• 대한전자공학회논문지SD
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• 제46권10호
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• pp.53-60
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• 2009

반도체 공정의 발달로 집적도가 증가하고 문턱전압이 감소하면서, 반도체 집적회로 소모 전력에서 누설전류(leakage current)의 비중이 점차 증가하고 있다. 대기 상태에서 CMOS 조합 회로(combinational circuit)는 입력 값에 따라 누설전류가 크게 달라진다. 본 연구에서는 누설전류로 인한 소모전력을 줄이기 위해 대기 상태 (standby state) 회로의 입력 신호를 제어하며, 작은 누설전류를 갖는 입력 신호를 찾기 위한 새로운 효율적인 알고리즘을 개발하였다. 이 방법을 벤치마크 예제에 실험적으로 적용하여 누설전류 평균값에 비해 15.7%, simulated evolution 방법에 비해 6.7% 누설전류를 줄일 수 있음을 보였다. 또한 순차 회로에서도 idle 입력을 이용하여 누설전류 평균값에 비해 6.8%, simulated evolution 방법에 비해 3.2% 누설전류를 줄일 수 있었다.

• 전자공학회논문지 IE
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• 제45권3호
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• pp.27-35
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• 2008

본 논문은 다중 가스 필터 휠 (multi gas filter correlation wheel: multi GFC wheel)을 갖는 비분산 적외선법(NDIR method : non-dispersive infrared method)을 이용하여 대기 중 다종환경오염물질(CO, $SO_2$, NOx 등)을 동시에 실시간 측정할 수 있는 광학분석장치 개발을 위한 미세신호 검출 알고리즘을 제안한다. MCT(mercury cadmium telluride) 센서를 통해 측정된 각각의 환경오염물질의 미세신호는 고유한 NDIR 흡수 특성을 갖는다. 제안한 방법은 임계값과 하나의 외부 동기신호를 사용하여 연속적으로 측정된 신호로부터 각각의 오염물질 특정농도에 해당하는 데이터를 분리 검출한다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3211-3217
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• 2014

Background: The current study investigated the effects of Piper longumine on radio-sensitization of human breast cancer MDA-MB-231 cells and underlying mechanisms. Materials and Methods: Human breast cancer MDA-MB-231 cells were cultured in vitro and those in logarithmic growth phase were selected for experiments divided into four groups: control, X-ray exposed, Piper longumine, and Piper longumine combined with X-rays. Conogenic assays were performed to determine the radio-sensitizing effects. Cell survival curves were fitted by single-hit multi-target model and then the survival fraction (SF), average lethal dose ($D_0$), quasi-threshold dose ($D_q$) and sensitive enhancement ratio (SER) were calculated. Cell apoptosis was analyzed by flow cytometry (FCM). Western blot assays were employed for expression of apoptosis-related proteins (Bc1-2 and Bax) after treatment with Piper longumine and/or X-ray radiation. The intracellular reactive oxygen species (ROS) level was detected by FCM with a DCFH-DA probe. Results: The cloning formation capacity was decreased in the group of piperlongumine plus radiation, which displayed the values of SF2, D0, Dq significantly lower than those of radiation alone group and the sensitive enhancement ratio (SER) of D0 was1.22 and 1.29, respectively. The cell apoptosis rate was increased by the combination treatment of Piper longumine and radiation. Piper longumine increased the radiation-induced intracellular levels of ROS. Compared with the control group and individual group, the combination group demonstrated significantly decreased expression of Bcl-2 with increased Bax. Conclusions: Piper longumine at a non-cytotoxic concentration can enhance the radio-sensitivity of MDA-MB-231cells, which may be related to its regulation of apoptosis-related protein expression and the increase of intracellular ROS level, thus increasing radiation-induced apoptosis.

