• Title/Summary/Keyword: thermo-sensitive

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Thermo-sensitive lipid nanoparticles as a novel topical delivery system of retinol

  • Jee, Jun-Pil;Lee, Mi-Kyung;Kim, Chong-Kook
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.425.2-425.2
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    • 2002
  • The purpose of this study was to prepare thermo-sensitive solid-lipid nanoparticles (SLNs) with a lipid melted at human body temperature and to evaluate physicochemical properties of SLNs containing retinol. anti-wrinkle agent. as a model drug. SLNs were prepared using a high pressure homogenizing method. The SLNs were composed of retinol as a model drug. thermo-sensitive lipid (DS-CBS) as a lipid core. and egg phosphatidylcholine and Tween 80 as surfactants. Manufacturing variables such as homogenization pressure. (omitted)

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Experimental study of heat transfer in the surrounding for bubble attached at the upper cooled surface of square cavity using the Thermo-sensitive Liquid-crystal Tracer (열감응액정을 이용한 사각공동내의 상단냉각평판에 형성된 기포 주위의 열전달현상 구명)

  • Kwon, Gi-Han;Eom, Yong-Kyoon
    • Proceedings of the KSME Conference
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    • 2001.06d
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    • pp.509-515
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    • 2001
  • In a square cavity, the flow phenomena in the surrounding of the bubble attached at the upper cooled solid wall were studied by using a thermo-sensitive liquid-crystal tracer and image processing techniques. This method offers the advantage of measuring the entire flow field in a selected plane within the fluid at a given instant of time in contrast to point by point method like T/C. Quantitative data of the temperature were obtained by applying a colour-image-processing to the. visualized image. As the growing of a bubble, In a bubble size appears the flow phenomena which the direction of flow is reversed in the entire temperature and flow field. The observed phenomena are described with regard to thermocapillary convection.

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Thermo-sensitive Clothing Development by Consumer Investigation and Wearing Test (소비자 조사와 착의 실험을 통한 온도감응형 기능성 의류개발을 위한 기초연구)

  • Sang, Jeong-Seon;Chung, Kyunghwa;Park, Juhyun;Oh, Kyung Wha
    • Fashion & Textile Research Journal
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    • v.19 no.1
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    • pp.90-100
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    • 2017
  • In this research, consumer awareness investigation and wearing test were carried out for obtaining useful data on the development of thermo-sensitive functional clothing material. A survey involved 216 people in Seoul and Kyeonggi-do, and 200 questionnaires data were analyzed by descriptive statistics and frequency using SPSS 17.0. Four healthy men in twenties were participated for wearing test. Subjects in normal loungewear were exposed to temperature change from the initial temperature $30^{\circ}C$ down to $5^{\circ}C$ for an hour in a climate chamber. The environmental temperature, surface temperature of garment and skin were measured. As a result, most of respondents have all season clothing products such as underwear, hosiery, and jogging suit for loungewear. Also, thermo regulator y functional clothes are frequently used as underwear and sweat shirt. The consumer awareness investigation on thermo regulatory functional clothing showed that the most important key buying factor is quick climate temperature response, easy maintenance, design and cost, in that order. Surface temperature of garment went down with the cooling down of environmental temperature. The lower environmental temperature, the greater temperature difference by body part showed. Skin temperature change by environmental temperature showed similar tendency of garment surface temperature. In comparison between garment surface and body skin, temperature difference became larger under the lower environmental temperature.

The Applications of the Duplex Stainless Steel as Hyperthermia Materials

  • Kim, Young-Kon
    • Proceedings of the Materials Research Society of Korea Conference
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    • 2009.05a
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    • pp.7.1-7.1
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    • 2009
  • The use of Duplex stainless steel as a thermo-implant categorizes into two clinical applications: hyperthermia and thermal ablation or destruction. The goal of hyperthermia is to destroy the heat-sensitive abnormal cells and minimize normal cell death maintaining heat between $42^{\circ}C$ and $46^{\circ}C$. Thermal ablation takes place when the local tissue temperature increases greater than $46^{\circ}C$. This elevated temperature denatures protein irreversibly resulting cellular death. The author introduced several thermo-implants such as thermo-rod, thermo-stent, thermo-coil and thermoacupuncture-needle. Those thermo-implants are made of duplex stainless steel which can produce regulated heat by itself within an induction magnetic field. Thermal ablation characteristics of the thermo-rod on tumor hyperthermia depend on configurations of the thermo-rods and the magnitude of the induction magnetic strength. The exothermic properties of the thermo-implants can be characterized using the calorimetric test and the heat affected zone(HAZ) analyses in vitro. Thermal radiation studies using thermo-coils and thermo-stents show the capability of the occlusion of animal blood vessels and inhibiting the proliferation of the abnormal smooth muscle cell growth and inflammatory cell reactions maintaining the heat between $42^{\circ}C$ and $46^{\circ}C$ minimizing a normal cell death in the study on external iliac artery of the New Zealand White (NZW) rabbit. Thermal stimulation study using thermo-acupuncture needles suggests the potential applications of the automated acupunctural therapies.

