• Tuberculosis and Respiratory Diseases
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• v.59 no.4
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• pp.423-426
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• 2005

Imatinib-mesylate (Gleevec, Glivec) is a protein-tyrosine kinase inhibitor that inhibits the Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality in CML. Imatinib is also used to treat patients with c-kit (CD 117)-positive unresectable tumors, or metastatic malignant gastrointestinal stromal tumors, or both. Imatinib is a welltolerated drug with few side effects. However, it has been associated with gastrointestinal irritation, fluid retention and edema, skin rashes, depigmentation, hepatotoxicity, hemorrhage, and hematological toxicity (anemia, neutropenia, and thrombocytopenia). In addition, imatinib has been associated with dyspnea and cough, which are mainly secondary to the pleural effusion and pulmonary edema, which represent local or general fluid retention. These events appear to be dose related and are more common encountered in the elderly. However, there has been no report of hypersensitivity pneumonitis associated with imatinib-mesylate in Korea. We report a case of 51-year old woman who developed hypersensitivity pneumonitis that might have been induced by imatinib-mesylate during the treatment of a gastrointestinal stromal tumor.

• Tuberculosis and Respiratory Diseases
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• v.40 no.6
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• pp.646-652
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• 1993

Background: Lung cancer and chronic obstructive lung disease often coexist in the same person who are elderly and cigarette smoking. There are several reports that the presence of chronic obstructive pulmonary disease constitutes an independent risk factor for the development of lung cancer. Moreover, the association between mucus hypersecrtion and lung cacer has been reported. Method: In 72 cases with primary lung cancer which were confirmed histopathologically at Chonbuk University Hospital from August 1986 to July 1991, We evaluated the relationship between spirometry and lung cancer characteristics. Results: Six cases(8.3%) showed normal lung function, 16(22.2%) cases showed pure restrictive lung disease, 46(63.9%) cases showed moderated obstructive lung disease and 4(5.6%) cases showed severe obstructive lung disease. $FEV_1$(%) was lower in central type than in peripheral type, lower in advanced non-small cell cancer and lower in subjects with phlegm. $FEV_1$/FVC(%) was higher in small cell cancer than in squamous cell cancer and higher in patients without previous pulmonary disease than with previous pulmonary disease. But there was no statistically significant difference in lung function according to histologic types and smoking history. Lung cancers with $FEV_1$/FVC less than 75% consisted of 35 cases of squamous cell cancer, 7 of small cell cancer(14%), 5 of adenocarcinoma(10%), 2 of large-cell carcinoma and 1 of unclassified carcinoma. Squamous cell carcinoma occured more in patients with $FEV_1$/FVC<75% than with $FEV_1$/FVC$\geq$75%(p<0.05). Conclusion: It was suggest that low $FEV_1$/FVC, as reflection of obstructive lung disease, may be at greater risk for squamous cell carcinoma in cigarette smoker.

• 재활복지
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• v.20 no.3
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• pp.141-161
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• 2016

This research is to anticipate problems of Ray's disabled experiment welfare vehicles for 17 drivers with disability, improving them. In addition it is to provide the criteria for ergonomic design based on perspective of drivers with disability by investigating 18 items of usability test. The results are as follows. First, satisfaction degree of Ray, disabled experiment welfare vehicle, was shown to be 3.88 which is higher than normal vehicles whose degree is 3.20. This showed that the disabled experiment welfare vehicle is the one with much improvement. Second, so as to develop a welfare vehicle it needs to take into account some factors including rear slope, wheelchair locker, seat belt, safety grip, and high roof. Third, in case of rear slope, high roof and width of manual or automatic wheel chairs should be considered and motor-operated device should also be taken into account for safety lockers, which make a wheelchair firmly fixed. Moreover, motor-operated seat and rear slope can be chosen for either of the disabled and the elderly.

• Food Science and Industry
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• v.55 no.2
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• pp.128-139
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• 2022

Although edible insects are attracting attention as future alternative food because of their nutritional, eco-friendly, and economic advantages and functionality, consumption is low, so measures to promote consumption are needed. The problems in edible insect consumption were identified as the aversion to the edible insects, lack of publicity for edible insects newly registered in the Food Code, and difficulties in continuously supplying high-quality edible insects and selling products. To solve these problems, it is necessary to establish effective public relations plans for new edible insects and develop processing methods for improving their taste and flavor, education content about edible insects, and products interesting to the target age. In addition, it is necessary to establish a one-stop cluster that can perform quality control of harmful substances and nutrients, purchase raw materials, sell products, educate, and publicize.

