the method of plant tissue culture system without possible injury to the host plant. The result of this report is the fact the strongest bacteriacidal agent among the above three Antibiotics was Chloramphenicol(Succinate free 1000 p.p.m). and that there happened no injury to the tissue cultures in a White's 10X media containing 1000 p.p.m. of Chloramphenicol.

• 대한본초학회지
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• 제30권6호
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• pp.55-61
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• 2015

Objectives : Yongdamgosam-hwan(YGH) has been used as a traditional medicine from old times for antiinflammatory effects. Streptococcus mutans(S. mutans) is known as a prime bacteria responsible for causing caries by forming a biofilm referred to as dental plaque on the tooth surface. But antimicrobial activity of YGH with dental disease is not sufficiently understood. This study was designed to investigate the effects of YGH ethanol extract on antimicrobial effect against Streptococcus mutans.Methods : The antimicrobial effect of YGH ethanol extract was assessed by the paper disk diffusion method and optical density method to determine minimum inhibition concentration(MIC), also observed by fractional inhibitory concentration index(FICI) and time-kill assay to figure out the synergic effect on the combination of YGH ethanol extract with antibiotics.Results : The YGH ethanol extract 500 μg was 7.5-8.5 mm diameter of clear zone of inhibition against Streptococcus mutans in a concentration-dependent manner and MIC was 250 μg/mL. The administration of the ethanol extract in combination with gentamicin and streptomycin induced a reduction of ≥4-8-fold in all tested bacteria. Furthermore, time-kill study was found that a combination of YGH ethanol extract with oxacillin and streptomycin produced a more rapid decrease in the concentration of bacteria CFU/mL than the YGH ethanol extract or antibiotics alone.Conclusions : As a result, the YGH ethanol extract has good antimicrobial effects. And the results suggest that YGH could be employed as a natural antibacterial agent in dental care products.

• 한국정보통신학회논문지
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• 제20권5호
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• pp.1040-1048
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• 2016

최근 전투 시스템의 신뢰도를 분석하는 것에 대한 연구가 활발하게 진행되고 있으며, 특히 선행 연구의 한계점을 보완하기 위한 연구와 보다 통합적인 분석에 관한 연구의 필요성이 강조되고 있다. 본 논문에서는 선행 연구에서 분석된 전면과 측면의 피격 확률을 활용하여 시간-효율성을 향상시키기 위한 통합 피격 확률 도출 기법을 제안한다. 또한 도출된 통합 피격 확률을 기반으로 각 구성 요소의 신뢰도를 구하고, 전체 전투 시스템의 기능별 신뢰도를 분석하기 위하여 RBD 기법을 적용하는 방법을 제안한다. 전차 모델에 적용하여 신뢰도 분석을 수행하였으며, 이를 통해 제안하는 방법의 유용성을 검증하였다. 제안하는 방법은 선행 연구에서는 고려되지 않았던 승무원까지도 고려하며, 분석된 기능별 신뢰도는 선행 연구 대비 분석의 정확도 및 시간-효율성을 향상시킬 수 있을 것으로 기대된다.

• Journal of Microbiology and Biotechnology
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• 제24권8호
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• pp.1059-1064
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• 2014

Staphylococcus aureus is a major human pathogen, implicated in both community and hospital acquired infections. The therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections is becoming more difficult because of multidrug resistance and strong biofilm-forming properties. Schiff bases have attracted attention as promising antibacterial agents. In this study, we investigated the in vitro activity of taurine-5-bromosalicylaldehyde Schiff base (TBSSB) against MRSA. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC) were determined using a microtiter broth dilution method. TBSSB effectively inhibited planktonic MRSA, with an MIC of $32{\mu}g/ml$. The time-kill curve confirmed that TBSSB exhibited bactericidal activity against MRSA. TBSSB was also found to significantly inhibit MRSA biofilm formation at 24 h, especially at $1{\times}MIC$ and sub-MIC levels. Furthermore, scanning electron microscopy and transmission electron microscopy showed remarkable morphological and ultrastructural changes on the MRSA cell surface, due to exposure to TBSSB. This study indicated that TBSSB may be an effective bactericidal agent against MRSA.

• 한방재활의학과학회지
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• 제23권3호
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• pp.15-26
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• 2013

Objectives The aim of this study was to investigate antimicrobial activity of Huanggeumjakyak- tang water extract against MRSA. Methods The antibacterial activities of Huanggeumjakyak-tang were evaluated against 3 strains of Methicillin-resistant Staphylococcus aureus (MRSA) and 1 standard Methicillinsusceptible S. aureus (MSSA) strain by using the disc diffusion method, minimal inhibitory concentrations (MICs) assay, colorimetric assay using MTT test, checkerboard dilution test and time-kill assay was performed under dark. Results The MIC (minimum inhibitory concentration) of Huanggeumjakyak-tang water extract against S. aureus strains ranged from 1,000 to $2,000{\mu}g/ml$. So we confirmed that it has a strong antibacterial effect. Also the combinations of Huanggeumjakyak-tang water extract and conventional antibiotics exhibited improved inhibition of MRSA with synergy effect. Conclusions The results obtained in this study suggest that Huanggeumjakyak-tang water extract showed antibacterial effect against MRSA, and it also showed reducing effect on the side-effect problems that are the major weak points of traditional antibiotics.