• Composites Research
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• 제23권3호
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• pp.50-57
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• 2010

섬유 보강 시멘트계 복합재료의 성능 예측 및 평가에 있어서 중요한 영향을 미치는 섬유 분포 특성을 정량적으로 평가하기 위해서는 복합재료의 단면 이미지에서 섬유를 정확히 검출하여야 한다. 이 논문은 형광원리를 이용하여 합성섬유를 매트릭스로부터 개별적으로 검출하기 위한 기초 연구로써 섬유 보강 시멘트계 복합재료 중의 하나인 ECC에 일반적으로 사용되는 PVA 섬유, PET 섬유, PE 섬유, 그리고 PP 섬유의 형광특성을 분석하였다. 또한 하이브리드 된 경우 합성섬유들 간의 상대 형광 광도값의 차이를 비교하여 종류별로 구분하기 위한 최적의 파장대를 선정하였으며, 그 파장대에서 두 분류대상을 구별할 수 있는 최적의 경계값을 통계적 방법을 이용하여 산출하였다. 또한 형광 현미경을 이용하여 각 섬유를 촬영하여 상대적인 밝기값을 비교하였다.

• 한국의학물리학회지:의학물리
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• 제21권4호
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• pp.354-359
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• 2010

뇌하수체 종양의 치료 계획 시 다양한 영상 융합 프로토콜이 실제 PTV (planning target volume) coverage 및 OAR (organ at risk) 보호에 미치는 선량학적 영향을 확인하고자 하였다. 선량 체적 히스토그램(DVH, dose volume histogram)을 이용하여 각 프로토콜 별 실제 PTV의 coverage 및 그 변화 그리고 시각경로(optic pathway) 및 뇌간(brainstem)의 최대 흡수 선량과 임계 선량을 초과한 체적을 획득하였고 축상면(axial plane)과 관상면(coronal) 영상을 함께 사용하여 S-I (superior-inferior) 방향의 불확정도를 보정한 영상 융합 프로토콜이 축상면 만을 이용한 경우보다 시각경로 및 뇌간의 최대 흡수 선량과 임계 선량을 초과한 체적 모두 감소된 수치를 보임을 확인 하였다. 본 case에 한해 축상면 그리고 관상면 영상을 함께 사용하는 것이 OARs 보호에 가중치를 둔 방사선 수술 치료 계획 수립에 도움을 줄 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5149-5153
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• 2012

Introduction: This study assessed the relationship of E-cadherin mRNA and protein expression with the diagnosis of lung cancer with the aim of providing an auxiliary diagnostic method. Methods: Semi-quantitative nested RT-PCR and western blotting were applied to detect E-cadherin mRNA transcripts and protein, respectively, in 30 cases of diagnostic lung cancer, 30 cases of clinically suspected patients with lung cancer and 30 cases of other disease. Immunohistochemical staining was also used to detect E-cadherin. Results: Remarkably decreased levels of relative E-cadherin mRNA value and increased E-cadherin protein negativity were observed in probable lung cancer, when compared with possible lung cancer and others. With a threshold of 1.45, relative E-cadherin mRNA value showed a sensitivity of 90% and a specifity of 83% for the diagnosis of lung cancer. The combination of decreased relative E-cadherin mRNA value and negative E-cadherin protein increased the specificity and sensitivity. Conclusion: These data suggest that Chinese patients with diagnostic lung cancer have similar decreased levels of relative E-cadherin mRNA and E-cadherin protein value in the lung cancer tissues as in lung cancer patients in other countries. Measurement of relative E-cadherin mRNA and protein values in lung cancer tissues has potential for lung cancer diagnosis.

• 한국주조공학회지
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• 제25권1호
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• pp.16-22
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• 2005

This study aims to investigate the effects of the microstructures and nodule type on the fatigue characteristics of cast iron. Fatigue tests were carried out in tension-tension mode using a servo-hydraulic testing machine with load control mode operating at a frequency of 15 Hz. The tests were conducted at stress ratio R=Kmin/Kmax, of 0.1. Initial crack ${\Dalta}K$ values were highly performed with increase in tensile strength of DCI fatigue specimens. ${\Dalta}K_{th}$ region, fatigue crack propagation was primarily advanced through cell boundary and in periphery of near nodule. Fatigue crack propagation rate of D2 consisted with 2Phase(Ferrite+Pearlite) was slow due to crack closure enhanced by crack deflection and occurred crack branching. The generation of crack branch was occurred due to interaction of crack-nodule. At Threshold and Paris zone, the fractographs of the fatigue fracture surface for DCI show typical striations of a ductile fracture and isolated cleavage planes near graphite. The effect of microstructure on fatigue crack propagation of GC strongly depends on the type of flake. The generation of crack branch occurred due to interaction of crack-nodule. The fractographs of the fatigue fracture surface for GC show cleavage plane along the flake graphite.