• 한국체육학회지인문사회과학편
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• v.57 no.6
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• pp.263-272
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• 2018

This study examined the association of gait variability and physical fitness with frailty status in older women. In a cross-sectional design, 168 elderly women, aged 65 years and older (75.07±5.40 years), measured body composition, gait parameters gait variability, physical fitness variables, MMSE-DS and CES-D. Subjects were classified as robust, pre-frail, and frailty based on the Fried et al.(2001) criteria for frailty weight loss, exhaustion, low hand-grip strength, low gait speed, and physical inactivity. Logistic regression analyses were used to determine the odds ratio (ORs) and 95% confidence interval (CI) of frailty status for having gait variability and physical fitness levels. Compared to the robust group (OR=1), the frailty group had significantly higher ORs of having terminal double limb stance (OR=1.48, 95% CI=0.10-2.21, p=.049), step cadence (OR=2.06, 95%CI=1.20-3.43, p=.009) variability, and significantly lower ORs of having upper-strength (OR=0.49, 95%CI=0.31-0.77, p=.002) even after adjusting for age, education, comorbidity, K-IADL, MMSE-KC and CES-D score. The finding of this study suggested that terminal double limb stance, step cadence and upper body muscular strength were independent predictors of frailty.

• Health Policy and Management
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• v.34 no.2
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• pp.156-162
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• 2024

Background: This study aimed to explore the relationship between frailty and Area Deprivation Index (ADI) among older adults in Korea. Methods: We used data from the Korea National Health and Nutrition Examination Survey from 2014 to 2019, focusing on individuals aged 65 years and older. Frailty was assessed using Fried phenotype of frailty criteria. A multiple logistic regression analysis was conducted to assess the relationship between frailty and ADI adjusted for all covariates. Results: Among 9,825 older adults, those who lived in an area with a high ADI had a 1.2-fold higher risk of frailty compared to those who lived in an area with a low ADI (odds ratio [OR], 1.23; 95% confidence interval [CI], 1.09-1.37). Particularly, married individuals living in areas with a high ADI had an approximately 1.4-fold higher risk of frailty compared to those living in areas with a low ADI (OR, 1.35; 95% CI, 1.16-1.57). Conclusion: This study reveal a significant relationship between frailty and the ADI among older adults. In particular, married individuals who live in areas with a high ADI were found more vulnerable to frailty than those who live in areas with a low ADI. Therefore, policy intervention should be implemented to reduce health inequalities among older people, especially those living in the most deprived areas groups.

• Journal of Chest Surgery
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• v.30 no.5
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• pp.501-505
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• 1997

It was reported that use of aprotinin in elderly patients undergoing hypothermic circulatory arrest was associated with an increased risk of renal dysfunction, and myocardial infarction as a result of intravascular coagulation. We reviewed 20 patients who received high-dose aprotinin under deep hypothermic circulatory arrest with(NP group, n= 11) or without selective cerebral perfusion(SP group, n=9). The activated clotting time was exceeded 750 seconds in all but 1 patient. After opening aortic arch, retrograde low flow perfusion was maintained through femoral artery to prevent air embolization to the visceral arteries. Four patients among 20 died during hospitalization'due to bleeding, coronary artery dissection pulmonary hemorrhage and multiple cerebral infarction. Postoperatively, cerebrovascular accidents occurred in two patients; one with preoperative carotid artery dissection and the other with unknown multiple cerebral infarction. In conclusion, use of aprotinin in young patients undergoing hypothermic circulatory arrest did not increase the risk of renal dysfunction or intravascular coagulation if ACT during circulatory arrest is maintained to exceed 750 seconds with low-flow perfusion.

• Korean Institute of Interior Design Journal
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• v.13 no.2
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• pp.120-132
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• 2004