• 융합보안논문지
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• 제22권3호
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• pp.25-32
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• 2022

최근 이미지 인식 및 탐지 분야에 딥러닝 기반의 기술이 도입되면서 영상 처리 산업이 활성화되고 있다. 딥러닝 기술의 발전과 함께 적대적 공격에 대한 학습 모델 취약점이 계속해서 보고되고 있지만, 학습 시점에 악의적인 데이터를 주입하는 포이즈닝 공격의 대응 방안에 대한 연구가 미흡한 실정이다. 종래 포이즈닝 공격의 대응 방안은 매번 학습 데이터를 검사하여 별도의 탐지 및 제거 작업을 수행해야 한다는 한계가 있었다. 따라서, 본 논문에서는 포이즌 데이터에 대해 별도의 탐지 및 제거과정 없이 학습 데이터와 추론 데이터에 약간의 변형을 가함으로써 공격 성공률을 저하시키는 기법을 제안한다. 선행연구에서 제안된 클린 라벨 포이즌 공격인 원샷킬 포이즌 공격을 공격 모델로 활용하였고, 공격자의 공격 전략에 따라 일반 공격자와 지능형 공격자로 나누어 공격 성능을 확인하였다. 실험 결과에 따르면 제안하는 방어 메커니즘을 적용하면 종래 방법 대비 최대 65%의 공격 성공률을 저하시킬 수 있었다.

• 한국지능시스템학회논문지
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• 제25권5호
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• pp.495-501
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• 2015

해상에서 운용되는 함정은 다양한 위협에 둘러싸여 있는데 그중에서도 가장 위협적인 것은 다양한 환경과 플랫폼에서 발사가 가능한 대함미사일이다. 대함미사일은 함정의 레이더나 전자전 장비에 대하여 회피 기능까지 보유하고 있어 함정에 치명적인 피해를 줄 수 있다. 대함미사일에 의한 함정에 직접적인 피해를 줄이는 능동기만기는 대함미사일이 함정 대신 기만기를 추적하도록 유인하여 함정의 생존성을 높이는 장비로써 대함미사일 방어에 효과적인 방법이다. 본 논문에서 제안 기법은 해상 환경에서 함정의 능동기만기를 사용하여 대함미사일에 대응하기 위해 시뮬레이션 방법론인 DEVS (Discrete Event System Specification)를 적용하여 능동기만기의 효과적인 운용 시간을 검증한다. 이를 위해 함정, 대함미사일, 그리고 능동기만기를 각각 모델링하고 정의된 모델을 결합하여 시뮬레이션을 수행하였다. 시뮬레이션 수행을 통해 도출된 결과는 수동형 기만기, 체공 고정형 기만기, 그리고 이동형 능동기만기 중에서 이동형 능동기만기의 운용 시간 우수성을 검증했고, 대함미사일로부터 함정 방어를 위한 이동형 능동기만기의 운용 시간에 따른 방어구역을 추정하였다.

• International Journal of Advanced Culture Technology
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• 제6권4호
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• pp.275-283
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• 2018

Cancer show distinct pattern of gene expression when it is compared to normal. This difference results malignant characteristic of cancer. Many cancer drugs are targeting this difference so that it can selectively kill cancer cells. One of the recent demand for personalized treating cancer is retrieving normal tissue from a patient so that the gene expression difference between cancer and normal be assessed. However, in most clinical situation it is hard to retrieve normal tissue from a patient. This is because biopsy of normal tissues may cause damage to the organ function or a risk of infection or side effect what a patient to take. Thus, there is a challenge to estimate normal cell's gene expression where cancers are originated from without taking additional biopsy. In this paper, we propose in-silico based prediction of normal cell's gene expression from gene expression data of a tumor sample. We call this challenge as reverting the cancer into normal. We divided this challenge into two parts. The first part is making a generator that is able to fool a pretrained discriminator. Pretrained discriminator is from the training of public data (9,601 cancers, 7,240 normals) which shows 0.997 of accuracy to discriminate if a given gene expression pattern is cancer or normal. Deceiving this pretrained discriminator means our method is capable of generating very normal-like gene expression data. The second part of the challenge is to address whether generated normal is similar to true reverse form of the input cancer data. We used, cycle-consistent adversarial networks to approach our challenges, since this network is capable of translating one domain to the other while maintaining original domain's feature and at the same time adding the new domain's feature. We evaluated that, if we put cancer data into a cycle-consistent adversarial network, it could retain most of the information from the input (cancer) and at the same time change the data into normal. We also evaluated if this generated gene expression of normal tissue would be the biological reverse form of the gene expression of cancer used as an input.

• 융합보안논문지
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• 제17권5호
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• pp.153-161
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• 2017

미래의 전쟁은 정보우위와 전장의 가시화를 통한 신속한 지휘결심체계가 구축되어 있어야 전쟁의 승리를 보장 받을 수 있다. 전장감시, 지휘결심, 타격을 위한 전 과정이 네트워크를 통하여 모든 전투원이 정보를 실시간 공유하여, 지휘결심과 이를 수행하는 말단 전투원까지 일치감이 조성되어 전투를 수행하여야 승리를 보장 받을 수 있다. 즉 GPS, 무인정찰기에서 보내오는 영상정보, 첩보위성에서 보내는 정보를 실시간 수집하고 네트워크화 함으로서 정보우위를 달성할 수 있다. NCW는 미래 작전유형이 작전에 참여하는 모든 요소들의 네트워킹에 의해 유기적으로 연동되는 네트워크 중심 전장을 의미한다. 따라서 정보수집센서, 지휘 결심, 타격체계들이 지리적 여건에 제한되지 않고 네트워킹 되어 전투에 참여하는 지휘관에서부터 각개 병사에 이르기까지 원하는 시간에 원하는 정보를 획득할 수 있는 전쟁수행개념을 말한다. 미래의 전쟁은 확장된 전장공간으로 지상, 공중, 해상, 우주, 사이버 등 5차원 공간이 될 것이다. 네트워크 중심의 정밀 타격을 위하여 C4ISR+PGM과 Soft Kill 전자정보전이 요구될 것이다. NCW의 체계를 이해하고 이를 전투력향상에 적용하여 보고자 한다.