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Thermo-Sensitive Polyurethane Membrane with Controllable Water Vapor Permeation for Food Packaging

  • Zhou, Hu;Shit, Huanhuan;Fan, Haojun;Zhou, Jian;Yuan, Jixin
    • Macromolecular Research
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    • v.17 no.7
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    • pp.528-532
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    • 2009
  • The size and shape of free volume (FV) holes available in membrane materials control the rate of gas diffusion and its permeability. Based on this principle, a segmented, thermo-sensitive polyurethane (TSPU) membrane with functional gate, i.e., the ability to sense and respond to external thermo-stimuli, was synthesized. This smart membrane exhibited close-open characteristics to the size of the FV hole and water vapor permeation and thus can be used as smart food packaging materials. Differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), positron annihilation lifetimes (PAL) and water vapor permeability (WVP) were used to evaluate how the morphological structure of TSPU and the temperature influence the FV holes size. In DSC and DMA studies, TSPU with a crystalline transition reversible phase showed an obvious phase-separated structure and a phase transition temperature at $53^{\circ}C$ (defined as the switch temperature and used as a functional gate). Moreover, the switch temperature ($T_s$) and the thermal-sensitivity of TSPU remained available after two or three thermal cyclic processes. The PAL study indicated that the FV hole size of TSPU is closely related to the $T_s$. When the temperature varied cyclically from $T_s-10{\circ}C$ to $T_s+10^{\circ}C$, the average radius (R) of the FV holes of the TSPU membrane also shifted cyclically from 0.23 to 0.467 nm, exhibiting an "open-close" feature. As a result, the WVP of the TSPU membrane also shifted cyclically from 4.30 to $8.58\;kg/m^2{\cdot}d$, which produced an "increase-decrease" response to the thermo-stimuli. This phase transition accompanying significant changes in the FV hole size and WVP can be used to develop "smart materials" with functional gates and controllable water vapor permeation, which support the possible applications of TSPU for food packaging.

Highly sensitive temperature sensor based on etched fiber with thermally expanded core (식각된 열확산 코어 광섬유를 이용한 고감도 온도 센서)

  • Kim, Kwang-Taek;Song, Hyun-Suk;Shin, Eun-Soo;Hong, Ki-Bum
    • Journal of Sensor Science and Technology
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    • v.15 no.4
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    • pp.263-268
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    • 2006
  • We have demonstrated a highly sensitive temperature sensor using an etched single mode fiber with a thermally expanded core region. Large core size of thermally expanded core facilitates access to evanescent wave by the wet etching. The etched region was surrounded by a low dispersive external medium with high thermo-optic coefficient. Due to the large difference between the dispersion property of the fiber and that of the external medium, the device reveals a cut-off properties at spectral region. The cut-off wavelength was shifted by the variations of the environmental temperatures because of thermo-optic effect of the external medium. The sensitivity of the fabricated device was found to be $45nm/^{\circ}C$.

Synthesis and Characterization of Thermo Sensitive Poly(styrene-co-N-isopropylacrylamide) Microgels (열 감응성 Poly(styrene-co-N-isopropylacrylamide) 마이크로겔의 합성 및 특성)

  • Cho, Suk Hyeong;Kim, Kong Soo;Jung, Tea Uk
    • Applied Chemistry for Engineering
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    • v.16 no.3
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    • pp.397-402
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    • 2005
  • Core-shell Poly(styrene-co-N-isopropylacrylamide) (poly(St-co-NIPAm) was prepared by soap-free emulsion polymerization of styrene (St) and N-isopropylacrylamide (NIPAm) in aqueous solution with potassium persulfate (KPS) as an initiator. The effects of St/NIPAm ratio, concentrations of monomer and crosslinker were studied. Also, Thermo sensitivity of microgels prepared was investigated. Particle size of microgels increased with increasing mol ratio of NIPAm to styrene. Transmittance of the microgel dispersion decreased rapidly when heated above a low critical solution temperature (near $32{\sim}34^{\circ}C$, cloud point). Swelling ratio of the microgel increased with increasing of the concentration of monomer (NIPAm) and decreased proportional to the concentration of crosslinker.

THERMO-SENSITIVITY OF N-VINYL PYRROLODONE-CO-2- HYDROXYETHYLMETHACRYLATE HYDROGELS

  • Irina Nam;Park, Jung-Ki;Lee, Seong-Nam;Sung, Shi-Joon;Min, Yong-Jin
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2004.05a
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    • pp.9-15
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    • 2004
  • The copolymerization of HEMA with different hydrophilic and hydrophobic co-monomers allows for the manipulation of their intrinsic properties. 2-Hydroxyethylmethacrylate (HEMA)-based hydrogels thus are of great interest due to their outstanding physico-mechanical properties and chemical stability. The idea to use HEMA in order to create thermo-sensitive polymers was based on our assumption that thermal-sensitivity comes from a suitable hydrophilic-hydrophobic balance of macromolecules. In this work we have chosen N-vinyl pyrrolidone as a hydrophilic co-monomer with the relatively hydrophobic HEMA due to its good polymerizing properties as well as its non-toxicity in a polymer state and deserved recognition as a biocompatible material. As a result, copolymerization of NVP and HEMA was successful in obtaining new types of thermo-sensitive polymers composed of hydrophilic and hydrophobic monomers.

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