고령사회 2001의 발표에 의하면, 노년인구의 증가는 전 세계적으로 21세기까지 지속될 전망이며, 우리나라도 예외가 아니어서 이에 대한 심각한 사회문제가 예상되고, 이들을 위한 특수주거시설에 대한 환경개선이 요망된다. 본 연구는 노인주거복지시설에서 색채와 조명에 대한 개선방향을 제시하기 위한 것으로, 색채와 조명환경을 정량적, 정성적으로 비교 분석하는데 연구의 목적이 있다. 이를 위해 2003년 2월부터 8월까지 우리나라와 미국의 양로시설 20사례에 대한 현장방문조사가 수행되었고, 모든 시설이 공통적으로 가지고 있는 로비, 복도, 식당, 침실 등 4개 영역이 집중적으로 조사되었다. 1) 색상분포도 조사 결과, 한국시설은 미국 시설과 달리 주조색으로 한색을 많이 사용하고 있으며, 보조색, 강조색의 활용도가 낮은 것으로 나타났다. 2) 색상$\cdot$명도의 간격별 조화 정도에 대한 정량적 평가를 통해 한국시설은 명도대비보다는 색상대비가, 유사조화보다는 대비조화가 두드러졌는데 기능적 측면에서는 이상적이나 친근한 분위기를 만들기에는 한계가 있다. 3) 미도(Aesthetic Measure) 측정 결과, 한국과 미국 시설 모두 평균 이상을 보였는데, 특히 한국시설은 색상 대비 이외에 유사색 조화와 같은 질서요소를 강화시킬 필요가 있다. 4) 한국시설은 미국에 비해 조명 환경이 매우 열악하였는데, 자연채광의 유입은 어느정도 만족스러우나 이를 양질의 조명으로 만들기 방안이 요구된다. 5) 조명방식, 광원유형 등 인공조명에 대한 분석 결과, 한국시설은 매우 단순하며 경제적인 방법에 의존하고 있는데 광원의 선택, 배치, 설치 등 기술적인 보완이 요구된다. 6) 한국시설들의 시설별, 영역별 평균조도는 매우 낮은데, 활동시간대의 권장조도 유지는 물론, 영역 간의 조도 차이를 줄이는 방안이 요구된다.신만의 고유한 해결책으로 발전시키는지를 고찰하고자 한다. 본 논문의 목적은 서울을 사례분석 중 하나로 사용하여 인테리어 디자인 분야의 경계를 대도시로 확장하는 동시에 새로운 적용영역의 가능성을 탐구하는데 있다 하겠다.[C/N]의 값을 나타내었다.다.다.화 기술, 구동방법등에 대한 기술개요와 국내외 기술동향에 대하여 소개하고자 한다.었다.다._{2}$가 0.25[wt%] 첨가된 시편의 20[.deg.C]에서의 유전상수는 16,700으로 최대값을 유전손실을 1.28[%]로 최소값을 나타내었다. 또한 모든 시편은 온도 및 주파수에 따라 유전상수가 완만하게 변화하는 유전이완 특성을 나타내었다.다.수적인 물의 양에 따른 DIAION WA30의 라세미화 효율에 관하여 실험한 결과, 물의 양이 증가할수록 그 효율은 감소하였다. DIAION WA30을 라세미화 촉매로 사용하여 아이소옥탄 내에서 라세믹 나프록센 2,2,2-트리플로로에틸 씨오에스터의 효소적 DKR 반응을 수행해 보았다. 그 결과 DIAION WA30을 사용하지 않은 경우에 비해 반응 전환율과 생성물의 광학 순도는 급격히 향상되었다. 전통적 광학분할 반응의 최대 50%라는 전환율의 제한이 본 연구에서 찾은 DIAION WA30을 첨가함으로써 성공적으로 극복되었다. 또한 고체 염기촉매인 DIAION WA30의 사용은 라세미화 촉매의 회수 및 재사용이 가능하게 해준다.해준다.다. TN5 세포주를 0.2 L 규모 (1 L spinner flask)oJl에서 세포간의 응집현상 없이 부유배양에 적응,배양시킨 후 세포성장 시기에 따른 발현을 조사한 결과 1 MOI의 감염조건 하에서는 $0.6\times10^6$cell/mL의 early exponential시기의 세포밀도에서 72시간 배양하였을 대 최대 발현양을 나타내었다. 나타내었다.

• Journal of radiological science and technology
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• v.36 no.4
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• pp.273-280
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• 2013

This study was proven for the T-spine breathing technique in lateral projection, using computer radiography (CR), charge coupled device (CCD), indirect digital radiography (IDR) and direct digital radiography (DDR). All images were evaluated and compared with CNR and SNR measured with the mean pixels and the standard deviation as setting ROI of spinous process, pedicle, vertebral body, intervertebral foramen and intervertebral disk using Image J. In experiment results of 4 type detectors, T-spine breathing technique was indicated as excellent in ROI of spinous process, pedicle, vertebral body, intervertebral foramen and intervertebral disk. As T-spine breathing technique indicated excellent images compared to the existing T-spine lateral radiography, this method would be useful for elderly patients who have difficulty in deep exhalation. This study was indicated the application possibility of T-spine breathing technique by presenting contrast to noise ratio (CNR) and signal to noise ratio (SNR) with quantitative value in 4 type detectors.

• Therapeutic Science for Rehabilitation
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• v.7 no.1
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• pp.51-62
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• 2018

Objective : This study was to verify the effects of occupation-based training with errorless learning and spaced retrieval on task learning and satisfaction of elderly with mild vascular dementia. Methods : The subjects of this study were 3 geriatric individuals with mild vascular dementia, ABA' + follow-up design was used. Intervention period was provided occupation-based training with errorless learning and spaced retrieval. The dependent variable was converted to ability of task performance every session and satisfaction before and after intervention. Result analysis was suggested through visual analysis and bar graph. Results : After the occupation-based training with errorless learning and spaced retrieval, Ability of task performance and satisfaction improved for all subjects. Conclusions : From this study, occupation-based training with errorless learning and spaced retrieval training was found to be an effective mediation for improving independence of task and satisfaction for people with mild dementia. This study could provide evidence for clinical application for occupation-based training.