• Fisheries and Aquatic Sciences
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• 제3권2호
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• pp.111-117
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• 2000

To clarify the ichthyotoxic mechanisms of a harmful dinoflagellate Cochlodinium polykrikoides, hematological responses of the flounder Paralichthys olivaceus and red sea bream Pagrus major exposed to this algal bloom were investigated. The mortality of red sea bream was considerably larger than that of flounder, and the threshold lethal density of C. polykrikoides to the test fish was approximately 3,000 cells/ml. Blood $PO_2$declined in proportion to the increasing density of algal cells. The blood $PO_2$ of moribund fish was about $40-60\% of control test fish. Particularly, the fishes began to be killed when the blood $PO_2$ fell below 30-40 mmHg. However, the blood pH dropped almost 1.0 unit just before fish kill. Hemoglobin and hematocrit levels of fish exposed to C. polykrikoides of 5,000 cells/ml for 24 h and of moribund fish did not show great difference. The concentrations of plasma $Na^+$, $K^+$ and $Cl^-$ were slightly elevated to different magnitudes except $Ca^{2+}$ and plasma osmolality was also increased in Cochlodinium-exposed fish. In the plasma cortisol level, these values of moribund flounder and red sea bream were 4- 5 times higher than those of control fish. These results suggest that the drop of blood $PO_2$ was may be one of the principal causes of fish kill by C. polykrikoides, and the changes of other hematological parameters were secondary responses elicited by the decrease in blood $PO_2$.

• 대기
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• 제18권4호
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• pp.267-277
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• 2008

The occurrence and strength of the Asian Dust over the Korea Peninsular have been increased by the expansion of the desert area. For the continuous monitoring of the Asian Dust event, the geostationary satellites provide useful information by detecting the outbreak of the event as well as the long-range transportation of dust. The Infrared Optical Depth Index (IODI) derived from the MTSAT-1R data, indicating a quantitative index of the dust intensity, has been produced in real-time at Korea Meteorological Administration (KMA) since spring of 2007 for the forecast of Asian dust. The data processing algorithm for IODI consists of mainly two steps. The first step is to detect dust area by using brightness temperature difference between two thermal window channels which are influenced with different extinction coefficients by dust. Here we use dynamic threshold values based on the change of surface temperature. In the second step, the IODI is calculated using the ratio between current IR1 brightness temperature and the maximum brightness temperature of the last 10 days which we assume the clear sky. Validation with AOD retrieved from MODIS shows a good agreement over the ocean. Comparison of IODI with the ground based PM10 observation network in Korea shows distinct characteristics depending on the altitude of dust layer estimated from the Lidar data. In the case that the altitude of dust layer is relatively high, the intensity of IODI is larger than that of PM10. On the other hand, when the altitude of dust layer is lower, IODI seems to be relatively small comparing with PM10 measurement.

• 한국콘텐츠학회논문지
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• 제10권4호
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• pp.45-54
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• 2010

본 논문에서 우리는 차세대 통합망 환경에서 다양한 멀티미디어 서비스를 이용하는 서비스 이용자의 체감 품질이 저하될 경우 체감 품질과 관련된 QoS 파라미터를 네트워크 계층에서 제어함으로써 품질 만족도를 향상시킬 수 있는 품질 연동 제어 시스템을 제안한다. 제안된 시스템은 RTCP와 같은 제어 패킷을 통해 네트워크 계층의 QoS 파라미터 정보를 수집하고 이 수집된 정보를 이용하여 멀티미디어 서비스의 QoE를 평가한다. 이렇게 평가된 QoE와 응용계층에서 측정된 QoE와 비교하여 기준값보다 낮을 경우 품질 저하로 판단하고 이와 관련된 QoS 파라미터 도출 및 각 파라미터의 상대적 중요도를 결정한다. 결정된 정보를 토대로 QCS는 서비스 품질 제어 시스템(SCS)에서 각 라우터 및 스위치에 적용하는 정책(policy)의 기반이 될 수 있는 QoS 제어값 정보를 생성하여 SCS로 전송한다. 이런 제안된 시스템을 통해 서비스 및 네트워크 사업자들은 서비스 특성 및 네트워크 상황을 고려하여 서비스 이용자에게 향상된 품질의 멀티미디어 서비스를 제공할 수 있다.